| Project/Area Number |
22406018
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Hygiene
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| Research Institution | Teikyo University |
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Principal Investigator |
YANO Eiji 帝京大学, 大学院公衆衛生学研究科, 教授 (50114690)
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| Co-Investigator(Renkei-kenkyūsha) |
KOHYAMA Nobuhiko 東洋大学, 経済学部, 教授 (80133643)
WANG Xiaorong 香港中文大学, 公共衛生学院, 准教授
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2010: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Keywords | 石綿 / 肺がん / 喫煙 / 死因別死亡率 / 疫学研究 / クリソタイル / アンフィボール / 石綿鉱山 / 中国 / 繊維種別 / コホート研究 / 胸膜悪性中皮腫 / 相乗作用 / 疫学 |
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| Research Abstract |
A cohort study for 37 years follow-up was undertaken in an asbestos textile plant in China, where only chrysotile had been used. Cox proportional hazard ratio (HR) of cause-specific mortality was estimated, while taking into account age, smoking, and asbestos exposure level. In asbestos workers, HRs for mortality by all causes, all cancers, lung cancer, and respiratory diseases were 2.05 (95% CI:1.56 to 2.68), 1.89 (1.25 to 2.87), 3.31(1.60 to 6.87), and 3.23 (1.68 to 6.22), respectively. By a case-control study within a cohort in the same plant, we found 5 times elevation of the incidence of lung cancer among high exposed non-smoking workers but it was 3 times for smokers with low asbestos exposure. However, it elevated to more than10 times when workers smoke and exposed to high level of asbestos, suggesting the synergistic effects of the two for lung cancer. Also in a chrysotile miners cohort in China, mortality by lung cancer and non-malignant pulmonary diseases were elevated.
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