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Clinical application of diagnosis method of bovine major histocompatibility complex genes associated with resistanceand susceptibility to bovine leukemia virus-induced lymphomain East Asia

Research Project

Project/Area Number 22405040
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Applied veterinary science
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

AIDA Yoko  独立行政法人理化学研究所, 分子ウイルス学特別研究ユニット, ユニットリーダー (50182994)

Co-Investigator(Renkei-kenkyūsha) ONUMA Misao  北海道大学, (連合)獣医学研究科, 名誉教授 (70109510)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
KeywordsBoLA クラスIIDRB3 / PCR-Sequence based typing(SBT)法 / BLV,BLV nested PCR / フィリピン / ホルスタイン / ブラーマン / Native cattle / BoLAクラスIIDRB3 / PCR-SBT法 / 新規・既知アリル / 東南アジア / 固有品種 / 交雑種 / 多型性 / BoLAクラスII DRB3・DQA1 / BLV nested PCR / 中国山東省
Research Abstract

We previously demonstrated that bovine leukocyte antigens (BoLA)-DRB3 alleles associated with resistance or susceptibility to development of bovine leukemia virus (BLV)-induced B lymphoma and analyzed distribution of these alleles in Japan and South-America. However, until now, none of the South-east Asian breed had been characterized for BoLA-DRB3 genes by PCR-sequence based typing (SBT). Hence, we here sequenced exon 2 of the BoLA class II DRB3 gene from 981 cattle including Holstein, Sahiwal, Brahman, Philippine Native and its cross breed, corrected from five islands of Philippine using modified SBT method which is suitable for Philippine cattle. In addition, we detected BLV by a new BLV-CoCoMo-qPCR. We identified the 75 previously reported alleles and 6 novel alleles. Interestingly, the number found in each breed is extent high level, indicating that that Asian breeds reveal extent high level of polymorphism for BoLA-DRB3 distributions. Our result also showed BLV-infected cattle with the susceptibility-associated allele was significantly lower than that in Japan.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (140 results)

All 2013 2012 2011 2010

All Journal Article (53 results) (of which Peer Reviewed: 52 results) Presentation (83 results) (of which Invited: 4 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] Characterization of bovine MHC class II DRB3 diversity in Latin America Creole cattle breeds2013

    • Author(s)
      Giovambattista G., Takeshima S-n., Veronica M.R., Matsumoto Y, Angela A. Franco, Saito H., Onuma M., and Aida Y
    • Journal Title

      Gene

      Volume: 519 Pages: 150-158

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of bovine leukemia virus proviral load in Japanese Black cattle2013

    • Author(s)
      Miyasaka T. , Takeshima S-n. , Jimba M. , Kobayashi N. , Matsuhashi T. , Matsumoto Y. , Sentsui H. and Aida Y
    • Journal Title

      Tissue Antigens

      Volume: 81 Pages: 72-82

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 兵庫県中部でみられたホルスタイン種における牛白血病の病態及び発症要因の検討2013

    • Author(s)
      富田啓介, 中条正樹,加茂前優花,矢島和枝,浦本京也,竹嶋伸之輔,間 陽子
    • Journal Title

      日本獣医師会雑誌

      Volume: 2、66 Pages: 109-114

    • NAID

      10031168955

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ohashi K., Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus2013

    • Author(s)
      Konnai, S., Suzuki, S., Shirai, T., Ikebuchi, R., Okagawa, T., Sunden., Y, Mingala C.N., Onuma, M., Murata, S
    • Journal Title

      Comp. Immunol. Microbiol. Infect. Dis

      Volume: 36 Pages: 63-69

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importin α/Qip1 Is Involved in Multiplication of Mutant Influenza Virus with Alanine Mutation at Amino Acid 9 Independently of Nuclear Tranport Function2013

    • Author(s)
      Sasaki Y. , Hagiwara K. , Kakisaka M. , Yamada K. , Murakami T. , Aida Y.
    • Journal Title

      PLoS ONE

      Volume: 8-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Meq proteins from field isolates of Marek’s disease virus in Japan.2013

    • Author(s)
      Murata, S., Hashiguchi T., Hayashi, Y., Yamamoto Y., Matsuyama-Kato A., Takasaki S., Isezaki M., Onuma M., Konnai S., Ohashi K.
    • Journal Title

      Infect. Genet. Evol.

      Volume: -

    • NAID

      120005317003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation, cloning and pathologic analysis of Trypanosoma evansi field isolates2013

    • Author(s)
      Mekata H., Konnai S., Mingala C.N., Abes N.S., Gutierrez A., Dargantes A.P., Witola W.H., Inoue N., Onuma M., Murata S., Ohash K.
    • Journal Title

      Parasitol. Res.

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced expression of LAG-3 on lymphocyte subpopulations from persistently lymphocytotic cattle infected with bovine leukemia virus2013

    • Author(s)
      Konnai S., Suzuki S., Shirai T., Ikebuchi R., Okagawa T., Sunden Y, Mingala C.N., Onuma M., Murata S., Ohashi K.
    • Journal Title

      Comp. Immunol. Microbiol. Infect. Dis

      Volume: 36 Pages: 63-69

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BLV-CoCoMo-qPCR: a useful tool for evaluating bovine leukemia virus infection status2012

    • Author(s)
      Jimba M, Takeshima S-n, Kohara J, Kobayashi N, Matsuhashi T, Omori T, Nunoya T and Aida Y
    • Journal Title

      BMC Vet Res

      Volume: 8 Pages: 167-167

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The pH-sensitive fusogenic3-methyl-glutarylated hyperbranched oly(glycidol) (MGlu-HPG)-conjugated liposome induces antigen-specific cellular and humoral immunity2012

    • Author(s)
      Hebishima T, Yuba E, Kono K, Takeshima S-n, Ito Y and Aida Y
    • Journal Title

      Clin. Vaccine Immunol

      Volume: 19 Pages: 1492-1498

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between BoLA-DRB3 and somatic cell count in Holstein cattle from Argentina2012

    • Author(s)
      Baltian L. , Ripoli M. , Sanfilippo S. , Takeshima S-n., Aida Y., Giovambattista G
    • Journal Title

      Molecular Biology Reports

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarraybased gene expression analysis2012

