The role of calmodulin-kinase II in the mechanism of amygdala-dependent learning and memory.

• Project/Area Number: 22500301
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: YAMAGATA Yoko 生理学研究所, 生体情報研究系, 助教 (20210338)
• Co-Investigator(Renkei-kenkyūsha): IMOTO Keiji 生理学研究所, 生体情報研究系, 教授 (00176512) ; SAKAGAMI Hiroyuki 北里大学, 医学部, 教授 (90261528) ; YANAGAWA Yuchio 群馬大学, 医学系研究科, 教授 (90202366)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 分子・細胞神経科学 / プロテインキナーゼ / 神経科学 / 脳・神経 / 生理学 / 学習・記憶 / 蛋白質リン酸化

Research Abstract

）：To examine the role of calmodulin-kinase II in the mechanism of amygdala-dependent learning and memory, we analyzed genetically-engineered mice with a mutation that rendered the kinase inactive. We found that kinase activity of calmodulin-kinase II plays a major role in the mechanism of amygdala-dependent learning and memory, while the extent of its contribution was different from that to the mechanism of hippocampus-dependent learning and memory. These results indicate that combination of different types of molecules seems to be involved in the formation of brain region-specific types of learning and memory.

Research Products

• [Journal Article] Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices (2013)
  • Author(s): Yamagata, Y., Kaneko, K., Kase, D., Ishihara, H., Nairn, A.C., Obata, K., Imoto, K
  • Journal Title: Brain Res Volume: 1507 Pages: 1-10
  • Peer Reviewed
• [Journal Article] Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices. (2013)
  • Author(s): Yamagata, Y.
  • Journal Title: Brain Res. Volume: 1507 Pages: 1-10
  • DOI: 10.1016/j.brainres.2013.02.015
  • Peer Reviewed
• [Journal Article] 長期記憶の分子機構 (2011)
  • Author(s): 山肩葉子, 井本敬二
  • Journal Title: Clinical Neuroscience Volume: 29 Pages: 777-781
• [Presentation] Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices (2012)
  • Author(s): Yamagata, Y., Kaneko, K., Kase, D., Ishihara, H., Nairn, A.C., Obata, K., Imoto, K
  • Organizer: 名古屋大学グローバルCOEプログラム 第4回国際シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2012-11-16
• [Presentation] Distinct activation of ERK1/2 mitogen-activated protein kinase in NMDA-receptor-induced seizure activity in cortical slices (2012)
  • Author(s): Yamagata, Y., Kaneko, K., Nairn, A.C., Obata, K., Imoto, K
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-19
• [Presentation] Distinct activation of ERK1/2 mitogen-activated protein kinase in a cortical slice model of seizure activity (2012)
  • Author(s): Yamagata, Y., Kaneko, K., Nairn, A.C., Obata, K., Imoto, K
  • Organizer: FENS (The Federation of European Neuroscience Societies) Forum 2012
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2012-07-15
• [Presentation] Distinct activation of ERK1/2 mitogen-activated protein kinase in a cortical slice model of seizure activity. (2012)
  • Author(s): Yamagata, Y.
  • Organizer: FENS Forum 2012
  • Place of Presentation: Barcelona, Spain
• [Presentation] Distinct activation of ERK1/2 mitogen-activated protein kinase in NMDA-receptor-induced seizure activity in cortical slices. (2012)
  • Author(s): Yamagata, Y.
  • Organizer: Neuroscience 2012
  • Place of Presentation: Nagoya, Japan
• [Presentation] Contribution of kinase activity of Ca2+/calmodulin-dependent protein kinase IIα to hippocampus- and amygdala-dependent memory formation (2011)
  • Author(s): Yamagata, Y., Yanagawa, Y, Imoto, K
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-15
• [Presentation] Contribution of kinase activity of Ca^<2+>/calmodulin-dependent protein kinase IIα to hippocampus- and amygdala-dependent memory formation (2011)
  • Author(s): Yamagata, Y., Yanagawa, Y., Imoto, K.
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-15
• [Presentation] Ca2+/カルモジュリン依存性プロテインキナーゼ IIαは海馬依存性学習のみならず扁桃体依存性学習にも必要か? (2011)
  • Author(s): 山肩葉子, 井本敬二
  • Organizer: 第2回名古屋大学医学研究科・生理学研究所合同シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2011-08-20
