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Elucidation of Odor Information Coding in Higher Olfactory Centers

Research Project

Project/Area Number 22500303
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

MIYASAKA Nobuhiko  独立行政法人理化学研究所, シナプス分子機構研究チーム, 副チームリーダー (70332335)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords嗅覚 / 神経回路 / 脳 / 軸索投射 / 遺伝子工学 / 動物行動 / ゼブラフィッシュ / 蛍光タンパク質 / 行動 / 国際情報交換 / 軸索 / 可視化
Research Abstract

In the olfactory system, odor information is represented as a topographic map of neural activities across glomeruli in the olfactory bulb (OB). However, it remains largely unknown how this odor map is transferred to higher brain centers. In the present study, I combined genetic single-neuron labeling and image registration techniques to address this issue in zebrafish. I found that 1) individual OB neurons send axons to multiple forebrain regions, and that 2) each target region receives either non-selective or biased projections from the OB with respect to glomerular classes. These results suggest that different forebrain regions sample distinct combinations of glomerular inputs and create various forms of olfactory representations.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2013 2012 2011 2010 Other

All Presentation (16 results)

  • [Presentation] From the olfactory bulb to higher brain centers: a comprehensive axon projection map revealed by genetic single-neuron labeling in zebrafish2013

    • Author(s)
      Miyasaka N, Wakisaka N, Masuda M, Arganda-Carreras I, Seung HS, Yoshihara Y
    • Organizer
      Symposium on Sensory Systems & Neural Circuits
    • Place of Presentation
      Ito Hall, Univ. Tokyo
    • Related Report
      2012 Final Research Report
  • [Presentation] From the olfactory bulb to higher brain centers: a comprehensive axon projection map revealed by genetic single-neuron labeling in zebrafish2013

    • Author(s)
      Nobuhiko Miyasaka
    • Organizer
      Symposium on Sensory Systems & Neural Circuits
    • Place of Presentation
      Ito Hall, University of Tokyo
    • Related Report
      2012 Annual Research Report
  • [Presentation] 嗅球から高次中枢へ:ゼブラフィッシュ二次嗅覚系の包括的軸索投射マップ2012

    • Author(s)
      宮坂信彦、脇阪紀子、増田美和、Ignacio Arganda-Carreras、H. Sebastian Seung、吉原良浩
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] From the olfactory bulb to higher brain centers: a comprehensive axon projection map revealed by genetic single-neuron labeling in zebrafish2012

    • Author(s)
      Miyasaka N, Wakisaka N, Masuda M, Arganda-Carreras I, Seung HS, Yoshihara Y.
    • Organizer
      16^(th) International Symposium on Olfaction and Taste (ISOT)
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Final Research Report
  • [Presentation] From the olfactory bulb to higher brain centers: a comprehensive axon projection map revealed by genetic single-neuron labeling in zebrafish2012

    • Author(s)
      Nobuhiko Miyasaka
    • Organizer
      16th International Symposium on Olfaction and Taste
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Annual Research Report
  • [Presentation] 嗅球から高次中枢へ:ゼブラフィッシュ嗅覚系の機構構築2011

    • Author(s)
      宮坂信彦、吉原良浩
    • Organizer
      第82回日本動物学大会
    • Place of Presentation
      大雪クリスタルホール・旭川
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 嗅球から高次中枢へ:ゼビラフィッシュ嗅覚系の機能構築2011

    • Author(s)
      宮坂信彦
    • Organizer
      日本動物学会第82回大会
    • Place of Presentation
      大雪クリスタルホール(旭川)(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 嗅球から高次中枢へと至るゼブラフィッシュ嗅覚経路の包括的遺伝学的解析2011

    • Author(s)
      宮坂信彦、吉原良浩
    • Organizer
      第34回に本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 嗅球から高次中枢へと至るゼブラフィッシュ嗅覚経路の包括的遺伝学的解析2011

    • Author(s)
      宮坂信彦
    • Organizer
      日本神経科学会第34回大会
    • Place of Presentation
      パシフィコ横浜(横浜市)(招待講演)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゼブラフィッシュ嗅覚神経回路の形成と機能構築2010

    • Author(s)
      宮坂信彦
    • Organizer
      日本味と匂学会第44回大会・研究奨励賞受賞講演
    • Place of Presentation
      北九州国際会議場
    • Year and Date
      2010-09-09
    • Related Report
      2012 Final Research Report
  • [Presentation] ゼブラフィッシュ嗅覚神経回路の形成と機能構築2010

    • Author(s)
      宮坂信彦
    • Organizer
      日本味と匂学会
    • Place of Presentation
      北九州
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 遺伝子工学的単一ニューロン標識によるゼブラフィッシュ二次嗅覚経路の解析2010

    • Author(s)
      宮坂信彦、吉原良浩
    • Organizer
      Neuro2010
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic single-neuron tracing from the olfactory bulb to higher brain centers in zebrafish2010

    • Author(s)
      宮坂信彦
    • Organizer
      Neuro 2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic tracing of axonal projections from the olfactory bulb to higher brain centers in zebrafish. Janelia Conference2010

    • Author(s)
      Miyasaka N, Koide T, Okamoto H, Yoshihara Y.
    • Organizer
      Form and Function of the Olfactory System
    • Place of Presentation
      Janelia Farm Research Campus, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Genetic tracing of axonal projections from the olfactory bulb to higher brain centers in zebrafish2010

    • Author(s)
      宮坂信彦
    • Organizer
      Janelia Farm Conference
    • Place of Presentation
      米国・バージニア州・アッシュバーン
    • Related Report
      2010 Annual Research Report
  • [Presentation] 嗅球から高次中枢へ:ゼブラフィッシュ二次嗅覚系の包括的軸索投射マップ

    • Author(s)
      宮坂信彦
    • Organizer
      日本神経科学会 第35回大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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