Development of the detection method for Plasmodium vivax hypnozoites
| Project/Area Number |
22406007
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Ehime University |
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Principal Investigator |
ISHINO Tomoko 愛媛大学, 大学院・医学系研究科, 准教授 (40402680)
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| Co-Investigator(Kenkyū-buntansha) |
SHINZAWA Naoaki 愛媛大学, 大学院・医学系研究科, 助教 (10583015)
TACHIBANA Mayumi 愛媛大学, 大学院・医学系研究科, 助教 (00301325)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 三日熱マラリア原虫 / 肝臓ステージ / 休眠体 / 顧みられない熱帯病 / タイ王国 / 三日熱マラリア / 人工吸血法 / 国際研究者交流 / 再発 / 寄生胞 / マラリア原虫 / タイ |
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| Research Abstract |
The liver stage culture condition has been improved by using rodent malaria parasites, Plasmodium berghei. Then, to detect the P. vivax liver stage parasite development, several antibodies against liver stage antigens were prepared. P. vivax sporozoites were collected from mosquitoes fed on patients blood in Thailand, then incubated with hepatocytes for 1 week. Liver stage parasites development could be detected by IFA using several antibodies.
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Report
(4 results)
Research Products
(29 results)