    • Author(s)
      Arainga M., Murakami H., Aida Y
    • Journal Title

      BMC Genomics

      Volume: 13 Pages: 275-275

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of bovine leukemia virus Tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis2012

    • Author(s)
      Arainga M., Takeda E., Aida Y
    • Journal Title

      BMC Genomics

      Volume: 13 Pages: 121-121

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of interferon tau on cattle persistently infected with bovine viral diarrhea virus2012

    • Author(s)
      Kohara, J., Nishikura, Y., Konnai, S., Tajima, M., Onuma, M
    • Journal Title

      Jpn. J. Vet. Res

      Volume: 60 Pages: 63-70

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection2012

    • Author(s)
      Okagawa, T., Konnai, S., Ikebuchi, R., Suzuki, S., Shirai, T., Sunden, Y., Onuma M., Murata, S., Ohashi, K
    • Journal Title

      Vet. Res

      Volume: 43 Pages: 45-45

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] BLV-CoCoMo-qPCR: a useful tool for evaluating bovine leukemia virus infection status2012

    • Author(s)
      Jimba M., Takeshima S-n., Kohara J., Kobayashi N., Matsuhashi T., Omori T., Nunoya T., Aida Y.
    • Journal Title

      BMC Vet. Res

      Volume: 8 Pages: 167-167

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between BoLA-DRB3 and somatic cell count in Holstein cattle from Argentina2012

    • Author(s)
      Baltian L. , Ripoli M. , Sanfilippo S. , Takeshima S-n., Aida Y.,Giovambattista G.
    • Journal Title

      Molecular Biology Reports

      Volume: -

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The pH-sensitive fusogenic3-methyl-glutarylated hyperbranched poly(glycidol) (MGlu-HPG)-conjugated liposome induces antigen-specific cellular and2012

    • Author(s)
      Hebishima T., Yuba E., Kono K., Takeshima S-n., Ito Y., Aida Y.
    • Journal Title

      Clin. Vaccine Immunol.

      Volume: 19 Pages: 1492-1498

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a novel compound with anitiviral activity against influenza A virus depending on PA subunit of viral RNA polymerase2012

    • Author(s)
      Yamada K. , Koyama H., Hagiwara K., Ueda A. , Sasaki Y. , Kanesashi S-n. , Ueno R. , Nakamura H. , Kuwata K. , Shimizu K. , Suzuki M. , Aida Y.
    • Journal Title

      Microbes and Infection

      Volume: 14 Pages: 740-747

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 5’Flanking Reagion and Intron1 of the Bovine Prion Protein Gene(PRNP)Are Responsible for Negative Feedback Regulation of the Prion Protein2012

    • Author(s)
      Xue G. , Aida Y. , Onodera T. , Sakudo A.
    • Journal Title

      PLoS ONE

      Volume: 7, e32870 Pages: 1-7

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-2012

    • Author(s)
      Arainga M., Murakami H., Aida Y.
    • Journal Title

      BMC Genomics

      Volume: 13 Pages: 275-275

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of bovine leukemia virus Tax function associated with host cell transcription, signaling, stress response and immune response pathway by microarray-based gene expression analysis2012

    • Author(s)
      Arainga M., Takeda E., Aida Y.
    • Journal Title

      BMC Genomics

      Volume: 13 Pages: 121-121

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of interferon tau on cattle persistently infected with bovine viral diarrhea virus2012

    • Author(s)
      Kohara J., Nishikura Y., Konnai S., Tajima M., Onuma M.
    • Journal Title

      Jpn. J. Vet. Res.

      Volume: 60 Pages: 63-70

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased bovine Tim-3 and its ligand expressions during bovine leukemia virus infection.2012

    • Author(s)
      Okagawa T., Konnai S., Ikebuchi R., Suzuki S., Shirai T., Sunden Y., Onuma M., Murata S., Ohashi K.
    • Journal Title

      Vet. Res

      Volume: 43 Pages: 45-45

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kinetics of regulatory dendritic cells in inflammatory responses during Trypanosoma evansi infection2012

    • Author(s)
      Mekata H., Konnai S., Mingala C.N., Abes N.S., Gutierrez A., Dargantes A.P., Witola W.H., Inoue N., Onuma M., Murata S., Ohash K.
    • Journal Title

      Parasite Immunol.

      Volume: 34 Pages: 318-329

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between BoLA-DRB3 and somatic cell score in Holstein cattle from Argentina2012

    • Author(s)
      Baltian LR, Ripoli MV, Sanfilippo S, Takeshima S-N, Aida Y, Giovambattista G
    • Journal Title

      Molecular Biology Reports

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of bovine leukemia virus Tax function associated with Host cell transcription, signaling, stress response and immune Response pathway by Microarray-based gene exoression analysis2012

    • Author(s)
      Mariluz Arainga-Ramirez, Eri Takeda, Yoko Aida
    • Journal Title

      BMC Genomics

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis2012

    • Author(s)
      Mariluz Arainga-Ramirez, Hironobu Murakami, Yoko Aida
    • Journal Title

      BMC Genomics

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ホルスタイン種における牛白血病の病態及び発症要因の検討2012

    • Author(s)
      富田啓介, 中条正樹, 加茂前優花, 塚本洋, 柴折浩幸, 岡畑一幸, 矢島和枝, 浦本京也, 竹嶋伸之輔, 間陽子
    • Journal Title

      日本獣医師会雑誌

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The 5' flanking region and intronl of the bovine prion protein gene (PRNP) are responsible for negative feedback regulation of the prion protein2012

    • Author(s)
      Guangai Xue, Yoko Aida, Takashi Onodera, Akikazu Sakudo
    • Journal Title

      PLoS ONE

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] pH-sensitive fusogenic3-methyl-glutarylated hyperbranchedpoly(glycidol) (MGlu-HPG)- onjugatedliposome induces antigen-specificcellular and humoral immunity2011

    • Author(s)
      Hebishima T, Yuba E, Kono K, Takeshima S-n,Ito Y and Aida Y
    • Journal Title

      Clin. Vaccine Immunol

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Imaging and microarray analyses of cell cycle arrest and apoptosis by Human T cell Leukemia Virus type 1 (HTLV-1) Tax2011

