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A cohort study on the relationship between oral and systemic health conditions of island inhabitants

Research Project

Project/Area Number 22390402
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionNagasaki University

Principal Investigator

SAITO Toshiyuki  長崎大学, 医歯薬学総合研究科(歯学系), 教授 (10170515)

Co-Investigator(Kenkyū-buntansha) HAYASHIDA Hideaki  長崎大学, 病院(歯学系), 講師 (20238140)
KAWASAKI Koji  長崎大学, 病院(医学系), 准教授 (60161303)
MAEDA Takahiro  長崎大学, 医歯薬学総合研究科(医学系), 教授 (40284674)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords歯周病 / 歯周疾患 / 動脈硬化 / 疫学 / 頸動脈超音波検査 / 血清抗体価 / 酸化ストレス / 慢性炎症 / 頸動脈内膜中膜複合体厚(IMT) / アディポカイン
Outline of Final Research Achievements

Recent studies suggested an association between periodontitis and atherosclerosis; however, the relationship between periodontal status and arterial alterations was not clarified. We examined associations between periodontal status and carotid intimaemedia thickness (cIMT) and arterial stiffness using the cardio-ankle vascular index (CAVI) in a total of 1053 community dwellers (>=40 years with 10 teeth or more).
As results, in multi-variate analyses adjusted for age, sex, number of present teeth, and other confounders, both deep pocket and severe attachment loss were related to cIMT and also CAVI, significantly.
A linear, dose-dependent relationship was found between periodontal pocket depth, cIMT, and arterial stiffness.

Report

(5 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2014 2013 2012 2011 2010

All Journal Article (6 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Oxidative stress and antibody levels to periodontal bacteria in adults: The Nagasaki Islands study2014

    • Author(s)
      Tamaki N, Hayashida H, Fukui M, Kitamura M, Kawasaki K , Nakazato M, Maeda T, Saito T, Ito H.-O
    • Journal Title

      Oral Diseases

      Volume: 20(3) Issue: 3

    • DOI

      10.1111/odi.12127

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Association of periodontitis with carotid artery intima-media thickness and arterial stiffness in community-dwelling people in Japan: The Nagaski Islands Study2013

    • Author(s)
      Hayashida H
    • Journal Title

      Atherosclerosis

      Volume: in press Issue: 1 Pages: 186-191

    • DOI

      10.1016/j.atherosclerosis.2013.04.002

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress and antibody levels to periodontal bacteria in adults: The Nagasaki Islands Study2013

    • Author(s)
      Tamaki N
    • Journal Title

      Oral Diseases

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between adipokines and periodontitis.2010

    • Author(s)
      Furugen R
    • Journal Title

      Japanese Dental Science Review

      Volume: 46 Pages: 159-164

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周病が関連する疾患1,肥満2010

    • Author(s)
      齋藤俊行
    • Journal Title

      月刊糖尿病

      Volume: 2 Pages: 61-69

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 口腔疾患と生活習慣病の関係2010

    • Author(s)
      齋藤俊行
    • Journal Title

      Progress in Medicine

      Volume: 30 Pages: 2783-2788

    • Related Report
      2010 Annual Research Report
  • [Presentation] Levels of serum markers of oxidative stress and antibodies against periodontal pathogens in community-dwelling adults with and without periodontitis: Goto study2012

    • Author(s)
      Tamaki N
    • Organizer
      First International Conference on Porphyromonas gingivalis and Related Bacterial Species
    • Place of Presentation
      Nagasaki, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Relationship between atherosclerosis and anti-phosphorylcholine antibody in saliva and plasma2012

    • Author(s)
      Fukui M
    • Organizer
      10th International conference of Asian academy of preventive dentistry
    • Place of Presentation
      Ulaanbaatar Mongolia
    • Related Report
      2012 Annual Research Report
  • [Presentation] 離島地域住民における歯科保健行動について:五島研究2012

    • Author(s)
      林田淑子
    • Organizer
      第61回日本口腔衛生学会・総会
    • Place of Presentation
      横須賀市
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性-第二報-2012

    • Author(s)
      福井 誠
    • Organizer
      第61回日本口腔衛生学会・総会
    • Place of Presentation
      横須賀市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 動脈硬化リス評価のための唾液・血中の抗ホスホリルコリン抗体の測定2012

    • Author(s)
      福井 誠
    • Organizer
      日本口腔検査学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 歯周病と動脈硬化に関する疫学調査:五島研究2011

    • Author(s)
      岩崎理浩
    • Organizer
      九州口腔衛生学会総会
    • Place of Presentation
      熊本
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯周病と動脈硬化に関する疫学調査:五島研究2011

    • Author(s)
      林田秀明
    • Organizer
      日本口腔衛生学会総会
    • Place of Presentation
      日本口腔衛生学会総会
    • Year and Date
      2011-10-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性:五島研究2011

    • Author(s)
      福井誠
    • Organizer
      日本口腔衛生学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-10
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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