Prediction of carbohydrate chain-protein interaction by using carbohydrate chain structure information and its experimental verification
| Project/Area Number |
22500276
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
ITO Masahiro 立命館大学, 生命科学部, 教授 (50388112)
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| Co-Investigator(Kenkyū-buntansha) |
ITONORI Saki 滋賀大学, 教育学部, 教授 (90324558)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 糖鎖 / 相互作用 / MD 計算 / 構造 / SVM / サポートベクターマシン / バイオインフォマティクス / 糖転移酵素 / 糖脂質 / 進化系統解 / アノマー配置 / 類似距離 / タンパク質 / 分子進化 / ラマチャンドラマップ / 構造解析 |
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| Research Abstract |
The interaction of carbohydrate chains was analyzed to the 7 types of carbohydrate chains by using molecular dynamics simulation. We suggested three factors of changing the conformation. Moreover, we predicted inhibitory activity of two lipid mediators using support vector machine. The predicted chemical structures were analyzed a partial structures for activity in detail.
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Report
(4 results)
Research Products
(86 results)
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[Journal Article] Biochemical studies on sphingolipids of Artemia franciscana : novel neutral glycosphingolipids2011
Author(s)
Kojima, H., Shimizu, T., Sugita, M., Itonori, S., Fujita, N., Ito, M.
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Journal Title
J.Lipid Res.
Volume: 52
Pages: 308-317
Related Report
Peer Reviewed
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[Journal Article] Dengue virus type 2 recognizes the carbohydrate moiety of neutral glycosphingolipids in mammalian and mosquito cells2011
Author(s)
Wichit, S., Jittmittraphap, A., Hidari, K.I.P.J., Thaisomboonsuk, B., Petmitr, S., Ubol, S., Aoki, C., Itonori, S., Morita, K., Suzuki, T., Suzuki, Y., Jampangern, W.
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Journal Title
Microbiol Immunol
Volume: 55
Pages: 135-140
NAID
Related Report
Peer Reviewed
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[Journal Article] アメリカオオアカイカDosidicus gigasのスフィンゴ脂質の構造決定2011
Author(s)
糸乗前, 野崎仁崇, 原畠鷹, 秋田悠里, 橋本恭平, 小島寿夫, 西尾匡, 石川哲, 齋藤洋昭, 伊藤將弘, 杉田陸海
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Journal Title
滋賀大学教育学部紀要,自然科学
Volume: 60
Pages: 11-22
NAID
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[Journal Article] Novel neogala-series glycosphingolipids with terminal mannose and glucose residues from Hirsutella rhossiliensis, an aureobasidin A-resistant ascomycete fungus2010
Author(s)
Tani, Y., Funatsu, T., Ashida, H., Ito, M., Itonori, S., Sugita, M., Yamamoto, K
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Journal Title
Glycobiology
Volume: 20
Pages: 433-441
Related Report
Peer Reviewed
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[Journal Article] Invariant Vα14 natural killer T cell activation by edible mushroom acidic glycosphingolipids2010
Author(s)
Nozaki, H., Itonori, S., Sugita, M., Nakamura, K., Ohba, K., Ohnishi, M., Imai, K., Igarashi, Y., Suzuki, A., Kushi, Y.
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Journal Title
Biol Pharm Bull.
Volume: 33
Pages: 580-584
NAID
Related Report
Peer Reviewed
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[Presentation] Characterization of Glucuronic Acid-containing Glycosphingolipid from the Giant Ezo Scallop Pationopecten yessoensis2010
Author(s)
Itonori, S., Higashino, A., Hashimoto, K., Nozaki, H., Kojima, H., Ito, M., Saito, H., Sugita, M.
Organizer
25th International Carbohydrate Symposium
Place of Presentation
幕張メッセ(千葉県)
Year and Date
2010-08-02
Related Report
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