The BDNF pro-peptide is a novel facilitator of hippocampal LTD and the biological action is altered by a common BDNF polymorphism Val66Met
| Project/Area Number |
22500305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
KOJIMA Masami 独立行政法人産業技術総合研究所, 健康工学研究部門, 研究グループ長 (40344171)
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| Co-Investigator(Kenkyū-buntansha) |
UEGAKI Kouichi 独立行政法人産業技術総合研究所, 生体分子創製研究グループ, 研究グループ長 (00356544)
ISHIKAWA Yasuyuki 奈良先端科学技術大学院大学, バイオサイエンス研究科, 助教授 (90346320)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経栄養因子 / 神経細胞 / 神経伝達 / プロセッシング / 分泌 / シナプス / 成長因子 / 一塩基多型 / 海馬 / LTD / endocytosis / 細胞イメージング |
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| Research Abstract |
Most growth factors are initially synthesized as precursors and subsequently processed into their mature form and its pro-peptide by proteolytic cleavage in the secretory pathway and extracellular spaces. Compared to that of the mature form, the biologica
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] BDNF and its pro-peptide are stored in presynaptic dense core vesicles in brain neurons2012
Author(s)
S. Dieni, T. Matsumoto, M. Dekkers, S. Rauskolb, M. Ionescu, R. Deogracias, E. D.Gundelfinger, M. Kojima, S. Nestel, M. Frotscher, Y.-A. Barde
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Journal Title
Journal of cell Biology
Volume: vol. 196 no. 6
Pages: 775-788
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[Journal Article] ultiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival2009
Author(s)
Koshimizu, H., Kiyosue, K., Hara, T.,Hazama, S., Suzuki, S., Uegaki, K., Nagappan, G., Zaitsev, E., Hirokawa, T., Tatsu, Y., Ogura, A., Lu, B. & Kojima, M
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Journal Title
Mol. Brain
Volume: vol.2,no.1-19
Related Report
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[Journal Article] The BDNF pro-peptide is a novelfacilitator of hippocampal LTD and the biological action is modulated by a common BDNF polymorphism Val66Met
Author(s)
Uegaki K., Ishikawa Y., Mizui T., Hirokawa T., Hara T., Suzuki S., Takahashi M., Shiosaka S., Itami C., Kumanogoh H., Kojima M
Volume
(in press)
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