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The toxic substances as a factor of causing the region of a high risk of cancer incidencein China.

Research Project

Project/Area Number 22401008
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Environmental impact assessment/Environmental policy
Research InstitutionPrefectural University of Kumamoto

Principal Investigator

ARIZONO Koji  熊本県立大学, 環境共生学部, 教授 (70128148)

Co-Investigator(Kenkyū-buntansha) WATANABE Chiho  東京大学, 医学系研究科 (70220902)
ISHIBASHI Hiroshi  尚絅大学, 短期大学部 (90403857)
YOSHIDA Yoshitoku  名古屋大学, 医学研究科 (90506635)
ISHIBASHI Yasuhiro  熊本県立大学, 環境共生学部 (00212928)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords環境影響評価 / 環境政策 / 汚染 / 中国 / 癌村 / 水質汚染 / バイオアッセイ / リスク評価 / 遺伝毒性 / 一斉スクリーニング / データベース / イムノクロマト / 重金属類 / マイクロアレイ / 遺伝子発現
Research Abstract

The environmental samples (living environment water considered to contain toxic substance) were collected from the region and several the provinces which have a high risk of cancer incidence, and were analyzed the concentration of various chemical substances based on the information on the industrial area in China. As a result, o,p’-DDT was detected. Therefore, the ecology impact evaluation was performed using the DNA microarray of medaka. On the other hand, environmental water and food (agricultural products and a marine product) contamination of metals study using ICP-MS and the immune-chromatography whichspecialized in cadmium were cooperated with China Hainan CDC. At the area which conducted metallic pollution investigation of the heavy metal (cadmium and lead). The local resident's health survey was performed with metal analysis. The lead pollution of the Hainan marine products was detected in 0.005-0.717mg/kg, and River contamination of cadmium was detected 0.100x10-3 - 0.648 mg/kg was detected.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (63 results)

All 2013 2012 2011 2010 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (43 results) (of which Invited: 1 results) Book (2 results)

  • [Journal Article] Development of a novel GC/MS database for the determination of additives for containers and packaging and its application to processed foods' analysis2013

    • Author(s)
      Nakashima S, Ji H,Ishitobi S, Yamagami T, Asai K, K, Kadokami K, Musuga M, Kawamura Y, Koga M, Shinohara R , Ishibashi H, Tominaga N, Arizono K
    • Journal Title

      Japanese Journal of Food Chemistry

      Volume: 12(1) Pages: 42-51

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Theoretical estimation of measurement precision for materials in database of GC/MS2013

    • Author(s)
      Nakashima S, Ono Y, Yamagami T, Koga S, Shinohara R, Arizono K, Hayashi Y
    • Journal Title

      Environment and safety

      Volume: vol. 4(1) Pages: 3-8

    • NAID

      130003378386

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acute toxicity of 4-nonylphenol isomers to larval medaka Oryzias latipes2013

    • Author(s)
      Kobayashi J, Sun C, Ji H,Ishibash Y, Shinohara R, KogaM, Arizono K
    • Journal Title

      Environment and safety

      Volume: 4(1) Pages: 9-14

    • NAID

      130003378390

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel GC/MS database for the determination of additives for containers and packaging and its application to processed foods’ analysis,2013

    • Author(s)
      Nakashima S
    • Journal Title

      Japanese Journal of Food Chemistry

      Volume: 20(1) Pages: 42-51

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study of dietary phytoestrogens and estrogenic activity in pet animal diets2013

    • Author(s)
      Nakashima S,
    • Journal Title

      Japanese Journal of Food Chemistry

      Volume: 20(1) Pages: 22-30

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uncertainty depended on standard solution preparation for water quality examination and influence on accuracy of quantitative analysis2012

    • Author(s)
      Tahara M, Nakashima S, Sugimoto N, Ariozno K, Nishimura T
    • Journal Title

      Journal of Japan Water Works Association

      Volume: Vol81 (5) Pages: 10-16

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxicological effects of glyphosate formulation in Japanese medaka(Oryzas Latipes)2012

    • Author(s)
      Uchida M, Takumi, S, Tachikawa K, Yamauchi R, Goto Y, Matsusaki H,Nakamura H, Kagami Y, Kusano T, Arizono K
    • Journal Title

