Elucidation of the evasion mechanism of cytokine storm in disease resistant native livestock

• Project/Area Number: 22405036
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: Hokkaido University
• Principal Investigator: KONNAI Satoru 北海道大学, 大学院・獣医学研究科, 准教授 (40396304)
• Co-Investigator(Kenkyū-buntansha): OHASHI Kazuhiko 北海道大学, 大学院・獣医学研究科, 教授 (90250498)
• Co-Investigator(Renkei-kenkyūsha): CRUZ L. フィリピン国立カラバオセンター, フィリピン・サイエンスシティームニョス, 同センター所長 ; ABES N. フィリピン国立カラバオセンター, フィリピン・サイエンスシティームニョス, 主任研究員 ; MINGALA C. フィリピン国立カラバオセンター, フィリピン・サイエンスシティームニョス, 研究員 ; SKILTON R. 国際家畜研究所, ケニア・ナイロビ, 主任研究員 ; BISHOP R. 国際家畜研究所, ケニア・ナイロビ, 主任研究員 ; NENE V. 国際家畜研究所, ケニア・ナイロビ, 原虫部門室長 ; KANDUMA E. 国際家畜研究所, ケニア・ナイロビ国際家畜研究所, 研究員 ; GITHAKA N. 国際家畜研究所, ケニア・ナイロビ国際家畜研究所, 研究員 ; GAKUYA F. ケニア野生動物公社, ケニア・ナイロビ, 獣医部門長 ; KARIUKI E. ケニア野生動物公社, ケニア・ナイロビ, 研究員 ; SIMMUNZA M. ザンビア大学獣医学部, ザンビア・ルサカ, 講師 ; LOGULLO C. ブラジル州立北フルミネンス大学, ブラジル・カンポス, 准教授 ; ITABAJARA S. リオグランデ・ド・スル大学, ブラジル・ポルトアレグレ, 教授
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 疾患抵抗性 / 在来種家畜 / サイトカインストーム / 制御性樹状細胞 / トリパノソーマ病 / 東海岸熱 / 牛白血病 / ダニ媒介性疾患 / 炎症性サイトカイン / トリパノソーマ / タイレリア・パルバ

Research Abstract

In African, Asian and South American countries, native livestock is relatively a disease-resistant animal, but they can be infected with infectious agents. Therefore, there is a need to investigate the immunological events during disease development. Our study has shown that, in T. evansi (causative agent for Sura disease) and T. parva (causative agent for East Cost fever)-infected native animals, there is an augmentation of a subset of regulatory DCs that act as potential regulators of the inflammatory responses including cytokine storm.

Research Products

• [Journal Article] Isolation, cloning and pathologic analysis of Trypanosoma evansi field isolates. (2013)
  • Author(s): Mekata, H., Konnai, S., Mingala, C.N., Abes, N.S., Gutierrez, A., Dargantes, A.P., Witola, W.H., Inoue, N., Onuma, M., Murata, S., Ohashi,K.
  • Journal Title: Parasitol Res Volume: 112 Pages: 1513-1521
  • Peer Reviewed
• [Journal Article] Characterization of Meq proteins from field isolates of Marek's disease virus in Japan. (2013)
  • Author(s): Murata, S., Hashiguchi, T., Hayashi, Y., Yamamoto, Y., Matsuyama-Kato, A., Takasaki, S., Isezaki, M., Onuma, M., Konnai, S., Ohashi, K.
  • Journal Title: Infect Genet Evol Volume: 16C Pages: 137-143
  • NAID: 120005317003
  • Peer Reviewed
• [Journal Article] Prevalence of Lyme borrelia in Ixodes persulcatus ticks from an area with a confirmed case of Lyme disease. (2013)
  • Author(s): Murase, Y., Konnai, S., Githaka, W.N, Hidano, A., Taler, K., Ito, T., Takano, A., Ando, S., Kawabata, H., Tsubota, T., Murata, S., Ohashi,K.
  • Journal Title: J. Vet. Med. Sci Volume: 75 Pages: 215-218
  • NAID: 130001879630
  • Peer Reviewed
• [Journal Article] ウシの感染免疫に関する最近の知見 (2013)
  • Author(s): 今内覚
  • Journal Title: 日本獣医師会学会学術誌 Volume: 第66巻 Pages: 171-179
  • Peer Reviewed
• [Journal Article] Differential tick burdens may explain differential Borrelia afzelii and Borrelia garinii infection rates among four, wild, rodent species in Hokkaido (2013)
  • Author(s): Taylor, K.R., Takano, A., Konnai, S.,Shimozuru, M., Kawabata, H., Tsubota, T.
  • Journal Title: Japan.J. Vet. Med. Sci Volume: (in press)
  • Peer Reviewed
• [Journal Article] Borrelia miyamotoi Infections among Wild Rodents Show Age and Month Independence and Correlation with Ixodes persulcatus Larval Attachment in Hokkaido (2013)
  • Author(s): Taylor, K.R., Takano, A., Konnai, S., Shimozuru, M., Kawabata, H., Tsubota, T.
  • Journal Title: Japan. Vector Borne Zoonotic Dis Volume: 13 Pages: 92-97
  • Peer Reviewed
• [Journal Article] Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus. (2013)
  • Author(s): Konnai, S., Suzuki, S., Shirai, T., Ikebuchi, R., Okagawa, T., Sunden., Y, Mingala C.N., Onuma, M., Murata, S., Ohashi K.
  • Journal Title: Comp Immunol Microbiol Infect Dis Volume: 36 Pages: 63-69
  • Peer Reviewed
• [Journal Article] Isolation, cloning and pathologic analysis of Trypanosoma evansi field isolates (2013)
  • Author(s): Mekata, H., Konnai, S., Mingala, C.N., Abes, N.S., Gutierrez, A., Dargantes, A.P., Witola, W.H., Inoue, N., Onuma, M., Murata, S., Ohash, K.
  • Journal Title: Parasitol Res. Volume: 112 Issue: 4 Pages: 1513-1521
  • DOI: 10.1007/s00436-013-3297-3
  • Peer Reviewed
• [Journal Article] Bovine whole-blood culture as a tool for the measurement of endotoxin activities in Gram-negative bacterial vaccines (2013)
  • Author(s): Imamura S, Nakamizo M, Kawanishi M, Nakajima N, Yamamoto K, Uchiyama M, Hirano F, Nagai H, Kijima M, Ikebuchi R, Mekata H, Murata S, Konnai S, Ohashi K.
  • Journal Title: Vet Immunol Immunopathol. Volume: in press Issue: 1-2 Pages: 153-158
  • DOI: 10.1016/j.vetimm.2013.02.002
  • Peer Reviewed
• [Journal Article] Characterization of Meq proteins from field isolates of Marek’s disease virus in Japan (2013)
  • Author(s): Murata, S., Hashiguchi, T., Hayashi, Y., Yamamoto, Y., Matsuyama-Kato, A., Takasaki, S., Isezaki, M., Onuma, M., Konnai, S., Ohashi, K.
  • Journal Title: Infect Genet Evol. Volume: 16C Pages: 137-143
  • DOI: 10.1016/j.meegid.2012.12.032
  • NAID: 120005317003
  • Peer Reviewed
• [Journal Article] Prevalence of Lyme borrelia in Ixodes persulcatus ticks from an area with a confirmed case of Lyme disease (2013)
  • Author(s): Murase, Y., Konnai, S., Githaka, W.N, Hidano, A., Taler, K., Ito, T., Takano, A., Ando, S., Kawabata, H., Tsubota, T., Murata, S., Ohashi.
  • Journal Title: J. Vet. Med. Sci. Volume: 75 Pages: 215-8
  • NAID: 130001879630
  • Peer Reviewed
• [Journal Article] Differential tick burdens may explain differential Borrelia afzelii and Borrelia garinii infection rates among four, wild, rodent species in Hokkaido, Japan (2013)
  • Author(s): Taylor, K.R., Takano, A., Konnai, S., Shimozuru, M., Kawabata, H., Tsubota, T.
