Prediction of carbohydrate chain-protein interaction by using carbohydrate chain structure information and its experimental verification

• Project/Area Number: 22500276
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Bioinformatics/Life informatics
• Research Institution: Ritsumeikan University
• Principal Investigator: ITO Masahiro 立命館大学, 生命科学部, 教授 (50388112)
• Co-Investigator(Kenkyū-buntansha): ITONORI Saki 滋賀大学, 教育学部, 教授 (90324558)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 糖鎖 / 相互作用 / MD 計算 / 構造 / SVM / サポートベクターマシン / バイオインフォマティクス / 糖転移酵素 / 糖脂質 / 進化系統解 / アノマー配置 / 類似距離 / タンパク質 / 分子進化 / ラマチャンドラマップ / 構造解析

Research Abstract

The interaction of carbohydrate chains was analyzed to the 7 types of carbohydrate chains by using molecular dynamics simulation. We suggested three factors of changing the conformation. Moreover, we predicted inhibitory activity of two lipid mediators using support vector machine. The predicted chemical structures were analyzed a partial structures for activity in detail.

Research Products

• [Journal Article] Biochemical studies on sphingolipids of Artemia franciscana:complex neutral glycosphingolipids (2013)
  • Author(s): H.Kojima, Y.Tohsato, K.Kobayama, S.Itonori, M.Ito
  • Journal Title: Glycoconjugate Journal Volume: 30 Issue: 3 Pages: 257-268
  • DOI: 10.1007/s10719-012-9436-8
  • Peer Reviewed
• [Journal Article] Parameter optimization and sensitivity analysis forlarge kinetic models using a real-coded genetic algorithm (2013)
  • Author(s): Y.Tohsato, K.Ikuta, A.Shionoya, Y.Mazaki, M .I t o
  • Journal Title: Genes Volume: 518 Issue: 1 Pages: 84-90
  • DOI: 10.1016/j.gene.2012.11.080
  • Peer Reviewed
• [Journal Article] ECOH: An Enzyme Commission number predictor using mutual information and a support vector machine (2013)
  • Author(s): Y.Matsuta, M. I to , Y. Tohsato
  • Journal Title: Bioinformatics Volume: 29 Issue: 3 Pages: 365-372
  • DOI: 10.1093/bioinformatics/bts700
  • Peer Reviewed
• [Journal Article] Intrinsically disordered proteins in Human mitochondria (2012)
  • Author(s): M.Ito, Y.Tohsato, H.Sugisawa, S.Kohara, S.Fukuchi, I.Nishikawa, K. Nishikawa
  • Journal Title: Genes to Cells Volume: 17 Issue: 10 Pages: 817-825
  • DOI: 10.1111/gtc.12000
  • Peer Reviewed
• [Journal Article] Comparative proteomic analysis reveals differentially expressed proteins in Caenorhabditis eleganspgl-1 mutants grown at 20°C and 25°C (2012)
  • Author(s): Y.Tohsato, K.Monobe, K. Suzuki, T.Hayano, I.Kawasaki, M .I t o
  • Journal Title: Journal of Proteomics Volume: 75 Issue: 15 Pages: 4792-4801
  • DOI: 10.1016/j.jprot.2012.04.038
  • Peer Reviewed
• [Journal Article] 機械学習によるEP2受容体を標的とした化合物の探索手法の開発 (2012)
  • Author(s): 小原祥平, 遠里由佳子, 伊藤將弘
  • Journal Title: 情報処理学会バイオ情報学(BIO) Volume: 26(8) Pages: 1-2
  • NAID: 110008605712
• [Journal Article] 相互情報量とSVMを用いた酵素反応におけるEC番号の推定手法の開発 (2012)
  • Author(s): 松田祥彦, 伊藤將弘, 遠里由佳子
  • Journal Title: 情報処理学会バイオ情報学(BIO) Volume: 26(7) Pages: 1-6
  • NAID: 110008605711
• [Journal Article] 線虫C.elegansの発生ステージにおける定量プロテオーム解析 (2012)
  • Author(s): 物部香奈美, 遠里由佳子, 早野俊哉, 伊藤將弘
  • Journal Title: 立命館大学理工学研究所紀要 Volume: 70 Pages: 13-20
• [Journal Article] 相互情報量とSVMを用いた酵素反応におけるEC番号の推定手法の開発 (2012)
  • Author(s): 松田祥彦, 伊藤將弘, 遠里由佳子
  • Journal Title: 立命館大学理工学研究所紀要 Volume: 70 Pages: 21-28
  • NAID: 110008605711
• [Journal Article] Biochemical Studies on Sphingolipids of Artemia franciscana: Novel Neutral Glycosphingolipids (2011)
  • Author(s): H.Kojima, T.Shimizu, M.Sugita, S . I to n or i , N.Fujita, M .I t o
  • Journal Title: Journal of Lipid Research Volume: 52 Issue: 2 Pages: 308-317
  • DOI: 10.1194/jlr.m010173
  • Peer Reviewed
• [Journal Article] Biochemical studies on sphingolipids of Artemia franciscana : novel neutral glycosphingolipids (2011)
  • Author(s): Kojima, H., Shimizu, T., Sugita, M., Itonori, S., Fujita, N., Ito, M.
