| Project/Area Number |
22500298
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
AKEMA Tatsuo 聖マリアンナ医科大学, 医学部, 教授 (60128585)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIOKA Hitomi 聖マリアンナ医科大学, 医学部, 講師 (50410064)
KAKEHASHI Chiaki 聖マリアンナ医科大学, 医学部, 研究技術 (80535683)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | GnRHニューロン / ミクログリア / シクロオキシゲナーゼ / プロスタグランジン / GnRH / ストレス / COX-1 / ゴナドトロピン放出ホルモン |
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| Research Abstract |
The present studies were aimed to examine whether microglia may be involved in regulation of functions of GnRH neurons which govern reproductive functions. We revealed that cyclooxygenase (COX) -1 immunoreactivity in the vicinity of GnRH neurons was almost entirely localized in microglia in the preoptic area, and prostaglandin E2, which is one of the products catalyzed by COX, modulated electrophysiological properties of GnRH neurons in an estrus cycle-dependent manner. We also found pretreatment of an inhibitor of microglial activation reversed suppression of gonadotropin secretion by inflammatory stress. These results suggest that microglia may be involved in regulation of GnRH neural function in both physiological and inflammatory conditions.
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