  • Journal Title: J. Vet. Med. Sci. Volume: in press
  • NAID: 130003362123
  • Peer Reviewed
• [Journal Article] Borrelia miyamotoi Infections among Wild Rodents Show Age and Month Independence and Correlation with Ixodes persulcatus Larval Attachment in Hokkaido, Japan. (2013)
  • Author(s): Taylor, K.R., Takano, A., Konnai, S., Shimozuru, M., Kawabata, H., Tsubota, T.
  • Journal Title: Vector Borne Zoonotic Dis. Volume: 13 Issue: 2 Pages: 92-7
  • DOI: 10.1089/vbz.2012.1027
  • NAID: 120005228303
  • Peer Reviewed
• [Journal Article] Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus (2013)
  • Author(s): Konnai, S., Suzuki, S., Shirai, T., Ikebuchi, R., Okagawa, T., Sunden., Y, Mingala C.N., Onuma, M., Murata, S., Ohashi K.
  • Journal Title: Comp Immunol Microbiol Infect Dis. Volume: 36 Issue: 1 Pages: 63-9
  • DOI: 10.1016/j.cimid.2012.09.005
  • Peer Reviewed
• [Journal Article] Identification and partial characterization of a gut Rhipicephalus appendiculatus cystatin (2013)
  • Author(s): Imamura, S., Konnai, S., Yamada, S., Parizi, L.F., Githaka, N., Vaz, I. da S. Jr., Murata, S., Ohashi, K.
  • Journal Title: Ticks Tick Borne Dis. Volume: 4 Issue: 1-2 Pages: 138-44
  • DOI: 10.1016/j.ttbdis.2012.11.001
  • Peer Reviewed
• [Journal Article] Transcriptional profiling of inflammatory cytokine genes in Theileria parva-infected African buffalo (Syncerus caffer). (2012)
  • Author(s): Okagawa, T., Konnai, S., Mekata, H., Githaka, N., Suzuki, S., Kariuki, E., Gakuya, F., Kanduma, E., Shirai, T., Ikebuchi, R., Ikenaka, Y., Ishizuka, M., Murata, S., Ohashi.K.
  • Journal Title: Vet Immunol Immunopathol Volume: 148 Pages: 373-379
  • Peer Reviewed
• [Journal Article] Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer). (2012)
  • Author(s): Suzuki, S., Konnai, S., Okagawa, T., Githaka, N., Kariuki, E., Gakuya, F., Kanduma, E., Shirai, T., Ikebuchi, R., Ikenaka, Y., Ishizuka, M., Murata, S., Ohashi, K.
  • Journal Title: Int J Immunogenet Volume: 39 Pages: 170-182
  • Peer Reviewed
• [Journal Article] The conserved role of the AKT/GSK3 axis in cell survival and glycogen metabolism in Rhipicephalus (Boophilus) microplus embryo tick cell line BME26. (2012)
  • Author(s): de Abreu, L.A., Calixto, C., Waltero, C.F., Pita, B., Githaka, N.W., Seixas, A., Parizi, L.F., Konnai, S., da Silva, Vaz. I. Jr., Ohashi, K., Logullo, C.
  • Journal Title: Biochim Biophys Acta Volume: 1830 Pages: 2574-2582
  • Peer Reviewed
• [Journal Article] Molecular detection of new Babesia and Theileria species/variants in wild felids from Kenya. (2012)
  • Author(s): Githaka, N., Konnai, S., Kariuki, E., Kanduma, E., Murata, S., Ohashi, K.
  • Journal Title: Acta Trop Volume: 124 Pages: 71-78
  • Peer Reviewed
• [Journal Article] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in chickens infected with Marek's disease virus. (2012)
  • Author(s): Matsuyama-Kato, A., Murata, S., Isezaki, M., Kano, R., Takasaki, S., Ichii, O., Konnai, S., Ohashi, K.
  • Journal Title: Virol J Volume: 9 Pages: 94-94
  • Peer Reviewed
• [Journal Article] Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection. (2012)
  • Author(s): Okagawa, T., Konnai, S., Ikebuchi, R., Suzuki, S., Shirai, T., Sunden, Y., Onuma M., Murata, S., Ohashi, K.
  • Journal Title: Vet. Res Volume: 43 Pages: 45-45
  • Peer Reviewed
• [Journal Article] Identification of TROSPA homologue in Ixodes persulcatus, Schulze, the specific vector for human Lyme borreliosis in Japan. (2012)
  • Author(s): Konnai, S., Yamada, S., Imamura, S., Nishikado, H., Githaka, W.N., Ito, T., Takano, A., Kawabata, H., Murata, S., Ohashi, K.
  • Journal Title: Ticks Tick Borne Dis Volume: 3 Pages: 75-77
  • Peer Reviewed
• [Journal Article] Kinetics ofregulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection. (2012)
  • Author(s): Mekata, H., Konnai, S., Mingala, C.N., Abes, N.S., Gutierrez, A., Dargantes, A.P., Witola, W.H., Inoue, N., Onuma, M., Murata, S., Ohash, K.
  • Journal Title: Parasite Immunol Volume: 34 Pages: 318-329
  • Peer Reviewed
• [Journal Article] The quest for a universal vaccine against ticks: Cross-immunity insights. (2012)
  • Author(s): Parizi, L.F., Githaka, N.W., Logullo, C., Konnai, S., Masuda, A., Ohashi, K., da Silva, Vaz, Jr. I.
  • Journal Title: Vet. J Volume: 194 Pages: 158-165
  • Peer Reviewed
• [Journal Article] Surveillance of Marek's disease virus in migratory and sedentary birds in Hokkaido (2012)
  • Author(s): Murata, S., Hayashi, Y., Kato, A., Isezaki, M., Takasaki, S., Onuma, M., Osa, Y., Asakawa, M., Konnai, S., Ohashi, K.
  • Journal Title: Japan. Vet. J. Volume: 192 Pages: 538-540
  • Peer Reviewed
• [Journal Article] Transcriptional profiling of inflammatory cytokine genes in Theileria parva-infected African buffalo (Syncerus caffer). (2012)
  • Author(s): Okagawa, T., Konnai, S., Mekata, H., Githaka, N., Suzuki, S., Kariuki, E., Gakuya, F., Kanduma, E., Shirai, T., Ikebuchi, R., Ikenaka, Y., Ishizuka, M., Murata, S., Ohashi.
  • Journal Title: Vet Immunol Immunopathol. Volume: 148 Issue: 3-4 Pages: 373-9
  • DOI: 10.1016/j.vetimm.2012.06.015
  • Peer Reviewed
• [Journal Article] Molecular cloning and characterization of Th1 and Th2 cytokines of African buffalo (Syncerus caffer) (2012)
  • Author(s): Suzuki S, Konnai S, Okagawa T, Githaka N W, Kariuki E, Gakuya F, Kanduma E, Shirai T, Ikebuchi R, Ikenaka Y, Ishizuka M, Murata S, Ohashi K
  • Journal Title: Int J Immunogenet Volume: 39 Issue: 2 Pages: 170-182
  • DOI: 10.1111/j.1744-313x.2011.01062.x
  • Peer Reviewed
• [Journal Article] The conserved role of the AKT/GSK3 axis in cell survival and glycogen metabolism in Rhipicephalus (Boophilus) microplus embryo tick cell line BME26 (2012)
  • Author(s): de Abreu, L.A., Calixto, C., Waltero, C.F., Pita, B., Githaka, N.W., Seixas, A., Parizi, L.F., Konnai, S., da Silva, Vaz. I. Jr., Ohashi, K., Logullo, C.
  • Journal Title: Biochim Biophys Acta. Volume: 1830 Issue: 3 Pages: 2574-2582
  • DOI: 10.1016/j.bbagen.2012.12.016
  • Peer Reviewed
• [Journal Article] Molecular detection of new Babesia and Theileria species/variants in wild felids from Kenya (2012)
  • Author(s): Githaka, N., Konnai, S., Kariuki, E., Kanduma, E., Murata, S., Ohashi, K.
