Molecular epidemiology of nasopharyngeal carcinoma in southern Chinaand searching for early detection biomarkers

• Project/Area Number: 22406016
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Hygiene
• Research Institution: Mie University
• Principal Investigator: MURATA Mariko 三重大学, 大学院・医学系研究科, 教授 (10171141)
• Co-Investigator(Kenkyū-buntansha): OIKAWA Shinji 三重大学, 大学院・医学系研究科, 准教授 (10277006) ; HIRAKU Yusuke 三重大学, 大学院・医学系研究科, 講師 (30324510) ; MA Nei 鈴鹿医療科学大学, 保健衛生学部, 教授 (30263015) ; MIDORIKAWA Kaoru 三重大学, 大学院・医学系研究科, リサーチアソシエイト (20393366)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000); Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 中国南部 / 上咽頭癌 / Epstein-Barrウィルス / 環境要因 / 酸化ニトロ化ストレス / DNA損傷 / DNAメチル化異常 / 発がん機構 / DNAメチル化 / 活性酸素 / 次世代シークエンサー / RRAD / TFPI2 / がん抑制遺伝子 / 8-ニトログアニン / 8-ハイドロキシデオキシグアノシン / 炎症

Research Abstract

Epstein-Barr virus-associated nasopharyngeal carcinoma (NPC) is endemic in southern China. Questionnaire investigation suggested significant association between NPC and environmental factors such as smoking and foods. Strongimmunnoreactivities of 8-oxodG and 8-nitroguanine were observed in the cancer cells of NPC patients. The difference in the serum levels of 8-oxodG between the NPC patients and controls showed statistically significant, suggesting that 8-nitroguanine and 8-oxodG could be potential biomarkers for evaluating the risk of NPC. We revealed the epigenetic inactivation of several genes by promoter hypermethylation in NPC.

Research Products

• [Journal Article] Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma (2012)
  • Author(s): Mo Y, Midorikawa K, Zhang Z, Zhou X, Ma N, Huang G, Hiraku Y, Oikawa S, Murata M
  • Journal Title: Cancer Lett2. Volume: 323(2) Pages: 147-54
  • Peer Reviewed
• [Journal Article] Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis. (2012)
  • Author(s): Murata M, Thanan R, Ma N, Kawanishi S
  • Journal Title: J Biomed Biotechnol Volume: 2012 Pages: 623109-623109
  • Peer Reviewed
• [Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression (2012)
  • Author(s): Thanan R、Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, Murata M, Kawanishi S
  • Journal Title: Biochem Biophys Res Commun Volume: 421(2) Pages: 280-5
  • Peer Reviewed
• [Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis of cholangiocarcinoma (2012)
  • Author(s): Thanan R, Oikawa S, Yongvanit P, Hiraku Y, Ma N, Pinlaor S, Pairojkul C, Wongkham C, Sripa B, Khuntikeo N, Kawanishi S, Murata M
  • Journal Title: Free Radic. Biol. Med Volume: 52(8) Pages: 1465-72
  • Peer Reviewed
• [Journal Article] Kawanishi S. Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer (2012)
  • Author(s): Thanan R, Murata M, Ma N, Hiraku Y, Oikawa S, Hammam O, Wishahi M, El Leithy T
  • Journal Title: Mediat. Inflamm Volume: 2012 Pages: 165879-165879
  • Peer Reviewed
• [Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression. Biochem. (2012)
  • Author(s): Thanan R, Ma N, Iijima K, Abe Y, Koike T, Shimosegawa T, Pinlaor S, Hiraku Y, Oikawa S, Murata M, Kawanishi S
  • Journal Title: Biophys. Res. Commun Volume: 421 Pages: 280-285
  • Peer Reviewed
• [Journal Article] CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure (2012)
  • Author(s): Huang S, Guo S, Guo F, Yang Q, Xiao X, Murata M, Ohnishi S, Kawanishi S, Ma N
  • Journal Title: Eur. J. Histochem
  • Peer Reviewed
• [Journal Article] Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cell (2012)
  • Author(s): Guo F, Ma N, Horibe Y, Kawanishi S, Murata M, Hiraku Y
  • Journal Title: Toxicol. Appl. Pharmacol Volume: 260(2) Pages: 183-92
  • Peer Reviewed
• [Journal Article] Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma. (2012)
  • Author(s): Mo Y
  • Journal Title: Cancer Lett Volume: 323 Issue: 2 Pages: 147-154
  • DOI: 10.1016/j.canlet.2012.03.042
  • Peer Reviewed
• [Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis of cholangiocarcinoma (2012)
  • Author(s): Thanan, R.
