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Morphological classification and synaptic connectivity analysis of retinal neurons by three-dimensional reconstruction

Research Project

Project/Area Number 22500317
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionHyogo Medical University

Principal Investigator

TSUKAMOTO Yoshihiko  兵庫医科大学, 医学部, 名誉教授 (20104250)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywordsニューロン / 網膜 / 神経回路 / シナプス / マウス / サル / 電子顕微鏡 / 神経科学 / 細胞・組織
Research Abstract

(1) We analyzed the allocations of synaptic contacts in microcircuits from rods via rod bipolar to AII amacrine cells, the gap junctions between AII amacrine and ON cone bipolar cells, and the synaptic contacts from OFF bipolar to OFF ganglion cells in the mouse retina.We also made a map of 30 ganglion cells. (2) We made two maps of cones and rods in the fovea (Eccentricity: 0.25~0.45mm) and the peri-fovea (3.06~3.22mm) and discovered thedirect chemical synaptic pathway from rods to OFF cone bipolar cells in the monkey retina.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2013 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (5 results) Book (2 results)

  • [Journal Article] Functional Allocation of Synaptic Contacts in Microcircuits from Rods via Rod Bipolar to AII Amacrine Cells in the Mouse Retina2013

    • Author(s)
      Yoshihiko Tsukamoto
    • Journal Title

      Journal of Comparative Neurology

      Volume: 印刷中

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物情報の基礎2011

    • Author(s)
      塚本吉彦
    • Journal Title

      兵庫医大医学会雑誌

      Volume: 36 Pages: 1-5

    • Related Report
      2011 Annual Research Report
  • [Presentation] サル網膜において杆体・錐体双方から基底型シナプス結合を介して入力する双極細胞型とマウス網膜における相当する細胞型との比較2013

    • Author(s)
      塚本吉彦、臣尚子
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-20
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] マウス神経節細胞とその双極細胞入力の三次元再構築と分類2012

    • Author(s)
      塚本吉彦、臣尚子
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] マウス網膜における同一杆体信号の杆体双極細胞への発散を介するAIIアマクリン細胞への再集束2011

    • Author(s)
      塚本吉彦、臣尚子
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] マウス網膜の杆体双 極細胞とAIIアマクリン細胞を経由する杆体 信号経路2010

    • Author(s)
      塚本吉彦、臣尚子
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス網膜の杆体双極細胞とAIIアマクリン細胞を経由する杆体信号経路2010

    • Author(s)
      塚本吉彦
    • Organizer
      第33回日本神経科学大会
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2010-09-01
    • Related Report
      2010 Annual Research Report
  • [Book] 新編色彩科学ハンドブック第3版、第8章・色の生理-3・色覚の情報処理-3.3・網膜2011

    • Author(s)
      日本色彩学会編
    • Publisher
      東京大学出版会
    • Related Report
      2012 Final Research Report
  • [Book] 新編色彩科学ハンドブック第3版第8章・色の生理-3・色覚の情報処理-3.3・網膜2011

    • Author(s)
      日本色彩学会編, 大田, 他約200名分担執筆
    • Publisher
      東京大学出版会
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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