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Effects of rotavirus vaccine on circulating strains in Africa

Research Project

Project/Area Number 22406014
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Virology
Research InstitutionNagasaki University

Principal Investigator

NAKAGOMI Toyoko  長崎大学, 医歯(薬)学総合研究科, 准教授 (40155693)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Keywordsロタウイルス / ワクチン / 遺伝子型 / 全ゲノム解析 / アフリカ / マラウイ / 血清型 / 流行株 / G8
Research Abstract

Safe and efficacious vaccines have been introduced to protect children from rotavirus, a major cause of severe acute gastroenteritis in children worldwide. This study aimed at providing a molecular epidemiologic basis on which to understand the effects of rotavirus vaccines on circulating wild-type rotavirus strains by analyzing clinical samples collected from children admitted to a sentinel hospital in Blantyre, Malawi. This study revealed that Malawian G8 strains evolved over the last decade through genetic reassortment with other human rotaviruses, changing their VP4 genotypes while maintaining conserved genotype constellations for the remaining structural and non-structural proteins. Analysis of Malawian G12P[6] strains and representative, co-circulating strains provided molecular evidence for complex stages of reassortment events that a G12 VP7 gene donor strain underwent with contemporary, locally-circulating strains possessing different genetic backgrounds.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (18 results)

All 2013 2012 2011 2010

All Journal Article (12 results) (of which Peer Reviewed: 10 results) Presentation (6 results)

  • [Journal Article] G8 rotaviruses with conserved genotype constellations detected in Malawi over 10 years (1997-2007) display frequent gene reassortment among strains co-circulating in humans2013

    • Author(s)
      Nakagomi T, Doan YH, Dove W, Ngwira B, Iturriza-Gomara M, Nakagomi O, Cunliffe NA
    • Journal Title

      J Gen Virol

      Volume: 94 Pages: 1273-1295

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection and molecular characterisation of noroviruses in hospitalised children in Malawi, 1997-20072013

    • Author(s)
      Trainor E, Lopman B, Iturriza-Gomara M, Dove W, Ngwira B, Nakagomi O, Nakagomi T, Parashar U, Cunliffe N
    • Journal Title

      J Med Virol

      Volume: 85(7) Pages: 1299-1306

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification by full genome analysis of a bovine rotavirus transmitted directly to, and causing diarrhea in a human child2013

    • Author(s)
      Doan YH, Nakagomi T, Aboudy Y, Silberstein I, Behar-Novat E, Nakagomi O, Shulman LM
    • Journal Title

      J Clin Microbiol

      Volume: 51(1) Pages: 182-189

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] G8 rotaviruses with conserved genotype constellations detected in Malawi over 10 years (1997-2007) display frequent gene reassortment among strains co-circulating in humans.2013

    • Author(s)
      Nakagomi T, Doan YH, Dove W, Ngwira B, Iturriza-Gómara M, Nakagomi O, Cunliffe NA
    • Journal Title

      J Gen Virol

      Volume: 94 Issue: 6 Pages: 1273-1295

    • DOI

      10.1099/vir.0.050625-0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of rotavirus strains detected during a clinical trial of a human rotavirus vaccine in Blantyre, Malawi.2012

    • Author(s)
      Nakagomi T
    • Journal Title

      Vaccine

      Volume: 30 Supple 1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of rotavirus strains detected during a clinical trial of a human rotavirus vaccine in Blantyre, Malawi2012

    • Author(s)
      Nakagomi T
    • Journal Title

      Vaccine

      Volume: (in press) Pages: A140-A151

    • DOI

      10.1016/j.vaccine.2011.09.119

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of rotavirus strains detected during a clinical trial of a human rotavirus vaccine in Blantyre, Malawi2011

    • Author(s)
      Nakagomi T, Nakagomi O, Dove W, Doan YH, Witte D, Ngwira B, Todd S, Duncan Steele A, Neuzil KM, Cunliffe NA
    • Journal Title

      Vaccine

      Volume: 30 Suppl 1

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features and molecular epidemiology of rotavirus and norovirus infections in Libyan children2011

    • Author(s)
      Abugalia M
    • Journal Title

      J Med Virol

      Volume: 83 Issue: 10 Pages: 1849-1856

    • DOI

      10.1002/jmv.22141

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection and molecular characterisation of rotavirus and norovirus infections in Jordanian children with acute gastroenteritis2011

    • Author(s)
      Kaplan NM
    • Journal Title

      Arch Virol

      Volume: 156 Issue: 8 Pages: 1477-1480

    • DOI

      10.1007/s00705-011-0996-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular characterization of rotavirus strains circulating among children with acute gastroenteritis in Madagascar during 2004-20052010

    • Author(s)
      Adiku TK
    • Journal Title

      J Infect Dis

      Volume: 202(Suppl 1) Pages: 175-179

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新時代のワクチン戦略について考える:ロタウイルスワクチン2010

    • Author(s)
      中込とよ子
    • Journal Title

      臨床検査

      Volume: 54 Pages: 1392-1399

    • Related Report
      2010 Annual Research Report
  • [Journal Article] ロタウイルスワクチン:わが国への導入の展望と課題2010

    • Author(s)
      中込治
    • Journal Title

      臨床とウイルス

      Volume: 38 Pages: 454-465

    • Related Report
      2010 Annual Research Report
  • [Presentation] G8 rotaviruses with conserved genotype constellations detected in Malawi over 10 years display frequent gene reassortment among strains co-circulating in humans2013

    • Author(s)
      Nakagomi T
    • Organizer
      15th International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim
    • Place of Presentation
      Singapore
    • Related Report
      2013 Final Research Report
  • [Presentation] Full-genome analysis of G8 rotavirus strains in Malawi over a 10-year-period2012

    • Author(s)
      Nakagomi T, Doan YH, Dove W. Iturriza-Gomara M, Ngwera B, Nakagomi, O, Cunliffe N
    • Organizer
      The 11th International Symposium on Double-Stranded RNA Viruses
    • Place of Presentation
      Puerto Rico, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] FULL-GENOME ANALYSIS OF G8 ROTAVIRUS STRAINS IN MALAWI OVER A 10-YEAR-PERIOD2012

    • Author(s)
      Nakagomi T
    • Organizer
      11th International Symposium on dsRNA Viruses
    • Place of Presentation
      Puerto Rico
    • Related Report
      2012 Annual Research Report
  • [Presentation] Molecular characterization of rotavirus strains detected during a clinical trial of a human rotavirus vaccine in Blantyre, Malawi2011

    • Author(s)
      Nakagomi T, Nakagomi O, Dove W, Doan YH, Witte D, Ngwira B, Todd S, Steele AD, Neuzil KM, Han HH, Cunliffe NA
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular characterization of rotavirus strains detected during a clinicaltrial of a human rotavirus vaccine in Blantyre, Malawi2011

    • Author(s)
      Nakagomi T
    • Organizer
      XV International Congress of Virology
    • Place of Presentation
      Sapporo (Hokkaido)
    • Related Report
      2011 Annual Research Report
  • [Presentation] What makes live-attenuated, orally-administrable rotavirus vaccines less efficacious in resource-poor countries?2010

    • Author(s)
      Nakagomi T
    • Organizer
      An international symposium on mucosal immunology
    • Place of Presentation
      Sapporo
    • Year and Date
      2010-06-21
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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