    • Author(s)
      Arainga M., Aida Y
    • Volume
      A175
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of host cellular gene transcription by Bovine Leukemia Virus (BLV) Tax, wild type and mutants2011

    • Author(s)
      Arainga M., Takeda E., Aida Y
    • Journal Title

      Retovirology

      Volume: 8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] BLV-CoCoMo-qPCR: comparison of other detection methods for BLV infection and kinetics analysis in experimental transmission of BLV in cattle2011

    • Author(s)
      Jimba M., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T., Kohara J., Aida Y
    • Journal Title

      Retovirology

      Volume: A21

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bovine MHC class II molecule plays a key role in bovine leukemia virus (BLV)-induced lymophoma2011

    • Author(s)
      Aida Y., Takeshima S-n., Matsumoto Y., Miyasaka T., Miyazaki Y., Tanabe Y., W. C. Davis, Okada K.
    • Journal Title

      Retovirology

      Volume: A7

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of antigen-specific cellular and humoral immunity by pH-sensitive carbonate apatite2011

    • Author(s)
      Hebishima T, Tada S., Takeshima S-n, Akaike T, Ito Y, Aida Y
    • Journal Title

      revised in Biochem. Biophys. Res. Commun

      Volume: 415 Pages: 597-601

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indentification and bovine majot histocompatibility complex class II haplotypes in JapaneseBlack and Holstein cattle in Japan2011

    • Author(s)
      Miyasaka T., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T.,Miyazaki Y., Tanabe Y., Ishibashi K., Sentsui S., and Aida Y
    • Journal Title

      J. Dairy Sci

      Volume: 95 Pages: 420-31

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A New Method for Typing Bovine Major Histocompatibility Complex Class II DRB3 Alleles by Combining Two Established PCR Sequence-Based2011

    • Author(s)
      Takeshima S-n., Matsumoto Y, Miyasaka T, Arainga M., Saito H., Onuma M. and Aida Y
    • Journal Title

      Techniques, Tissue Antigens

      Volume: 78 Pages: 208-213

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increase of cells expressing PD-L1 in bovine leukemia virus infection and enhancement of anti-viral immune responses in vitro via PD-L1 blockade2011

    • Author(s)
      Ikebuchi, R., Konnai, S., Shirai, T., Sunden, Y., Murata, S., Onuma M., Ohashi, K
    • Journal Title

      Vet. Res

      Volume: 42 Pages: 103-103

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular cloning of bovine lymphocyte activation gene-3 and its expression characteristics in bovine leukemia virus-infected cattle. Vet. Immunol2011

    • Author(s)
      Shirai, T., Konnai, S., Ikebuchi, R., Okagawa, T., Suzuki, S., Sunden, Y., Onuma, M., Murata, S., Ohashi, K
    • Journal Title

      Immunopathol

      Volume: 44 Pages: 462-467

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A New Method for Typing Bovine Major Histocompatibility Complex Class II DRB3 Alleles by Combining Two Established PCR Sequence-Based Techniques2011

    • Author(s)
      Shin-nosuke Takeshima, Yuki Matsumoto, Taku Miyasaka, Arainga Ramirez, Maliruz Anamelva, Hideki Saito, Misao Onuma, Yoko Aida
    • Journal Title

      Tissue Antigens

      Volume: 78 Pages: 208-213

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan2011

    • Author(s)
      Taku Miyasaka, Shin-nosuke Takeshima, Yuki Matusmoto, Naohiko Kobayashi, Tamako Matsuhashi, Yoshiyuki Miyazaki, Yoshihiro Tanabe, Kazuki Ishibashi, Hiroshi Sentsui, Yoko Aida
    • Journal Title

      Gene

      Volume: 472 Pages: 42-49

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Indentification and bovine majot histocompatibility complex class II haplotypes in Japanese Black and Hlstein cattle in Japan2011

    • Author(s)
      Taku Miyasaka, Shin-nosuke Takeshima, Hiroshi Sentsui, Yoko Aida
    • Journal Title

      J.Dairy Sci.

      Volume: 95 Pages: 420-431

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of antigen-specific cellular and humoral immunity by pH-sensitive carbonate apatite2011

    • Author(s)
      Takehisa Hebishima, Seiichi Tada, Shin-nosuke Takeshima, Toshihiro Akaike, Yoshihiro Ito, Yoko Aida
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 415 Pages: 597-601

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bovine MHC class II molecule plays a key role in bovine leukemia virus (BLV)-induced lymophoma2011

    • Author(s)
      Yoko Aida, Shin-nosuke Takeshima, Yuki Matsumoto, Taku Miyasaka, Yoshiyuki Miyazaki, Yoshiro Tanabe, William C.Davis, Kosuke Okada
    • Journal Title

      Retovirology

      Volume: 8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BLV-CoCoMo-qPCR : comparison of other detection methods for BLV infection and kinetics analysis in experimental transmission of BLV in cattle2011

    • Author(s)
      Mayuko Jimba, Shin-nosuke Takeshima, Yuki Matsumoto, Naohiko Kobayashi, Tamako Matsuhashi, Junko Kohara, Yoko Aida
    • Journal Title

      Retovirology

      Volume: 8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of host cellular gene transcription by Bovine Leukemia Virus (BLV) Tax, wild type and mutants2011

    • Author(s)
      Mariluz Arainga-Ramirez, Eri Takeda, Yoko Aida
    • Journal Title

      Retovirology

      Volume: 8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 牛白血病ワクチンの開発と新しい疾病防御戦略2011

    • Author(s)
      間陽子、竹嶋伸之輔
    • Journal Title

      臨床獣医

      Volume: 29 Pages: 23-29

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 牛白血病の世界における感染拡大の現状と防御対策2011

    • Author(s)
      間陽子、竹嶋伸之輔
    • Journal Title

      Journal of Veterinary Medicine

      Volume: 64(2) Pages: 115-120

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan2010

    • Author(s)
      Miyasaka T., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T.,Miyazaki Y., Tanabe Y., Ishibashi K., Sentsui S., and Aida Y
    • Journal Title

      Gene

      Volume: 472 Pages: 42-49

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] BLV-CoCoMo-qPCR: Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm2010

    • Author(s)
      Jimba M., Takeshima S-n, Matoba K., Daiji Endoh D., Aida Y
    • Journal Title