  • Journal Title: Free Radic.Biol.Med. Volume: (印刷中) Issue: 8 Pages: 1465-1472
  • DOI: 10.1016/j.freeradbiomed.2012.01.018
  • Peer Reviewed
• [Journal Article] Nuclear Localization of COX-2 in relation to the Expression of Stemness Markers in Urinary Bladder Cancer (2012)
  • Author(s): Thanan R, Murata M, Ma N, Hammam O, Wishahi M, El Leithy T, Hiraku Y, Oikawa S, Kawanishi S
  • Journal Title: Mediators Inflamm Volume: 2012 Pages: 165879-165879
  • DOI: 10.1155/2012/165879
  • Peer Reviewed
• [Journal Article] Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression. (2012)
  • Author(s): Thanan R
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 421 Issue: 2 Pages: 280-285
  • DOI: 10.1016/j.bbrc.2012.03.152
  • Peer Reviewed
• [Journal Article] Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells (2012)
  • Author(s): Guo, F.
  • Journal Title: Toxicol.Appl.Pharmacol. Volume: (印刷中) Issue: 2 Pages: 183-192
  • DOI: 10.1016/j.taap.2012.02.010
  • Peer Reviewed
• [Journal Article] Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells (2012)
  • Author(s): Guo, F., Ma, N., Horibe, Y., Kawanishi, S., Murata, M., Hiraku, Y.
  • Journal Title: Toxicol.Appl.Pharmacol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Inflammation-induced protein carbonylation contributes to poor prognosis of cholangiocarcinoma (2012)
  • Author(s): Thanan, R., Oikawa, S., Yongvanit, P., Hiraku, Y., Ma, N., Pinlaor, S., Pairojkul, C, Wongkham, C, Sripa, B., Khuntikeo, N., Kawanishi, S., Murata, M.
  • Journal Title: Free Radic.Biol.Med. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer (2012)
  • Author(s): Thanan, R., Murata, M., Ma, N., Hiraku, Y., Oikawa, S., Hammam, O., Wishahi, M., El Leithy, T., Kawanishi, S
  • Journal Title: Mediat.Inflamm. Volume: (in press)
  • Peer Reviewed
• [Journal Article] Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis (review) (2012)
  • Author(s): Murata M., Thanan R., Ma N., Kawanishi S.
  • Journal Title: J.Biomed.Biotechnol. Volume: (in press)
  • Peer Reviewed
• [Journal Article] 8-Nitroguanine : A potential biomarker to evaluate the risk of inflammation-related carcinogenesis (2012)
  • Author(s): Ma, N., Murata, M., Ohnishi, S., Thanan, R., Hiraku, Y., Kawanishi, S.
  • Journal Title: Biomarker Volume: (in press)
  • Peer Reviewed
• [Journal Article] Mechanisms of oxidative DNA damage induced by carcinogenic arylamines. (2011)
  • Author(s): Murata M、Kawanishi S
  • Journal Title: Front Biosci Volume: 1(16) Pages: 1132-43
  • Peer Reviewed
• [Journal Article] Nitrative and oxidative DNA damage caused by K-ras mutation in mice (2011)
  • Author(s): Ohnishi S, Saito H, Suzuki N, Ma N, Hiraku Y, Murata M, Kawanishi S
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 413 Pages: 236-240
  • Peer Reviewed
• [Journal Article] Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma (2011)
  • Author(s): Huang Y-J, Zhang B-B, Ma N, Murata M.,Tang A-Z, Huang G-W.
  • Journal Title: Med Oncol Volume: 28 Pages: 377-84
  • Peer Reviewed
• [Journal Article] Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosomahaematobium infection (2011)
  • Author(s): Ma N, Thanan R, Kobayashi H, Hammam O, Wishahi M, Leithy TE, Hiraku Y, Amro el K, Oikawa S, Ohnishi S, Murata M、Kawanishi S
  • Journal Title: Biochem. Biophys. Res. Commun Volume: 414 Pages: 344-349
  • Peer Reviewed
• [Journal Article] Astrocytic neuroprotection through induction of cytoprotective molecules; a proteomic analysis of mutant P301S tau-transgenic mouse (2011)
  • Author(s): Yata K, Oikawa S, Sasaki R, Shindo A, Yang R, Murata M, Kanamaru K, Tomimoto H.
  • Journal Title: Brain Res Volume: 1410 Pages: 12-23
  • Peer Reviewed
• [Journal Article] Proteomic identification of hippocampal proteins vulnerable to oxidative stress in excitotoxin-induced acute neuronal injury. (2011)
  • Author(s): Furukawa A, Kawamoto Y, Chiba Y, Takei S, Hasegawa-Ishii S, Kawamura N, Yoshikawa K, Hosokawa M, Oikawa S, Kato M, Shimada A.
  • Journal Title: Neurobiol Dis Volume: 43 Pages: 706-714
  • Peer Reviewed
• [Journal Article] Nitrative and oxidative DNA damage caused by K-ras mutation in mice (2011)
  • Author(s): Ohnishi, S.