  • Journal Title: J.Lipid Res. Volume: 52 Pages: 308-317
  • Peer Reviewed
• [Journal Article] Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells (2011)
  • Author(s): Wichit, S., Jittmittraphap, A., Hidari, K.I.P.J., Thaisomboonsuk, B., Petmitr, S., Ubol, S., Aoki, C., Itonori, S., Morita, K., Suzuki, T., Suzuki, Y., Jampangern, W.
  • Journal Title: Microbiol Immunol Volume: 55 Pages: 135-140
  • NAID: 10031121452
  • Peer Reviewed
• [Journal Article] アメリカオオアカイカDosidicus gigasのスフィンゴ脂質の構造決定 (2011)
  • Author(s): 糸乗前, 野崎仁崇, 原畠鷹, 秋田悠里, 橋本恭平, 小島寿夫, 西尾匡, 石川哲, 齋藤洋昭, 伊藤將弘, 杉田陸海
  • Journal Title: 滋賀大学教育学部紀要,自然科学 Volume: 60 Pages: 11-22
  • NAID: 120003004422
• [Journal Article] セイヨウミツバチApis mellifera(雄蜂20日齢)におけるスフィンゴ糖脂質の構造解析 (2011)
  • Author(s): 西尾匡, 小島寿夫, 遠里由佳子, 寺内白梅薫, 杉田陸海, 糸乗前, 伊藤將弘
  • Journal Title: 立命館大学理工学研究所紀要 Volume: 69 Pages: 99-108
• [Journal Article] Computational Prediction of O-linked Glycosylation Sites that are Preferentially Mapped on Intrinsically Disordered Regions of Extracellular Proteins (2010)
  • Author(s): I.Nishikawa, Y.Nakajima,M.Ito, S.Fukuchi, K.Homma,K.Nishikawa
  • Journal Title: International Journal of Molecular Sciences Volume: 11 Issue: 12 Pages: 4991-5008
  • DOI: 10.3390/ijms11124991
  • Peer Reviewed
• [Journal Article] Environmental dependency of gene knockouts on phenotype microarray analysis in Escherichia coli (2010)
  • Author(s): Y.Tohsato, T.Baba, Y. Mazaki,M.Ito, B.L.Wanner, H.Mori
  • Journal Title: Journal Bioinformatics and Computational Biology Volume: 8 Pages: 1-17
  • Peer Reviewed
• [Journal Article] Biochemical Studies on Sphingolipiof Artemia franciscana (I) Isolatioand Characterization of Sphingomyeli (2010)
  • Author(s): H.Kojima, T.Inoue, M.SugitaS.Itonori, M.Ito
  • Journal Title: Lipids Volume: 45 Issue: 7 Pages: 635-643
  • DOI: 10.1007/s11745-010-3438-8
  • Peer Reviewed
• [Journal Article] Biochemical studies on sphingolipid of Artemia franciscana (I) isolation and characterization of sphingomyelin (2010)
  • Author(s): Kojima, H., Inoue, T., Sugita, M., Itonori, S., Ito, M.
