Clinicopathological study of central nervous system rhabdoid tumors with or without INI1 protein expression
| Project/Area Number |
22500319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Gunma University |
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Principal Investigator |
HIRATO Junko 群馬大学, 医学部, 准教授 (60208832)
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| Co-Investigator(Kenkyū-buntansha) |
MIYANAGA Tomomi 群馬大学, 医学部, 助教 (30455951)
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| Co-Investigator(Renkei-kenkyūsha) |
NOBUSAWA Sumihito 群馬大学, 大学院・医学系研究科, 助教 (80635318)
NAKAZATO Yoichi 群馬大学, 大学院・医学系研究科, 教授 (10106908)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | ラブドイド腫瘍 / INI1 蛋白 / ラブドイド細胞 / グリオーマ / epithelioid/rhabdoid cell / composite rhabdoid tumor / array CGH / brain tumor / rhabdoid tumor / INI1 / epithelioid glioblastoma / rhabdoid glioblastoma / AT/RT / BRG1 / INI1蛋白 / 非定型奇形腫様ラブドイド腫瘍 / rhabdoid cell / epithelioid/rhabdoid glioblastoma / choroid plexus carcinoma |
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| Research Abstract |
Central nervous system rhabdoid tumors(CNS RTs) were divided into INI1 protein-negative and -positive groups. All INI1-negative RTs were consistent with atypical teratoid rhabdoid tumor (AT/RT) in the histopathological features. Moreover, there were a few cases with combined tumors composed of INI1-positive glioma and INI1-negative rhabdoid tumors. In the INI1-positive RTs, high-grade gliomas with epithelioid/rhabdoid cells were identified, and the presence of INI1-positive AT/RT was possibly considered.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Cerebral astroblastoma in an adult: An immunohistochemical, ultrastructural and genetic study2012
Author(s)
Fu YJ, Taniguchi Y, Takeuchi S, ShigaA, Okamoto K, Hirato J, Nobusawa S,Nakazato Y, Kakita A, Takahashi H.
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Journal Title
Neuropathology
Volume: 33
Issue: 3
Pages: 312-319
DOI
Related Report
Peer Reviewed
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