| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
NG2 is one of chondroitin sulfate proteoglycans. NG2+ cells are abundant in the adult brain. The function of NG2+ cells is not clear, but it is suggested that NG2+ cells can be multi-potent in in vitro culture system. In this study, I analyzed the function of NG2+ cells in vivo. Because previous studies show that excessive neuronal excitation induce proliferation of NG2+ cells, I analyzed and compared responses of NG2+ cells and endogenous neural stem/precursors against neuronal excitation in the seizure model mice. Present study showed that these precursors exhibit differential responses in terms of cell cycle progression.
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