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A retrospective cohort study of the mutual association between periodontal etiology and metabolic syndrome

Research Project

Project/Area Number 22390401
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionKyushu University

Principal Investigator

YAMASHITA Yoshihisa  九州大学, 歯学研究院, 教授 (20192403)

Co-Investigator(Kenkyū-buntansha) SHIMAZAKI Yoshihiro  九州大学, 大学院・歯学研究院, 准教授 (10291519)
TAKESHITA Toru  九州大学, 大学院・歯学研究院, 助教 (50546471)
ESHIMA Nobuoki  大分大学, 医学部, 教授 (20203630)
NISHIMURA Fusanori  広島大学, 医歯薬学総合研究科, 教授 (80208222)
Co-Investigator(Renkei-kenkyūsha) TANAKA Shunichi  日本赤十字社熊本健康管理センター
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2010: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywordsメタボリックシンドローム / 歯周疾患 / 抗体価 / 歯周病細菌 / 後ろ向きコホート研究
Research Abstract

We investigated the effect of serum Porphyromonas gingivalis (Pg) antibody level and general health on periodontal disease in Japanese people. This study included 447 subjects who had the medical and dental check-up in both 2003 and 2011. Excluding the subjects with had missing date, 430 subjects (mean age 58.6 +- 11.1 years, 308 males and 122 females) were analyzed in this study. Periodontal condition was assessed by Community Periodontal Index (CPI) in 2003 and 2011. Serum Pg antibody level in 2003 was measured. Additionally, general health such as overweight, fasting glucose, high-sensitivity C-reactive protein (hs-CRP) was assessed.The percentage of the subjects with CPI code <= 3 (periodontal disease) was 47.8% (males 49.7%, females 43.4%). We defined periodontal condition indicating CPI <= 2 in 2003 and CPI <= 3in 2011 or CPI <= 3 in both 2003 and 2011 as periodontal deterioration. Males and females with periodontal deterioration were 53.2% and 34.4%, respectively. Males and females with highest quintile of serum Pg antibody level were 18.2 and 25.4%. In logistic regression analysis, males having highest quintile of serum Pg antibody level and females with higher level of hs-CRP were more likely to have periodontal deterioration. These results suggest that serum Pg antibody level in males and general inflammation in females predict the incidence of periodontal disease.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (27 results)

All 2013 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (16 results)

  • [Journal Article] Relationship between normal serum creatinine concentration and periodontal disease in Japanese middle-aged males2013

    • Author(s)
      Shimazaki Yoshihiro, Kushiyama Misato, Murakamai Masatoshi, Yamashita Yoshihisa
    • Journal Title

      J Periodontol

      Volume: 84 (1) Issue: 1 Pages: 94-99

    • DOI

      10.1902/jop.2012.110528

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal status and metabolic syndrome in middle-aged Japanese2012

    • Author(s)
      Fukui Nao, Shimazaki Yoshihiro, Shinagawa Takashi, Yamashita Yoshihisa
    • Journal Title

      J Periodontol

      Volume: 83(11) Issue: 11 Pages: 1363-1371

    • DOI

      10.1902/jop.2012.110605

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal status and metabolic syndrome in middle-aged Japanese2012

    • Author(s)
      Nao Fukui, et al
    • Journal Title

      Journal of Periodontology

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周病とメタボリックシンドローム2011

    • Author(s)
      山下喜久
    • Journal Title

      The Bone

      Volume: 25 (4) Pages: 433-439

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effectiveness of the salivary occult blood test as a screening method for periodontal status2011

    • Author(s)
      Shimazaki, Y., et.al.
    • Journal Title

      J Periodontol

      Volume: 82(4) Issue: 4 Pages: 581-7

    • DOI

      10.1902/jop.2010.100304

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 歯周病とメクボリックシンドローム2011

    • Author(s)
      山下喜久
    • Journal Title

      The Bone

      Volume: 25 Pages: 433-439

    • Related Report
      2011 Annual Research Report
  • [Journal Article] メタボと歯周病の関係は?歯周病あると、メタボになりやすいですか2010

    • Author(s)
      山下喜久
    • Journal Title

      肥満と糖尿病

      Volume: 9 (5) Pages: 757-759

    • Related Report
      2012 Final Research Report
  • [Journal Article] 歯周病と糖尿病の疫学 -Hisayama Studyを中心として2010

    • Author(s)
      山下喜久
    • Journal Title

      Diabetes Frontier

      Volume: 21 (5) Pages: 537-541

    • Related Report
      2012 Final Research Report
  • [Journal Article] 歯周病と糖尿病の疫学-Hisayama Studyを中心として2010

    • Author(s)
      山下喜久
    • Journal Title

      Diabetes Frontier

      Volume: 21 Pages: 537-541

    • Related Report
      2010 Annual Research Report
  • [Journal Article] メタボと歯周病の関係は?歯周病があると、メタボになりやすいですか2010

    • Author(s)
      山下喜久
    • Journal Title

      肥満と糖尿病

      Volume: 9 Pages: 757-759

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Gender differences in the association between metabolic syndrome and periodontal disease:the Hisayama Study

    • Author(s)
      Furuta Michiko, Shimazaki Yoshihiro, Takeshita Toru, Shibata Yukie, Akifusa Sumio, Eshima Nobuoki, KiyoharaYutaka, Ninomiya Toshiharu, HirakawaYoichiro, Mukai Naoko, NagataMasaharu, Yamashita Yoshihisa
    • Journal Title

      J Clin Periodontol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Relationship between physical activity and periodontal disease: The Hisayama Study2013