      Retroviology

      Volume: 7 Pages: 91-91

    • NAID

      120005761598

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] BLV-CoCoMo-qPCR : Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm2010

    • Author(s)
      Mayuko Jimba, Shin-nosuke Takeshima, Kazuhiro Matoba, Daiji Endoh, Yoko Aida
    • Journal Title

      Retorovirology

      Volume: 7 Pages: 91-110

    • NAID

      120005761598

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The diversity of bovine MHC class II DRB3 and DQA1 alleles in different Herds of Japanese Black and Holstein cattle in Japan2010

    • Author(s)
      Taku Miyasaka, Shin-nosuke Takeshima, Yuki Matsumoto, Naohiko Kobayashi, Tamako Matsuhashi, Yoshiyuki Miyazaki, Yoshihiro Tanabe, Kazuki Ishibashi, Hiroshi Sentsui, Yoko Aida
    • Journal Title

      Gene

      Volume: 472 Pages: 42-49

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 地方病性牛白血病の宿主発症要因の一考察2013

    • Author(s)
      斉藤 恵津子、間 陽子、竹嶋 伸之輔、松本 有生
    • Organizer
      平成24年度食肉衛生技術研修会・食肉衛生発表会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] インシリコ牛白血病ナノワクチンの開発2012

    • Author(s)
      間 陽子
    • Organizer
      ナノバイオテクノロジーに基づくDDS 技術による新世代ワクチン技術
    • Place of Presentation
      東京
    • Year and Date
      2012-12-18
    • Related Report
      2012 Final Research Report
  • [Presentation] BLV 発症感受性を標的にしたワクチン開発2012

    • Author(s)
      竹嶋伸之輔
    • Organizer
      シンポジウム牛白血病の新しい制圧戦略平成23 年度日本獣医師会獣医学術年次大会
    • Place of Presentation
      札幌
    • Year and Date
      2012-02-05
    • Related Report
      2012 Final Research Report
  • [Presentation] BLV 発症を制御するMHC 遺伝子と新たなる疾病対策2012

    • Author(s)
      間陽子
    • Organizer
      シンポジウム牛白血病の新しい制圧戦略平成23 年度日本獣医師会獣医学術年次大会
    • Place of Presentation
      札幌
    • Year and Date
      2012-02-05
    • Related Report
      2012 Final Research Report
  • [Presentation] BLV発症を制御するMHC遺伝子と新たなる疾病対策2012

    • Author(s)
      間陽子
    • Organizer
      シンポジウム牛白血病の新しい制圧戦略平成23年度日本獣医師会獣医学術年次大会
    • Place of Presentation
      札幌コンベンションホール(札幌市)(招待講演)
    • Year and Date
      2012-02-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 南米大陸におけるウシMHC クラスIIDRB3 遺伝子の頻度調査2012

    • Author(s)
      竹嶋 伸之輔、松本 有生、金 智潤、宮坂 卓、Valdivia G., Guillermo G.、 小沼 操、間陽子
    • Organizer
      日本動物遺伝育種学会第13回大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Final Research Report
  • [Presentation] フィリピン固有品種におけるウシMHC クラスII DRB3 およびミトコンドリアDNA D-loop 領域の解析2012

    • Author(s)
      竹嶋 伸之輔、大橋 未来、宮坂 卓、松本有生、Mingala Claro、小沼 操、間 陽子
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 牛白血病ウイルス(BLV)プロウイルスロードとBoLA クラスII 遺伝子多型相関性の解析2012

    • Author(s)
      宮坂 卓 、竹嶋 伸之輔 、松本 有生、神馬 繭子、小林 直彦、 松橋 珠子、 泉對博 、間 陽子
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of bovine leukocyte antigen (BoLA) class II haprotypes that are regulated bovine leukemia virus (BLV) proviral load in Japanese Black cattle2012

    • Author(s)
      Aida Y., Miyasaka T., Jimba M., Matsumoto Y., Kobayashi N., Matsuhashi T., Sentsui H.,Takeshima S-n.
    • Organizer
      33rd Conference of the International Society for Animal Genetics
    • Place of Presentation
      Cairns, Australia
    • Related Report
      2012 Final Research Report
  • [Presentation] Novel Th epitope of bovine leukemia virus detected in disease susceptibility cattle determined by BoLA-DRB3 allele2012

    • Author(s)
      Takeshima S-n., Kim,J.,Kyoj H., Matsumoto Y., Ohmori T., Nunoya T., Matoba K., Aida Y.
    • Organizer
      33rd Conference of the International Society for Animal Genetics
    • Place of Presentation
      Cairns, Australia.
    • Related Report
      2012 Final Research Report
  • [Presentation] インシリコ牛白血病ナノワクチンの開発2012

    • Author(s)
      間陽子
    • Organizer
      ナノバイオテクノロジーに基づくDDS技術による新世代ワクチン技術
    • Place of Presentation
      東京大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Identification of BLV Tax Function Associated with Host Cell Transcription, Signaling, Stress Response and Immune Response Pathway by Microarray2012

    • Author(s)
      Yoko Aida, Mariluz Arainga
    • Organizer
      24th Workshop on Retroviral Pathogenesis
    • Place of Presentation
      アメリカ
    • Related Report
      2012 Annual Research Report
  • [Presentation] 南米大陸におけるウシMHCクラスIIDRB3遺伝子の頻度調査2012

    • Author(s)
      竹嶋 伸之輔、松本 有生、金 智潤、宮坂 卓、Valdivia Gabriela Guillermo Giovambattista、 小沼 操、間 陽子
    • Organizer
      日本動物遺伝育種学会第13回大会
    • Place of Presentation
      東北大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] i n silico およびナノ粒子を用いた新しい牛白血病ワクチン開発動物用ワクチン2012

    • Author(s)
      竹嶋 伸之輔、金 智潤、蛇島 武久、萩原 恭二、松本 有生、多田 誠一、Pallavi Ananda、 伊藤 嘉浩、沖本 憲明、山岸 純也、弓場 英司、河野 健司、大森 崇司、布谷 鉄夫、的場 和弘、間 陽子
    • Organizer
      バイオ医薬品研究会学術集会
    • Place of Presentation
      岩手大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 牛白血病ウイルス感染牛における乳汁中ウイルス遺伝子の検出2012