  • Journal Title: Acta Trop. Volume: 124 Issue: 1 Pages: 71-8
  • DOI: 10.1016/j.actatropica.2012.06.013
  • Peer Reviewed
• [Journal Article] A novel relapsing fever Borrelia sp. infects the salivary glands of the molted hard tick, Amblyomma geoemydae (2012)
  • Author(s): Takano, A., Sugimori, C., Fujita, H., Kadosaka, T., Taylor, K.R., Tsubota, T., Konnai, S., Tajima, T., Sato, K., Watanabe, H., Ohnishi, M., Kawabata, H.
  • Journal Title: Ticks Tick Borne Dis. Volume: 3 Issue: 4 Pages: 259-61
  • DOI: 10.1016/j.ttbdis.2012.06.003
  • Peer Reviewed
• [Journal Article] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in chickens infected with Marek’s disease virus (2012)
  • Author(s): Matsuyama-Kato, A., Murata, S., Isezaki, M., Kano, R., Takasaki, S., Ichii, O., Konnai, S., Ohashi, K.
  • Journal Title: Virol J. Volume: 9 Pages: 94-94
  • Peer Reviewed
• [Journal Article] Effects of interferon tau on cattle persistently infected with bovine viral diarrhea virus (2012)
  • Author(s): Kohara, J., Nishikura, Y., Konnai, S., Tajima, M., Onuma, M.
  • Journal Title: Jpn. J. Vet. Res. Volume: 60 Pages: 63-70
  • Peer Reviewed
• [Journal Article] Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection (2012)
  • Author(s): Okagawa, T., Konnai, S., Ikebuchi, R., Suzuki, S., Shirai, T., Sunden, Y., Onuma M., Murata, S., Ohashi, K.
  • Journal Title: Vet. Res. Volume: 43 Issue: 1 Pages: 45-45
  • DOI: 10.1186/1297-9716-43-45
  • Peer Reviewed
• [Journal Article] Identification of TROSPA homologue in Ixodes persulcatus, Schulze, the specific vector for human Lyme borreliosis in Japan (2012)
  • Author(s): Konnai, S., Yamada, S., Imamura, S., Nishikado, H., Githaka, W.N., Ito, T., Takano, A., Kawabata, H., Murata, S., Ohashi, K.
  • Journal Title: Ticks Tick Borne Dis. Volume: 3 Issue: 2 Pages: 75-7
  • DOI: 10.1016/j.ttbdis.2012.02.001
  • Peer Reviewed
• [Journal Article] Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection (2012)
  • Author(s): Hirohisa Mekata
  • Journal Title: Parasite Immunology Volume: 34 Issue: 6 Pages: 318-329
  • DOI: 10.1111/j.1365-3024.2012.01362.x
  • Peer Reviewed
• [Journal Article] The quest for a universal vaccine against ticks: Cross-immunity insights (2012)
  • Author(s): Parizi, L.F., Githaka, N.W., Logullo, C., Konnai, S., Masuda, A., Ohashi, K., da Silva, Vaz, Jr. I.
  • Journal Title: Vet. J. Volume: 194 Issue: 2 Pages: 158-65
  • DOI: 10.1016/j.tvjl.2012.05.023
  • Peer Reviewed
• [Journal Article] 牛難治性疾病に対する多機能型新規治療法の開発 (招待論文) (2012)
  • Author(s): 岡川朋弘、今内 覚、池渕良洋、鈴木紗織、村田史 郎、大橋和彦
  • Journal Title: 動物用ワクチン-バイオ医薬品研究会ニュースレター Volume: 5 Pages: 27-27
• [Journal Article] 感染症と免疫の基礎 免疫とは何か (招待論文) (2012)
  • Author(s): 大橋 和彦、村田 史郎、今内 覚
  • Journal Title: 臨床獣医 Volume: 8 Pages: 60-62
• [Journal Article] 感染症と免疫の基礎 液性免疫 (招待論文) (2012)
  • Author(s): 村田 史郎、今内 覚、大橋 和彦
  • Journal Title: 臨床獣医 Volume: 9 Pages: 60-62
• [Journal Article] 感染症と免疫の基礎 細胞性免疫 (招待論文) (2012)
  • Author(s): 今内 覚、村田 史郎、大橋 和彦
  • Journal Title: 臨床獣医 Volume: 10 Pages: 40-42
• [Journal Article] 感染症と免疫の基礎 臨床現場で役立つ免疫の知識 (招待論文) (2012)
  • Author(s): 大橋 和彦、村田 史郎、今内 覚
  • Journal Title: 臨床獣医 Volume: 11 Pages: 50-52
• [Journal Article] ウシの感染免疫に関する最近の知見 (招待論文) (2012)
  • Author(s): 今内 覚
  • Journal Title: 日本獣医師会学会学術誌 Volume: 12 Pages: 171-179
• [Journal Article] Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection (2012)
  • Author(s): Mekata H, Konnai S, Mingala CN, Abes NS, Gutierrez A, Dargantes AP, Witola WH, Inoue N, Onuma M, Murata S, Ohash K
  • Journal Title: Parasite Immunol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection (2012)
  • Author(s): Okagawa T, Konnai S, Ikebuchi R, Suzuki S, Shirai T, Sunden Y, Onuma M, Murata S, Ohashi K
  • Journal Title: Vet.Res. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Identification of TROSPA homologue in Ixodes persulcatus, Schulze, the specific vector for human Lyme borreliosis in Japan (2012)
  • Author(s): Konnai S, Yamada S, Imamura S, Nishikado H, Githaka WN, Ito T, Takano A, Kawabata H, Murata S, Ohashi K
  • Journal Title: Ticks Tick Borne Dis. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Surveillance of Marek's disease virus in migratory and sedentary birds in Hokkaido, Japan (2012)
  • Author(s): Murata S, Hayashi Y, Kato A, Isezaki M, Takasaki S, Onuma M, Osa Y, Asakawa M, Konnai S, Ohashi K
  • Journal Title: Vet.J Volume: (in press)
  • NAID: 120004448517
  • Peer Reviewed
• [Journal Article] Increase of cells expressing PD-L1 in bovine leukemiavirus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade. (2011)
  • Author(s): Ikebuchi, R., Konnai, S., Shirai, T., Sunden, Y., Murata, S., Onuma, M., Ohashi, K.
  • Journal Title: Vet. Res Volume: 42 Pages: 103-103
  • Peer Reviewed
• [Journal Article] Molecular detection of Anaplasma phagocytophilum in cattle and Ixodes persulcatus ticks. (2011)
  • Author(s): Murase, Y., Konnai, S., Hidano, A., Githaka, W.N., Ito, T., Takano, A., Kawabata, H., Ato, M., Tajima, T., Tajima, M., Onuma, M., Murata, S., Ohashi, K.
  • Journal Title: Vet. Microbiol Volume: 49 Pages: 504-507
  • Peer Reviewed
• [Journal Article] Molecularidentification and expression analysis of lipocalins from blood feeding taiga tick (2011)
  • Author(s): Konnai, S., Nishikado, H., Yamada, S., Imamura, S., Ito, T., Onuma, M., Murata, S., Ohashi, K.
  • Journal Title: Ixodes persulcatus Schulze. Exp. Parasitol Volume: 27 Pages: 467-474
  • Peer Reviewed
• [Journal Article] Molecular cloning of bovine lymphocyte activation gene-3 and its expression characteristics in bovine leukemia virus-infected cattle. (2011)
  • Author(s): Shirai, T., Konnai, S., Ikebuchi, R., Okagawa, T., Suzuki, S., Sunden, Y., Onuma, M., Murata, S., Ohashi, K.
  • Journal Title: Vet. Immunol. Immunopathol Volume: 44 Pages: 462-467
  • Peer Reviewed
• [Journal Article] Characterization of reptile-associated Borrelia sp. in the vector tick, Amblyomma geoemydae, andits association with Lyme disease and relapsing fever Borrelia spp. (2011)
  • Author(s): Takano, A., Fujita, H., Kadosaka, T., Konnai, S., Tajima, T., Watanabe, H., Ohnishi, M., Kawabata, H.
