Study on nerve regeneration in the Maxillofacial domain due to the artificial neural tube (PGA-Collagen tube) using the iPS cell
Project/Area Number |
22390385
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Surgical dentistry
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Research Institution | Kyoto University |
Principal Investigator |
SHIGENO Keiji 京都大学, 再生医科学研究所, 非常勤講師 (00162587)
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Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Tatsuo 京都大学, 再生医科学研究所, 准教授 (70227908)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
|
Keywords | 人工神経管 / PGA-コラーゲンチューブ / イヌiPS細胞 / 神経幹細胞様細胞 / 細胞誘導 / iPS(多分化能)状態の維持 / 神経再生実験 / iPS(多分化能)状態の維持 / iPS / 神経再生 / in situ Tissue Engineering / 分化誘導 / C.R.P.S / 人工神経 / 下顎 / 組織工学 / 口腔外科 / 再生医療 / 機能再生 |
Research Abstract |
We were able to get early healing of motor nerves and mixed nerve reproduction by three dimensions culturing dog induced pluripotent stem cells (embryo stem cells) made for the first time in the world in our laboratory to the artificial neural tube which was synthetic macromolecule + collagen complex, and rearranging this with nerve damage region. For neuropathic sharp pain (particularly intractable sharp pain - so-called C.R.P.S) that was taking place for the mandibular nerve damage by this, We were able to develop an effective cure.
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Report
(4 results)
Research Products
(131 results)
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[Journal Article] Transforming Growth Factor/33 for the prevention of vocal fold scarring2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Kitani, Y., Kojima, T., Ishikawa, S., Mizuta, M., Tateya, I., Nakamura, T., Ito, J.
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Journal Title
Laryngoscope
Volume: 122
Issue: 3
Pages: 583-589
DOI
Related Report
Peer Reviewed
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[Journal Article] Regeneration of Tracheal Epithelium Using a Collagen Vitrigel-Sponge Scaffold Containing Basic Fibroblast Growth Factor2012
Author(s)
Tani, A., Tada, Y., Takezawa, T., Imaizumi, M., Nomoto, Y., Nakamura, T., Omori, K
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Journal Title
Annals of Otology, Rhinology & Laryngology
Volume: 121(4)
Pages: 261-268
Related Report
Peer Reviewed
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[Journal Article] Regeneration of canine inferior alveolar nerve by polyglycolic acid-collagen tube2012
Author(s)
Shigeno, K., Nakada, A., Kaneko, M., Wakatsuki, M., Hashimoto, Y., Inada, Y., Nakamura, T
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 569-569
Related Report
Peer Reviewed
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[Journal Article] Promotion of bone repairing by use of novel Collagen scaffold in Rabbit skull defect model2012
Author(s)
Wakatsuki, M., Kaneko, M., Sasauchi, K., Nakada, A., Shigeno, k., Nakamura, T
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 591-591
Related Report
Peer Reviewed
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[Journal Article] Artificial trachea and In situ tissue engineering:twelve gean-follow up.in canine model2012
Author(s)
Nakamura, T., Fumitsugu, K., Sato, T., Nakada, A., Wakatsuki, M., Sasauchi, K., Kida, N., Kanemaru, S., Omori, K., Kaneko, M., Shigeno, k., Inada, Y., Endo, K
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Journal Title
Int Artif Organs
Volume: 35(8)
Pages: 608-608
Related Report
Peer Reviewed
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[Journal Article] Role of Circulating Mesenchymal Stem Cells in Vocal Fold Wound Healing2012
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Mizuta, M., Ishikawa, S., Tateya, I., Nakamura, T., Ito, J
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Journal Title
Laryngoscope
Volume: 122(11)
Issue: 11
Pages: 2503-2510
DOI
Related Report
Peer Reviewed
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[Journal Article] Increased expression of phosphatidylcholine (16:0/18:1) and (16:0/18:2) in thyroid papillary cancer2012
Author(s)
Ishikawa, S., Tateya, I., Hayakawa, T., Masaki, N., Takizawa, Y., Ohno, S., Kojima, T., Kitani, Y., Kitamura, M., Hirano, S., Setou, M., Ito, J
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Journal Title
PLoS One
Volume: 7(11)
Issue: 11
Pages: e48873-e48873
DOI
Related Report
Peer Reviewed
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[Journal Article] Malignant melanoma of the head and neck : A multi-institutional retrospective analysis of cases in Northern Japan2012