      The Journal of Toxicological. Sciences

      Volume: Vol. 37 (2) Pages: 245-254

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phytoremediation of various bisphenol derivatives by Portulaca oleraceacv2012

    • Author(s)
      Okuhata H, NinagawaM, TakemotoN, JiH, Miyasaka H, Ishibashi Y, Arizono K
    • Journal Title

      Bioengineerin

      Volume: Vol 115(1) Pages: 55-57

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of triclosan degradation process using pulse discharge in pure water (in Japanese).2012

    • Author(s)
      Matsuo H, Morodome A Sankoda K, Kobayashi J, Koga M, Ishibashi Y, Arizono K, Shinohara, R
    • Journal Title

      Environment and safety

      Volume: vol.3 Pages: 27-31

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toxicological effects of glyphosate formulation in Japanese medaka (Oryzas Latipes)2012

    • Author(s)
      Uchida M, Takumi, S, Tachikawa K, Yamaushi R, Goto Y, Matsusaki H, Nakamura H, Kagami Y, Kusano T, Arizono K
    • Journal Title

      The Journal of Toxicological. Sciences, Vol.2012

      Volume: 37(2) Pages: 245-254

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Removal of bisphenol A related compounds by Portulaca oleracea (in Japanese)2011

    • Author(s)
      Ninagawa M, Takemoto N, JiH, Miyasaka H, Okuhata H, Ishibashi Y, Arizono K
    • Journal Title

      Environment and safety

      Volume: vol. 2(1) Pages: 23-29

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Study on GC/MS analytical methods for branced nonylphenol isomers, (in Japanese)2011

    • Author(s)
      Ji H, Kawakami S, Inokuchi A, Shinohara R, M. Koga, Uchiyama, T, Katase T, Arizono K
    • Journal Title

      Environment and safety

      Volume: vol. 2(1) Pages: 31-37

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The applicability of GC/MS detection and quantification using a database for the determination of pesticides in river water, (in Japanese)2011

    • Author(s)
      Yamagami T, Nakashima S, Ono Y, Ishibashi Y, Arizono K, Kadokami K
    • Journal Title

      Environment and safety

      Volume: vol. 2(2) Pages: 159-169

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavior of pharmaceuticals in waste water treatment plant in Japan2011

    • Author(s)
      Matsuo H, Sakamoto H, Arizono K, Shinohara R
    • Journal Title

      Bull Environ Contam Toxicol

      Volume: 87(1) Pages: 31-35

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression analysis of Japanese medaka (Oryzias latipes) exposed to o,p'-DDT using DNA microarray2011

    • Author(s)
      Uchida M, Nakamura H, Kagami Y, Kusana T, Arizono K
    • Journal Title

      Organohalogen Compounds

      Volume: 73 Pages: 484-487

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Research on the Generation Control of Dioxines from the Small Incinerator2011

    • Author(s)
      Ishibashi Y, Arizono K, Nakamichi T, Takemoto N, Kai H, Shimase H, Takemasa T
    • Journal Title

      Organohalogen Compounds

      Volume: 73 Pages: 1788-1791

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Behavior of Pharmaceuticals in waste water treatment plant in Japan2011

    • Author(s)
      Matsuo H, Sakamoto H, Arizono K, Shinohara R
    • Journal Title

      Bull Environ Contain Toxicol.

      Volume: 87(1) Pages: 31-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The applicability of GC/MS detection and quantification using a data base for the determination of pesticides in river water, (in Japanese)2011

    • Author(s)
      Yamagami T, Nakashima S, Ono Y, Ishibashi Y, Arizono K, Kadokami K.
    • Journal Title

      Environment and safety

      Volume: 2(2) Pages: 159-169

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] The trial of phytoremediation of environmental water by plant root2013

    • Author(s)
      Koji Arizono
    • Organizer
      The 2nd International Conference on Environmental Pollution, Restoration and Management
    • Place of Presentation
      Hanoi, Vietnam
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] メダカDNAマイクロアレイを用いたDDTの生態影響評価2012

    • Author(s)
      内田雅也、中村浩、鏡良弘、草野輝彦、古賀実、有薗幸司
    • Organizer
      第14回日本水環境学会シンポジウム
    • Place of Presentation
      北九州市立大学(北九州市)
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Toxicity of triclosan and triclocarban in mysid crustacean2012

