| Project/Area Number |
22390388
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Sapporo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
DEHARI Hironari 札幌医科大学, 医学部, 助教 (00381260)
MIYAZAKI Akihiro 札幌医科大学, 医学部, 准教授 (10305237)
OGI Kazuhiro 札幌医科大学, 医学部, 訪問研究員 (40433114)
SASAKI Takanori 札幌医科大学, 医学部, 研究員 (50548732)
NAKAMORI Kenji 札幌医科大学, 医学部, 講師 (60295334)
KOBAYASHI Jyunichi 札幌医科大学, 医学部, 助教 (80404739)
SOGABE Youhei 札幌医科大学, 医学部, 研究員 (50468104)
YAMAMOTO Takashi 札幌医科大学, 医学部, 研究員 (50448594)
SHIMANISHI Makoto 札幌医科大学, 医学部, 研究員 (10516561)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2010: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
|---|
| Keywords | 口腔がん / βカテニン / 低酸素 / 上皮-間葉転換 / GLUT-1 / NF-κB/p65 / 口腔癌 / EMT / 化学療法 / がん発育先進部 / HIF-1 |
|---|
| Research Abstract |
Hypoxic regions in solid tumors mediate malignant transformation, cancer cell proliferation, resistance to anti-cancer agents, and enhanced cellular invasion and metastasis. In this study, we found that the wnt/β-catenin pathway activation mediates the acquisition of invasion and metastatic potential in oral squamous cell carcinoma cells. Hypoxia enhances the expression of glucose transporter 1 (GLUT1) and anticancer drug resistance, and activates NF-κB/p65 to trigger cell proliferation.
|