  • Journal Title: Environ. Microbiol. Rep. Volume: 3 Pages: 632-637
  • Peer Reviewed
• [Journal Article] Multi-locus sequence typing implicates rodents as the main reservoir host of human pathogenic Borrelia garinii in Japan (2011)
  • Author(s): Takano, A., Nakao, M., Masuzawa, T., Takada, N., Yano, Y., Ishiguro, F., Fujita, H., Ito, T., Ma, X., Oikawa, Y., Kawamori, F., Kumagai, K., Mikami, T., Hanaoka, N., Ando, S., Honda, N., Taylor, K., Tsubota, T., Konnai, S., Watanabe, H., Ohnishi, M., Kawabata, H.
  • Journal Title: J. Clin. Microbiol. Volume: 49 Pages: 2035-2039
  • Peer Reviewed
• [Journal Article] Characterization of CTLA-4, PD-1 and PDL-1 of swamp and riverine type water buffaloes. (2011)
  • Author(s): Mingala, C.N., Konnai, S., Ikebuchi, R., Onuma, M., Ohashi, K.
  • Journal Title: Comp. Immunol. Microbiol. Infect. Dis. Volume: 34 Pages: 55-63
  • Peer Reviewed
• [Journal Article] Analysis of transcriptional activities of the Meq proteins present in highly virulent Marek's disease virus strains (2011)
  • Author(s): Murata, S., Okada, T., Kano, R., Hayashi, Y., Hashiguchi, T., Onuma, M., Konnai, S., Ohashi, K.
  • Journal Title: RB1B and Md5. Virus Genes Volume: 43 Pages: 66-71
  • Peer Reviewed
• [Journal Article] Cross immunity with Haemaphysalis longicornis glutathione S-transferase reduces an experimental Rhipicephalus (Boophilus) microplusinfestation. (2011)
  • Author(s): Parizi, L.F., Utiumi, K.U., Imamura, S., Onuma, M., Ohashi, K., Masuda, A., da Silva Vaz I. Jr.
  • Journal Title: Exp. Parasitol. Volume: 127 Pages: 113-118
  • Peer Reviewed
• [Journal Article] Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade (2011)
  • Author(s): R.Ikebuchi, S.Konnai, T.Shirai, Y.Sunden, S.Murata, M.Onuma, K.Ohashi
  • Journal Title: Veterinary Research Volume: 42 Issue: 1 Pages: 103-103
  • DOI: 10.1186/1297-9716-42-103
  • Peer Reviewed
• [Journal Article] Molecular detection of Anaplasma phagocytophilum in cattle and Ixodes persulcatus ticks (2011)
  • Author(s): Murase Y, Konnai S, Hidano A, Githaka W.N, Ito T, Takano A, Kawabata H, Ato M, Tajima T, Tajima M, Onuma M, Murata S, Ohashi K
  • Journal Title: Vet.Microbiol. Volume: 49 Issue: 3-4 Pages: 504-507
  • DOI: 10.1016/j.vetmic.2010.11.025
  • Peer Reviewed
• [Journal Article] Molecular cloning of bovine lymphocyte activation gene-3 and its expression characteristics in bovine leukemia virus-infected cattle (2011)
  • Author(s): Shirai T, Konnai S, Ikebuchi R, Okagawa T, Suzuki S, Sunden Y, Onuma M, Murata S, Ohashi K
  • Journal Title: Vet.Immunol.Immunopathol. Volume: 44 Issue: 3-4 Pages: 462-467
  • DOI: 10.1016/j.vetimm.2011.08.018
  • Peer Reviewed
• [Journal Article] Characterization of CTLA-4, PD-1 and PDL-1 of swamp and riverine type water buffaloes (2011)
  • Author(s): Mingala CN, Konnai S, Ikebuchi R, Onuma M, Ohashi K
  • Journal Title: Comp.Immunol.Microbiol.Infect.Dis. Volume: 34 Issue: 1 Pages: 55-63
  • DOI: 10.1016/j.cimid.2010.02.002
  • Peer Reviewed
• [Journal Article] Molecular identification and expression analysis of lipocalins from blood feeding taiga tick, Ixodes persulcatus Schulze (2011)
  • Author(s): Konnai S, Nishikado H, Yamada S, Imamura S, Ito T, Onuma M, Murata S, Ohashi K
  • Journal Title: Exp.Parasitol. Volume: 127 Issue: 2 Pages: 467-474
  • DOI: 10.1016/j.exppara.2010.10.002
  • Peer Reviewed
• [Journal Article] Characterization of reptile-associated Borrelia sp.in the vector tick, Amblyomma geoemydae, and its association with Lyme disease and relapsing fever Borrelia spp (2011)
  • Author(s): Takano A, Fujita H, Kadosaka T, Konnai S, Tajima T, Watanabe H, Ohnishi M, Kawabata H
  • Journal Title: Environ.Microbiol.Rep. Volume: 3 Issue: 5 Pages: 632-637
  • DOI: 10.1111/j.1758-2229.2011.00280.x
  • Peer Reviewed
• [Journal Article] Analysis of transcriptional activities of the Meq proteins present in highly virulent Marek's disease virus strains, RB1B and Md5 (2011)
  • Author(s): Murata S, Okada T, Kano R, Hayashi Y, Hashiguchi T, Onuma M, Konnai S, Ohashi K
  • Journal Title: Virus Genes Volume: 43 Pages: 66-71
  • Peer Reviewed
• [Journal Article] Multi-locus sequence typing implicates rodents as the main reservoir host of human pathogenic Borrelia garinii in Japan (2011)
  • Author(s): Takano A, Nakao M, Masuzawa T, Takada N, Yano Y, Ishiguro F, Fujita H, Ito T, Ma X, Oikawa Y, Kawamori F, Kumagai K, Mikami T, Hanaoka N, Ando S, Honda N, Taylor K, Tsubota T, Konnai S, Watanabe H, Ohnishi M, Kawabata H
  • Journal Title: J.Clin.Microbiol. Volume: 49 Issue: 5 Pages: 2035-2039
  • DOI: 10.1128/jcm.02544-10
  • Peer Reviewed
• [Journal Article] Molecular detection of Anaplasma phagocytophilum in cattle and Ixodes persulcatus ticks (2011)
  • Author(s): Murase Y, Konnai S, Hidano A, Githaka W.N, Ito T, Takano A, Kawabata H, Ato M, Tajima T, Tajima M, Onuma M, Murata S, Ohashi K
  • Journal Title: Vet.Microbiol Volume: in press
  • Peer Reviewed
• [Journal Article] Multi-locus sequence typing implicates rodents as the main reservoir host of human pathogenic Borrelia garinii in Japan (2011)
  • Author(s): Takano A, Nakao M, Masuzawa T, Takada N, Yano Y, Ishiguro F, Fujito H, Ito T, Ma X, Oikawa Y, Kawamori F, Kumagai K, Mikami T, Hanaoka N, Ando S, Honda N, Taylor K, Tsubota T, Konnai S, Watanabe H, Ohnishi M, Kawabata H.
  • Journal Title: J.Clin.Microbiol Volume: in press
  • Peer Reviewed
• [Journal Article] Molecular identification and expression analysis of lipocalins from blood feeding taiga tick, Ixodes persulcatus Schulze (2011)
  • Author(s): Konnai S, Nishikado H, Yamada S, Imamura S, Ito T, Onuma M, Murata S, Ohashi K
  • Journal Title: Exp.Parasitol Volume: 127 Pages: 467-474
  • Peer Reviewed
• [Journal Article] 牛白血病の感染防御対策 (2011)
  • Author(s): 今内覚、田島誉士、小沼操、村田史郎、大橋和彦
  • Journal Title: 北海道しゃくなげ会会報 Volume: 50 Pages: 10-12
• [Journal Article] Molecular cloning and expression analysis of bovine programmed death-1. (2010)
  • Author(s): Ikebuchi, R., Konnai, S., Sunden, Y., Onuma M., Ohashi K.
