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Immunogenetic analysis of early onset schistosomal fibrosis in the Philippines

Research Project

Project/Area Number 22406009
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Parasitology (including Sanitary zoology)
Research InstitutionNagasaki University

Principal Investigator

KIKUCHI Mihoko  長崎大学, 熱帯医学研究所, 講師 (40336186)

Co-Investigator(Kenkyū-buntansha) CHIGUSA Yuichi  獨協医科大学, 医学部, 教授 (20171936)
HIRAYAMA Kenji  長崎大学, 熱帯医学研究所, 教授 (60189868)
Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywords日本住血吸虫 / フィリピン / 肝線維化症 / 免疫応答性 / 遺伝解析 / HLA-DRB1*1501 / mRNA / 若年性肝線維化症 / 免疫応答 / 国際研究者交流 / 若年性 / 住血吸虫中卵抗原 / 宿主遺伝要因 / 組織適合抗原(HLA)
Research Abstract

Post-schistosomal hepatic fibrosis and cirrhosis are the major sequelae resulting from excessive immune response to deposited eggs in the portal area. In humans little is known about immunoregulatory mechanisms controlling the development of hepatosplenic disease. The objective of the study is to determine the prevalence of the early onset schistosomal fibrosis and the different host genetic factors and mechanism behind the immune responses in patients with early onset schistosomal liver fibrosis in the Sorsogon Province, Philippines. The subjects were subjected to Kato-katz stool examination, ultrasonographic examination, and detection of anti-SEA antibody, located in the schistosomiasis endemic barangays of the municipality of Irosin, in the province of Sorsogon. Results of imuunogenetical analysis showed measure immune-responses in early onset post schistosomal fibrosis was restricted HLA-DRB1*15:01 and progression was related on expression level of HLA-DRB1 gene.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (25 results)

All 2014 2013 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 8 results) Presentation (13 results) Book (2 results)

  • [Journal Article] Detection of active schistosome infection by cell-free circulating DNA of Schistosoma japonicum in highly endemic areas in Sorsogon Province, the Philippines2014

    • Author(s)
      Kato-Hayashi N, Leonardo LR, Arevalo NL, Tagum MN, Apin J, Agsolid LM, Chua JC, Villacorte EA, Kirinoki M, Kikuchi M, Ohmae H, Haruki K, Chigusa Y
    • Journal Title

      Acta Trop

      Volume: (pii : S0001-706X(14)00168-5)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Characterization of a gene family encoding SEA (sea-urchin sperm protein, enterokinase and agrin)-domain proteins with lectin-like and heme-binding properties from Schistosoma japonicum2014

    • Author(s)
      Mbanefo EC, Kikuchi M, Huy NT, Shuaibu MN, Cherif MS, Yu C, Wakao M, Suda Y, Hirayama K
    • Journal Title

      PLoS Negl Trop Dis

      Volume: 8(1) Issue: 1 Pages: 2644-2644

    • DOI

      10.1371/journal.pntd.0002644

    • NAID

      120006986695

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genetic Structure Inferred from Mitochondrial 12S Ribosomal RNA Sequence of Oncomelaniaquadrasi, the Intermediate Snail Host of Schistosoma japonicum in the Philippines2014

    • Author(s)
      Weerachai Saijuntha, Blanca Jarilla, Alvin K. Leonardo, Louie S. Sunico, Lydia R. Leonardo, Ross H. Andrews, Paiboon Sithithaworn, Trevor N. Petney, Masashi Kirinoki, Naoko Kato-Hayashi, Mihoko Kikuchi, Yuichi Chigusa, and Takeshi Agatsuma
    • Journal Title

      American Jornal of Tropical Medicine and Hygene

      Volume: (Epub ahead of print) Issue: 6 Pages: 1-12

    • DOI

      10.4269/ajtmh.13-0260

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] New endemic foci of schistosomiasis infections in the Philippines.2014

    • Author(s)
      Leonardo L
    • Journal Title

      Acta trop

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Use of cell-free circulating schistosome DNA in serum, urine, semen, and saliva to monitor a case of refractory imported schistosomiasis hematobia2013

    • Author(s)
      Kato-Hayashi N, Yasuda M, Yuasa J, Isaka S, Haruki K, Ohmae H, Osada Y, Kanazawa T, Chigusa Y
    • Journal Title

      J Clin Microbiol

      Volume: 51(10) Issue: 10 Pages: 3435-8

    • DOI

      10.1128/jcm.01219-13

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] フィリピンにおける日本住血吸虫症有病地の現状2013

    • Author(s)
      林尚子、菊池三穂子、千種雄一
    • Journal Title

      日本獣医寄生虫学雑誌JPN.J. Vet. Parasitol

      Volume: Vol.12 (2) Pages: 79-86

    • URL

      http://jsvp.umin.jp/index.html

    • Related Report
      2013 Final Research Report
  • [Journal Article] 21-Hydroxylase gene mutant allele CYP21A2*15 strongly linked to the resistant HLA Haplotype B*14:02-DRB1*01:02 in Chronic Chagas Disease2013

    • Author(s)
      Puerto FD
    • Journal Title

      Hum Immunol

      Volume: 74(6) Pages: 783-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Origin of a novel protein-coding gene family with similar signal sequence in Schistosoma japonicum2012

    • Author(s)
      Mbanefo EC, Chuanxin Y, Kikuchi M, Shuaibu MN, Boamah D, Kirinoki M, Hayashi N, Chigusa Y, Osada Y, Hamano S, Hirayama K
    • Journal Title

      BMC Genomics

      Volume: 13 Issue: 1 Pages: 260-260

    • DOI

      10.1186/1471-2164-13-260

    • NAID

      120006986371

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunoproteomics Identification of Major IgE and IgG4 Reactive Schistosoma japonicum Adult Worm Antigens Using Chronically Infected Human Plasma.2012

    • Author(s)
      Boamah D,
    • Journal Title

      Trop Med Health.

