Drug resistant genes of Plasmodium falciparum: Characteristic polymorphisms in each malaria endemic countries

• Project/Area Number: 22406010
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Parasitology (including Sanitary zoology)
• Research Institution: Nagasaki University
• Principal Investigator: UEMURA Haruki 長崎大学, 熱帯医学研究所, 講師 (60184975)
• Co-Investigator(Kenkyū-buntansha): KANEKO Satoshi 長崎大学, 熱帯医学研究所, 教授 (00342907)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
• Keywords: 熱帯熱マラリア原虫 / 薬剤耐性 / pfdhfr遺伝子 / pfdhps遺伝子 / pfcrt遺伝子 / pfmdr 1遺伝子 / インドネシア、ミャンマー / インドネシア / ミャンマー / pfmdr1遺伝子 / インドネシア:ミャンマー

Research Abstract

Due to no effective vaccine available for malaria, drug treatment of infected patients are important strategy for malaria control, thus emergence and spread of parasites resistant to commonly used anti-malarials are serious problem. We have analyzed polymorphisms of drug resistant genes of Plasmodium falciparum isolated from Myanmar, Iran, Indonesia and some African countries for obtaining information of drug efficacy and efficiencies. Genotypes of each countries and areas are unique and this indicates appropriate control strategies are required in each countries and areas for efficient malaria control.

Research Products

• [Journal Article] Polymorphism of Plasmodium Falciparum Dihydrofolate Reductase and Dihydropteroate Synthase Genes among Pregnant Women with Falciparum Malaria in BanjarDistrict, South Kalimantan Province, Indonesia (2012)
  • Author(s): Fitriah1, Sri Wijayanti Sulistyawati, Sugeng Riyanto, Budiono, Sukmawati Basuki, Yoes Prijatna Dachlan and Haruki Uemura.
  • Journal Title: Journal of Tropical Life Science Volume: 2(2) Pages: 92-98
  • Peer Reviewed
• [Journal Article] Polymorphism of Plasmodium FalciparumDihydrofolate Reductase and Dihydropteroate Synthase Genes among Pregnant Women with Falciparum Malaria in BanjarDistrict, South Kalimantan Province, Indonesia (2012)
  • Author(s): Fitriah et al.
  • Journal Title: Journal of Tropical Life Science Volume: 2 Pages: 92-98
  • Peer Reviewed
• [Journal Article] Plasmodium falciparum: Differential Selection of Drug Resistance Alleles in Contiguous Urban and Peri-Urban Areas of Brazzaville, Republic of Congo (2011)
  • Author(s): Yoko Tsumori, Mathieu Ndounga, Toshihiko Sunahara, Nozomi Hayashida, Megumi Inoue, Shusuke Nakazawa, Prisca Casimiro, Rie Isozumi, Haruki Uemura, Kazuyuki Tanabe, Osamu Kaneko and Richard Culleton
  • Journal Title: PLoS ONE Volume: 6(8)
  • NAID: 120006985283
  • Peer Reviewed
• [Journal Article] Plasmodium falciparum : Differential Selection of Drug Resistance Alleles in Contiguous Urban and Peri-Urban Areas of Brazzaville, Republic of Congo (2011)
  • Author(s): Tsumori, Y., et al
  • Journal Title: PLoS ONE Volume: 6 Issue: 8 Pages: e23430-e23430
  • DOI: 10.1371/journal.pone.0023430
  • Peer Reviewed
• [Presentation] The efficacy of Dihydroartemisinin and the mutation of 769 codon of PfATPase gene in uncomplicated falciparum malaria in Jayapura District, Papua Province, Indonesia. (2012)
  • Author(s): Petronella Maria Risamasu
  • Organizer: The 2ndInternational Congress of Life Sciences 2012: "Prospective and Contribution of Life Sciences for Better Life
  • Place of Presentation: University of Brawijaya, Malang, East Java, (Indonesia)
  • Year and Date: 2012-07-14
• [Presentation] Polymorphism gene Plasmodium falciparum DHFR and DHPS among Pregnant Women with Falciparum Malaria in Banjar District, South Kalimantan Province. (2012)
  • Author(s): Fitriah
  • Organizer: The 2ndInternational Congress of Life Sciences 2012: "Prospective and Contribution of Life Sciences for Better Life
  • Place of Presentation: University of Brawijaya, Malang, East Java, (Indonesia)
  • Year and Date: 2012-07-14
• [Presentation] ミャンマーの熱帯熱マラリア原虫薬剤耐性関連遺伝子の多型 (2012)
  • Author(s): Hla Myat Mon
  • Organizer: 第81回日本寄生虫学会大会
  • Place of Presentation: 兵庫医科大学(兵庫県)
  • Year and Date: 2012-03-24
• [Presentation] The efficacy of Dihydroartemisinin and the mutation of 769 codon of PfATPase gene in uncomplicated falciparum malaria in Jayapura District, Papua Province, Indonesia (2012)
  • Author(s): Petronella Maria Risamasu et al.,
  • Organizer: The 2nd International Congress of Life Sciences 2012: “Prospective and Contribution of Life Sciences for Better Life”
  • Place of Presentation: University of Brawijaya, Malang, East Java, Indonesia
• [Presentation] Polymorphism gene Plasmodium falciparum DHFR and DHPS among Pregnant Women with Falciparum Malaria in Banjar District, South Kalimantan Province (2012)
  • Author(s): Fitriah et al.,
  • Organizer: The 2nd International Congress of Life Sciences 2012: “Prospective and Contribution of Life Sciences for Better Life”
  • Place of Presentation: University of Brawijaya, Malang, East Java, Indonesia
• [Remarks] 長崎大学熱帯医学研究所原虫学分野
  • URL: http://www.tm.nagasaki-u.ac.jp/nekken/research/protozoology.html