  • Journal Title: Biochem.Biophys.Res.Commun. Volume: 413 Issue: 2 Pages: 236-240
  • DOI: 10.1016/j.bbrc.2011.08.076
  • Peer Reviewed
• [Journal Article] Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection (2011)
  • Author(s): Ma N, et al
  • Journal Title: Biochem Biophys Res Commun Volume: 414 Issue: 2 Pages: 44-349
  • DOI: 10.1016/j.bbrc.2011.09.073
  • Peer Reviewed
• [Journal Article] Mechanisms of oxidative DNA damage induced by carcinogenic arylamines (2011)
  • Author(s): Murata M, Kawanishi S
  • Journal Title: Front Biosci Volume: 16 Issue: 1 Pages: 1132-43
  • DOI: 10.2741/3739
  • Peer Reviewed
• [Journal Article] Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma (2011)
  • Author(s): Huang Y-J., Zhang B-B., Ma N., Murata M., Tang A-z., Huang G-W.
  • Journal Title: Med.Oncol. Volume: 28 Pages: 377-84
  • Peer Reviewed
• [Journal Article] Mechanisms of oxidative DNA damage induced by carcinogenic arylamines (2011)
  • Author(s): Murata M, Kawanishi S
  • Journal Title: Front.Biosci. Volume: 16 Pages: 1132-43
  • Peer Reviewed
• [Journal Article] Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment. (2010)
  • Author(s): Pinlaor S, Prakobwong S, Hiraku Y, Pinlaor P, Laothong U, Yongvanit P.
  • Journal Title: Eur. J. Pharmacol. Volume: 638 Pages: 134-141
  • Peer Reviewed
• [Journal Article] Protective effect of melatonin against Opisthorchis viverrini-induced oxidative and nitrosative DNA damage and liver injury in hamsters (2010)
  • Author(s): Laothong U, Pinlaor P, Hiraku Y, Boonsiri P, Prakobwong S, Khoontawad J, Pinlaor S
  • Journal Title: J. Pineal Res Volume: 49 Pages: 271-282
  • Peer Reviewed
• [Journal Article] DNA damage and estrogenic activity induced by the environmental pollutant2-nitrotoluene and its metabolite. (2010)
  • Author(s): Watanebe C, Egami T, Midorikawa K, Hiraku Y, Oikawa S, Kawanishi S, Murata M
  • Journal Title: Environ Health Prev Med Volume: 15 Pages: 319-326
  • Peer Reviewed
• [Journal Article] Role of Peroxisome Proliferator-activated Receptor-alpha in Hepatobiliary Injury Induced by Ammonium Perfluorooctanoate in Mouse Liver (2010)
  • Author(s): Minata M, Harada KH, Karrman A, Hitomi T, Hirosawa M, Murata M、Gonzalez FJ,Koizumi A
  • Journal Title: Ind Health Volume: 48(1) Pages: 96-107
  • Peer Reviewed
• [Journal Article] Proteomic analysis of aging brain in SAMP10 mouse: a model of age-related cerebral degeneration (2010)
  • Author(s): Furukawa A, Oikawa S, Hasegawa-Ishii S, Chiba Y, Kawamura N, Takei S, Yoshikawa K, Hosokawa M, Kawanishi S, Shimada A
  • Journal Title: Mech Ageing Dev Volume: 131(6) Pages: 397-88
  • Peer Reviewed
• [Journal Article] TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma. (2010)
  • Author(s): Wang S, Xiao X, Zhou X, Huang T, Du C, Yu N, Mo Y, Lin L, Zhang J, Ma N, Murata M, Huang G, Zhang Z
  • Journal Title: BMC Cancer Volume: 10 Pages: 617-617
  • Peer Reviewed
• [Journal Article] Preferential induction of apoptosis in regulatory T cells by tributyltin: possible involvement in the exacerbation of allergic diseases. (2010)
  • Author(s): Tada-Oikawa S,Murata M, Kato T.
  • Journal Title: Nippon Eiseigaku Zasshi Volume: 65(4) Pages: 530-5
  • Peer Reviewed
• [Journal Article] Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole (2010)
  • Author(s): Furukawa A, 査読有Oikawa S, Harada K, Sugiyama H, Hiraku Y, Murata M, Shimada A, Kawanishi S
  • Journal Title: Mutat Res Volume: 694(1-2) Pages: 7-12
  • Peer Reviewed
• [Journal Article] High incidence of tumors in diabetic thrombin activatable fibrinolysis inhibitor and apolipoprotein E double deficient mice. (2010)
  • Author(s): Beppu T, Gil-Bernabe P, Boveda-Ruiz D, D'Alessandro-Gabazza C, Matsuda Y, Toda M, Miyake Y, Shiraki K,Murata M, Murata T, Yano Y, Morser J, Gabazza EC, Takei Y.
  • Journal Title: J Thromb Haemost. Volume: 8(11) Pages: 2514-22
  • Peer Reviewed
• [Journal Article] Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide. (2010)
  • Author(s): Mizutani H,Hiraku Y, Tada-Oikawa S, Murata M, Ikemura K, Iwamoto T, Kagawa Y, Okuda M, Kawanishi S.
