| Project/Area Number |
22390398
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
OCHIAI Tomoko 日本大学, 松戸歯学部, 准教授 (20130594)
|
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Masafumi 日本大学, 松戸歯学部, 教授 (80210558)
OGUCHI Sumito 日本大学, 松戸歯学部, 准教授 (30366611)
OGATA Yorimasa 日本大学, 松戸歯学部, 教授 (90204065)
HASHIZUME Tomomi 日本大学, 松戸歯学部, 助手 (50419785)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 感染 / 歯周病 / 歯周病原細菌 / 動脈硬化 / 自己免疫疾患 / 経口免疫寛容 |
|---|
| Research Abstract |
Not only live bacteria but also the cellular components, such as LPS have been participated in acceleration of the atherosclerosis by periodontopathic bacteria,and affected expression of TLR,MLR and oxidant stress,or HSP. The increase in autoantigens by periodontal infection was TLR dependent and correlated with the increase in autoantibody in clinical samples.Furthermore, it was suggested that oxidative modefication of LDL by periodontopathic bacteria induced autoimmune disorder.In contrast, immunization with P.gingivalis GroEL suppressed atherosclerosis with the reduction of inflammatory markers and autoimmune markers. These results suggest that oral tolerance induction is effective in reducing arteriosclerosis.
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