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Research on association between dry mouth and digestive diseases and role as a clinical predictor

Research Project

Project/Area Number 22390403
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionKyushu Dental College

Principal Investigator

ANSAI Toshihiro  九州歯科大学, 歯学部, 教授 (80244789)

Co-Investigator(Kenkyū-buntansha) SOH Inho  九州歯科大学, 歯学部, 助教 (10285463)
AWANO Shuji  九州歯科大学, 歯学部, 講師 (20301442)
YOSHIDA Akihiro  九州歯科大学, 歯学部, 助教 (20364151)
TAKATA Yutaka  九州歯科大学, 歯学部, 教授 (40163208)
SONOKI Kazuo  九州歯科大学, 歯学部, 准教授 (50316155)
NAKAMICHI Ikuo  九州歯科大学, 歯学部, 講師 (60419570)
INENAGA Kiyotoshi  九州歯科大学, 歯学部, 教授 (90131903)
TAKEHARA Tadamichi  九州歯科大学, 歯学部, 名誉教授 (00038879)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords口腔乾燥症 / 上部消化器疾患 / GERD / 唾液 / 口臭
Research Abstract

Oral dryness and its related diseases including burning mouth and disgeusia is being increasing among the elderly, while gastro esophageal reflux disease (GERD) and non-erosive reflux disease (NERD) is also increasing. The aim of this study was to investigate the association between oral dryness-related diseases and digestive diseases such as GERD/NERD in the elderly individuals of care houses and senior college. Our items of the survey were oral examination including tongue and swallowing function. The results showed that the 60% of individuals with GERD/NERD had oral dryness, and 25% of the individuals had burning mouth and disgeusia. The elderly with oral dryness had higher risk of GERD/NERD approximately 5 times than those without oral dryness (Odds ratio, 4.8, 95% Confidence Intervals, 1.1 -21.0). Furthermore, there were significant associations between oral dryness and gastrointestinal hypomotility, and between burning mouth/disguesia and gastrointestinal reflux. These findings suggest that dental practitioners need to know the association between oral dryness and digestive diseases, and also promote the medical-dental cooperation.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2013 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 7 results) Presentation (6 results) (of which Invited: 1 results) Book (4 results) Remarks (4 results)

  • [Journal Article] Salivary levels of cortisol and chromogranin A in patients with burning mouth syndrome: A case-control study2013

    • Author(s)
      Shigeyama-Haruna, C., Soh, I., Yoshida, A., Awano, S., Anan, H. and Ansai, T
    • Journal Title

      Open Journal of Stomatology

      Volume: 3 Pages: 39-43

    • Related Report
      2012 Final Research Report
  • [Journal Article] Salivary levels of cortisol and chromogranin A in patients with burning mouth syndrom2013

    • Author(s)
      Shigeyama-Haruna, C. et al.
    • Journal Title

      Open J Stomatology

      Volume: 3 Pages: 39-43

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 虚弱(frailty)の視点からみたドライマウス2012

    • Author(s)
      安細敏弘
    • Journal Title

      8020会誌

      Volume: 11 Pages: 99-103

    • Related Report
      2012 Final Research Report
  • [Journal Article] 虚弱の視点からみたドライマウス2012

    • Author(s)
      安細敏弘
    • Journal Title

      8020会誌

      Volume: 11 Pages: 99-103

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Glomerular filtration rate and 10-year mortality in a 70-year-old community-dwelling Japanese population2011

    • Author(s)
      Takata, Y., Ansai, T., et al
    • Journal Title

      Aging Clin Res

      Volume: 23 Pages: 223-230

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between impaired dental status and cardiovascular mortality in elderly subjects2011

    • Author(s)
      Ansai, T., et al
    • Journal Title

      J Dent Hlth

      Volume: 61 Pages: 153-158

    • NAID

      40018835977

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation between health status and oralChroma-determined volatile sulfide levels in mouth air of the elderly2011

    • Author(s)
      Awano, S., et al
    • Journal Title

      J Breath Res

      Volume: 5 Issue: 4 Pages: 46007-46007

    • DOI

      10.1088/1752-7155/5/4/046007

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum albumin levels as an independent predictor of 4-year mortality in a community-dwelling 80-year-old population.2010

    • Author(s)
      Takata, Y., Ansai, T., et al.
    • Journal Title

      Aging Clin.Experimental Res.

      Volume: 22 Pages: 31-35

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quality of life and physical fitness in an 85-year-old population.2010

    • Author(s)
      Takata, Y., Ansai, T., et al.
    • Journal Title

      Arch Gerontol.Geriatr.

      Volume: 50 Pages: 272-276

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between tooth loss and mortality in 80-year-old Japanese community-dwelling subjects.2010

    • Author(s)
      Ansai, T., et al.
    • Journal Title

      BMC Public Health

      Volume: 10 Pages: 386-386

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 在宅高齢者の栄養状態と歯科との関連2013

    • Author(s)
      安細敏弘
    • Organizer
      平成240度研究教育事業部九州ブロック研修会(特別講演)
    • Place of Presentation
      北九州
    • Related Report
      2012 Final Research Report
  • [Presentation] 福岡県在住80歳高齢者を対象にした追跡コホート研究2011

    • Author(s)
      安細敏弘, ほか
    • Organizer
      九州歯科学会
    • Place of Presentation
      北九州
    • Year and Date
      2011-05-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Association between salivary cortisol levels and BMS2010

    • Author(s)
      Shigeyama, C., et al.
    • Organizer
      88th IADR
    • Place of Presentation
      Barcelona
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム「口は禍のもと‐口腔から考える全身医療」.80歳高齢住民の120間追跡による生命予後と喪失歯数との関連

    • Author(s)
      安細敏弘
    • Organizer
      第12回日本抗加齢医学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム「チーム医療‐嚥下食への取り組み」. 咀嚼・嚥下からみた介護予防

    • Author(s)
      安細敏弘
    • Organizer
      第11回日本健康・栄養システム学会九州地方会
    • Place of Presentation
      北九州
    • Related Report
      2012 Final Research Report
  • [Presentation] 咀嚼・嚥下からみた介護予防

    • Author(s)
      安細敏弘
    • Organizer
      第11回日本健康・栄養システム学会
    • Place of Presentation
      九州共立大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Association between tooth loss and cancer mortality in elderly subjects. In: Oral Health Care-Prosthodontics, Periodontology, Biology, Research and Systemic Conditions (ed. by Mandeep Singh Virdi)2012

    • Author(s)
      Ansai, T. and Takata, Y
    • Publisher
      InTech
    • Related Report
      2012 Final Research Report
  • [Book] Oral Health Care2012

    • Author(s)
      Ansai, T. et al.
    • Total Pages
      372
    • Publisher
      In Tech
    • Related Report
      2012 Annual Research Report
  • [Book] Oral health care-prosthodontics, periodontology, biology, research and systemic conditions2012

    • Author(s)
      Ansai, T., et al
    • Total Pages
      372
    • Publisher
      Intech
    • Related Report
      2011 Annual Research Report
  • [Book] これからはじめる 口腔機能向上事業ハンドブック2010

    • Author(s)
      安細敏弘
    • Total Pages
      60
    • Publisher
      永末書店
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www2.kyu-dent.ac.jp/dept/oral-health/

    • Related Report
      2012 Final Research Report
  • [Remarks] 九州歯科大学地域健康開発歯学分野

    • URL

      http://www2.kyu-dent.ac.jp/dept/oral-health

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www2.kyu-dent.ac.jp/dept/oral-health/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.kenkoyobou.net

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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