    • Author(s)
      小原 潤子、櫻井 由絵、松本 有生、竹嶋 伸之輔、間 陽子
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Haplotype determination of upstream regulatory region and the second exon of bovine DRB3 gene2012

    • Author(s)
      Guillermo Giovambattista、 Ripoli Maria、竹嶋 伸之輔、Laura Baltian、間 陽子
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] インシリコ手法によるウシMHCクラスII分子を標的とする抗BLV高親和性ペプチドワクチンの設計2012

    • Author(s)
      山岸 純也、沖本 憲明、竹嶋 伸之輔、金 智潤、萩原 恭二、間 陽子、泰地 真弘人
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規ウシ主要組織適合抗原(MHC)クラスII遺伝子ハプロタイプの同定とその分布2012

    • Author(s)
      宮坂 卓、竹嶋 伸之輔、泉對 博、間 陽子
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] フィリピン固有品種におけるウシMHCクラスII DRB3およびミトコンドリアDNA D-loop領域の解析2012

    • Author(s)
      竹嶋 伸之輔、大橋 未来、宮坂 卓、松本 有生、Mingala Claro、小沼 操、間 陽子
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウシレトロウイルスによる白血病発症を規定する感受性MHCアリルに対するGagおよびEnv由来ペプチドのエピトープマッピング2012

    • Author(s)
      竹嶋 伸之輔、的場 和弘、萩原 恭二、金 智潤、山岸 純也、Davis William、大森 崇司、 布谷 鉄夫、沖本 憲明、間 陽子
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 発症感受性アリル情報に基づく牛白血病ワクチンの開発2012

    • Author(s)
      間陽子
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 牛白血病ウイルス(BLV)プロウイルスロードとBoLAクラスII遺伝子多型相関性の解析2012

    • Author(s)
      宮坂 卓 、竹嶋 伸之輔 、松本 有生、 神馬 繭子、小林 直彦、 松橋 珠子、 泉對 博 、間 陽子
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association of bovine leukemia virus (BLV) Tax function and various host responses by gene expression microarray2012

    • Author(s)
      Yoko Aida, Mariluz Arainga, Eri Takeda, Kazunori Yamada, Mayuko Jimba, Shin-nosuke Takeshima
    • Organizer
      33rd Conference of the International Society for Animal Genetics
    • Place of Presentation
      オーストラリア
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of bovine leukocyte antigen (BoLA) class II haprotypes that are regulated bovine leukemia virus (BLV) proviral load in Japanese Black cattle2012

    • Author(s)
      Yoko Aida, Taku Miyasaka, Mayuko Jimba, Yuki Matsumoto, Naohiko Kobayashi, Tamako Matsuhashi, Hiroshi Sentsui and Shin-nosuke Takeshima
    • Organizer
      33rd Conference of the International Society for Animal Genetics
    • Place of Presentation
      オーストラリア
    • Related Report
      2012 Annual Research Report
  • [Presentation] Novel Th epitope of bovine leukemia virus detected in disease susceptibility cattle determined by BoLA-DRB3 allele2012

    • Author(s)
      Shin-nosuke Takeshima, Jiyun Kim, Kyoji Hagiwara, Yuki Matsumoto, Takashi Ohmori, Tetsuo Nunoya, Kazuhiro Matoba, and Yoko Aida
    • Organizer
      33rd Conference of the International Society for Animal Genetics
    • Place of Presentation
      オーストラリア
    • Related Report
      2012 Annual Research Report
  • [Presentation] Nuclear Import process as potential antiviral target for flu and AIDS2012

    • Author(s)
      間陽子
    • Organizer
      Loveland/Jans Lab Seminar
    • Place of Presentation
      オーストラリア
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Synthesis of positively and negatively charged cholesterol-recombinant human gelatins for the cellular uptake of proteins and immune reactions2012

    • Author(s)
      Kadengodlu Ananda、蛇島 武久、竹嶋 伸之輔、伊藤 美香、LIU MINGZHE、阿部 洋、 間 陽子、Aigaki Toshiro、伊藤 嘉浩
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      明治大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] HIV-1 Vprによる細胞周期G2期停止に関与する宿主因子のハイスループットスクリーニング法の確立2012

    • Author(s)
      村上知行、間陽子
    • Organizer
      第26回日本エイズ学会学術集会・総会
    • Place of Presentation
      慶応大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] HIV Vprによる細胞周期G2期停止に関与する新規宿主因子の同定2012

    • Author(s)
      村上知行、間陽子
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] FucciおよびSCAT3.1を用いたHIV-1 Vprによる細胞周期停止とアポトーシス誘導のライブイメージング2012

    • Author(s)
      村上知行、間陽子
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] インポーチンα3/Qip1とヌクレオプロテイン(NP)の結合を介した核移行非依存的なA型インフルエンザウイルス増殖2012

    • Author(s)
      佐々木 裕、萩原 恭二、山田 和範、村上 知行、間 陽子
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪
    • Related Report
      2012 Annual Research Report
  • [Presentation] Visualizing Vpr-induced G2 Arrest and Apoptosis2012

    • Author(s)
      Tomoyuki Murakami , Yoko Aida
    • Organizer
      24th Workshop on Retroviral Pathogenesis
    • Place of Presentation
      アメリカ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of Conserved Amino Acids in the Influenza a Virus Nucleoprotein by Homology Analysis and Mutational Analysis2012

    • Author(s)
      Michinori Kakisaka, Yutaka Sasaki, Kazunori Yamada, Yoko Aida
    • Organizer
      4th Workshop on Retroviral Pathogenesis
    • Place of Presentation
      アメリカ
    • Related Report
      2012 Annual Research Report
  • [Presentation] どうする?牛白血病2011

    • Author(s)
      間陽子
    • Organizer
      牛白血病の新しい疾病防御対策、平成23年度技術懇談会-第2回-
    • Place of Presentation
      千葉県農業共済組合連合会中央家畜診療所(千葉市)(招待講演)
    • Year and Date
      2011-12-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 牛白血病のワクチン開発と新しい疾病防御対策2011