  • Journal Title: Lipids Volume: 45 Pages: 635-643
  • Peer Reviewed
• [Journal Article] Novel neogala-series glycosphingolipids with terminal mannose and glucose residues from Hirsutella rhossiliensis, an aureobasidin A-resistant ascomycete fungus (2010)
  • Author(s): Tani, Y., Funatsu, T., Ashida, H., Ito, M., Itonori, S., Sugita, M., Yamamoto, K
  • Journal Title: Glycobiology Volume: 20 Pages: 433-441
  • Peer Reviewed
• [Journal Article] Computational Prediction of O-linked Glycosylation Sites that are Preferentially Mapped on Intrinsically Disordered Regions of Extracellular Proteins (2010)
  • Author(s): Ikuko Nishikawa, Yukiko Nakajima, Masahiro Ito, Satoshi Fukuchi, Keiichi Homma, Ken Nishikawa
  • Journal Title: Int.J.Mol.Sci. Volume: 11 Pages: 4991-5008
  • Peer Reviewed
• [Journal Article] Environmental dependency of gene knockouts on phenotype microarray analysis in Escherichia coli. (2010)
  • Author(s): Yukako Tohsato, Tomoya Baba, Yusaku Mazaki, Masahiro Ito, Barry L.Wanner, Hirotada Mori
  • Journal Title: Journal of Bioinformatics and Computational Biology Volume: 8 Pages: 1-17
  • Peer Reviewed
• [Journal Article] Invariant Vα14 natural killer T cell activation by edible mushroom acidic glycosphingolipids (2010)
  • Author(s): Nozaki, H., Itonori, S., Sugita, M., Nakamura, K., Ohba, K., Ohnishi, M., Imai, K., Igarashi, Y., Suzuki, A., Kushi, Y.
  • Journal Title: Biol Pharm Bull. Volume: 33 Pages: 580-584
  • NAID: 120006390475
  • Peer Reviewed
• [Presentation] Parameter optimization and sensitivity analysis for large kinetic models using a real-coded genetic algorithm (2012)
  • Author(s): Y.Tohsato, K.Ikuta, A.Shionoya, Y.Mazaki, M .I t o
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: 発表場所:台南(台湾)
  • Year and Date: 2012-12-13
• [Presentation] Phenotype microarrayanalysis of Escherichia coli using infinite relational model (2012)
  • Author(s): H.Sugisawa, H.Fukuda,H.Mori, M.Ito, T.Taniguchi, Y.Tohsato
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: 発表場所:台南(台湾)
  • Year and Date: 2012-12-13
• [Presentation] Modeling of central metabolism with regulation of rpoS gene in Escherichia coli (2012)
  • Author(s): A.Shionoya, K.Ikuta, H.Dose,H.Mori, M.Ito, Y.Tohsato
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: 台南(台湾)
  • Year and Date: 2012-12-13
• [Presentation] Parameter optimization and correlation analysis for a large kinetic model using a real-coded genetic algorithm (2012)
  • Author(s): K.Ikuta, A.Shionoya, M .I t o, Y.Tohsato
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: 台南(台湾)
  • Year and Date: 2012-12-13
• [Presentation] Analysis of the phylogenetic profile of human glycosyltransferases (2012)
  • Author(s): T.Tomono, Y.Tohsato, M.Ito
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: 台南(台湾)
  • Year and Date: 2012-12-13