Author(s)
Shiga K, Ogawa T, Kobayashi T, Ueda S, Kondo A, Nanba A, Kuwashima S, Asada Y, Suzuki S, Nagahashi T, Takahashi M, Suzuki M, Ishida A, Watanabe K, Harabuchi Y, Himi T, Shinkawa H, Sato H, Saijyo S, Fukuda S, Tanaka K, Ishikawa K, Omori K, Aoyagi M, Hashimoto S
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Journal Title
Head Neck
Volume: (in press)
Issue: 11
Pages: 1537-1541
DOI
Related Report
Peer Reviewed
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[Journal Article] Implantation of an atelocollagen sponge with autologous bone marrow-derived mesenchymal stromal cells for treatment of vocal fold scarring in a canine model2011
Author(s)
Ohno, S., Hirano, S., Kanemaru, S., Kitani, Y., Kojima, T., Tateya, I.Nakamura, T., Ito, J
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 120
Pages: 401-408
Related Report
Peer Reviewed
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[Journal Article] Feasibility study of corticosteroid treatment for esophageal ulcer after EMR in a canine model2011
Author(s)
Honda, M., Nakamura, T., Hori, Y., Shionoya, Y., Yamamoto, K., Nishizawa, Y., Kojima, F., Shigeno, K.
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Journal Title
Journal of Gastroenterology
Volume: 46
Issue: 7
Pages: 866-872
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Development of a novel ant adhesive material, alginate flakes, ex vivo and in vivo2011
Author(s)
Hirasaki, Y., Fukunaga, M., Kidokoro, A., Hashimoto, A., Nakamura, T., Tsujimoto, H., Hagiwara, A.
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Journal Title
Surg today
Volume: 41
Issue: 7
Pages: 970-977
DOI
Related Report
Peer Reviewed
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[Journal Article] A tissue-engineering approach for stenos is of the trachea and/or cricoid2010
Author(s)
Kanemaru, S., Hirano, S., Umeda, H., Yamashita, M., Suehiro, A., Nakamura, T., Maetani, T., Omori, K., Ito, J.
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Journal Title
Acta Otolaryngol Suppl
Volume: 130
Issue: sup563
Pages: 79-83
DOI
Related Report
Peer Reviewed
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[Journal Article] Potential of induced pluripotent stem cells for the regeneration of the tracheal wall2010
Author(s)
Imaizumi, M., Nomoto, Y., Sugino, T., Miyake, M., Wada, I., Nakamura, T., Omori, K
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 119
Pages: 697-703
URL
Related Report
Peer Reviewed
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[Journal Article] A tissue-engineered trachea derived from a framed collagen scaffold gingival fibroblasts and adipose-derived stem cells2010
Author(s)
Kobayashi, K., Suzuki, T., Nomoto, Y., Tada, Y., Miyake, M., Hazama, A., Wada, I., Nakamura, T., Omori, K
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Journal Title
Biomaterials
Volume: 31
Issue: 18
Pages: 4855-4863
DOI
Related Report
Peer Reviewed
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[Journal Article] Generation of canine induced pluripotent stem cells by retroviral transduction and chemical inhibitors2010
Author(s)
Shimada, H., Nakada, A., Hashimoto, Y., Shigeno, K., Shionoya, Y., Nakamura, T.
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Journal Title
Molecular Reproduction and Development
Volume: 77
Issue: 1
Pages: 2-2
DOI
Related Report
Peer Reviewed
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[Journal Article] Treatment of acute vocal fold scar with local injection of basic fibroblast growth factor : a canine study2010
Author(s)
Suehiro, A., Hirano, S., Kishimoto, Y., Rousseau, B., Nakamura, T., Ito, J.
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Journal Title
Acta Otolaryngol
Volume: 130
Issue: 7
Pages: 844-850
DOI
Related Report
Peer Reviewed
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[Journal Article] Male sexual dysfunction after rectal cancer surgery2010
Author(s)
Nishizawa, Y., Saito, N., Ito, M., Sugito, M., Kobayashi, A., Nishizawa, Y
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Journal Title
Colorectal Dis
Volume: 12
Pages: 8-8
Related Report
Peer Reviewed
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[Journal Article] Observation of the esophagus, pharynx and lingual root by gastrointestinal endoscopy with a percutaneous retrograde approach2010
Author(s)
Honda, M., Hori, Y., Shionoya, Y., Nakada, A., Sato, T., Kobayashi, T., Shimada, H., Kida, N., Nakamura, T.