  • Journal Title: Microbiol. Immunol. Volume: 54 Pages: 291-298
  • NAID: 10029544893
  • Peer Reviewed
• [Journal Article] Two novel Salp15-like immunosuppressant genes from salivary glands of Ixodes persulcatus Schulze tick. (2010)
  • Author(s): Mori, A., Konnai, S., Yamada, S., Hidano, A., Murase, Y., Ito, T., Takano, A., Kawabata, H., Onuma, M., Ohashi, K.
  • Journal Title: Insect Mol. Biol. Volume: 19 Pages: 359-365
  • Peer Reviewed
• [Journal Article] Molecular cloning and expression analysis of bovine programmed death-1 (2010)
  • Author(s): Ikebuchi R, Konnai S, Sunden Y, Onuma M.Ohashi K
  • Journal Title: Microbiol.Immunol Volume: 5 Pages: 291-298
  • NAID: 10029544893
  • Peer Reviewed
• [Journal Article] Two novel Salp 15-like immunosuppressant genes from salivary glands of Ixodes persulcatus Schulze tick (2010)
  • Author(s): Mori A, Konnai S, Yamada S, Hidano A, Murase Y, Takano A, Kawabata H, Ito T, Onuma M, Ohachi K
  • Journal Title: Insect Mol.Biol Volume: 19 Pages: 359-365
  • Peer Reviewed
• [Journal Article] The detection and characterization of the meq variants of Marek's diseases virus (2010)
  • Author(s): Ohashi K, Murata S, Okada T, Konnai S
  • Journal Title: Animal Viruses Volume: 16 Pages: 117-132
• [Journal Article] 牛白血病の正体と予防を考察する (2010)
  • Author(s): 今内覚, 安富一郎, 田島誉士, 村田史郎, 大橋和彦
  • Journal Title: Holstein Volume: In press
• [Journal Article] ダニ媒介性感染症に対する抗ダニワクチンの開発 (2010)
  • Author(s): 今内覚
  • Journal Title: 家畜衛生学雑誌 Volume: 36 Pages: 73-75
• [Journal Article] 難治性慢性疾病における免疫疲弊化機序の解明と新規治療法への応用～獣医医療への応用に向けて～ (2010)
  • Author(s): 池渕良洋、今内覚、寸田祐嗣、小沼操、村田史郎、大橋和彦
  • Journal Title: NIBS Letter Volume: 56 Pages: 77-81
• [Journal Article] 増加傾向にある牛白血病の現状と対策～診療現場からの声に対して～ (2010)
  • Author(s): 今内覚、田島誉士、小沼操、村田史郎、大橋和彦
  • Journal Title: 産業動物臨床医学雑誌 Volume: 1 Pages: 110-114
  • NAID: 130003358460
• [Journal Article] 増加傾向にある牛白血病の現状と対策～診療・生産現場からの声に対して～ (2010)
  • Author(s): 今内覚, 田島誉士, 小沼操, 大橋和彦
  • Journal Title: 家畜診療 Volume: 57 Pages: 1-7
• [Presentation] スーラ病の分子疫学調査および野外分離株を用いた比較病原性解析と病態発生機序の解明 (2013)
  • Author(s): 目堅博久、今内覚、ClaroNMingala、井上昇、村田史郎、小沼操、大橋和彦
  • Organizer: 第155回日本獣医学会学術集会プレナリーセッション
  • Place of Presentation: 東京大学(東京都)
  • Year and Date: 2013-03-28
• [Presentation] Role of Inhibitory Molecules in Bovine Chronic Infectious Diseases and as Target for Therapy (2013)
  • Author(s): Satoru Konnai
  • Organizer: Philippines Carabao Center Special Seminar(
  • Place of Presentation: Philippines Carabao Center (Science city of Munos, Philippines).
  • Year and Date: 2013-03-01
• [Presentation] Investigation of immunoinhibitory receptors as novel therapeutic targets for multiple infectious diseases in cattle (2013)
  • Author(s): Tomohiro Okagawa, Satoru Konnai, Ryoyo Ikebuchi, Yuji Sunden, Shiro Murata, Kazuhiko Ohashi
  • Organizer: Philippines Carabao Center Special Seminar, Philippines Carabao Center Special Seminar
  • Place of Presentation: Philippines Carabao Center (Science city of Munos, Philippines).
  • Year and Date: 2013-03-01
• [Presentation] 牛難治性疾病に対する免疫抑制因子を標的とした新規制御法の開発 (2013)
  • Author(s): 今内覚
  • Organizer: 日本大学生物資源科学部動物医科学研究センター特別セミナー
  • Place of Presentation: 日本大学生物資源科学部(藤沢市)
  • Year and Date: 2013-01-15
• [Presentation] Role of Inhibitory Molecules in Bovine Chronic Infectious Diseases and as Target for Therapy (2013)
  • Author(s): Satoru KONNAI
  • Organizer: Philippines Carabao Center Special Seminar
  • Place of Presentation: Philippines Carabao Center (Philippines)
  • Invited
• [Presentation] 牛難治性疾病に対する免疫抑制因子を標的とした新規制御法の開発 (2013)
  • Author(s): 今内 覚
  • Organizer: 日本大学生物資源科学部 動物医科学研究センター特別セミ ナー
  • Place of Presentation: 日本大学生物資源科学部(藤沢市)
  • Invited
• [Presentation] Investigation of immunoinhibitory receptors as novel therapeutic targets for multiple infectious diseases in cattle (2013)
  • Author(s): Tomohiro Okagawa, Satoru Konnai, Ryoyo Ikebuchi, Yuji Sunden, Shiro Murata, Kazuhiko Ohashi
  • Organizer: Philippines Carabao Center Special Seminar
  • Place of Presentation: Philippines Carabao Center (Philippines)
• [Presentation] スーラ病の分子疫学調査および野外分離株を用いた比較病原性解析と病態発生機序の解明 (2013)
  • Author(s): 目堅博久、今内 覚、Claro N Mingala、井上 昇、村田史郎、小沼 操、大橋和彦
  • Organizer: 第155回日本獣医学会学術集会
  • Place of Presentation: 東京大学(東京都)
• [Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in bovine leukemia virus- infected cattle (2012)
  • Author(s): Ryoyo Ikebuchi, Satoru Konnai, Tomohiro Okagawa, Yuji Sunden, Shiro Murata, Kazuhiko Ohashi
  • Organizer: The 4nd International Young Researcher Seminar in Zoonosis Control 2012
  • Place of Presentation: 北海道大学(札幌市).
  • Year and Date: 2012-09-20
• [Presentation] Molecular characterization of an immunoinhibitory receptor Tim-3 inbovine leukemia virus-infected cattle (2012)
  • Author(s): Tomohiro Okagawa, Satoru Konnai, Ryoyo Ikebuchi, Yuji Sunden, Shiro Murata, Kazuhiko Ohashi
  • Organizer: The 4nd International Young Researcher Seminar in Zoonosis Control 2012
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-09-20
• [Presentation] Identification of target antigens with anti-tick vaccine potential (2012)
  • Author(s): Naftaly Githaka, Satoru Konnai, Shiro Murata, Kazuhiko Ohashi
  • Organizer: The 4nd International Young Researcher Seminar in Zoonosis Control 2012
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-09-20
• [Presentation] Molecular characterization of expressed sequence tags for Dermanyssus gallinae for thedevelopment of a novel control methodof the mite (2012)
  • Author(s): Masayoshi Isezaki, Satoru Konnai, Shiro Murata, Kazuhiko Ohashi
  • Organizer: The 4nd InternationalYoung Researcher Seminar in ZoonosisControl 2012
  • Place of Presentation: 北海道大学(札幌市).