• [Presentation] Expression and phenotype analyses of the sphingomyelin synthase genes in Caenorhabditis elegans (2012)
  • Author(s): H.Yamaji, Y.Tohsato,K.Suzuki, M.Ito
  • Organizer: 第35回日本分子生物学学会年会
  • Place of Presentation: マリンメッセ福岡,福岡県
  • Year and Date: 2012-12-13
• [Presentation] Proteomic analysis of hydrophobic proteins in nematode Caenorhabditis briggsae (2012)
  • Author(s): T.Itami, N.Enna, Y.Tohsato,T.Hayano, M.Ito
  • Organizer: 第35回日本分子生物学学会年会
  • Place of Presentation: マリンメッセ福岡,福岡県
  • Year and Date: 2012-12-13
• [Presentation] Comparative proteomic analysis for Caenorhabditis elegans pgl-1 mutants grown at 20°C and 25°C using 2D-DIGE (2012)
  • Author(s): Y.Tohsato, K.Monobe,K.Suzuki, T.Hayano, I.Kawasaki, M.Ito
  • Organizer: 5th East Asia C. elegans Meeting
  • Place of Presentation: 台北(台湾)
  • Year and Date: 2012-06-28
• [Presentation] Quantitative analysis of mRNA expression profiles of ceramide-related genes using qRT-PCR (2012)
  • Author(s): H.Yamaji, K.Hori, E.Watase,Y.Tohsato, K.Suzuki, M.Ito
  • Organizer: 5th East Asia C. elegansMeeting
  • Place of Presentation: 台北(台湾)
  • Year and Date: 2012-06-28
• [Presentation] Modeling and Parameter Optimization of the Central Carbon Metabolism of Escherichia coli using Real-coded Genetic Algorithm (2011)
  • Author(s): Y.Mazaki, M .It o , H.Mori, Y.Tohsato
  • Organizer: The 21th International Conference on Genome Informatics
  • Place of Presentation: 杭州,中国
  • Year and Date: 2011-12-17
• [Presentation] Prediction of EC Numbers from Chemical Structures in Enzymatic Reactions using Mutual Information (2011)
  • Author(s): Y.Matsuda, M. I to , Y.Tohsato
  • Organizer: The 21th International Conference on Genome Informatics
  • Place of Presentation: 杭州,中国
  • Year and Date: 2011-12-17
• [Presentation] Intrinsically Disordered Regions in HumanMitochondrial Proteins (2011)
  • Author(s): M.Ito, Y.Tohsato,H.Sugisawa, S.Kohara, I.Nishikawa,K.Nishikawa
  • Organizer: 第34回日本分子生物学学会年会
  • Place of Presentation: パシフィコ横浜,神奈川県
  • Year and Date: 2011-12-15
• [Presentation] Phenotype Analysis for Single Knockout Mutants in Escherichia coli Using Phenotype MicroArray (2011)
  • Author(s): H.Sugisawa, M .I t o, Y.Tohsato
  • Organizer: 第34回日本分子生物学学会年会
  • Place of Presentation: パシフィコ横浜,神奈川県
  • Year and Date: 2011-12-15
• [Presentation] Phenotype Analysis for Single Knockout Mutants in Escherichia coli Using Phenotype MicroArray (2011)
  • Author(s): Hitoshi Sugisawa, Masahiro Ito, Yukako Tohsato
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-15
• [Presentation] Quantitative Proteomic Analysis of3 Developmental Stages in Caenorhabditis elegans (2011)
  • Author(s): K.Monobe, Y.Ishido, Y.Tohsato, T.Hayano, M.Ito
  • Organizer: 第34回日本分子生物学学会年会
  • Place of Presentation: パシフィコ横浜,神奈川県
  • Year and Date: 2011-12-14
