| Project/Area Number |
22500311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Maebashi Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAO Tomoaki 群馬大学, 大学院・医学系研究科, 教授 (20171043)
|
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 眼優位可塑性 / 視覚野 / ドレブリン / 中枢アミン系 / 免疫組織化学 / ノックアウトマウス / 電気生理学 / c-fos / 脳・神経 / 神経科学 / 解剖学 / 生理学 / 生物・生体工学 |
|---|
| Research Abstract |
An unique activity-mapping method (cFAMM) was established to evaluate mouse ocular dominance (OD) plasticity. cFAMM was applied first to examine the effect of destruction of central aminergic system. It was found that noradr enaline (NA) and serotonergic (5HT) system differentially regulate OD plasticity. In drebrin-knockout mouse, the visual evoked expression of c-fos was suppressed as in the mice with NA-depletion, suggesting drebrin plays cruicial role in the regulation of OD plasticity.
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