Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Research Abstract |
Genome-wide transcriptome profiles of single mouse cortical progenitors identified a set of temporally-regulated genes in embryonic neural stem cells (NSCs). Early NSCs showed cell-to-cell variations of Notch signaling-related gene expression, while later NSDs were more homogenous in Notch signaling status, suggesting a shift of NSC-maintaining strategy. I also found that neither initial oscillatory Notch activation nor cell cycle progression is necessary for NSCs’ internal “clock” mechanisms.
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