| Project/Area Number |
22390395
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | Seijoh University |
|---|
Principal Investigator |
KUBO Kin-ya 星城大学, リハビリテーション学部, 教授 (00329492)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
IINUMA Mitsuo 朝日大学, 歯学部, 准教授 (70184364)
CHEN Huayue 岐阜大学, 医学研究科, 講師 (20273146)
ONOZUKA Minoru 神奈川歯科大学, 歯学部, 名誉教授 (90084780)
ICHIHASHI Yukiko 朝日大学, 歯学部, 助教 (70515634)
KARASAWA Nobuyuki 星城大学, リハビリテーション学部, 名誉教授 (70148287)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 小児歯科学 / チューイング / 母胎ストレス / 空間認知能 / 情動行動 / 神経細胞新生 / コルチコステロン / 神経細胞成長 / カテコールアミン / 妊婦ストレス / 神経発達 / 細胞新生 / グルココルチコイド / 海馬 / 妊娠ストレス / 認知機能 / 情動 |
|---|
| Research Abstract |
Maternal stress induces developmental brain impairment, emotional abnormalities, and learning deficits in pups. Maternal chewing prevents the stress-induced increase in plasma corticosterone levels in dams, as well as neurodevelopmental disorders, anxiety-like behavior, and learning deficits in the pups. Maternal chewing is an effective stress-coping method for the dams to prevent learning deficits in pups.
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