  • Year and Date: 2012-09-20
• [Presentation] 牛慢性疾患の新たなる治療法の可能性免疫抑制因子を標的とした新規治療薬の開発 (2012)
  • Author(s): 今内覚
  • Organizer: 酪農学園大学大動物研究セミナー
  • Place of Presentation: 酪農学園大学(江別市)
  • Year and Date: 2012-09-18
• [Presentation] ウシの免疫抑制受容体PD-1に対するモノクローナル抗体の作製および免疫活性化能の検討 (2012)
  • Author(s): 池渕良洋、今内覚、岡川朋弘、村田史郎、大橋和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)
  • Year and Date: 2012-09-14
• [Presentation] 牛白血病ウイルス感染牛における免疫抑制因子Tim-3/Gal-9の発現解析および機能解析 (2012)
  • Author(s): 岡川朋弘、今内覚、池渕良洋、鈴木紗織、寸田祐嗣、村田史郎、大橋和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)。
  • Year and Date: 2012-09-14
• [Presentation] マレック病感染鶏由来腫瘍病変部における免疫抑制因子PD-1/PD-L1発現の形態学的解析 (2012)
  • Author(s): 村田史郎、松山あゆ美、伊勢崎政美、高崎紗蘭、市居修、今内覚、大橋和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)
  • Year and Date: 2012-09-14
• [Presentation] マレック病ウイルスワクチン接種鶏における免疫抑制因子PD-1およびPD-L1の発現解析 (2012)
  • Author(s): 高崎紗蘭、村田史郎、松山あゆ美、伊勢崎政美、今内覚、大橋和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)
  • Year and Date: 2012-09-14
• [Presentation] ワクモDermanyssus gallinae由来発現遺伝子の網羅的解析 (2012)
  • Author(s): 伊勢崎政美、村田史郎、今内覚大橋factorsPD-1/PD-L1The3nd和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)
  • Year and Date: 2012-09-14
• [Presentation] シュルツェマダニ(Ixodes persulcatus)唾液腺由来免疫抑制因子sL2の同定および発現解析 (2012)
  • Author(s): 高田春奈、今内覚、NaftalyGithaka、伊勢崎政美、伊東拓也、安藤秀二、川端寛樹、村田史郎、大橋和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)
  • Year and Date: 2012-09-14
• [Presentation] フィリピン共和国におけるTrypanosoma evansi野外流行株の分離および比較病原性解析 (2012)
  • Author(s): 今内覚、目堅博久、Claro Mingala、Nancy Abes、Alan Dargantes、井上昇、村田史郎、大橋和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)
  • Year and Date: 2012-09-14
• [Presentation] 牛難治性疾病に対する免疫抑制因子を標的とした治療型ワクチンの開発 (2012)
  • Author(s): 今内覚
  • Organizer: 第153回日本獣医学会学術集会微生物分科会シンポジウム
  • Place of Presentation: 大宮ソニックシティー(さいたま市)
  • Year and Date: 2012-03-27
• [Presentation] 牛難治性疾病に対する免疫抑制因子を標的とした治療型ワクチンの開発 (2012)
  • Author(s): 今内覚
  • Organizer: 第153回日本獣医学会学術集会微生物分科会シンポジウム
  • Place of Presentation: 大宮ソニックシティー(さいたま市)(招待講演)
  • Year and Date: 2012-03-27
• [Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in bovine leukemia virus infection (2012)
  • Author(s): Ikebuchi R, Konnai S, Murata S, Ohashi K
  • Organizer: International symposium on worldwide infectious diseases of farm animal in production medicine; prospective and perspective
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2012-02-03
• [Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in bovine leukemia virus infection (2012)
  • Author(s): Ikebuchi R, Konnai S, Murata S, Ohashi K
  • Organizer: International symposium on worldwide infectious diseases of farm animal in production medicine ; prospective and perspective
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2012-02-03
• [Presentation] 牛白血病ウイルス感染症の現状と対策 (2012)
  • Author(s): 今内覚
  • Organizer: 平成23年度北海道家畜保健衛生所病性鑑定技術検討会特別講演
  • Place of Presentation: 十勝家畜保健衛生所(帯広市)(招待講演)
  • Year and Date: 2012-01-11
• [Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in bovine leukemia virus-infected cattle (2012)
  • Author(s): Ryoyo Ikebuchi, Satoru Konnai, Tomohiro Okagawa, Yuji Sunden, Shiro Murata, Kazuhiko Ohashi
  • Organizer: The 4nd International Young Researcher Seminar in Zoonosis Control 2012
  • Place of Presentation: 北海道大学(札幌市)
• [Presentation] Molecular characterization of an immunoinhibitory receptor Tim-3 in bovine leukemia virus-infected cattle (2012)
  • Author(s): Tomohiro Okagawa, Satoru Konnai, Ryoyo Ikebuchi, Yuji Sunden, Shiro Murata, Kazuhiko Ohashi
  • Organizer: The 4nd International Young Researcher Seminar in Zoonosis Control 2012
  • Place of Presentation: 北海道大学(札幌市)
• [Presentation] Molecular characterization of expressed sequence tags for Dermanyssus gallinae for the development of a novel control method of the mite (2012)
  • Author(s): Masayoshi Isezaki, Satoru Konnai, Shiro Murata, Kazuhiko Ohashi
  • Organizer: The 4nd International Young Researcher Seminar in Zoonosis Control 2012
  • Place of Presentation: 北海道大学(札幌市)
• [Presentation] 牛慢性疾患の新たなる治療法の可能性 免疫抑制因子を標的とした新規治療薬の開発 (2012)
  • Author(s): 今内 覚
  • Organizer: 酪農学園大学大動物研究セミナー
  • Place of Presentation: 酪農学園大学(江別市)
  • Invited
• [Presentation] 第154回日本獣医学会学術集会 (2012)
  • Author(s): 池渕良洋、今内覚、岡川朋弘、村田史郎、大橋和彦
  • Organizer: ウシの免疫抑制受容体PD-1に対するモノクローナル抗体の作製および免疫活性化能の検討
  • Place of Presentation: 岩手大学(盛岡市)
• [Presentation] 牛白血病ウイルス感染牛における免疫抑制因子Tim-3/Gal-9の発現解析および機能解析 (2012)
  • Author(s): 岡川朋弘、今内覚、池渕良洋、鈴木紗織、寸田祐 嗣、村田史郎、大橋和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)
• [Presentation] ワクモDermanyssusgallinae由来発現遺伝子の網羅的解析 (2012)
  • Author(s): 伊勢崎 政美、村田 史郎、今内 覚、大橋 和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)
• [Presentation] シュルツェマダニ(Ixodes persulcatus)唾液腺由来免疫抑制因子sL2の同定および発現解析 (2012)
  • Author(s): 高田 春奈、今内 覚、Naftaly Githaka、伊勢崎 政美、伊東 拓也、安藤 秀二、川端 寛樹、村田史郎、大橋和彦
  • Organizer: 第154回日本獣医学会学術集会
  • Place of Presentation: 岩手大学(盛岡市)
• [Presentation] 牛白血病の現状と感染予防対策について～ある農場における清浄化の取り組み事例から～ (2011)
  • Author(s): 今内覚
  • Organizer: 道央農業振興公社牛白血病講習会(畜産研修会)
  • Place of Presentation: 道央農業振興公社(北広島市)(招待講演)
  • Year and Date: 2011-12-16
• [Presentation] 牛の難治性疾病に対する多機能型ワクチン戦略 (2011)
  • Author(s): 今内覚
  • Organizer: 第51回家畜衛生学会シンポジウム
  • Place of Presentation: MeijiSeikaファルマ(株)本社(東京都)
  • Year and Date: 2011-11-25
• [Presentation] 牛の難治性疾病に対する多機能型ワクチン戦略 (2011)
  • Author(s): 今内覚
  • Organizer: 第51回家畜衛生学会シンポジウム
  • Place of Presentation: Meiji Seikaファルマ(株)本社(東京都)(招待講演)
  • Year and Date: 2011-11-25
• [Presentation] 牛白血病の現状とその対策 (2011)
  • Author(s): 今内覚
  • Organizer: 岩手県獣医師会特別講演
  • Place of Presentation: 盛岡家畜保健衛生所(盛岡市)(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] 国内の牛白血病の現状と今後に対策について (2011)
  • Author(s): 今内覚
  • Organizer: 牛臨床寄生虫研究会・家畜臨床学会ジョイントシンポジウム
  • Place of Presentation: 長崎ブリックホール(長崎市)(招待講演)
  • Year and Date: 2011-10-29
• [Presentation] 牛白血病の現状とその対策 (2011)
  • Author(s): 今内覚
  • Organizer: 栃木県獣医師会特別講演
  • Place of Presentation: 都ホテル(那須塩原市)(招待講演)
  • Year and Date: 2011-10-07
• [Presentation] 牛白血病ウイルス感染牛における制御性T細胞の動態解析 (2011)
  • Author(s): 鈴木紗織, 今内覚, 池渕良洋, 岡川朋弘, 寸田祐嗣, 村田史郎, 大橋和彦
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2011-09-19