  • Journal Title: Cancer Sci. Volume: 101(10) Pages: 2214-9
  • NAID: 10027832563
  • Peer Reviewed
• [Journal Article] roteomic identification of peroxiredoxin 6 for host defense against Opisthorchis viverriniinfection (2010)
  • Author(s): Khoontawad J, Wongkham C, Hiraku Y, Yongvanit P, Prakobwong S, Boonmars T, Pinlaor P, Pinlaor S
  • Journal Title: Parasite Immunol. Volume: 32 Pages: 314-323
  • Peer Reviewed
• [Journal Article] The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis (2010)
  • Author(s): Hiraku Y, Kawanishi S, Ichinose T, Murata M
  • Journal Title: Ann. NY Acad. Sci Volume: 1203 Pages: 15-2
  • Peer Reviewed
• [Journal Article] Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma (2010)
  • Author(s): Huang Y-J, Zhang B-B, Ma N, Murata M, Tang A-Z, Huang G-W
  • Journal Title: Med.Oncol. Volume: 28 Pages: 377-84
  • Peer Reviewed
• [Journal Article] TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma (2010)
  • Author(s): Wang S, Xiao X, Zhou X, Huang T, Du C, Yu N, Mo Y, Lin L, Zhang J, Ma N, Murata M, Huang G-W, Zhang Z
  • Journal Title: BMC Cancer Volume: 10 Pages: 617-617
  • Peer Reviewed
• [Journal Article] The role of iNOS-mediated DNA damage in infection-and asbestos-induced carcinogenesis (2010)
  • Author(s): Hiraku Y, Kawanishi S, Ichinose T, Murata, M
  • Journal Title: Ann.NY Acad.Sci. Volume: 1203 Pages: 15-22
  • Peer Reviewed
• [Journal Article] DNA damage and estrogenic activity induced by the environmental pollutant 2-nitrotoluene and its metabolite (2010)
  • Author(s): Watanebe C, Egami T, Midorikawa K, Hiraku Y, Oikawa S, Kawanishi S, Murata M
  • Journal Title: Environmental Health and Preventive Medicine Volume: 15 Pages: 319-326
  • NAID: 10029519330
  • Peer Reviewed
• [Journal Article] Oxidatively generated DNA damage induced by 3-amino-5-mercapto-1,2,4-triazole, a metabolite of carcinogenic amitrole (2010)
  • Author(s): Furukawa A, Oikawa s, Harada K, Sugiyama H, Hiraku Y, Murata M, Shimada A, Kawanishi S
  • Journal Title: Mutat.Res. Volume: 694 Pages: 7-12
  • Peer Reviewed
• [Presentation] シンポジウム2健康長寿社会における学会活動の方向性、がんとエピジェネティクス (2013)
  • Author(s): 村田真理子
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢市
• [Presentation] Melatonin protects against Opisthorchis viverrini-associated cholangiocarcinoma and liver injury in hamsters (2013)
  • Author(s): Umawadee Laothong, Yusuke Hiraku, Shinji Oikawa, Mariko Murata, Somchai Pinlaor
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢市
• [Presentation] Identification of dysregulated microRNA in nasopharyngeal carcinoma (2013)
  • Author(s): Shumin Wang, Yingxi Mo, Kaoru Midorikawa, Zhe Zhang, Guangwu Huang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢市
• [Presentation] Up-regulation of GLRX3 is associated with invasion and metastasis in nasopharyngeal carcinoma (2013)
  • Author(s): Bo Hou, Yingxi Mo, Zhe Zhang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Kaoru Midorikawa, Mariko Murata.
