| Project/Area Number |
22500304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | 防衛医科大学校 (2012)
National Defense Medical College (2010-2011) |
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Principal Investigator |
SATOH Yasushi 防衛医科大学校, 病院, 講師 (10505267)
|
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| Co-Investigator(Kenkyū-buntansha) |
ENDO Shogo 地方独立行政法人東京都健康長寿医療センター研究所, 老化制御研究チーム, 研究部長 (60192514)
ADACHI Takeshi 防衛医科大学校, 医学教育学部医学科専門課程, 教授 (50231931)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ERK / 神経 / 細胞内情報伝達 / 神経幹細胞 / 分化・増殖 / 自閉症 / 育児 / 記憶・学習 |
|---|
| Research Abstract |
Signaling through extracellular signal-regulated kinase (ERK) is important in multiple signal transduction networks in the central nervous system (CNS). However, the specific role of ERK2 in in vivo brain functions is not fully understood. Here we show that ERK2 play a critical role in regulating social behaviors as well as cognitive and emotional behaviors in mice. To study the brain function of ERK2, we employed a conditional, region-specific, genetic approach to target Erk2 using the Cre/loxP strategy with a nestin promoter-driven cre transgenic mouse line to induce recombination in the CNS. The resulting Erk2 conditional knockout (CKO) mice, in which Erk2 was abrogated specifically in the CNS, exhibited marked anomalies in multiple aspects of social behaviors related to facets of autism-spectrum disorders (ASD). Our findings suggest that ERK2 has complex and multiple roles in the CNS, with important implications for human psychiatric disorders characterized by deficits in social behaviors.
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