    • Author(s)
      Arizono K, Uchida M, Koga M
    • Place of Presentation
      Dioxin
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional analyses of the mysid ecdysteroid receptor: DNA binding ability, ligand-induced transactivation and in silico modeling.2012

    • Author(s)
      Hirano M, Ishibashi H, Kim EY Arizono K , Iwata H
    • Place of Presentation
      SETAC Asia Pacific
    • Related Report
      2012 Final Research Report
  • [Presentation] (12) First results from a ring study of a new rapid alga test estimating chemical influence on algal growth.2012

    • Author(s)
      Katsumata M, Arizono K etc
    • Place of Presentation
      SETAC Asia Pacific
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of PFOA and fluorotelomer alcohol on Caenorhabditis elegans reproduction.2012

    • Author(s)
      Tominaga N, Furukawa R, Yamashita S, Yamaguchi A, Arizono K
    • Place of Presentation
      SETAC Asia Pacific
    • Related Report
      2012 Final Research Report
  • [Presentation] GC/MS Software and Database for Screening Analysis: Mechanism and Evaluation UsingRiver Water Samples.2012

    • Author(s)
      Nakashima S, Yamagami T, Ogawa Y, Kadokami K, Arizono K
    • Place of Presentation
      SETAC Asia Pacific
    • Related Report
      2012 Final Research Report
  • [Presentation] Rapid analyticalmethod for surfactant in wastewater using biosensor.2012

    • Author(s)
      Oshima S, Takagi Y, Sawadaishi K, Kataoka C, Arizono K
    • Place of Presentation
      SETAC Asia Pacific
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of ecological toxicity of glyphosate agrochemical components in Japanese medaka.2012

    • Author(s)
      Uchida M, Takumi S, Nakamura Y,Kagami Y, Kusano T, Arizono K
    • Place of Presentation
      SETAC Asia Pacific
    • Related Report
      2012 Final Research Report
  • [Presentation] Miyasaka H, Removal of bisphenol A related compounds by Portulaca oleracearoot and horse radish peroxidase.2012

    • Author(s)
      Arizono K, Takemoto N, Okuhata H
    • Place of Presentation
      SETAC North America
    • Related Report
      2012 Final Research Report
  • [Presentation] GC/MS Software and Database for Screening Analysis: Mechanism and Evaluation Using River Water Sample2012

    • Author(s)
      Shinya Nakashima
    • Organizer
      SETAC Asia Pacific 2012
    • Place of Presentation
      Kumamoto, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Rapid analytical method for surfactant in wastewater using biosensor2012

    • Author(s)
      Shigenobu Oshima
    • Organizer
      SETAC Asia Pacific 2012
    • Place of Presentation
      Kumamoto, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gene expression analysis of Japanese medaka (Oryzias latipes) exposed to DDT using DNA microarray2012

    • Author(s)
      M.Uchid, H.Nakamura, Y.Kagami, T.Kusano, K.Arizono
    • Organizer
      DIOXIN2011
    • Place of Presentation
      Brussels, Belgium
    • Related Report
      2011 Annual Research Report
  • [Presentation] Construction of chemical toxicity prediction model by using experiment date, mainly on branched nonylphenol isomers2012

    • Author(s)
      K.Arizono Hezhe Ji, Chenfu Sun
    • Organizer
      SETAC North America 32nd Annual Meeting
    • Place of Presentation
      Boston
    • Related Report
      2011 Annual Research Report
  • [Presentation] メダカDNAマイクロアレイによる助剤(界面活性剤)と製剤の影響評価2011

    • Author(s)
      内田雅也、中村浩、鏡良弘、草野輝彦、有薗幸司
    • Organizer
      第14回日本水環境学会シンポジウム
    • Place of Presentation
      東北工業大学(仙台市)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海産甲殻類・アミを用いた抗菌剤類の生態影響評価2011

    • Author(s)
      内田雅也、平野将司、中村浩、鏡良弘、草野輝彦、山内良子、三浦苑子、吉津伶美、古賀実、有薗幸司
    • Organizer
      第17回日本環境毒性学会・バイオアッセイ研究会合同研究発表会
    • Place of Presentation
      鹿児島大学水産学部(鹿児島市)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Research on the Generation Control of Dioxines from the Small Incinerator.2011