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢市
• [Presentation] Nitrative DNA damage induced by multi-walled carbon nanotube in cultured cells: a comparison with oxidative DNA damage (2013)
  • Author(s): Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata, Yusuke Hiraku
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢市
• [Presentation] 多層カーボンナノチューブによるDNA損傷:肺上皮細胞における8-ニトログアニン生成 (2013)
  • Author(s): 平工雄介、Feiye Guo、馬寧、川西正祐、村田真理子
  • Organizer: 第12回分子予防環境医学研究会
  • Place of Presentation: つくば市
• [Presentation] 多層カーボンナノチューブによるDNA損傷：肺上皮細胞における8-ニトログアニン生成 (2013)
  • Author(s): 平工雄介
  • Organizer: 第12回分子予防環境医学研究会
  • Place of Presentation: つくばサイエンス・インフォメーションセンター（つくば市）
• [Presentation] 虚血再灌流後のサル海馬CA1と歯状回(DG)における酸化損傷タンパク質の比較 (2013)
  • Author(s): 栗本将多
  • Organizer: 第1回日本酸化ストレス学会東海支部
  • Place of Presentation: 名古屋市立大学（名古屋市）
• [Presentation] Nitrative DNA damage induced by multi-walled carbon nanotube in cultured cells: a comparison with oxidative DNA damage (2013)
  • Author(s): Feiye Guo
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学医学部（金沢市）
• [Presentation] 東南アジアにおける生活習慣病の現状について：その5年後 (2013)
  • Author(s): 翠川薫
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学医学部（金沢市）
• [Presentation] 虚血再灌流後のサル海馬CA1と歯状回(DG)における酸化損傷タンパク質の比較 (2013)
  • Author(s): 栗本将多
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学医学部（金沢市）
• [Presentation] Up-regulation of GLRX3 is associated with invasion and metastasis in nasopharyngeal carcinoma (2013)
  • Author(s): Bo Hou
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学医学部（金沢市）
• [Presentation] シンポジウム2健康長寿社会における学会活動の方向性、がんとエピジェネティクス (2013)
  • Author(s): 村田真理子
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学医学部（金沢市）
• [Presentation] Melatonin protects against Opisthorchis viverrini-associated cholangiocarcinoma and liver injury in hamsters (2013)
  • Author(s): Umawadee Laothong
  • Organizer: 第83回日本衛生学会総会
  • Place of Presentation: 金沢大学医学部（金沢市）
• [Presentation] 上咽頭癌におけるmicroRNA調節異常の検討 (2012)
  • Author(s): 王淑民、莫穎禧、翠川薫、張哲、黄光武、馬寧、平工雄介、及川伸二, 村田真理子
  • Organizer: 第41回日本環境変異原学会
  • Place of Presentation: 静岡市
• [Presentation] ビルハルツ住血吸虫感染による膀胱癌におけるDNA損傷と幹細胞マーカー (2012)
  • Author(s): 大西志保、馬寧、タナン レイヌー、小林 果、平工雄介、及川伸二、村田真理子、川西正祐
  • Organizer: フォーラム2012衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋市
• [Presentation] バレット食道におけるプロトンポンプ阻害剤のMn-SOD発現を介したDNA損傷への効果 (2012)
  • Author(s): 村田真理子,平工雄介,及川伸二,タナン レイヌー,ピラオール ソムチャイ,馬寧,川西正祐
  • Organizer: フォーラム2012衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋市
• [Presentation] カーボンナノチューブによる細胞内ニトロ化DNA損傷 (2012)
  • Author(s): 平工雄介、Feiye Guo、馬寧、川西正祐、村田真理子
  • Organizer: フォーラム2012衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋市
• [Presentation] Association of asbestos fiber contents with oxidative and nitrative DNA damage in human lung (2012)
  • Author(s): 平工雄介、馬寧、川西正祐、村田真理子
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌市
• [Presentation] Genome-wide DNA methylation study of nasopharyngeal carcinoma in Chinese patients with Epstein-Barr virus infection (2012)
  • Author(s): Yingxi Mo, Kaoru Midorikawa, Ning Ma, Xiaoying Zhou, Guangwu Huang, Zhe Zhang, Yusuke Hiraku, Shinji Oikawa, Mariko Murata.
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌市
• [Presentation] Nitrative DNA damage induced by multi-walled carbon nanotube with different lengths in cultured cells (2012)
  • Author(s): Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata, Yusuke Hiraku
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌市
• [Presentation] Stromal expression of alpha-smooth muscle actin correlates with SDF-1 in nasopharyngeal carcinoma (2012)
  • Author(s): Shumin Wang, Ning Ma, Shosuke Kawanishi, Yusuke Hiraku, Shinji Oikawa, Ying Xie, Zhe Zhang, Guangwu Huang, Mariko Murata
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌市
• [Presentation] 食品中に含まれる有効成分の安全性評価:酸化促進作用によるDNA損傷性とエストロゲン感受性乳癌細胞の増殖促進作用 (2012)
  • Author(s): 大西志保、村田真理子、川西正祐
  • Organizer: 日本社会薬学会第31年会
  • Place of Presentation: 鈴鹿市
• [Presentation] Cytosine methylation in EBV-mediated nasopharyngeal carcinoma in relati on to nitrative stress (2012)
  • Author(s): Yingxi Mo, Ning Ma, Shumin Wang, Zhe Zhang, Ying Xie, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa Shosuke Kawanishi, Mariko Murata
  • Organizer: The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh, UK
• [Presentation] Nitrative DNA damage in human lung tissues in association with asbestos exposure (2012)
  • Author(s): The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Organizer: The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh, UK
• [Presentation] Arsenic-induced nitrative DNA damage in human HaCaT kerationcytes (2012)
  • Author(s): Ning Ma, Shiwen Huang, Feiye Guo, Songchao Guo, Mariko Murata, Shosuke Kawanishi.