    • Author(s)
      間陽子
    • Organizer
      平成23年度大分県家畜保健衛生及び畜産関係業発表会
    • Place of Presentation
      大分県庁(大分市)(招待講演)
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 『私も獣医です』色々な職場に勤める先輩獣医師の話を聞こう2011

    • Author(s)
      間陽子
    • Organizer
      日本大学講演
    • Place of Presentation
      日本大学(藤沢市)(招待講演)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] フィリピン固有品種におけるウシMHC クラスII DRB3 遺伝子の頻度解析2011

    • Author(s)
      大橋未来、竹嶋伸之輔、宮坂卓、松本有生、Claro N. Mingala、小沼操、間陽子
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 主成分分析および立体構造解析によ るMHC の多様性に基づく牛MHC クラスII 分 子の機能予測2011

    • Author(s)
      竹嶋伸之輔、松本有生、Giovambattista G., 山岸純也、沖本憲明、Arainga M.,宮坂卓、 間陽子
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Polymorphism of major histocompatibility complex class II associated to disease progression of bovine leukemia virus induced lymphosarcoma2011

    • Author(s)
      間陽子、竹嶋伸之輔、松本有生、宮坂卓、宮崎義之、田邉義弘、W. C. Davis、岡田幸助
    • Organizer
      第4回HTLV-1研究会
    • Related Report
      2012 Final Research Report
  • [Presentation] BLV-CoCoMo-qPCR: comparison of other real-time PCR methods for BLV proviral detection2011

    • Author(s)
      Jimba M., Takeshima S-n., Matusmoto Y., Arainga M., Ymadada K., Miyazaki K., Kim J., Miyasaka T., Aida Y
    • Organizer
      The XXV Symposium of the International Association for Comparative Researchi on Leukemia and Related Diseases
    • Related Report
      2012 Final Research Report
  • [Presentation] Th epitope mapping of BLV envelope protein for disease susceptibility cattle determined by major hisutocompatibility complex class II DRB3 allele2011

    • Author(s)
      Takeshima S-n., Hagiwara K., Matsumoto Y., Kim J., Miyasaka T., Jimba M., Hibishima T., Ohmori T., Nunoya T., Matoba K., Aida Y
    • Organizer
      The XXV Symposium of the International Association for Comparative Researchi on Leukemia and Related Diseases
    • Related Report
      2012 Final Research Report
  • [Presentation] Bovine MHC class II DR molecule plays A key role in bovine leukemia virus(BLV) . induced lymphoma2011

    • Author(s)
      Aida Y., Takeshima S-n., Matsumoto Y., Miyasaka T., Miyazaki Y., Tanabe Y., W. C.Davis, Okada K
    • Organizer
      15^(th) International Conference On Human Retrovirology HTLV And Related Viruses, Belgium
    • Related Report
      2012 Final Research Report
  • [Presentation] Bovine MHC class II DR molecule plays A key role in bovine leukemia virus (BLV)-induced lymphoma2011

    • Author(s)
      Yoko Aida, Shin-nosuke Takeshima, Yuki Matsumoto, Taku Miyasaka, Yoshiyuki Miyazaki, Yoshihiro Tanabe, William C.Davis, Kosuke Okada
    • Organizer
      15^<th> International Conference On Human Retrovirology HTLV And Related Viruses
    • Place of Presentation
      ベルギー
    • Related Report
      2011 Annual Research Report
  • [Presentation] BLV-CoCoMo-qPCR : comparison of other detection methods for BLV infection and kinetics analysis in experimental transmission of BLV in cattle2011

    • Author(s)
      Mayuko Jimba, Shin-nosuke Takeshima, Yuki Matsumoto, Naohiko Kobayashi, Tamako Matsuhashi, Junko Kohara, Yoko Aida
    • Organizer
      15^<th> International Conference On Human Retrovirology HTLV And Related Viruses
    • Place of Presentation
      ベルギー
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of host cellular gene transcription by Bovine Leukemia Virus (BLV) Tax, wild type and mutants2011

    • Author(s)
      Mariluz Arainga-Ramirez, Eri Takeda, Yoko Aida
    • Organizer
      15^<th> International Conference On Human Retrovirology HTLV And Related Viruses
    • Place of Presentation
      ベルギー
    • Related Report
      2011 Annual Research Report
  • [Presentation] Imaging and microarray analyses of cell cycle arrest and apoptosis by Human T cell Leukemia Virus type 1 (HTLV-1) Tax2011

    • Author(s)
      Mariluz Arainga-Ramirez, Yoko Aida
    • Organizer
      15^<th> International Conference On Human Retrovirology HTLV And Related Viruses
    • Place of Presentation
      ベルギー
    • Related Report
      2011 Annual Research Report
  • [Presentation] 炭酸アパタイト粒子によるマウスへの免疫誘導2011

    • Author(s)
      多田誠一、蛇島武久、竹嶋伸之輔、赤池敏広、間陽子、伊藤嘉浩
    • Organizer
      第27回日本DDS学会学術集会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 牛白血病ウイルス感受性ウシMHCクラスII分子から得られた抗原ペプチドの同定および結合親和力解析2011

    • Author(s)
      金智潤、竹嶋伸之輔、沖本憲明、山岸純也、堂前直、萩原恭二、間陽子
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      ツインメッセ静岡(静岡市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 主成分分析および立体構造解析によるMHCの多様性に基づく牛MHCクラスII分子の機能予測2011

    • Author(s)
      竹嶋伸之輔、松本有生、Guillermo Giovambattista、山岸純也、沖本憲明、Mariluz Arainga-Ramirez、宮坂卓、間陽子
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      ツインメッセ静岡(静岡市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] フィリピン固有品種におけるウシMHCクラスII DRB3遺伝子の頻度解析2011

    • Author(s)
      大橋未来、竹嶋伸之輔、宮坂卓、松本有生、Claro N.Mingala、小沼操、間陽子
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      ツインメッセ静岡(静岡市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Polymorphism of major histocompatibility complex class II associated to disease progression of bovine leukemia virus induced lymphosarcoma2011

    • Author(s)
      Yoko Aida, Shin-nosuke Takeshima, Yuki Matsumoto, Taku Miyasaka, Yoshiyuki Miyazaki, Yoshihiro Tanabe, William C.Davis, Kosuke Okada
    • Organizer
      The XXV Symposium of the Internarional Association for Comparative Reserch on Leukemia and Related Diseases
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Th epitope mapping of BLV envelope protein for desease susceptibility cattle determined by major hustocompatibility complex class II DRB3 allele2011

