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Epidemiological study for identifying risk factors of esophageal adenocarcinoma in north China.

Research Project

Project/Area Number 22406021
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Public health/Health science
Research InstitutionNiigata University

Principal Investigator

AKAZAWA Kohei  新潟大学, 医歯学総合病院, 教授 (10175771)

Co-Investigator(Kenkyū-buntansha) TERAJIMA Kenshi  新潟大学, 医歯学総合病院, 准教授 (00377160)
WAKAI Toshifumi  新潟大学, 医歯学系, 教授 (50372470)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords疫学 / 国際保健学 / 健康管理 / 保健医療行政 / 地域保健 / 集団検診 / 医療情報学 / 食道扁平上皮癌 / 中国疫学調査 / リスク因子 / 窒素化合物 / ロジスティック回帰分析 / ホットスポット分析 / 食道癌 / 腺癌 / 条件付きロジスティック回帰分析 / マッチングデータ / 環境因子 / 喫煙 / 飲酒 / 扁平上皮癌
Research Abstract

Purpose : A matched case-control study to clarify the risk factors of alcohol and tobacco intake on the development of esophageal adenocarcinoma was collected in Hebei Province of China. Multivariate conditional logistic regression analysis indicated that only alcohol consumption was a significant risk factor for esophageal adenocarcinoma. Additional analysis of the combination of amount and duration of alcohol consumption indicated that heavy drinkers (> 30 ml/day) had significantly higher ORs, irrespective of the duration of alcohol consumption. In conclusion, heavy alcohol consumption increases the risk for esophageal adenocarcinoma independent of the duration of such consumption.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2013 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (3 results)

  • [Journal Article] Heavy alcohol intake is a risk factor for esophageal squamous cell carcinoma among middle-aged Chinese men : a case-control study and simulation2013

    • Author(s)
      Kumagai N, Akazawa K, Wakai T et al
    • Journal Title

      Molecular and Clinical Oncology

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of Nitrogen Compounds in Drinking Water with Incidence of Esophageal Squamous Cell Carcinoma in Shexian, China2012

    • Author(s)
      Zhang N, Yu C, Wen D, Chen J, Ling Y, Terajima K, Akazawa K, Shan B, Wang S
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 226 Issue: 1 Pages: 11-17

    • DOI

      10.1620/tjem.226.11

    • NAID

      10030196665

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol Consumption as a Risk Factor for Esophageal Adenocarcinoma in North China2011

    • Author(s)
      Chen J, Zhang N, Ling Y, Wakai T, He Y, Wei L, Wang S, Akazawa K
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 224 Issue: 1 Pages: 21-27

    • DOI

      10.1620/tjem.224.21

    • NAID

      10028233735

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clustering and Geographic Variation of Upper Gastrointestinal Cancers in a High-risk Region of Esophageal Cancer in Northern China2011

    • Author(s)
      Zhang N, Wen D, Shan B, Wang S, Zhang L, Wei L, Zou W, Kitsu K, Akazawa K
    • Journal Title

      Asian Pac J Cancer Prev

      Volume: 12(1) Pages: 193-198

    • URL

      http://www.apocpcontrol.org/page/apjcp_issues_view.php?pno=1558&gubun=p&s_search=&s_paper_vol=12&s_number33=1

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clustering and geographic variation of upper gastrointestinal cancers in a high-risk region of esophageal cancer in northern China2011

    • Author(s)
      Zhang Nan
    • Journal Title

      Asian Pacific journal of cancer prevention

      Volume: 12 Pages: 193-198

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the interaction between the amount and duration of alcohol consumption and tobacco smoking on the risk of esophageal cancer:A case-control study2010

    • Author(s)
      Chen J, Zhang N, Wakai T, Wei L, He Y, Kumagai N, Kitsu K, Wang S, Akazawa K
    • Journal Title

      Experimental and therapeutic medicine

      Volume: 1(6) Issue: 6 Pages: 991-997

    • DOI

      10.3892/etm.2010.152

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of the interaction between the amount and duration of alcohol consumption and tobacco smoking on the risk of esophageal cancer : A case-control study2010

    • Author(s)
      Jun Chen
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 1 Pages: 991-997

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] マッチドケースコントロール研究で使われる条件付きロジスティック回帰分析のpower推定のためのシュミレーションプログラム2012

    • Author(s)
      熊谷 直子
    • Organizer
      第32回 医療情報学連合大会
    • Place of Presentation
      朱鷺メッセ新潟コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bias due to variation in matching criteria used for conditional logistic regression in a case-control study2010

    • Author(s)
      張楠
    • Organizer
      第6回中国腫瘍学会
    • Place of Presentation
      中国上海光大会展センター
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発癌リスク因子探索のための症例対象研究とその統計学的な性質の解明2009

    • Author(s)
      陳君
    • Organizer
      第29回医療情報学連合大会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2009-11-22
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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