  • Organizer: The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh, UK
• [Presentation] Nitrative DNA damage in human lung epithelial cells treated with multi-walled carbon nanotube (2012)
  • Author(s): Feiye Guo, Ning Ma, Shosuke Kawanishi, Mariko Murata, Yusuke Hiraku
  • Organizer: The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh, UK
• [Presentation] Protein carbonylation in liver fluke-induced cholangiocarcinoma in relation to poor prognosis. (2012)
  • Author(s): Raynoo Thanan, Shinji Oikawa, Puangrat Yongvanit, Yusuke Hiraku, Ning Ma, Somchai Pinlaor, Chawalit Pairojkul, Chaisiri Wongkham, Banchob Sripa, Shosuke Kawanishi and Mariko Murata.
  • Organizer: Mahidol International Conference on Infection and Cancer.
  • Place of Presentation: Bangkok, Thailand
• [Presentation] ヒト肺組織における石綿繊維量と酸化・ニトロ化DNA損傷およびDNA修復酵素発現との関連 (2012)
  • Author(s): 平工雄介
  • Organizer: 第85回日本産業衛生学会
  • Place of Presentation: 名古屋国際会議場(名古屋市)
• [Presentation] 酸化ストレス暴露サル海馬歯状回におけるタンパク質の発現変動 (2012)
  • Author(s): 栗本将多
  • Organizer: 第65回日本酸化ストレス学会学術集会
  • Place of Presentation: あわぎんホール徳島郷土文化会館（徳島市）
• [Presentation] 多層カーボンナノチューブによる細胞内8-ニトログアニン生成 (2012)
  • Author(s): 平工雄介
  • Organizer: 第12回日本NO学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸市）
• [Presentation] Cytosine methylation in EBV-mediated nasopharyngeal carcinoma in relati on to nitrative stress (2012)
  • Author(s): Yingxi Mo
  • Organizer: The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh University(Edinburgh, UK)
• [Presentation] Nitrative DNA damage in human lung tissues in association with asbestos exposure (2012)
  • Author(s): Yusuke Hiraku
  • Organizer: The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh University(Edinburgh, UK)
• [Presentation] Arsenic-induced nitrative DNA damage in human HaCaT kerationcytes (2012)
  • Author(s): Ning Ma
  • Organizer: The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh University(Edinburgh, UK)
• [Presentation] Nitrative DNA damage in human lung epithelial cells treated with multi-walled carbon nanotube (2012)
  • Author(s): Feiye Guo
  • Organizer: The 7th International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: Edinburgh University(Edinburgh, UK)
• [Presentation] プロテオミクス解析による酸化ストレス暴露サル海馬におけるタンパク質の変動解析 (2012)
  • Author(s): 栗本将多
  • Organizer: 第63回日本電気泳動学総会
  • Place of Presentation: 沖縄コンベンションセンター（宜野湾市）
• [Presentation] 食品中に含まれる有効成分の安全性評価：酸化促進作用によるDNA損傷性とエストロゲン感受性乳癌細胞の増殖促進作用 (2012)
  • Author(s): 大西志保
  • Organizer: 日本社会薬学会第31年会
  • Place of Presentation: 鈴鹿医療科学大学（鈴鹿市）
• [Presentation] 食品中に含まれる有効成分の安全性評価 その１：カテキン類によるDNA損傷性 (2012)
  • Author(s): 古川絢子
  • Organizer: 日本社会薬学会第31年会
  • Place of Presentation: 鈴鹿医療科学大学（鈴鹿市）
• [Presentation] Association of asbestos fiber contents with oxidative and nitrative DNA damage in human lung (2012)
  • Author(s): 平工雄介
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: ロイトン札幌（札幌市）
• [Presentation] Genome-wide DNA methylation study of nasopharyngeal carcinoma in Chinese patients with Epstein-Barr virus infection (2012)
  • Author(s): Yingxi Mo
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: ロイトン札幌（札幌市）
• [Presentation] Nitrative DNA damage induced by multi-walled carbon nanotube with different lengths in cultured cells (2012)
  • Author(s): Feiye Guo
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: ロイトン札幌（札幌市）
