Role of Drebrin in the regulation of ocular dominance plastiity

• Project/Area Number: 22500311
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Maebashi Institute of Technology
• Principal Investigator: IMAMURA Kazuyuki 前橋工科大学, 工学部, 教授 (30203326)
• Co-Investigator(Kenkyū-buntansha): SHIRAO Tomoaki 群馬大学, 大学院・医学系研究科, 教授 (20171043)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 眼優位可塑性 / 視覚野 / ドレブリン / 中枢アミン系 / 免疫組織化学 / ノックアウトマウス / 電気生理学 / c-fos / 脳・神経 / 神経科学 / 解剖学 / 生理学 / 生物・生体工学

Research Abstract

An unique activity-mapping method (cFAMM) was established to evaluate mouse ocular dominance (OD) plasticity. cFAMM was applied first to examine the effect of destruction of central aminergic system. It was found that noradr enaline (NA) and serotonergic (5HT) system differentially regulate OD plasticity. In drebrin-knockout mouse, the visual evoked expression of c-fos was suppressed as in the mice with NA-depletion, suggesting drebrin plays cruicial role in the regulation of OD plasticity.

Research Products

• [Journal Article] c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats (2013)
  • Author(s): Nakadate K., Imamura K., Wanatanbe Y
  • Journal Title: Neurosci Volume: 235 Pages: 1-9
  • URL: http://dx.doi.org/10.1016/j.neuroscience.2013.01.013
  • Peer Reviewed
• [Journal Article] Regulation of AMPA receptor recruitment by the actin binding protein drebrin in cultured hippocampal neurons. (2013)
  • Author(s): Kato K., Shirao T., Yamazaki H., Imamura K., Sekino Y
  • Journal Title: Journal of Neuroscience and Neuroengineering Volume: 1 Pages: 153-160
  • DOI: 10.1166/jnsne.2012.1018
  • Peer Reviewed
• [Journal Article] c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats. (2013)
  • Author(s): Nakadate K., Imamura K., Wanatanbe Y.
  • Journal Title: Neuroscience Volume: 235 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Effects of monocular deprivation on the spatial pattern of visually induced expression of c-Fos protein (2012)
  • Author(s): Nakadate K., Imamura K., Watanabe Y.
  • Journal Title: Neurosci Volume: 202 Pages: 17-28
  • DOI: 10.1016/j.neuroscience.2011.12.004
  • Peer Reviewed
• [Journal Article] An alteration in the lateral geniculate nucleus of experimental glaucoma monkeys: In vivo positron emission tomography imaging of glial activation. (2012)
  • Author(s): Shimazawa M., Ito Y., Inokuchi Y., Yamanaka H., Hayashi T., Jin B., Higuchi M., Suhara T., Imamura K., Araie M., Watanabe Y., Onoe H., Hara H
  • Journal Title: PLoS ONE Volume: 7(1) Pages: 1-14
  • DOI: 10.1371/journal.pone.0030526
  • Peer Reviewed
• [Journal Article] Involvement of endplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaycoma model (2011)
  • Author(s): Ito Y, Shimazawa M, Inokuchi Y, Yamanaka H, Tsuruma K, Imamura K, Onoe H, Watanabe Y, Aihara M, Araie M, Hara H
  • Journal Title: European Journal of Neuroscience Volume: 33 Pages: 843-55
  • DOI: 10.1111/j.1460-9568.2010.07578.x
  • Peer Reviewed
• [Journal Article] Involvement of endplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model. (2011)
  • Author(s): Ito Y.
  • Journal Title: Eur.J.Neurosci. Volume: 33 Pages: 843-855
  • Peer Reviewed
• [Journal Article] Cortical activation during color discrimination task in macaques as revealed by positron emission tomography. (2010)
  • Author(s): Katsuyama N.
  • Journal Title: Neurosci Lett. Volume: 484 Pages: 168-173
  • Peer Reviewed
• [Presentation] Evaluation of non-alcohol beer intake by elevated plus-maze (2013)
  • Author(s): T. Kobayashi, H. Murayama, K. Imamura
  • Organizer: The Journal of Physiological Sciences
  • Place of Presentation: タワーホール船堀、東京都
  • Year and Date: 2013-03-29
• [Presentation] 高架式十字迷路を用いたノンアルコールビール摂取効果の評価 (2013)
  • Author(s): 小林拓貴、村上隼人、今村一之
  • Organizer: 日本生理学会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2013-03-29
• [Presentation] 視覚と脳の可塑性 (2012)
  • Author(s): 今村一之
  • Organizer: 日本麻酔科学会東関東甲信越地方会
  • Place of Presentation: Maebashi, Gunma, Japan
  • Year and Date: 2012-01-28
• [Presentation] BMI technology and restorative bioengineering (2011)
  • Author(s): Kazuyuki Imamura
  • Organizer: 4th workshop on motor recovery of upper extremity after brain and cervical cord injury
  • Place of Presentation: Kakunodate, Akita, Japan
  • Year and Date: 2011-05-21
• [Presentation] Involvement of drebrin, an actin binding protein, in regulation of AMPA receptor recruitment in cultured hippocampal neurons (2011)
  • Author(s): K. Kato, K. Imamura and Y. Sekino
  • Organizer: International radiation neurobiology
  • Place of Presentation: 群馬大学医学部刀城会館、群馬県
  • Year and Date: 2011-01-29
• [Presentation] Ocular dominance plasticity in abnormally developed visual cortex (2011)
  • Author(s): K. Imamura
  • Organizer: International radiation neurobiology
  • Place of Presentation: 群馬大学医学部刀城会館、群馬県
  • Year and Date: 2011-01-29
• [Presentation] Ocular dominance plasticity in abnormally developed visual cortex. (2011)
  • Author(s): Imamrua K.
  • Organizer: 放射線神経生物学会
  • Place of Presentation: 群馬大学医学部刀城会館
  • Year and Date: 2011-01-29
• [Presentation] Involvement of drebrin, an actin binding protein, in regulation of AMPA receptor recruitment in cultured hippocampal neurons. (2011)
  • Author(s): Kato K., Imamura K., Sekino Y.
  • Organizer: 放射線神経生物学会
  • Place of Presentation: 群馬大学医学部刀城会館
  • Year and Date: 2011-01-29
• [Presentation] 機能回復を促進する神経可塑性のメカニズムについて:理論研究と動物実験による統合アプローチ (2010)
  • Author(s): 今村一之
  • Organizer: 第3回上肢の機能回復セミナー
  • Place of Presentation: 仙北市交流センター(特別講演)
  • Year and Date: 2010-05-14
• [Book] Central changes in glaucoma: neuroscientific study using animal models (2011)
  • Author(s): Imamura K., Shimazawa M., Onoe H., Watanabe Y., Ishii, K., Mayama C., Akasaki T., Shimegi S., Sato, H., Nakadate, K., Hara H., Araie M
  • Publisher: THE MISTERY OF GLAUCOMA, Kofronova M. and Kubena T. eds. INTEC
• [Book] Central changes in glaucoma : neuroscientific study using animal models. THE MISTERY OF GLAUCOMA (2011)
  • Author(s): Imamura K., Shimazawa M., Onoe H., Watanabe Y., Ishii, K., Mayama C., Akasaki T., Shimegi S., Sato, H., Nakadate, K., Hara H., Araie M.
  • Publisher: INTEC
• [Remarks]