      Volume: 40(3) Pages: 89-102

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of HLA and post-schistosomal hepatic disorder : A systematic review and meta-analysis2011

    • Author(s)
      Huy NT, Hamada M, Kikuchi M, Lan NT, Yasunami M, Zamora J, Hirayama K
    • Journal Title

      Parasitol Int

      Volume: 60(4) Pages: 347-356

    • NAID

      120006985063

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Surveyllance on Schistosomal Fibrosis in Sorsogon Province, the Phillippins2013

    • Author(s)
      菊池三穂子他
    • Organizer
      日本寄生虫学会
    • Place of Presentation
      東京東京医科歯科大学御茶ノ水キャンパス
    • Related Report
      2013 Final Research Report
  • [Presentation] Surveyllance on Schistosomal Fibrosis in Sorsogon Province, the Phillippins2013

    • Author(s)
      菊池三穂子
    • Organizer
      日本寄生虫学会
    • Place of Presentation
      東京医科歯科大学 御茶ノ水キャンパス、東京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Immunogenetic analysis of the patients with early onset schistosomal fibrosis in Sorsogon Province, the Philippines2012

    • Author(s)
      Kikuchi M, Leonardo LR, Chigusa Y, Segubre-Mercado EM, Kobayashi N, Hayashi N, Inoue T, Arevalo NL, Lim RR, Agsolid LM, Agatsuma K, Hirayama K
    • Organizer
      45th Annual Japan-U.S.Joint Conference on Parasitic Diseases, Japan-US Parasitic Diseases Panel Meeting, Japan-US Cooperative Medical Science Program
    • Place of Presentation
      東京
    • Year and Date
      2012-01-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immunogenetic analysis of the patients with early-onset of schistosomal liver fibrosis in Sorsogon Province, the Philippines2012

    • Author(s)
      Kikuchi. M. et al
    • Organizer
      5th The ASEAN Congress of Tropical Medicine and Parasitology (ACTMP)
    • Place of Presentation
      Manila, Philippine, University of Philippine
    • Related Report
      2013 Final Research Report
  • [Presentation] Immunogenetic analysis of the patients with early-onset of schistosomal liver fibrosis in Sorsogon Province, the Philippines2012

    • Author(s)
      Kikuchi. M. et al
    • Organizer
      Forum Cheju 15
    • Place of Presentation
      宮崎宮崎パームビーチホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Origin of novel protein-coding genes with similar signal sequence in Schistosoma japonicum2012

    • Author(s)
      Evaristus CM, Kikuchi M., et al
    • Organizer
      日本熱帯医学会
    • Place of Presentation
      北海道とかちプラザ
    • Related Report
      2013 Final Research Report
  • [Presentation] Surveyllance on Schistosomal Fibrosis in Sorsogon Province, the Phillippins2012

    • Author(s)
      菊池三穂子他
    • Organizer
      日本熱帯医学会
    • Place of Presentation
      北海道とかちプラザ
    • Related Report
      2013 Final Research Report
  • [Presentation] Immunogenetic analysis of the patients with early-onset of schistosomal liver fibrosis in Sorsogon Province, the Philippines.2012

    • Author(s)
      Kikuchi. M
    • Organizer
      5th The ASEAN Congress of Tropical Medicine and Parasitology (ACTMP)
    • Place of Presentation
      University of the philippines, Manila, Philippine
    • Related Report
      2012 Annual Research Report
  • [Presentation] Immunegenetic analysis of patients with early onset schistosomal fibrosis in Sorsogon Province, the Philippines.2012

    • Author(s)
      菊池三穂子
    • Organizer
      Forum Cheju 15
    • Place of Presentation
      宮崎パームビーチホテル, 宮崎市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Origin of novel protein-coding genes with similar signal sequence in Schistosoma japonicum2012

    • Author(s)
      Evaristus CM
    • Organizer
      日本熱帯医学会
    • Place of Presentation
      とかちプラザ、帯広市、北海道
    • Related Report
      2012 Annual Research Report
  • [Presentation] Surveyllance on Schistosomal Fibrosis in Sorsogon Province, the Phillippins2012

    • Author(s)
      菊池三穂子
    • Organizer
      日本熱帯医学会
    • Place of Presentation
      とかちプラザ、帯広市、北海道
    • Related Report
      2012 Annual Research Report
  • [Presentation] Immunogenetic analysis of the patients with early onset schistosomal fibrosis in Sorsogon Province, the Philippines2011

    • Author(s)
      Kikuchi M, et al
    • Organizer
      45th Annual Japan-U.S. Joint Conference on Parasitic Diseases, Japan-US Parasitic Diseases Panel Meeting, Japan-US Cooperative Medical Science Program
    • Place of Presentation
      東京、東京大学
    • Related Report
      2013 Final Research Report
  • [Presentation] フィリピンにおける若年性住血吸虫性肝線維化症の発症に関わる免疫関連遺伝2010

    • Author(s)
      菊池三穂子
    • Organizer
      第51回熱帯医学会大会
    • Place of Presentation
      仙台市
    • Related Report
      2010 Annual Research Report
  • [Book] 感染症事典2012

    • Author(s)
      感染症事典編集委員会編共著菊池三穂子
    • Total Pages
      617
    • Publisher
      オーム社
    • Related Report
      2013 Final Research Report
  • [Book] 感染症事典2012

    • Author(s)
      感染症事典編集委員会 編 共著 菊池三穂子
    • Publisher
      オーム社
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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