• [Presentation] Ca^<2+>/カルモジュリン依存性プロテインキナーゼIIαは海馬依存性学習のみならず扁桃体依存性学習にも必要か? (2011)
  • Author(s): 山肩葉子, 井本敬二
  • Organizer: 第2回名古屋大学医学研究科・生理学研究所合同シンポジウム
  • Place of Presentation: 名大病院中央診療棟(愛知県)
  • Year and Date: 2011-08-20
• [Presentation] The role of kinase activity of Ca2+/calmodulin- dependent protein kinase IIα in hippocampus- and amygdala-dependent memory (2011)
  • Author(s): Yamagata, Y
  • Organizer: The 13th Annual Meeting of the International Behavioural and Neural Genetics Society (IBANGS)
  • Place of Presentation: Rome, Italy
  • Year and Date: 2011-05-14
• [Presentation] The role of kinase activity of Ca^<2+>/calmodulin-dependent protein kinase IIα in hippocampus- and amygdala-dependent memory (2011)
  • Author(s): Yamagata, Y.
  • Organizer: The 13^<th> Annual Meeting of the International Behavioural and Neural Genetics Society
  • Place of Presentation: Istituto Superiore di Sanita (Italy)(招待講演)
  • Year and Date: 2011-05-14
• [Presentation] How important is the kinase activity of Ca^<+2>/calmodulin-dependent protein kinase IIα in hippocampus- and amygdala-dependent memory. (2010)
  • Author(s): Yamagata, Y., Yanagawa, Y., Imoto, K.
  • Organizer: 40th Annual Meeting, Society for Neuroscience, Neuroscience 2010
  • Place of Presentation: San Diego Convention Center(USA)
  • Year and Date: 2010-11-16
• [Presentation] Role of calcium/calmodulin-dependent protein kinase IIα(CaMKIIa)activity in spine formation and dendritic arborization during development. (2010)
  • Author(s): Karcher, S.C., Kondo, S., Bbihara, S., Yamagata, Y., Okabe, S.
  • Organizer: 第33回日本神経科学大会・第53回・日本神経化学会大会・第20回日本神経回路学会大会 合同大会Neuro2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-03
• [Presentation] Role of kinase activity of Ca^<2+>/calmodulin-dependent protein kinase IIα in hippocampus and amygdala-dependent memory. (2010)
  • Author(s): Yamagata, Y., Yanagawa, Y., Imoto, K.
  • Organizer: 第33回日本:神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会 合同大会Neuro2010
  • Place of Presentation: 神戸コンベンションセンター(兵庫県)
  • Year and Date: 2010-09-02
• [Presentation] Kinase activity of Ca2+/calmodulin-dependent protein kinase IIα is indispensable for hippocampus- dependent memory but not for amygdala- dependent memory (2010)
  • Author(s): Yamagata, Y., Yanagawa, Y. and Imoto, K
  • Organizer: SOKENDAI/NIPS symposium 2010
  • Place of Presentation: Okazaki, Japan
• [Presentation] How important is the kinase activity of Ca2+/calmodulin-dependent protein kinase IIα in hippocampus- and amygdala-dependent memory (2010)
  • Author(s): Yamagata, Y., Yanagawa, Y. and Imoto, K
  • Organizer: 40th Annual Meeting, Society for Neuroscience, Neuroscience 2010
  • Place of Presentation: San Diego, CA
• [Presentation] Role of calcium/calmodulin-dependent protein kinase IIα (CaMKIIα) activity in spine formation and dendritic arborization during development (2010)
  • Author(s): Karcher, S. C., Kondo, S., Ebihara, S., Yamagata, Y. and Okabe, S
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会 合同大会 Neuro2010
  • Place of Presentation: 神戸
• [Presentation] Role of kinase activity of Ca2+/calmodulin-dependent protein kinase IIα in hippocampus- and amygdala- dependent memory (2010)
  • Author(s): Yamagata, Y. , Yanagawa, Y. and Imoto, K
  • Organizer: 第33回日本神経科学大会・第53回日本神経化学会大会・第20回日本神経回路学会大会 合同大会 Neuro2010
  • Place of Presentation: 神戸
• [Remarks]
  • URL: http://www.nips.ac.jp/huinfo/research/ns_Res05.htm
• [Remarks] 神経活動におけるタンパク質リン酸化の役割
  • URL: http://www.nips.ac.jp/huinfo/research/ns_Res05.htm
• [Remarks]
  • URL: http://www.nips.ac.jp/huinfo/research/ns_Res05.htm
• [Remarks]
  • URL: http://www.nips.ac.jp/contents/release/entry/2009/06/post-7.html
• [Remarks]
  • URL: http://www.nips.ac.jp/huinfo/research/ns_ResO5.htm
• [Remarks]
  • URL: http://www.nips.ac.jp/contents/release/entry/2009/06/post-7.html