• [Presentation] Stromal expression of alpha-smooth muscle actin correlates with SDF-1 in nasopharyngeal carcinoma (2012)
  • Author(s): Shumin Wang
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: ロイトン札幌（札幌市）
• [Presentation] 虚血再灌流後のサル海馬CA1と歯状回 (DG)における酸化損傷タンパク質の比較 (2012)
  • Author(s): 栗本将多
  • Organizer: 第21回「海馬と高次脳機能」学会
  • Place of Presentation: 金沢湯涌創作の森（金沢市）
• [Presentation] バレット食道におけるプロトンポンプ阻害剤のMn-SOD発現を介したDNA損傷への効果 (2012)
  • Author(s): 村田真理子
  • Organizer: フォーラム2012 衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋観光ホテル（名古屋市）
• [Presentation] ビルハルツ住血吸虫感染による膀胱癌におけるDNA損傷と幹細胞マーカー (2012)
  • Author(s): 大西志保
  • Organizer: フォーラム2012 衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋観光ホテル（名古屋市）
• [Presentation] カーボンナノチューブによる細胞内ニトロ化DNA損傷 (2012)
  • Author(s): 平工雄介
  • Organizer: フォーラム2012 衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋観光ホテル（名古屋市）
• [Presentation] 多層カーボンナノチューブによる細胞内DNA損傷の解析(第２報) 繊維長の影響 (2012)
  • Author(s): 平工雄介
  • Organizer: 日本産業衛生学会東海地方会
  • Place of Presentation: じゅうろくプラザ（岐阜市)
• [Presentation] 上咽頭癌におけるmicroRNA調節異常の検討 (2012)
  • Author(s): 王 淑民
  • Organizer: 第41回日本環境変異原学会
  • Place of Presentation: グランシップ（静岡市）
• [Presentation] Protein carbonylation in liver fluke-induced cholangiocarcinoma in relation to poor prognosis (2012)
  • Author(s): Raynoo Thanan, Shinji Oikawa, Puangrat Yongvanit, Yusuke Hiraku, Ning Ma, Somchai Pinlaor, Chawalit Pairojkul, Chaisiri Wongkham, Banchob Sripa, Shosuke Kawanishi, Mariko Murata
  • Organizer: Mahidol International Conference on Infection and Cancer
  • Place of Presentation: Bangkok, Thailand
• [Presentation] プロテオミクス解析による虚血再灌流後のサル海馬歯状回におけるタンパク質の変動 (2012)
  • Author(s): 栗本将多、山嶋哲盛、村田真理子、及川伸二
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] 虚血再潅流後のサル黒質におけるカルボニル化タンパク質の同定 (2012)
  • Author(s): 及川伸二、栗本将多、小林果、村田真理子、山嶋哲盛
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] ヒト肺組織における石綿繊維量とDNA損傷との関連 (2012)
  • Author(s): 平工雄介、酒井潔、柴田英治、上島通浩、久永直見、馬寧、川西正祐、村田真理子
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] 多層カーボンナノチューブによる細胞内ニトロ化DNA損傷:繊維長との関連 (2012)
  • Author(s): Feiye Guo、 馬寧、川西正祐、村田真理子、平工雄介
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] RRAD with tumor suppressive function is aberrantly methylated innasopharyngeal carcinoma (2012)
  • Author(s): Yingxi Mo, Kaoru Midorikawa, Zhe Zhang, Xiaoying Zhou, Guangwu Huang, Ning Ma, Yusuke Hirakul, Shinji Oikawa, Mariko Murata
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] 上咽頭癌におけるTFPI-2プロモーター領域のメチル化によるがん抑制機能の不活化 (2012)
  • Author(s): 王淑民、莫穎禧、翠川薫、張哲、黄光武、馬寧、平工雄介、及川伸二、村田真理子
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都
• [Presentation] RRAD with tumor suppressive function is aberrantly methylated in nasopharyngeal carcinoma (2012)
  • Author(s): Mo Y, Midorikawa K, Zhang Z, Ying X, Huang G, Ma N, Hiraku Y, Oikawa S, Murata M
  • Organizer: 第82回日本衛生学会総会
  • Place of Presentation: 京都市
• [Presentation] 多層カーボンナノチューブによる細胞内DNA損傷の解析 (2011)
  • Author(s): 平工雄介、Feiye Guo、村田真理子
  • Organizer: 日本産業衛生学会東海地方会
  • Place of Presentation: 豊明市
  • Year and Date: 2011-11-05
• [Presentation] Parasite infection induces oxidative/nitrative DNA damage in stem-like cells in relation to carcinogenesis. (2011)
  • Author(s): Raynoo Thanan, Mariko Murata, Ning Ma,Yusuke Hiraku, Shinji Oikawa Shosuke Kawanishi.