    • Author(s)
      Shimazaki Yoshihiro, Kishimoto Hiro, Ninomiya Toshiharu, Kiyohara Yutaka, Kumagi Shuzou, Yamashita Yoshihisa
    • Organizer
      91st General Session & Exhibition of the IADR
    • Place of Presentation
      Seattle (USA)
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Relationship between Physical Activity and Periodontal Disease: The Hisayama Study2013

    • Author(s)
      Y Shimazaki, H Kishimoto, T Ninomiya, Y Kiyohara, S Kumagai, Y Yamashita
    • Organizer
      The 91st General session & exhibition of the IADR
    • Place of Presentation
      Seattle
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gender differences in the association between periodontitis and metabolic syndrome2013

    • Author(s)
      M Furuta, Y Shimazaki, T Takeshita, Y Shibata, S Akifusa, N Eshima, Y Kiyohara, T Ninomiya, Y Hirakawa, M Mukai, Masaharu N, Y Yamashita
    • Organizer
      The 91st General session & exhibition of the IADR
    • Place of Presentation
      Seattle
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gender difference in the association of periodontal status and metabolic syndrome2012

    • Author(s)
      Yamashita Yoshihisa
    • Organizer
      60th Annual Meeting of Japanese Association of Dental Research
    • Place of Presentation
      Niigata(Japan)
    • Year and Date
      2012-12-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Comparison of oral health environment between Korean and Japanese adult population2012

    • Author(s)
      Yamashita Yoshihisa
    • Organizer
      The 2012 Annual Meeting of Korean Academy of Oral Health
    • Place of Presentation
      Seoul (Korea)
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Population based screening of periodontal disease and its effect on the health behavior of a community2012

    • Author(s)
      Yamashita Yoshihisa, Furuta Michiko, Shimazaki Yoshihiro, Morita Manabu, Adachi Munehisa, Kinoshita Toshinori
    • Organizer
      EUROPERIO7, 7th Conference of the European Federation of Periodontology
    • Place of Presentation
      Vienna (Austria)
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Relationship between amount of stimulated saliva and oral health status: the Hisayama Study2012

    • Author(s)
      Fu B, Shimazaki Yoshihiro, Akifusa Sumio, Takeshita Toru, Shibata Yukie, Ninomiya Toshiharu, Doi Yasufumi, Hata Jun, Hirakawa Yoichiro, Kiyohara Yutaka, Yamashita Yoshihisa
    • Organizer
      Japan-China Dental Conference 2012
    • Place of Presentation
      Chengdu (China)
    • Year and Date
      2012-04-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯周疾患健診の代用法としての自己記入式質問調査の実施結果2012

    • Author(s)
      古田美智子、嶋崎義浩、秋房住郎、森田学、山下喜久
    • Organizer
      第22回日本疫学学術総会
    • Year and Date
      2012-01-28
    • Related Report
      2012 Final Research Report
  • [Presentation] Gender difference in the association of periodontal status and metabolic syndrome2012

    • Author(s)
      Y Yamashita
    • Organizer
      The 60th Annual Meeting of Japanese Association for Dental Research
    • Place of Presentation
      Niigata
    • Related Report
      2012 Annual Research Report
  • [Presentation] Comparison of Oral Health Environment between Korean and Japanese Adult Population2012

    • Author(s)
      Y Yamashita
    • Organizer
      The 2012 Annual Meeting of Korean Academy of Oral Health
    • Place of Presentation
      Seoul
    • Related Report
      2012 Annual Research Report
  • [Presentation] Population based screening of periodontal disease and its effect on the health behavior of a community2012

    • Author(s)
      Yamashita Y, Furuta M, Shimazaki Y, Morita M, Adachi M, Kinoshita T
    • Organizer
      EUROPERIO7, 7th Conference of the European Federation of Periodontology
    • Place of Presentation
      Vienna
    • Related Report
      2012 Annual Research Report
  • [Presentation] Relationship between normal serum creatinine concentration and periodontal disease2012

    • Author(s)
      Shimazaki Y, Kushiyama M, Murakami M, Yamashita Y
    • Organizer
      Japan-China Dental Conference 2012
    • Place of Presentation
      Chengdu, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] Relationship between amount of stimulated saliva and oral health status: the Hisayama Study2012

    • Author(s)
      Fu B, Shimazaki Y, Akifusa S, Takeshita T, Shibata Y, Ninomiya T, Doi Y, Hata J, Hirakawa Y, Kiyohara Y, Yamashita Y
    • Organizer
      Japan-China Dental Conference 2012
    • Place of Presentation
      Chengdu, China
    • Related Report
      2012 Annual Research Report
  • [Presentation] 地域成人集団における刺激唾液分泌量と口腔健康状態との関連性:久山町研究2011

    • Author(s)
      傅博涵、嶋崎義浩、秋房住郎、竹下徹、柴田幸江、清原裕、山下喜久
    • Organizer
      第60回日本口腔衛生学会
    • Year and Date
      2011-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Oral microflora and oral and general health connection2010

    • Author(s)
      Yamashita Yoshihisa
    • Organizer
      The 2010 Annual Meeting of Korean Academy of Oral Health
    • Place of Presentation
      Pusan (Korea)
    • Year and Date
      2010-10-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 職域成人におけるメタボリック症候群と歯周疾患との関連性2010

    • Author(s)
      福井尚、品川隆、嶋崎義浩、山下喜久
    • Organizer
      第32回九州口腔衛生学会総会
    • Year and Date
      2010-07-25
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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