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Journal Title
World J Gastrointest Endosc
Volume: 16
Issue: 8
Pages: 288-292
DOI
Related Report
Peer Reviewed
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[Journal Article] Process of healing of mucosal defects in the esophagus after endoscopic mucosal resection: histological evaluation in a dog model2010
Author(s)
Honda, M., Nakamura, T., Hori, Y., Shionoya, Y., Nakada, A., Sato, T., Yamamoto, K., Kobayashi, T., Shimada, H., Kida, N., Hashimoto, A., Hashimoto, Y
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Journal Title
Endoscopy
Volume: 42
Pages: 1092-1095
Related Report
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[Journal Article] Glottal reconstruction with a tissue engineering technique using polypropylene mesh: a canine experiment2010
Author(s)
Yamashita, M., Kanemaru, S., Hirano, S., Umeda, H., Kitani, Y., Omori, K., Nakamura, T., Ito, J
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Journal Title
Ann Otol Rhinol Laryngol
Volume: 119(2)
Pages: 110-117
Related Report
Peer Reviewed
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[Presentation] PROMOTION OF BONE REPAIRING BY USE OF NOVEL COLLAGEN SCAFFOLDS IN RABBIT SKULL DEFECT MODEL2012
Author(s)
Wakatsuki, M., Kaneko, M., Sasauchi, K., Nakada, A., Shigeno, K., Nakamura, T
Organizer
39th Annual ESAO Congress
Place of Presentation
Rostock (Germany)
Related Report
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[Presentation] REGENERATION OF CANINE INFERIER ALVEOLAR NERVE BY POLGLY-COLIC ACID-COLLAGEN TUBE2012
Author(s)
Shigeno, K., Shionoya, Y., Nakada, A., Kaneko, M., Wakatsuki, M., Hashimoto, Y., Inada, Y., Nakamura, T
Organizer
39th Annual ESAO Congress
Place of Presentation
Rostock (Germany)
Related Report
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[Presentation] Autologous transplantation of adipose-derived stromal cells prevent esophageal stricture after endoscopic mucosal resection in a canine model2010
Author(s)
Honda, M., Hori, Y., Nakada, A., Uji, M., Nishizawa, Y., Yamamoto, K., Kobayashi, T., Shimada, H., Kida, N., Sato, T., Nakamura, T
Organizer
第63回日本胸部外科学会
Place of Presentation
大阪
Year and Date
2010-10-26
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[Presentation] Transplantation of adipose-derived stromal cells prevent esophageal stricture after endoscopic mucosal resection in canine model2010
Author(s)
Honda, M., Hori, Y., Nakada, A., Uji, M., Nishizawa, Y., Yamamoto, K., Kobayashi, T., Shimada, H., Kida, N., Sato, T., Nakamura, T
Organizer
European Society for Artificial Organs 37thCongress
Place of Presentation
Skopje (Macedonia)
Year and Date
2010-09-10
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[Presentation] 人工神経の基礎と臨床2010
Author(s)
中村達雄、萩原明於、稲田有史、金丸眞一
Organizer
第21回末梢神経学会学術集会
Place of Presentation
仙台
Year and Date
2010-09-04
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[Presentation] The association between anal function and histological neural change after preoperative chemoradiotherapy followed by ISR2010
Author(s)
Nishizawa, Y., Saito, N., Ito, M., Sugito, M., Kobayashi, A., Nishizawa, Y.
Organizer
15th Congress of the European Society of Surgical Oncology (ESSO)
Place of Presentation
Bordeaux(FRANCE)
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[Presentation] Male sexual dysfunction after rctal cancer surgery2010
Author(s)
Nishizawa, Y., Saito, N., Ito, M., Sugito, M., Kobayashi, A., Nishizawa, Y
Organizer
5th EUROPIAN SOCIETY OF COLOPRPCTOLOGY (ESCP)
Place of Presentation
Sorrento(Italy)
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