A molecular epidemiological study to explore arsenic relation carcinogenesis and malignant progression in an arsenic endemic rural region in Shanxi province of China
| Project/Area Number |
22406006
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Human pathology
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| Research Institution | Suzuka University of Medical Science |
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Principal Investigator |
MA Ning 鈴鹿医療科学大学, 保健衛生学部, 教授 (30263015)
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| Co-Investigator(Kenkyū-buntansha) |
KAWANISHI Shosuke 鈴鹿医療科学大学, 薬学部, 教授 (10025637)
INOUE Sumiko 鈴鹿医療科学大学, 薬学部, 准教授 (20378657)
OHNISHI Shiho 鈴鹿医療科学大学, 薬学部, 助手 (80511914)
MURATA Mariko 三重大学, 医学研究科, 教授 (10171141)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | ヒ素 / 発がん / 臨床疫学 / がん幹細胞 / ニトロ化ストレス / HaCaT 細胞 / バイ オマーカー / リスク評価 / 炎症 / HaCaT細胞 / バイオマーカー / 癌幹細胞 |
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| Research Abstract |
We demonstrated that 8-OHdG was generated in polymorphonuclear leukocytes (PMN). The 8-OHdG in PMN was observed in all investigated populations, while it was frequently found along with the elevated amounts of cell debris in individuals with skin lesion including hypopigmentation and keratosis in arsenic exposed participants of Shanxi province, China. After the human skin cell line (HaCaT) was exposed to an environmentally relevant level of arsenic 0.05 ppm for about 4 months, we determined the8-nitroguanine and cancer stem cell marker CD44v6 in the acquired cancer phenotype. Treated cells with arsenic became apparently tumorigenic, that pathological studies of xenograft tumor in nude mice showed highly undifferentiated tumors.
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Report
(4 results)
Research Products
(110 results)
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[Journal Article] Oxidative DNA damage of peripheral blood polymorphonuclear leukocytes, selectively induced by chronic arsenic exposure, is associated with extent of arsenic-related skin lesions.2013
Author(s)
Pei Q, Ma N, Zhang J, Xu W, Li Y, Ma Z, Li Y, Tian F, Zhang W, Mu J, Li Y, Wang D, Liu H, Yang M, Ma C, Yun F.
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Journal Title
Toxicol Appl Pharmacol.
Volume: 266(1)
Issue: 1
Pages: 143-149
DOI
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Peer Reviewed
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[Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinoma.2012
Author(s)
Thanan R, Oikawa S, Yongvanit P, Hiraku Y, Ma N, Pinlaor S, Pairojkul C,Wongkham C, Sripa B, Khuntikeo N, Kawanishi S, Murata M.
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Journal Title
Free Radic Biol Med.
Volume: 52(8)
Pages: 1465-1472
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Peer Reviewed
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[Journal Article] TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma.2010
Author(s)
Wang S, Xiao X, Zhou X, Huang T, Du C, YuN, Mo Y, Lin L, Zhang J, Ma N, Murata M,Huang G, Zhang Z.
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Journal Title
BMC Cancer.
Volume: 10
Issue: 1
Pages: 617-617
DOI
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Peer Reviewed
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[Journal Article] Thioredoxin suppresses airway inflammation independently of systemic Th1/Th2 immune modulation.2010
Author(s)
Torii M, Wang L, Ma N, Saito K, Hori T, Sato-Ueshima M, Koyama Y, Nishikawa H, Katayama N, Mizoguchi A, Shiku H, Yodoi J,Kuribayashi K, Kato T.
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Journal Title
European Journal of Immunology.
Volume: 40(3)
Issue: 3
Pages: 787-796
DOI
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Peer Reviewed
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[Journal Article] Transgenic mice overproducing human thioredoxin-1, an antioxidative and anti-apoptotic protein, prevents diabetic embryopathy.2010
Author(s)
Kamimoto Y, Sugiyama T, Kihira T, Murabayashi N, Umekawa T, Nagao K, Ma N, Toyoda N, Yodoi J, Sagawa N.
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Journal Title
Diabetologia.
Volume: 53 (9)
Issue: 9
Pages: 2046-2055
DOI
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Peer Reviewed
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[Presentation] Cytosine methylation in EBV-mediated nasopharyngeal carcinoma in relation to nitrative stress.2012
Author(s)
Ying Mo, Ning Ma, Shumin Wang, Zhe Zhang, Ying Xie, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi, Mariko Murata
Organizer
Seventh International Conference on the Biology, Chemistry and Therapeutic Application of Nitric Oxide
Place of Presentation
Edinburgh, Scotland
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[Presentation] Epigenetic inactivation of paracrined-FSTL1 modulates macrophage functions in nasopharyngeal carcinoma2011
Author(s)
Xue Xiao, Xiaoying Zhou, Yingxi Mo, Guangwu Huang, Shumin Wang, Tingting Huang, Nana Yu, Chunping Du, Wensheng Wen, Wensheng Wen, Mariko Muraa, Ning Ma, Ingemar Ernberg, Zhe Zhang
Organizer
第70回日本癌学会学術総会
Place of Presentation
名古屋国際会議場
Year and Date
2011-10-03
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[Book] Biomarker2012
Author(s)
Ning Ma, Mariko Murata, Shiho Ohnishi, Raynoo Thanan, Yusuke Hiraku, Shosuke Kawanishi
Total Pages
402
Publisher
InTech
Related Report
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[Book] Biomarker2012
Author(s)
Ning Ma, Mariko Murata, Shiho Ohnishi, Raynoo Thanan, Yusuke Hiraku, Shosuke Kawanishi
Total Pages
402
Publisher
InTech, Janeza Trdine 9,51000 Rijeka, Croatia
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