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] 乳癌治療薬タモキシフェンによる子宮内膜発がん機構の検討 (2011)
  • Author(s): 中村朱里、翠川薫、平工雄介、及川伸二、福原潔、川西正祐、村田真理子
  • Organizer: 第81回日本衛生学会総会
  • Place of Presentation: 東京
• [Presentation] ヒト肺上皮細胞におけるカーボンブラックナノ粒子によるニトロ化DNA損傷 (2011)
  • Author(s): 平工雄介、西川嘉広、馬寧、川西正祐、村田真理子
  • Organizer: 第11回日本NO学会学術集会
  • Place of Presentation: 町田市
• [Presentation] ヒト肺組織における酸化・ニトロ化DNA損傷と石綿曝露との関連 (2011)
  • Author(s): 平工雄介、酒井潔、柴田英治、上島通浩、久永直見、村田真理子
  • Organizer: 第84回日本産業衛生学会
  • Place of Presentation: 東京(優秀演題)
• [Presentation] 多層カーボンナノチューブで処理したヒト肺上皮細胞におけるニトロ化DNA損傷 (2011)
  • Author(s): Feiye Guo、 馬寧、川西正祐、村田真理子、平工雄介
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Parasite infection induces oxidative/nitrative DNA damage in stem-like cells in relation to carcinogenesis (2011)
  • Author(s): Raynoo Thanan, Mariko Murata, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Epigenetic aberration of RRAD gene in nasopharyngeal carcinoma and NPC genome-wide methylation profile (2011)
  • Author(s): Yingxi Mo, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Xue Xiao, Xiaoying Zhou, Guangwu Huang, Zhe Zhang, Mariko Murata
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Epigenetic inactivation of paracrined-FSTL1 modulates macrophage functions in nasopharyngeal carcinoma (2011)
  • Author(s): Xue Xiao, Xiaoying Zhou, Ying Xi Mo, Guangwu Huang, Shumin Wang, Tingting Huang, Nana Yu, Chunping Du, Wensheng Wen, Mariko Murata, Ning Ma, Ingemar Ernberg, Zhe Zhang
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋市
• [Presentation] Genome-wide profiling of DNA methylation identifies epigenetic targets and aberrant methylation of TFPI2 in nasopharyngeal carcinoma (2011)
  • Author(s): Yingxi Mo, Shuming Wang, Kaoru Midorikawa, Zhe Zhang, Guangwu Huang, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Mariko Murata
  • Organizer: 40^<th> Annual Meeting of the Japanese Environmental Mutagen Society
  • Place of Presentation: 東京(ベストプレゼンテーション賞)
• [Presentation] Oxidative modification of alpha 1-antitrypsin in intrahepatic cholangiocarcinoma (2010)
  • Author(s): Raynoo Thanan, Shinji Oikawa, Yusuke Hiraku, Ning Ma, Shosuke Kawanishi,Mariko Murata
  • Organizer: 39th JEMS 2010 conference.日本環境変異原学会第39回大会
  • Place of Presentation: つくば市
• [Presentation] DNA damage in CD133-positive progenitor cells in liver fluke-induced cholangiocarcinoma (2010)
  • Author(s): Raynoo Thanan, Mariko Murata, Yusuke Hiraku, Shinji Oikawa, Shosuke Kawanishi
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪市
• [Presentation] Epstein-Barr virus感染上咽頭癌における酸化ストレスと脂肪組織酸化ストレス軽減効果 (2010)
  • Author(s): 村田真理子
  • Organizer: 第80回日本衛生学会総会、酸化ストレス研究会企画シンポジウム
  • Place of Presentation: 仙台市
• [Presentation] Epstein-Barr virus感染上咽頭癌における酸化ストレスと炎症関連因子の検討 (2010)
  • Author(s): 村田真理子
  • Organizer: 第80回日本衛生学会総会、酸化ストレス研究会企画シンポジウム
  • Place of Presentation: 仙台市
• [Presentation] Aberrant methylation of RRAD gene in nasopharyngeal carcinoma (2010)
  • Author(s): Mo Y, Midorikawa K, Ma N, Hiraku Y, Oikawa S, Murata M
  • Organizer: 第80回日本衛生学会総会
  • Place of Presentation: 仙台市
• [Presentation] Epigenetic aberration of RRAD gene in Nasopharyngeal Carcinoma (2010)
  • Author(s): Mo Y, Midorikawa K, Ma N, Hiraku Y, Oikawa S, Murata M
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪市
• [Presentation] Frequent inactivation of FSTL1 by promoter hypermethylation in nasopharyngeal carcinomas (2010)
  • Author(s): Xiao X, Zhou X, Mo Y, Zhang Z, Huang G-W, Ma N, Midorikawa K, Hiraku Y, Oikawa S, Murata M
  • Organizer: 日本環境変異原学会第39回大会
  • Place of Presentation: つくば市
• [Book] 8-Nitroguanine: A potential biomarker to evaluate the risk of inflammation-related carcinogenesis (2012)
  • Author(s): Ma N, Murata M, Ohnishi S, Thanan R, Hiraku Y, Kawanishi S
  • Publisher: Biomarker. Khan TK (ed.). InTech
• [Book] In: Biomarker. Khan TK (ed.). InTech (2012)
  • Author(s): Ma N
  • Publisher: 8-Nitroguanine: A potential biomarker to evaluate the risk of inflammation-related carcinogenesis.
• [Book] 第1章 がんの生物学、腫瘍薬学(川西正祐、他 編) (2010)
  • Author(s): 村田哲也、村田真理子
  • Publisher: 南山堂
• [Book] 第5章 子どもの病気とその予防、子どもの保健-理論と実践- (2010)
  • Author(s): 谷口アキ、村田真理子
  • Publisher: 日本小児医事出版社、第6版
• [Book] 第1章がんの生物学、腫瘍薬学(川西正祐、他編) (2010)
  • Author(s): 村田哲也、村田真理子
  • Publisher: 南山堂
• [Remarks]
  • URL: http://www.medic.mie-u.ac.jp/eiseigaku/