    • Author(s)
      Shin-nosuke Takeshima, Kyoji Hagiwara, Yuki Matsumoto, Jiyun Kim, Taku Miyasaka, Mayuko Jimba, Takehisa Hebishima, Takashi Ohmori, Tetsuo Nunoya, Kazuhiro Matoba, Yoko Aida
    • Organizer
      The XXV Symposium of the Internarional Association for Comparative Reserch on Leukemia and Related Diseases
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BLV-Co-Co-Mo-qPCR : comparison of other real-time PCR methods for BLV proviral detection2011

    • Author(s)
      Mayuko Jimba, Shin-nosuke Takeshima, Yuki Matsumoto, Mariluz Arainga-Ramirez, Kazunori Yamada, Kazuyuki Miyazaki, Jiyun Kim, Taku Miyasaka, Yoko Aida
    • Organizer
      The XXV Symposium of the Internarional Association for Comparative Reserch on Leukemia and Related Diseases
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Polymorphism of major histocompatibility complex class II associated to disease progression of bovine leukemia virus induced lymphosarcoma2011

    • Author(s)
      間陽子、竹嶋伸之輔、松本有生、宮坂卓、宮崎義之、田邉義弘、William C.Davis、岡田幸助
    • Organizer
      第4回HTLV-1研究会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Th epitope mapping of BLV envelope protein for desease susceptibility cattle determined by major hustocompatibility complex class II DRB3 allele2011

    • Author(s)
      竹嶋伸之輔、萩原恭二、松本有生、金智潤、宮坂卓、神馬繭子、蛇島武久、大森崇史、布谷鉄夫、的場和弘、間陽子
    • Organizer
      第4回HTLV-1研究会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BLV-Co-Co-Mo-qPCR : comparison of other real-time PCR methods for BLV proviral detection2011

    • Author(s)
      神馬繭子、竹嶋伸之輔、松本有生、Mariluz Arainga-Ramirez、山田和範、宮崎義之、金智潤、宮坂卓、間陽子
    • Organizer
      第4回HTLV-1研究会
    • Place of Presentation
      東京大学(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] BLV感染牛の凍結初乳給与による新生子牛の感染状況について2011

    • Author(s)
      山本祐輔、日高健雅、今井佳積、尾形康弘、吉上渉、間陽子、竹嶋伸之輔、松本有生
    • Organizer
      平成23年度広島県家畜保健衛生及び畜産関係業発表会
    • Place of Presentation
      ホテルグランヴィア広島(広島市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウシ主要組織適合抗原(MHC)クラスII遺伝子のハプロタイプの解析2011

    • Author(s)
      宮坂卓、竹嶋伸之輔、泉對博、間陽子
    • Organizer
      私立大学戦略的研究基盤形成支援事業「人獣共通感染症の戦略的国際疫学研究の推進と若手研究者の実践的育成」公開シンポジウム「野生動物における人獣共通感染症の実態と研究の取り組み」
    • Place of Presentation
      日本大学(藤沢市)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The distribution of bovine major histocompatibility complex class II DRB3 alleles in different herds of Japanese Black and Holstein cattle in Japan2010

    • Author(s)
      宮坂卓、竹嶋伸之輔、松本有生, 小林直彦、松橋珠子、石橋和樹, 泉對博、間陽子
    • Organizer
      「人獣共通感染症の戦略的国際疫学研究の推進と若手研究者の実践的育成」平成22年度公開シンポジウム「食品由来人獣共通感染症の現状と対策」におけるポスターセッション
    • Place of Presentation
      神奈川 藤沢
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 牛白血病毒致病机理的研究(牛白血病病原性発現機構の解明)2010

    • Author(s)
      間陽子
    • Organizer
      山東省農業大学講演
    • Place of Presentation
      中国 山東省 済南市
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 乳用牛における牛白血病の病態及び発症要因調査2010

    • Author(s)
      富田啓介、中条正樹、塚本洋、柴折浩幸、岡畑一幸、矢島和枝、浦本京也、竹嶋伸之輔、松本有生、間陽子
    • Organizer
      日本産業動物獣医学会
    • Place of Presentation
      大阪 泉佐野市
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanism of Leukemogenesis Induced by Bovine LeukemiaVirus2010

    • Author(s)
      間陽子
    • Organizer
      Philippine Carabao Center
    • Year and Date
      2010-09-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Mechanism of Leukemogenesis Induced by Bovine Leukemia Virus2010

    • Author(s)
      間陽子
    • Organizer
      Philippine Carabao Center
    • Place of Presentation
      Nueva Ecija, Philipine
    • Year and Date
      2010-09-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Association between bovine major histocompatibility complex (BOLA) class II alleles and cattle mastitis2010

    • Author(s)
      竹嶋伸之輔、間陽子
    • Organizer
      Institute for Animal Health, Compton Laboratory
    • Place of Presentation
      London, England
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanism of leukemogenesis induced by bovine leukemia virus2010

    • Author(s)
      間陽子
    • Organizer
      Institute for Animal Health, Compton Laboratory
    • Place of Presentation
      London, England
    • Year and Date
      2010-08-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 牛白血病の世界における感染拡大の現状2010

    • Author(s)
      間陽子
    • Organizer
      農林水産省動物医薬品検査所
    • Place of Presentation
      東京
    • Year and Date
      2010-07-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 牛白血病の世界における感染拡大の現状2010

    • Author(s)
      間陽子
    • Organizer
      農林水産省動物医薬品検査所講演
    • Place of Presentation
      国分寺市、東京
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 黒毛和種とホルスタイン集団におけるウシMHC クラスII 遺伝子の多様性2010

    • Author(s)
      宮坂卓、竹嶋伸之輔、松本有生、小林直彦、松橋珠子、石橋和樹、泉對博、間陽子
    • Organizer
      日本組織適合性学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 南米大陸におけるウシMHC クラスIIDRB3 遺伝子の頻度解析2010