• [Presentation] Quantitative Proteomic Analysis of Caenorhabditis elegans pgl-1Mutants Grown at 20 °C and 25 °C (2011)
  • Author(s): Y.Tohsato, K.Monobe, T.Hayano, I.Kawasaki, M .I t o
  • Organizer: 第34回日本分子生物学学会年会
  • Place of Presentation: パシフィコ横浜,神奈川県
  • Year and Date: 2011-12-14
• [Presentation] Quantitative Proteomic Analysis of Caenorhabditis elegans pgl-1 Mutants Grown at 20℃ and 25℃ (2011)
  • Author(s): Yukako Tohsato, Kanami Monobe, Toshiya Hayano, Ichiro Kawasaki, Masahiro Ito
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-14
• [Presentation] Quantitative Proteomic Analysis of 3 Developmental Stages in Caenorh abditis elegans (2011)
  • Author(s): Kanami Monobe, Yusuke Ishido, Yukako Tohsato, Toshiya Hayano, Masahiro Ito
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-14
• [Presentation] Intrinsically Disordered Regions in Human Mitochondrial Proteins (2011)
  • Author(s): Masahiro Ito, Yukako Tohsato, Hitoshi Sugisawa, Shohei Kohara, Ikuko Nishikawa, Ken Nishikawa
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-14
• [Presentation] 相互情報量とSVMを用いた酵素反応におけるEC番号の推定手法の開発 (2011)
  • Author(s): 松田祥彦,伊藤將弘,遠里由佳子
  • Organizer: 情報処理学会第26回BIO情報研究会
  • Place of Presentation: 神戸大学,兵庫県
  • Year and Date: 2011-09-13
• [Presentation] 機械学習によるEP2受容体を標的とした化合物の探索手法の開発 (2011)
  • Author(s): 小原祥平,遠里由佳子,伊藤將弘
  • Organizer: 情報処理学会第26回BIO情報研究会
  • Place of Presentation: 神戸大学,兵庫県
  • Year and Date: 2011-09-13
• [Presentation] 機械学習によるEP2受容体を標的とした化合物の探索手法の開発 (2011)
  • Author(s): 小原祥平, 遠里由佳子, 伊藤將弘
  • Organizer: 情報処理学会第26回バイオ情報学研究会
  • Place of Presentation: 神戸大学(兵庫県)
  • Year and Date: 2011-09-13
• [Presentation] 相互情報量とSVMを用いた酵素反応におけるEC番号の推定手法の開発 (2011)
  • Author(s): 松田祥彦, 伊藤將弘, 遠里由佳子
  • Organizer: 情報処理学会第26回バイオ情報学研究会
  • Place of Presentation: 神戸大学(兵庫県)
  • Year and Date: 2011-09-13
• [Presentation] ブラインシュリンプArtemiafranciscanaの中性糖脂質 (2011)
  • Author(s): 小島寿夫,樺山一哉,糸乗前,伊藤將弘
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡リリックホール,新潟県
  • Year and Date: 2011-07-11
• [Presentation] 糖鎖多様性を示すカイコBombyxmori蛹の糖脂質構造の解析 (2011)
  • Author(s): 橋本恭平,鈴木孝枝,小島寿夫,伊藤將弘,杉田陸海,糸乗前
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡リリックホール,新潟県
  • Year and Date: 2011-07-11
• [Presentation] Comparative proteome analysis of Caenorhabditis elegans cultured at 2 different temperatures 〓 20°C and 25°C (2011)
  • Author(s): K.Monobe, Y.Ishido,A.Terasaswa, Y.Tohsato, T.Hayano,M.Ito
  • Organizer: 18th International C. elegans Meeting
  • Place of Presentation: Los Angeles,U.S.A
  • Year and Date: 2011-06-24
• [Presentation] Quantitative Proteomic Analysis of 3 Developmental Stages of Caenorhabditis briggsae by Using 2D DIGE and iTRAQ (2011)
  • Author(s): A.Terasawa, Y.Tohsato,Y.Ishido, T.Hayano, M.Ito
  • Organizer: 18th International C. elegans Meeting
  • Place of Presentation: Los Angeles,U.S.A.