    • Author(s)
      Ishibashi Y, Nakamichi T, Arizono K
    • Place of Presentation
      Dioxin
    • Related Report
      2012 Final Research Report
  • [Presentation] Gene expression analysis of Japanese medaka exposed to o,p'-DDT using DNA microarray.2011

    • Author(s)
      Uchida M, Nakamura H, Kagami Y, Kusano T, Arizono K
    • Place of Presentation
      Dioxin
    • Related Report
      2012 Final Research Report
  • [Presentation] Construction of Chemical Toxicity Prediction Model by Using Experiment Data2011

    • Author(s)
      Arizono K, Ji H
    • Organizer
      Mainly on Branched Nonylphenol Isomers
    • Place of Presentation
      SETAC North America
    • Related Report
      2012 Final Research Report
  • [Presentation] 最終処分場由来浸出水のリスク評価-多元素分析からのアプローチ-2011

    • Author(s)
      竹本直道, 吉赫哲, 石橋康弘, 古賀実, 大場和彦, 有薗幸司
    • Organizer
      第20回環境化学討論会
    • Place of Presentation
      熊本県立大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 線虫C.elegansにおけるナノシリカの生体影響及び遺伝子発現変動解析2010

    • Author(s)
      井口綾子
    • Organizer
      第37回 日本トキシコロジー学会学術年会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Toxicological effects of silica nanoparticles on nematode C.elegans2010

    • Author(s)
      Ayako Inokuchi, Sayaka Ueda, Ryoko Yamamoto, Shota Takumi, Nobuaki Tominaga, Koji Arizono
    • Organizer
      SETAC Asia/Pacific 2010
    • Place of Presentation
      Marriott China Hotel Guangzhou
    • Year and Date
      2010-06-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Triclosan in urine : as the index of evaluation for human health assessment2010

    • Author(s)
      Hezhe Ji, Chenfu Sun, Shigeki Kawakami, Yu Lin, Mingming Wu, Yanni Lu, Masahiro Umezaki, Chiho Watanabe, Koji Arizono
    • Organizer
      SETAC Asia/Pacific 2010
    • Place of Presentation
      Marriott China Hotel Guangzhou
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] 線虫C. elegansにおけるナノシリカの生体影響及び遺伝子発現変動解析

    • Author(s)
      井口綾子、有薗幸司 ,他9 名
    • Organizer
      第37回 日本トキシコロジー学会学術年会
    • Related Report
      2012 Final Research Report
  • [Presentation] グリホサート製剤がヒメダカにおよぼす影響

    • Author(s)
      内田雅也、有薗幸司 ,他6名
    • Organizer
      第37回 日本トキシコロジー学会学術年会
    • Related Report
      2012 Final Research Report
  • [Presentation] 最終処分場由来の浸出水中有機フッ素化合物のリスク評価

    • Author(s)
      有薗幸司、竹本直道、川上茂樹、内田雅也、吉嚇哲
    • Organizer
      第19回環境化学討論会
    • Related Report
      2012 Final Research Report
  • [Presentation] 下水処理場の処理過程におけるノニルフェノール異性体の挙動

    • Author(s)
      吉嚇哲、川上茂樹、竹本直道、内山武人、片瀬隆雄、有薗幸司
    • Organizer
      第19回 環境化学討論会
    • Related Report
      2012 Final Research Report
  • [Presentation] 沖縄本島の漁港底質中の有機スズ化合物濃度および他地域との比較

    • Author(s)
      桑原和子、有薗幸司 ,他8名
    • Organizer
      第19回 環境化学討論会
    • Related Report
      2012 Final Research Report
  • [Presentation] タイヤチップに対するユスリカを用いた毒性試験法の検討

    • Author(s)
      中川理緒、鑪迫典久、有薗幸司
    • Organizer
      第16回日本環境毒性学会・パイオアッセイ研究会
    • Related Report
      2012 Final Research Report
  • [Presentation] メダカDNAマイクロアレイを用いたグリホサート製剤の生体影響評価

    • Author(s)
      内田雅也、有薗幸司 ,他6名
    • Organizer
      第16回日本環境毒性学会・パイオアッセイ研究会
    • Related Report
      2012 Final Research Report
  • [Presentation] 熊本県における大豆、大豆製品のRoundup Ready Soybean 混入状況

    • Author(s)
      渡辺郁子、井口綾子、本田栄子、有薗幸司
    • Organizer
      第100回 日本食品衛生学会
    • Related Report
      2012 Final Research Report
  • [Presentation] ICP-MSによる飼料米鶏卵中重金属類の一斉分析

    • Author(s)
      上田亜紀、吉嚇哲、田崎幸美、高橋まどか、白土英樹、有薗幸司
    • Organizer
      第100回日本食品衛生学会
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of endogenous and xenobiotic compounds on DNA binding and transactivation ofthe crustacean ecdysteroid receptor.

