Novel transcriptional repression mechanisms that negatively regulate neuronal differentiation
Project/Area Number |
22500292
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
|
Research Institution | Osaka University |
Principal Investigator |
KAMACHI Yusuke 大阪大学, 生命機能研究科, 准教授 (90263334)
|
Project Period (FY) |
2010-04-01 – 2013-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 遺伝子 / 発生・分化 / ゲノム |
Research Abstract |
Mechanisms of how neural stem/precursor cells are established and maintained have been important questions. In this study, we investigated mechanisms of how group B1 Sox transcription factors (Sox1/2/3/19) regulate neural stem cell states using zebrafish as a model system. We show that transcriptional repressors including Zic1 and several miRNA are involved in B1 Sox-dependent-inhibition of neuronal differentiation.
|
Report
(4 results)
Research Products
(16 results)