• [Presentation] ウシ免疫抑制受容体Tim-3の同定と牛白血病ウイルス感染牛における発現解析 (2011)
  • Author(s): 岡川朋弘, 今内覚, 池渕良洋, 鈴木紗織, 寸田祐嗣, 村田史郎, 大橋和彦
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2011-09-19
• [Presentation] トリパノソーマ原虫感染において制御性樹状細胞は炎症反応を抑制して病態の改善に関与する (2011)
  • Author(s): 目堅博久, 今内覚, 井上昇, 村田史郎, 大橋和彦
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2011-09-19
• [Presentation] Theileria parva感染牛属のサイトカイン発現比較解析 (2011)
  • Author(s): 今内覚, 岡川朋弘, Naftali Githka, 目堅博久, 鈴木紗織, Edward Kariuki, Robert Skilton, 石塚真由美, 村田史郎, 大橋和彦
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2011-09-19
• [Presentation] Genetic sub-structuring in field populations of Theileria parva in Kenya (2011)
  • Author(s): Githaka NW, Konnai S, Kariuki E, Murata S, Ohashi K
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2011-09-19
• [Presentation] シュルツェマダニ(Ixodes persulcatus)唾液腺由来免疫抑制因子の同定および発現解析 (2011)
  • Author(s): 丹羽彩乃, 今内覚, Githka NW, 伊東拓也, 川端寛樹, 村田史郎, 大橋和彦
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学(堺市)
  • Year and Date: 2011-09-19
• [Presentation] Molecular characterization of tick-borne piroplasms of livestock and wildlife in Kenya (2011)
  • Author(s): Githaka NW, Konnai S, Kariuki E, Murata S, Ohashi K
  • Organizer: The 3nd International Young Researcher Seminar in Zoonosis Control 2011
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2011-09-16
• [Presentation] Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection (2011)
  • Author(s): Mekata H, Konnai S, Murata S, Ohashi K.
  • Organizer: The 3nd International Young Researcher Seminar in Zoonosis Control 2011
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2011-09-16
• [Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 (2011)
  • Author(s): Ikebuchi R, Konnai S, Sunden Y, Onuma M, Murata S, Ohashi K
  • Organizer: The 3nd International Young Researcher Seminar in Zoonosis Control 2011
  • Place of Presentation: 北海道大学 (札幌市).
  • Year and Date: 2011-09-16
• [Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 (2011)
  • Author(s): Ikebuchi R, Konnai S, Sunden Y, Onuma M, Murata S, Ohashi K
  • Organizer: XV International Congress of Virology
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2011-09-16
• [Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 (2011)
  • Author(s): Ikebuchi R, Konnai S, Sunden Y, Onuma M, Murata S, Ohashi K
  • Organizer: The 3nd International Young Researcher Seminar in Zoonosis Control 2011
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2011-09-16
• [Presentation] Suppression of cell proliferation and cytokineexpression by HL-p36, a tick salivary gland-derived protein of Haemaphysalis longicornis. (2011)
  • Author(s): Konnai S, Nakajima C, Imamura S, YamadaS, Murata S, Ohashi K
  • Organizer: XIII International Congress of Mycology
  • Place of Presentation: 札幌コンベンションセ ンター(札幌市)
  • Year and Date: 2011-09-09
• [Presentation] Suppression of cell proliferation and cytokine expression by HL-p36, a tick salivary gland-derived protein of Haemaphysalis longicornis (2011)
  • Author(s): Konnai S, Nakajima G, Imamura S, Yamada S, Murata S, Ohashi K
  • Organizer: XIII International Congress of Mycology
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2011-09-09
• [Presentation] Prevalence and source of trypanosome infections in field-captured vector flies (Glossina pallidipes) in southeastern Zambia (2011)
  • Author(s): Mekata H, Konnai S, Murata S, Ohashi K
  • Organizer: XIII International Congress of Mycology
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2011-09-09
• [Presentation] Molecular characterization of tick-borne piroplasms of livestock and wildlife in Kenya (2011)
  • Author(s): Githaka NW, Konnai S, Kariuki E, Murata S, Ohashi K
  • Organizer: XIII International Congress of Mycology
  • Place of Presentation: 札幌コンベンションセンター(札幌市)
  • Year and Date: 2011-09-09
• [Presentation] 牛の難治性疾病に対する多機能型ワクチン戦略 (2011)
  • Author(s): 今内覚
  • Organizer: 宮崎大学農学部特別シンポジウム
  • Place of Presentation: 宮崎大学(宮崎市)
  • Year and Date: 2011-09-03
• [Presentation] 牛の難治性疾病に対する多機能型ワクチン戦略 (2011)
  • Author(s): 今内覚
  • Organizer: 宮崎大学農学部特別シンポジウム(集談会)
  • Place of Presentation: 宮崎大学(宮崎市)(招待講演)
  • Year and Date: 2011-09-03
• [Presentation] 牛白血病の現場でのコントロールについて (2011)
  • Author(s): 今内覚
  • Organizer: 宮崎大学農学部特別シンポジウム(教育プログラム)
  • Place of Presentation: 宮崎大学(宮崎市)(招待講演)
  • Year and Date: 2011-09-02
• [Presentation] Research on host-pathogen interactions for establishment of novel strategies for disease control (2011)
  • Author(s): Satoru Konnai
  • Organizer: Special seminar in Federal University of Rio Grande doSul
  • Place of Presentation: Federal University of Rio Grande do Sul (Porto Alegre, Brazil).
  • Year and Date: 2011-08-13
• [Presentation] Research on host-pathogen interactions for establishment of novel strategies for disease control (2011)
  • Author(s): Satoru KONNAI
  • Organizer: Special seminar in Federal University of Rio Grande do Sul
  • Place of Presentation: Federal University of Rio Grande do Sul (Porto Alegre, Brazil)(招待講演)
  • Year and Date: 2011-08-13
• [Presentation] Research on host-pathogen interactions for establishment of novel strategies for disease control (2011)
  • Author(s): Satoru Konnai
  • Organizer: Special seminar in Northern Fluminense State UniversityDarcy Ribeiro (Campos campus)
  • Place of Presentation: Northern Fluminense State University Darcy Ribeiro (Campos, Brazil).
  • Year and Date: 2011-07-28
• [Presentation] Research on host-pathogen interactions for establishment of novel strategies for disease control (2011)
  • Author(s): Satoru KONNAI
  • Organizer: Special seminar in Northern Fluminense State University Darcy Ribeiro (Campos campus)
  • Place of Presentation: Special seminar in Northern Fluminense State University Darcy Ribeiro (Campos, Brazil)(招待講演)
  • Year and Date: 2011-07-28
• [Presentation] Research onhost-pathogen interactions for establishment of novel strategies for disease control (2011)
  • Author(s): Satoru Konnai
  • Organizer: Special seminar in Northern Fluminense State University Darcy Ribeiro (Makae campus)
  • Place of Presentation: Northern Fluminense State University Darcy Ribeiro (Makae, Brazil).