  • Year and Date: 2011-06-24
• [Presentation] 軟体動物斧足類バカガイMactra chinensisの中性スフィンゴ糖脂質の構造解析 (2011)
  • Author(s): 原畠鷹, 秋田悠里, 野崎仁崇, 橋本恭平, 西尾匡, 小島寿夫, 齋藤洋昭, 伊藤將弘, 杉田陸海, 糸乗前
  • Organizer: 第53回日本脂質生化学会
  • Place of Presentation: ホテル東京ガーデンパレス(東京都)
  • Year and Date: 2011-05-13
• [Presentation] Quantitative Proteomic Anaysis of 3 Deveopmenta Stages of Caenorhabditis briggsae by Using 2D DIGE and iTRAQ (2011)
  • Author(s): Ayako Terasawa, Yukako Tohsato, Yusuke Ishido, Toshiya Hayano, Masahiro Ito
  • Organizer: 18th Internationa C.elegans Meeting
  • Place of Presentation: Los Angeles, USA
• [Presentation] Comparative proteome analysis of Caenorhabditis elegans cultured at 2 different temperatures-20℃ and 25℃ (2011)
  • Author(s): Kanami Monobe, Yusuke Ishido, Ayako Terasaswa, Yukako Tohsato, Toshiya Hayano, Masahiro Ito
  • Organizer: 18th Internationa C.elegans Meeting
  • Place of Presentation: Los Angeles, USA
• [Presentation] 糖鎖多様性を示すカイコBombyx mori蛹の糖脂質構造の解析 (2011)
  • Author(s): 橋本恭平, 鈴木孝枝, 小島寿夫, 伊藤將弘, 杉田陸海, 糸乗前
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡リリックホール(新潟県)
• [Presentation] ブラインシュリンプArtemia franciscanaの中性糖脂質 (2011)
  • Author(s): 小島寿夫, 樺山一哉, 糸乗前, 伊藤將弘
  • Organizer: 第30回日本糖質学会年会
  • Place of Presentation: 長岡リリックホール(新潟県)
• [Presentation] アメリカオオアカイカDosidicus gigas皮のヒト血液型糖鎖配列含有中性スフィンゴ糖脂質の構造解析 (2011)
  • Author(s): 秋田悠里, 原畠鷹, 畑中萌, 橋本恭平, 伊藤將弘, 齋藤洋昭, 松原久, 杉田陸海, 糸乗前
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] 子嚢菌類Mariannaea elegans由来の新奇糖脂質の構造解析 (2011)
  • Author(s): 谷泰史, 中村香里, 沢良太, 斉藤秀樹, 伊藤將弘, 糸乗前, 三原久明
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] Modeling and Parameter Optimization of the Central Carbon Metabolism of Escherichia coli using Real-coded Genetic Algorithm (2010)
  • Author(s): Yoshihiko Matsuda, Hirotada Mori, Masahiro Ito, Yukako Tohsato
  • Organizer: GIW2010 (The 21st International Conference on Genome Informatics)
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2010-12-16
• [Presentation] Prediction of EC Numbers from Chemical Structures in Enzymatic Reactions using Mutual Information (2010)
  • Author(s): Yoshihiko Matsuda, Masahiro Ito, Yukako Tohsato
  • Organizer: GIW2010 (The 21st International Conference on Genome Informatics)
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2010-12-16
• [Presentation] Environmental Dependency of Gene Knockouts on Phenotype Microarray Analysis Escherichia coli (2010)
  • Author(s): Yukako Tohsato, Tomboy Baba, Yusaku Mazaki, Masahiro Ito, Barry L.Wanner, Hirotada Mori
  • Organizer: GIW2010 (The 21st International Conference on Genome Informatics)
  • Place of Presentation: Hangzhou, China
  • Year and Date: 2010-12-16
• [Presentation] Prediction of partial gene regulatory network ofC.elegans early embryo (2010)
  • Author(s): 真栄城哲也, 岡野文香, 山中伸一, 物部香奈美, 松田祥彦, 伊藤將弘
  • Organizer: BMB2010(第33回日本分子生物学会年会,第83回日本生化学会年会)
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-10
• [Presentation] 線虫プロテオームプロジェクト:培養温度20□の線虫Caenorhabditis briggsaeの発生ステージ比較プロテオーム解析 (2010)
