| Project/Area Number |
22500301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
YAMAGATA Yoko 生理学研究所, 生体情報研究系, 助教 (20210338)
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| Co-Investigator(Renkei-kenkyūsha) |
IMOTO Keiji 生理学研究所, 生体情報研究系, 教授 (00176512)
SAKAGAMI Hiroyuki 北里大学, 医学部, 教授 (90261528)
YANAGAWA Yuchio 群馬大学, 医学系研究科, 教授 (90202366)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 分子・細胞神経科学 / プロテインキナーゼ / 神経科学 / 脳・神経 / 生理学 / 学習・記憶 / 蛋白質リン酸化 |
|---|
| Research Abstract |
）：To examine the role of calmodulin-kinase II in the mechanism of amygdala-dependent learning and memory, we analyzed genetically-engineered mice with a mutation that rendered the kinase inactive. We found that kinase activity of calmodulin-kinase II plays a major role in the mechanism of amygdala-dependent learning and memory, while the extent of its contribution was different from that to the mechanism of hippocampus-dependent learning and memory. These results indicate that combination of different types of molecules seems to be involved in the formation of brain region-specific types of learning and memory.
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