  • Year and Date: 2011-07-20
• [Presentation] Research on host-pathogen interactions for establishment of novel strategies for disease control (2011)
  • Author(s): Satoru KONNAI
  • Organizer: Special seminar in Northern Fluminense State University Darcy Ribeiro (Makae campus)
  • Place of Presentation: Northern Fluminense State University Darcy Ribeiro (Makae, Brazil)(招待講演)
  • Year and Date: 2011-07-20
• [Presentation] 牛の難治性疾病に対する多機能型ワクチン戦略 (2011)
  • Author(s): 今内覚
  • Organizer: 第151回日本獣医学会学術集会シンポジウム
  • Place of Presentation: 東京農工大学(東京都) 招待講演
  • Year and Date: 2011-03-30
• [Presentation] 牛白血病ウイルス感染症の現状と対策 (2011)
  • Author(s): 今内覚
  • Organizer: 福岡県獣医師会産業動物部会講習会
  • Place of Presentation: 福岡県獣医畜産会館(福岡県) 招待講演
  • Year and Date: 2011-02-25
• [Presentation] 牛白血病の感染防御対策 (2011)
  • Author(s): 今内覚
  • Organizer: 第43回北海道しゃくなげ会
  • Place of Presentation: 札幌グランドホテル(北海道) 招待講演
  • Year and Date: 2011-02-18
• [Presentation] 生産現場における白血病対策-現状と課題- (2011)
  • Author(s): 今内覚
  • Organizer: 平成22年度日本獣医師会獣医学術学会年次大会
  • Place of Presentation: 岐阜市国際会議場(岐阜県) 招待講演
  • Year and Date: 2011-02-12
• [Presentation] 増加傾向にある牛白血病の現状と対策 (2010)
  • Author(s): 今内覚
  • Organizer: 日本家畜臨床学会第41回学術集会
  • Place of Presentation: 天童ホテル(山形県) 招待講演
  • Year and Date: 2010-11-06
• [Presentation] 原虫病疾病制御のための新戦略 (2010)
  • Author(s): 今内覚
  • Organizer: 日本家畜衛生学会
  • Place of Presentation: 明治製菓本社講堂(東京都) 招待講演
  • Year and Date: 2010-11-05
• [Presentation] マガンおよび鶏におけるinterferon-γ遺伝子プロモーター活性の比較解析 (2010)
  • Author(s): 村田史郎, 加納里佳, 今内覚, 伊勢崎政美, 大橋和彦, ほか
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-19
• [Presentation] シュルツェマダニ(Ixodes persulcatsu)由来Salp16の宿主免疫抑制機構解析 (2010)
  • Author(s): 今内覚, 肥田野新, 村瀬優介, 伊東拓也, 川端寛樹, ほか
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] フィリピン共和国で分離したTrypanosoma evansiの病原性比較解析 (2010)
  • Author(s): 目堅博久, 今内覚, Mingala C, Dargants A, 井上昇, ほか
  • Organizer: 第150回日本獣医学会学術集会'
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] シュルツェマダニ(Ixodes persulcatus)由来Salp15様因子の性状解析 (2010)
  • Author(s): 村瀬優介, 今内覚, 伊東拓也, 高野愛, 川端寛樹, ほか
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] ワクモDermanyssus gallinaeに対する新規防除法開発のためのトランスクリプトーム解析 (2010)
  • Author(s): 伊勢崎政美, 村田史郎, 今内覚, 大橋和彦
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] アフリカスイギュウ(Syncerus caffer)のTh1、Th2および炎症性サイトカイン遺伝子の同定 (2010)
  • Author(s): 岡川朋弘, 鈴木紗織, 今内覚, Githaka N, Kariuki E, ほか
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] 牛白血病ウイルス感染牛における免疫抑制因子PD-1/PD-L1の発現解析と機能解析 (2010)
  • Author(s): 池渕良洋, 今内覚, 寸田祐嗣, 小沼操, 村田史郎, ほか
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] ウシ免疫抑制因子LAG-3の同定と牛白血病ウイルス感染牛における発現解析 (2010)
  • Author(s): 白井達哉, 今内覚, 池渕良洋, 寸田祐嗣, 小沼操, ほか
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] マレック病ウイルス感染鶏における免疫抑制受容体PD-1とそのリガンドPD-L1の発現解析 (2010)
  • Author(s): 河東あゆ美, 村田史郎, 加納里佳, 今内覚, 大橋和彦
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学(北海道)
  • Year and Date: 2010-09-18
• [Presentation] 増加傾向にある牛白血病の現状と対策 (2010)
  • Author(s): 今内覚
  • Organizer: 平成22年度北海道地区家畜診療技術研修会
  • Place of Presentation: 農業共済研修所(北海道) 招待講演
  • Year and Date: 2010-09-15
• [Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in bovine leukemia virus-infected cattle (2010)
  • Author(s): Ikebuchi R, Konnai S, Sunden Y, Onuma M, Murata S, Ohashi K
  • Organizer: The 2nd International Young Researcher Seminar in Zoonosis Control 2010
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2010-09-13
• [Presentation] メガファームにおける取り組み紹介-牛白血病ウイルス感染伝播阻止トライアルの実例- (2010)
  • Author(s): 今内覚
  • Organizer: 平成22年度獣医学術北海道地区学会シンポジウム
  • Place of Presentation: 函館湯の川ホテル(北海道) 招待講演
  • Year and Date: 2010-09-10
• [Presentation] Regulation of the interferon gamma expression by an oncoprotein of Marek's disease virus in wild waterfowls and chickens (2010)
  • Author(s): Murata S, Matsubara A, Kano R, Konnai S, Ohashi K
  • Organizer: The 9th International Veterinary Immunology Symposium
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-08-19
• [Presentation] Pro-inflammatory cytokine storm in Theileria parva-infected cattle (2010)
  • Author(s): Satoru KONNAI
  • Organizer: The 9th International Veterinary Immunology Symposium (Concurrent Session)
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-08-17
• [Presentation] Molecular characterization of immunoinhibitory factors PD-1/PD-L1 in bovine leukemia virus-infected cattle (2010)
  • Author(s): Ikebuchi R, Konnai S, Sunden Y, Onuma M, Murata S, Ohashi K
  • Organizer: The 9th International Veterinary Immunology Symposium (Workshop)
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-08-17
• [Presentation] 牛白血病ウイルス感染症の現状と対策 (2010)
  • Author(s): 今内覚
  • Organizer: 北海道獣医師会オホーツク支部大動物講習会
  • Place of Presentation: NOSAIオホーツク紋別診療所(北海道) 招待講演
  • Year and Date: 2010-07-28
• [Presentation] 牛白血病ウイルス感染症の現状と対策 (2010)
  • Author(s): 今内覚
  • Organizer: 北海道獣医師会オホーツク支部大動物講習会
  • Place of Presentation: NOSAIオホーツク大空診療所(北海道) 招待講演
  • Year and Date: 2010-07-27
• [Book] 牛病学(免疫疲弊化と免疫賦活化の項) (2013)
  • Author(s): 今内覚
  • Publisher: 近代出版(印刷中)
• [Book] 牛病学 (免疫疲弊化と免疫賦活化の項) (2013)
  • Author(s): 今内 覚
  • Publisher: 近代出版
• [Remarks]
  • URL: http://www.vetmed.hokudai.ac.jp/library/link/infectious_publications.html
• [Remarks]
  • URL: http://www.vetmed.hokudai.ac.jp/library/link/infectious_publications.html
• [Remarks] The 9th International Veterinaly Immunology Symposium(2010年8月19日、タワーホール船堀・東京都)にて、The 9th IVIS Student Awardsを受賞した(Ikebuchi R et al.)
• [Remarks] The 2nd International Young Researcher Seminar in Zoonosis Control 2010(2010年9月13日、北海道大学・札幌市)にて、The 2nd IYRSZC Best Poster Presentation Awardsを受賞した(Ikebuchi R et al.)