    • Author(s)
      竹嶋信之輔、松本有生、Arainga M.、金智潤、宮坂卓、薛光愛、Veronica Gabrieladela Barra、Giovambttista G.、小沼操、間陽子
    • Organizer
      日本組織適合性学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Distribution of Major histocompatibility complex DRB3 allelic frequencies in the 11 South American breeds of cattle2010

    • Author(s)
      竹嶋伸之輔、松本有生、Arainga M.、金智潤、宮坂卓、薛光愛、DE LA BARRA,Gabriela V., Giovambattista G.,小沼操、間陽子
    • Organizer
      9th IVIS
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Bovine MHC class II and infectious diseases2010

    • Author(s)
      竹嶋伸之輔、間陽子
    • Organizer
      9th IVIS
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Variation of cattle major histocompatibility complex(BOLA)DRB3 allele frequencies within different farm,breed and coutries in South America2010

    • Author(s)
      竹嶋伸之輔、松本有生、Arainga M., 金智潤、宮坂卓、薛光愛、 Veronica Gabriela de la Barra Diaz, Giovambattista G., Enrique PofcherJ., Hermelinda,Rivera-Geronimo, 斉藤英樹,Thomas Acosta J.,印牧美佐生、 Manuel Ortiz L., Jorge Oltra,小沼操、 間陽子
    • Organizer
      32nd Conference of the International Society for Animal Genetics
    • Place of Presentation
      スコットランド
    • Related Report
      2012 Final Research Report
  • [Presentation] Bovine major histocompatibility complex class II and disease association2010

    • Author(s)
      竹嶋伸之輔、間陽子
    • Organizer
      Molecular and population genetics for improvement of farm animals and their products
    • Place of Presentation
      Jastrzebiec, Poland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Variation of cattle major histocompatibility complex(BOLA)DRB3 allele frequencies within different farm, breed and coutries in South America2010

    • Author(s)
      竹嶋伸之輔, 松本有生, Arainga Ramirez Mariluz Anamelva, 金智潤, 宮坂卓, 薜光愛、Veronica Gabriela de la Barra Diaz, Guillermo Giovambattista, EnriquePofcher J., Hermelinda, Rivera-Geronimo, 斉藤英樹, Thomas Acosta J., 印牧美佐生, Manuel Ortiz L., Jorge Oltra, 小沼操, 間陽子
    • Organizer
      32nd Conference of the International Society for Animal Genetics
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2010 Annual Research Report
  • [Presentation] BLV-CoCoMo-qPCR : Quantitation of bovine leukemia virus proviral load using CoCoMo algorism2010

    • Author(s)
      間陽子、神馬繭子、竹嶋伸之輔、松本有生、小林直彦、松橋珠子、的場和弘、遠藤大二
    • Organizer
      2nd Conference of the International Society for Animal Genetics
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diversity of BOLA class II DRB3 and DQA1 alleles among different herds of Japanese Black and Holstein cattle in Japan2010

    • Author(s)
      宮坂卓、竹嶋伸之輔、松本有生、小林直彦、松橋珠子、石橋和樹、泉對博、間陽子
    • Organizer
      The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Characterization of Bovine Leukemia Virus Tax protein and its mutants2010

    • Author(s)
      Arainga Ramirez Mariluz Anamelva、武田英里、間陽子
    • Organizer
      The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Distribution of Major histocompatibility complex DRB3 allelic frequencies the 11 South American breeds of cattle2010

    • Author(s)
      竹嶋伸之輔, 松本有生, Arainga Ramirez Mariluz Anamelva, 金智潤, 宮坂卓, 薜光愛, DE LA BARRA, Veronica Gabriela, Giovambattista Guillermo, 小沼操、間陽子
    • Organizer
      The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] BoLa-DR molecule plays a key Role in bovine leukemia virus-induced lymphoma2010

    • Author(s)
      間陽子、竹嶋伸之輔、Davis William C、小沼操、岡田幸助
    • Organizer
      The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of A new quantitative real-time PCR method CoCoMo primers and its clinical application2010

    • Author(s)
      神馬繭子、竹嶋伸之輔、的場和弘、Davis William C、遠藤大二、間陽子
    • Organizer
      The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] Bovine MHC class II and infectious diseases2010

    • Author(s)
      竹嶋伸之輔、間陽子
    • Organizer
      The 9^<th> International Veterinary Immunology Symposium(9th IVIS)
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 黒毛和種とホルスタイン集団におけるウシMHCクラスII遺伝子の多様性2010

    • Author(s)
      宮坂卓、竹嶋伸之輔、松本有生, 小林直彦、松橋珠子、石橋和樹, 泉對博、間陽子
    • Organizer
      第19回日本組織適合性学会大会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] 南米大陸におけるウシMHCクラスIIDRB3遺伝子の頻度解析2010

    • Author(s)
      竹嶋伸之輔、松本有生、Mariluz Arainga、金智潤、宮坂卓、薜光愛、Veronica Gabriela de la Barra, Gullermo Giovambttista、小沼操、間陽子
    • Organizer
      第19回日本組織適合性学会大会
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規なポリペプチドとその応用2013

    • Inventor(s)
      間陽子、竹嶋伸之輔
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Industrial Property Number
      2013-067683
    • Filing Date
      2013-03-27
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Patent(Industrial Property Rights)] ウシ白血病ウイルス検出用プライマーセット、及びその利用2012

    • Inventor(s)
      間陽子、竹嶋伸之輔、神馬繭子、河原紀三郎、斎藤督、村松祐里、袁媛
    • Industrial Property Rights Holder
      独立行政法人理化学研究所 株式会社理研ジェネシス
    • Industrial Property Number
      2012-179972
    • Filing Date
      2012-08-14
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Patent(Industrial Property Rights)] BLV-CoCoMo-qPCR: Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm2010

    • Inventor(s)
      Yoko AIDA, Shin-nosuke TAKESHIMA, Mayuko JIMBA, Daiji ENDOH
    • Industrial Property Rights Holder
      独立行政法人理化学研究所
    • Filing Date
      2010-10-21
    • Related Report
      2012 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] BLV-CoCoMo-qPCR : Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm2010

    • Inventor(s)
      間陽子, 竹嶋伸之輔, 神馬繭子, 遠藤大二
    • Industrial Property Rights Holder
      理化学研究所
    • Filing Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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