| Project/Area Number |
22406006
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Human pathology
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
MA Ning 鈴鹿医療科学大学, 保健衛生学部, 教授 (30263015)
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| Co-Investigator(Kenkyū-buntansha) |
KAWANISHI Shosuke 鈴鹿医療科学大学, 薬学部, 教授 (10025637)
INOUE Sumiko 鈴鹿医療科学大学, 薬学部, 准教授 (20378657)
OHNISHI Shiho 鈴鹿医療科学大学, 薬学部, 助手 (80511914)
MURATA Mariko 三重大学, 医学研究科, 教授 (10171141)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | ヒ素 / 発がん / 臨床疫学 / がん幹細胞 / ニトロ化ストレス / HaCaT 細胞 / バイ オマーカー / リスク評価 / 炎症 / HaCaT細胞 / バイオマーカー / 癌幹細胞 |
|---|
| Research Abstract |
We demonstrated that 8-OHdG was generated in polymorphonuclear leukocytes (PMN). The 8-OHdG in PMN was observed in all investigated populations, while it was frequently found along with the elevated amounts of cell debris in individuals with skin lesion including hypopigmentation and keratosis in arsenic exposed participants of Shanxi province, China. After the human skin cell line (HaCaT) was exposed to an environmentally relevant level of arsenic 0.05 ppm for about 4 months, we determined the8-nitroguanine and cancer stem cell marker CD44v6 in the acquired cancer phenotype. Treated cells with arsenic became apparently tumorigenic, that pathological studies of xenograft tumor in nude mice showed highly undifferentiated tumors.
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