    • Author(s)
      Ishibashi H, Arizono K and Iwata H
    • Organizer
      日本内分泌撹乱化学物質学会第13回研究発表会
    • Related Report
      2012 Final Research Report
  • [Presentation] 線虫をモデル生物としたナノシリカの生態影響評価

    • Author(s)
      井口綾子、有薗幸司
    • Organizer
      日本薬学会年会
    • Related Report
      2012 Final Research Report
  • [Presentation] 最終処分場由来浸出水のリスク評価-多元素分析からのアプローチ-

    • Author(s)
      竹本直道、吉嚇哲、石橋康弘、大場和彦、有薗幸司
    • Organizer
      第20回 環境化学討論会
    • Related Report
      2012 Final Research Report
  • [Presentation] 乳がんおよび良性乳腺症例における脂肪組織中の有機塩素系化合物レベル

    • Author(s)
      郡山千早、有薗幸司 ,他10名
    • Organizer
      第20回 環境化学討論会
    • Related Report
      2012 Final Research Report
  • [Presentation] 使用方法の異なるPPCPsをマーカーとして用いた河川水の生活排水等による汚濁パターンの分類法の開発

    • Author(s)
      三浦嘉仁、有薗幸司 ,他5名
    • Organizer
      第20回 環境化学討論会
    • Related Report
      2012 Final Research Report
  • [Presentation] 高電界パルスを用いた化学物質の初期発生影響評価法の開発-パルス印加およびタンパク合成阻害剤曝露によるメダカ卵の遺伝子発現変動の調査-

    • Author(s)
      富永伸明、山口明美 有薗幸司
    • Organizer
      日本内分泌撹乱化学物質学会第14回研究発表会
    • Related Report
      2012 Final Research Report
  • [Presentation] In vitro and in silico analyses of the interaction of environmental chemicals with the mysid ecdysteroid receptor

    • Author(s)
      Hirano M, ArizonoK, Iwata H
    • Organizer
      日本内分泌撹乱化学物質学会第14回研究発表会
    • Related Report
      2012 Final Research Report
  • [Presentation] アミDNAマイクロアレイを用いたDDTの生態影響評価

    • Author(s)
      内田雅也 有薗幸司 ,他6名
    • Organizer
      水環境学会九州支部会
    • Related Report
      2012 Final Research Report
  • [Presentation] 液体合成培地を用いた線虫のin vivo 評価系によるCuの影響評価

    • Author(s)
      荒巻愛世、富永伸明、有薗幸司
    • Organizer
      第17回日本環境毒性学会・パイオアッセイ研究会
    • Related Report
      2012 Final Research Report
  • [Presentation] Transactivation potencies of the Baikal Seal peroxisome proliferator-Activated receptor by brominated flame retardants

    • Author(s)
      Ishibashi H, Arizono K, Iwata H
    • Organizer
      日本内分泌撹乱化学物質学会第15回研究発表会
    • Related Report
      2012 Final Research Report
  • [Presentation] Life Cycle Assessment Evaluation of dairy farming by input-output balance.

    • Author(s)
      Kai H, Nakamichi T, Takemoto N, Kamohara S, Arizono K, Ishibashi Y
    • Related Report
      2012 Final Research Report
  • [Book] エキスパート公衆衛生学木村恵美子/徳留信寛/圓藤吟史(編)2012

    • Author(s)
      有薗幸司 分担 環境汚染と健康
    • Total Pages
      236
    • Publisher
      化学同人
    • Related Report
      2011 Annual Research Report
  • [Book] 食品衛生学実験書白尾美佳/中村好志(編)2011

    • Author(s)
      有薗幸司 分担 食中毒/農薬/アレルギー
    • Total Pages
      170
    • Publisher
      光生館
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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