Efficient multiple testing methods for genome data

• Project/Area Number: 22500269
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Statistical science
• Research Institution: The Institute of Statistical Mathematics
• Principal Investigator: FUJISAWA Hironori 統計数理研究所, 数理・推論研究系, 准教授 (00301177)
• Co-Investigator(Renkei-kenkyūsha): NINOMIYA Yoshiyuki 九州大学, 数理学研究院, 准教授 (50343330) ; SAKAGUCHI Takayuki 大分県立看護科学大学, 看護学部, 助教 (10436496) ; TAKADA Toyoyuki 国立遺伝学研究所, 系統生物研究センター, 助教 (20356257)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 遺伝子発現差解析 / 有意性検定 / P値

Research Abstract

The P-value has often been estimated using the observations on other genes to overcome the small sample size. We have investigated necessary conditions to ensure the validity. Under such conditions, the uniformly most powerful test has been obtained. This test showed a good performance by simulations and data analyses. We have considered the equality of variance as well as the equality of mean.

Research Products

• [Journal Article] Optimal significance analysis of microarray data in a class of tests whose null statistic can be constructed (2012)
  • Author(s): Fujisawa, H. and Sakaguchi, T.
  • Journal Title: TEST Volume: Vol.21 Issue: 2 Pages: 280-300
  • DOI: 10.1007/s11749-011-0243-5
  • Peer Reviewed
• [Presentation] ゲノムデータのための統計的手法の開発 (2012)
  • Author(s): 藤澤洋徳
  • Organizer: 新領域融合プロジェクト外部レビュー
  • Place of Presentation: 東京
  • Year and Date: 2012-10-31
• [Presentation] ゲノムデータ解析のプロジェクトに携わって (2012)
  • Author(s): 藤澤洋徳
  • Organizer: 統計サマーセミナー
  • Place of Presentation: 熱海
  • Year and Date: 2012-08-05
• [Presentation] 遺伝子発現差解析におけるP値推定と最適な有意性検定 (2012)
  • Author(s): 藤澤洋徳
  • Organizer: 統計科学セミナー
  • Place of Presentation: 福岡
  • Year and Date: 2012-01-13
• [Presentation] 遺伝子発現差解析におけるＰ値推定と最適な有意性検定 (2012)
  • Author(s): 藤澤洋徳
  • Organizer: 統計科学セミナー
  • Place of Presentation: 福岡
• [Presentation] Optimal significance analysis of microarray data in a class of tests whose null statistic can be constructed (2011)
  • Author(s): Fujisawa, H.
  • Organizer: International Conference on Advances in Probability and Statistics
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2011-12-30
• [Presentation] Optimal significance analysis of microarray data in a class of tests whose null statistic can be constructed (2011)
  • Author(s): Fujisawa, H.
  • Organizer: 7th IASC-ARS Joint 2011 Taipei Symposium
  • Place of Presentation: Taipei, Taiwan,
  • Year and Date: 2011-12-17
• [Presentation] 遺伝子発現差解析における並べ替え技法によるP値推定,融合 (2011)
  • Author(s): 藤澤 洋徳
  • Organizer: 「遺伝機能」プロジェクト会議
  • Place of Presentation: 三島
  • Year and Date: 2011-10-20
• [Presentation] マイクロアレイデータを利用した遺伝子発現差解析において帰無統計量が構成できる検定の中で最適な有意性検定 (2011)
  • Author(s): 藤澤洋徳
  • Organizer: 名古屋統計セミナー
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-20
• [Presentation] 外れ値の割合が大きい場合にもバイアスが小さいロバスト推定 (2011)
  • Author(s): 藤澤洋徳
  • Organizer: 広島大学理学部数学教室談話会
  • Place of Presentation: 広島
  • Year and Date: 2011-01-25
• [Presentation] 遺伝子発現差解析における並べ替え技法によるＰ値推定 (2011)
  • Author(s): 藤澤洋徳
  • Organizer: 融合「遺伝機能」プロジェクト会議
  • Place of Presentation: 東京
• [Presentation] Optimal significance analysis of microarray data in a class of tests whose null statistic can be constructed (2011)
  • Author(s): Fujisawa, H.
  • Organizer: 7th IASC-ARS Joint 2011 Taipei Symposium
  • Place of Presentation: Taipei, Taiwan
  • Invited
• [Presentation] Optimal significance analysis of microarray data in a class of tests whose null statistic can be constructed (2011)
  • Author(s): Fujisawa, H.
  • Organizer: International Conference on Advances in Probability and Statistics
  • Place of Presentation: Hong-Kong, China
• [Presentation] 遺伝子発現差解析における並べ替え技法によるP 値推定と最適な有意性検定 (2010)
  • Author(s): 藤澤洋徳,坂口隆之
  • Organizer: 科研費研究集会「生物情報解析の理論的基礎とその応用」
  • Place of Presentation: 東京
  • Year and Date: 2010-12-07
• [Presentation] 遺伝子発現差解析における並べ替え技法によるP値推定と最適な有意性検定 (2010)
  • Author(s): 藤澤洋徳
  • Organizer: 研究集会「生物情報解析の理論的基礎とその応用」
  • Place of Presentation: 東京
  • Year and Date: 2010-12-07
• [Presentation] ロバスト推測の基礎とダイバージェンス型メソッドへの発展 (2010)
  • Author(s): 藤澤洋徳
  • Organizer: 第13回情報論的学習理論ワークショップ
  • Place of Presentation: 東京
  • Year and Date: 2010-11-05
• [Presentation] 遺伝子発現差解析における並べ替え技法によるP値の推定 (2010)
  • Author(s): 藤澤洋徳,坂口隆之
  • Organizer: 統計関連学会連合大会
  • Place of Presentation: 東京
  • Year and Date: 2010-09-07