  • Author(s): 生石剛規, 寺澤彩子, 石堂佑典, 遠里由佳子, 物部香奈美, 松田祥彦, 早野俊哉, 伊藤將弘
  • Organizer: BMB2010(第33回日本分子生物学会年会 第83回日本生化学会年会)
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] 線虫プロテオームプロジェクト:2D-DIGEとiTRAQを用いた培養温度27.5□における線虫Caenorhabditis briggsaeの発生ステージ比較定量プロテオーム解析 (2010)
  • Author(s): 寺澤彩子, 石堂佑典, 松田祥彦, 遠里由佳子, 早野俊哉, 伊藤將弘
  • Organizer: BMB2010(第33回日本分子生物学会年会 第83回日本生化学会年会)
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] 線虫プロテオームプロジェクト:培養温度25□における線虫Caenorhabditis elegansの発生ステージ比較プロテオーム解析 (2010)
  • Author(s): 石堂佑典, 物部香奈美, 寺澤彩子, 生石剛規, 遠里由佳子, 早野俊哉, 伊藤將弘
  • Organizer: BMB2010(第33回日本分子生物学会年会,第83回日本生化学会年会)
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] 線虫プロテオームプロジェクト:培養温度20□における線虫Caenorhabditis elegansの発生ステージ比較プロテオーム解析 (2010)
  • Author(s): 物部香奈美, 石堂佑典, 松田祥彦, 遠里由佳子, 早野俊哉, 伊藤將弘
  • Organizer: BMB2010(第33回日本分子生物学会年会,第83回日本生化学会年会)
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] ブラインシュリンプ(節足動物甲殻綱)における中性糖脂質 (2010)
  • Author(s): 小島寿夫, 糸乗前, 杉田陸海, 藤田典久, 伊藤將弘
  • Organizer: 第83回日本生化学会大会 第33回日本分子生物学年会 合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] セイヨウミツバチApis mellifera(雄蜂20日齢)におけるスフィンゴ型中性糖脂質の構造解析 (2010)
  • Author(s): 西尾匡, 小島寿夫, 橋本健, 立藤智基, 寺内白梅薫, 杉田陸海, 糸乗前, 伊藤將弘
  • Organizer: 第83回日本生化学会大会 第33回日本分子生物学年会 合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県)
  • Year and Date: 2010-12-09
• [Presentation] アメリカオオアカイカDosidicus gigas皮のスフィンゴ脂質 (2010)
  • Author(s): 野崎仁崇, 原畠鷹, 橋本恭平, 西尾匡, 小島寿夫, 石川哲, 齋藤洋昭, 伊藤將弘, 杉田陸海, 糸乗前
  • Organizer: 第49回日本油化学会年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] セイヨウミツバチApis mellifera(雄蜂20日齢)におけるセラミドホスホエタノールアミンとスフィンゴミエリンの構造解析 (2010)
  • Author(s): 西尾匡, 小島寿夫, 橋本健, 立藤智基, 寺内白梅薫, 杉田陸海, 糸乗前, 伊藤將弘
  • Organizer: 第49回日本油化学会年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2010-09-16
• [Presentation] Biochemical studies on the sphingolipids of Artemia franciscana (2010)
  • Author(s): H.Kojima, T.Inoue, M. Sugita,S.Itonori, M.Ito
  • Organizer: 51st International Conference on the Bioscience of Lipids
  • Place of Presentation: Bilbao,Spain
  • Year and Date: 2010-09-07
• [Presentation] Biochemical studies on the sphingolipids of Artemia franciscana (2010)
  • Author(s): Kojima, H., Sugita, M., Itonori, S., Ito, M.
  • Organizer: 51st International Conference on the Bioscience of Lipids
  • Place of Presentation: Bilbao, Spain
  • Year and Date: 2010-09-07
• [Presentation] Characterization of a Glucuronic Acid-containing Glycosphingolipid from the Giant Ezo Scallop Pationopecten yessoensis (2010)
  • Author(s): S.Itonori, A.Higashino,K.Hashimoto, H.Nozaki, H.Kojima,M.Ito, H.Saito, M.Sugita
  • Organizer: The 25th Inernational Carbohydratem Symposium
  • Place of Presentation: 幕張メッセ,千葉県
  • Year and Date: 2010-08-02
• [Presentation] Characterization of Glucuronic Acid-containing Glycosphingolipid from the Giant Ezo Scallop Pationopecten yessoensis (2010)
  • Author(s): Itonori, S., Higashino, A., Hashimoto, K., Nozaki, H., Kojima, H., Ito, M., Saito, H., Sugita, M.
