Functional analysis for differentiation and survival mechanism of excitatory neurons during the formation of cerebral cortex.
| Project/Area Number |
22500318
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
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Principal Investigator |
OKADO Haruo 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 副参事研究員 (60221842)
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Chiak 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 主席研究員 (00281626)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | RP58 / 大脳皮質 / 転写抑制 / ニューロン / Id / 転写抑制因子 / 分化 / 神経細胞化 / 放射状移動 |
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| Research Abstract |
We found that RP58 enhanced the cell-cycle exit resulting in neurogenesis via transcriptional repression of Id1-4 genes. In addition, we found that RP58 controls neuronal migration via transcriptional repression of Ngn2 gene independent on the cell cycle exit. This shows that RP58 is multifunctional regulator that suppresses the different downstream genes.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex.2013
Author(s)
Ohtaka-Maruyama C, Hirai S, Miwa A, Heng JI, Shitara H, Ishii R, Taya C, Kawano H, Kasai M, Nakajima K, Okado H.
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Journal Title
Cell Rep
Volume: 3(2)
Issue: 2
Pages: 458-71
DOI
Related Report
Peer Reviewed
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[Journal Article] RP58 controls neuron and astrocyte differentiation by downregulating the expression of Id1-4 genes in the developing cortex2012
Author(s)
Hirai, S.,Miwa, A., Ohtaka-Maruyama, C., Kasa,i M., Okabe, S., Hata, Y, and H. Okado
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Journal Title
EMBO Journal
Volume: 31
Issue: 5
Pages: 1190-1202
DOI
Related Report
Peer Reviewed
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[Journal Article] Developmental expression of sorting nexin 3 in the mouse central nervous system2011
Author(s)
Mizutani R, Nakamura K, Yokoyama S, Sanbe A, Kusakawa S, Miyamoto Y, Torii T, Asahara H, Okado H, Yamauchi J, Tanoue A
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Journal Title
Gene Expr Patterns
Volume: 11
Issue: 1-2
Pages: 33-40
DOI
Related Report
Peer Reviewed
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[Journal Article] Developmental expression of sorting nexin 3 in the mouse central nervous system.2011
Author(s)
Mizutani R, Nakamura K, Yokoyama S, Sanbe A, Kusakawa S, Miyamoto Y, Torii T, Asahara H, Okado H, Yamauchi J, Tanoue A
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Journal Title
Gene Expr Patterns
Volume: 11
Pages: 33-40
Related Report
Peer Reviewed
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