Functional analysis of nectin and afadin system in synaptogenesis
Project/Area Number |
22500293
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neuroscience in general
|
Research Institution | Kobe University |
Principal Investigator |
TOGASHI Hideru 神戸大学, 大学院・医学研究科, 助教 (90415240)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 樹状突起 / 細胞間接着 / ZO-1 / ネクチン / カドヘリン / シナプス形成 / 細胞接着 / アファディン |
Research Abstract |
Neuronal dendrites and their branches dynamically protrude many fine filopodia in the early stages of neuronal development thatgradually establish complex structures, but the role of these dendritic filopodia in dendritic arborization is unknown. The MAGUK family member, ZO-1, was concentrated at the filopodia-filopodia contact sites. Overexpression or knockdown of ZO-1 affected thedynamics of dendritic filopodial protrusions and their interactions, causing abnormaldendrite morphologies. These results indicate that ZO-1 regulates dendritic filopodialdynamics, and therefore dendrite morphogenesis, in cultured neurons.
|
Report
(4 results)
Research Products
(9 results)