  • Organizer: 25th International Carbohydrate Symposium
  • Place of Presentation: 幕張メッセ(千葉県)
  • Year and Date: 2010-08-02
• [Presentation] Identification and quantitative analysis of protein expression during the developmental stages of Caenorhabditis briggsae (2010)
  • Author(s): Ayako Terasawa, Dai Sasahara, Shizuka Hino, Toshiya Hayano, Masahiro Ito.
  • Organizer: 4th East Asia C.elegans Meeting
  • Place of Presentation: オリンピックメモリアルセンター(東京都)
  • Year and Date: 2010-07-11
• [Presentation] カイコBombyx mori蛹の中性スフィンゴ糖脂質の構造解析 (2010)
  • Author(s): 橋本恭平, 小島寿夫, 西尾匡, 伊藤將弘, 杉田陸海, 糸乗前
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 群馬大学(群馬県)
  • Year and Date: 2010-06-14
• [Presentation] Parameter optimization and sensitivity analysis for large kinetic models using a real-coded genetic algorithm
  • Author(s): Yukako Tohsato, Kunihiko Ikuta, Akitaka Shionoya, Yusaku Mazaki, Masahiro Ito
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: Tainan, Taiwan
• [Presentation] Phenotype microarray analysis of Escherichia coli using infinite relational model
  • Author(s): Hitoshi Sugisawa, Hajime Fukuda, Hirotada Mori, Masahiro Ito, Tadahiro Taniguchi, Yukako Tohsato
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: Tainan, Taiwan
• [Presentation] Modeling of central metabolism with regulation of rpoS gene in Escherichia coli
  • Author(s): Akitaka Shionoya, Kunihiko Ikuta, Hitomi Dose, Hirotada Mori, Masahiro Ito, Yukako Tohsato
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: Tainan, Taiwan
• [Presentation] Parameter optimization and correlation analysis for a large kinetic model using a real-coded genetic algorithm
  • Author(s): Kunihiko Ikuta, Akitaka Shionoya, Masahiro Ito, Yukako Tohsato
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: Tainan, Taiwan
• [Presentation] Analysis of the phylogenetic profile of human glycosyltransferases
  • Author(s): Takayoshi Tomono, Yukako Tohsato, Masahiro Ito
  • Organizer: The 23rd International Conference on Genome Informatics
  • Place of Presentation: Tainan, Taiwan
• [Presentation] Expression and phenotype analyses of the sphingomyelin synthase genes in Caenorhabditis elegans
  • Author(s): Haruka Yamaji, Yukako Tohsato, Kenji Suzuki, Masahiro Ito
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: マリンメッセ福岡，福岡県
• [Presentation] Proteomic analysis of hydrophobic proteins in nematode Caenorhabditis briggsae
  • Author(s): Tetsushi Itami, Narumi Enna, Yukako Tohsato, Toshiya Hayano, Masahiro Ito
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: マリンメッセ福岡，福岡県
• [Presentation] Quantitative proteomic analysis at 3 developmental stages of Caenorhabditis elegans cultured at 25°C
  • Author(s): Narumi Enna, Kanami Monobe, Yusuke Ishido, Yukako Tohsato, Toshiya Hayano, Masahiro Ito
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: マリンメッセ福岡，福岡県
• [Presentation] Comparative proteomic analysis for Caenorhabditis elegans pgl-1 mutants grown at 20°C and 25°C using 2D-DIGE
  • Author(s): Yukako Tohsato, Kanami Monobe, Kenji Suzuki, Toshiya Hayano, Ichiro Kawasaki, Masahiro Ito
  • Organizer: 5th East Asia C. elegans Meeting
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Quantitative analysis of mRNA expression profiles of ceramide-related genes using qRT-PCR
  • Author(s): Haruka Yamaji, Kousuke Hori, Emiko Watase, Yukako Tohsato, Kenji Suzuki, Masahiro Ito
  • Organizer: 5th East Asia C. elegans Meeting
  • Place of Presentation: Taipei, Taiwan
• [Remarks]
  • URL: http://research-db.ritsumei.ac.jp/Profiles/28/0002777/profile.html
• [Remarks]
  • URL: http://research-db.ritsumei.ac.jp/Profiles/28/0002777/profile.html