STUDY OF SYNAPTIC MODULATORY MECHANISMS IN RESPONSE TO STRESS MEDIATED BY 5-HT2A RECEPTOR
| Project/Area Number |
22500285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Saitama University |
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Principal Investigator |
OHKURA Masamichi 埼玉大学, 脳科学融合研究センター, 准教授 (70369172)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAI Junichi 埼玉大学, 脳科学融合研究センター, 教授 (80237198)
ANDO Keiko 埼玉大学, 脳科学融合研究センター, 特任准教授 (40221741)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | セロトニン2A / 神経活動 / シナプス / カルシウムシグナル / 蛍光イメージング / G-CaMP / 光刺激 / チャネルロドプシン / GCaMP |
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| Research Abstract |
To enable detection of small calcium signals of neurons in response to single action potentials or synaptic inputs, we developed high-performance genetically-encoded fluorescent calcium indicators (improved G-CaMPs and R-CaMPs). We also established an experimental system for simultaneous photo-stimulation and fluorescence imaging of C. elegans expressing channelrhodopsin-2 in the HSN neuron and GFP-labeled 5-HT^<2A> or an improved G-CaMP in the vulval muscle.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites2012
Author(s)
Kawabata, I., Kashiwagi, Y., Obashi, K., Ohkura, M., Nakai, J., Wynshaw-Boris, A., Yanagawa, Y., Okabe, S
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Journal Title
Nature Communications
Volume: 3
Issue: 1
Pages: 722-722
DOI
Related Report
Peer Reviewed
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