• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clinicopathological study of central nervous system rhabdoid tumors with or without INI1 protein expression

Research Project

Project/Area Number 22500319
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionGunma University

Principal Investigator

HIRATO Junko  群馬大学, 医学部, 准教授 (60208832)

Co-Investigator(Kenkyū-buntansha) MIYANAGA Tomomi  群馬大学, 医学部, 助教 (30455951)
Co-Investigator(Renkei-kenkyūsha) NOBUSAWA Sumihito  群馬大学, 大学院・医学系研究科, 助教 (80635318)
NAKAZATO Yoichi  群馬大学, 大学院・医学系研究科, 教授 (10106908)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsラブドイド腫瘍 / INI1 蛋白 / ラブドイド細胞 / グリオーマ / epithelioid/rhabdoid cell / composite rhabdoid tumor / array CGH / brain tumor / rhabdoid tumor / INI1 / epithelioid glioblastoma / rhabdoid glioblastoma / AT/RT / BRG1 / INI1蛋白 / 非定型奇形腫様ラブドイド腫瘍 / rhabdoid cell / epithelioid/rhabdoid glioblastoma / choroid plexus carcinoma
Research Abstract

Central nervous system rhabdoid tumors(CNS RTs) were divided into INI1 protein-negative and -positive groups. All INI1-negative RTs were consistent with atypical teratoid rhabdoid tumor (AT/RT) in the histopathological features. Moreover, there were a few cases with combined tumors composed of INI1-positive glioma and INI1-negative rhabdoid tumors. In the INI1-positive RTs, high-grade gliomas with epithelioid/rhabdoid cells were identified, and the presence of INI1-positive AT/RT was possibly considered.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (17 results)

All 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 7 results) Presentation (3 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] large congenital melanocytic nevi with atypical teratoid/rhabdoid tumor2013

    • Author(s)
      Yamazaki F, Osumi T, Kosaki K, Mikami S, Hirato J, Shimada H.
    • Journal Title

      Pediatr Blood Cancer

      Volume: 60 Issue: 7 Pages: 1240-1241

    • DOI

      10.1002/pbc.24515

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral astroblastoma in an adult: An immunohistochemical, ultrastructural and genetic study2012

    • Author(s)
      Fu YJ, Taniguchi Y, Takeuchi S, ShigaA, Okamoto K, Hirato J, Nobusawa S,Nakazato Y, Kakita A, Takahashi H.
    • Journal Title

      Neuropathology

      Volume: 33 Issue: 3 Pages: 312-319

    • DOI

      10.1111/j.1440-1789.2012.01351.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of chromosome 19q13.42 amplification in embryonal tumors2012

    • Author(s)
      Nobusawa-S, Yokoo-H, et al.
    • Journal Title

      Brain Pathol

      Volume: (in press) Issue: 5 Pages: 689-697

    • DOI

      10.1111/j.1750-3639.2012.00574.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rhabdoidfeatureを示す神経上皮性腫瘍2012

    • Author(s)
      平戸純子
    • Journal Title

      病理と臨床

      Volume: 30 Pages: 422-428

    • Related Report
      2012 Final Research Report
  • [Journal Article] Rapid progression of rhabdoid components of a composite high-grade glioma and rhabdoid tumor in the occipital lobe of an adult2012

    • Author(s)
      Yamamoto J, Takahashi M, Nakano Y, Soejima Y, Saito T, Akiba D, Hirato J, Nakazato Y, Nishizawa S.
    • Journal Title

      Brain Tumor Pathol

      Volume: 29 Issue: 2 Pages: 113-120

    • DOI

      10.1007/s10014-011-0069-6

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rhabdoid featureを示す神経上皮性腫瘍2012

    • Author(s)
      平戸純子
    • Journal Title

      病理と臨床

      Volume: 30 Pages: 422-428

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Nestin expression in brain tumors : its utility for pathological diagnosis and correlation with the prognosis of high grade gliomas2012

    • Author(s)
      Hideo Arai
    • Journal Title

      Brain Tumor Pathology

      Volume: Vol.29(In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An immunohistochemical finding in glioneuronal lesions associated with epilepsy: the appearance of nestin-positive, CD34-positive and tau-accumulating cells2011

    • Author(s)
      Nagaishi M, Arai M, Osawa T, Yokoo H, Hirato J, Yoshimoto Y, Nakazato Y.
    • Journal Title

      Neuropathology

      Volume: 31 Issue: 5 Pages: 468-75

    • DOI

      10.1111/j.1440-1789.2010.01188.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Primary intracranial leiomyosarcoma in an immunocompetent patient: case report2011

    • Author(s)
      Fujimoto Y, Hirato J, Wakayama A, Yoshimine T.
    • Journal Title

      J Neurooncol

      Volume: 103 Issue: 3 Pages: 785-790

    • DOI

      10.1007/s11060-010-0450-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 臨床医 のための神 経病理 Pilomyxoid astrocytoma2011

    • Author(s)
      平戸純子
    • Journal Title

      Clinical Neuroscience

      Volume: 29 Pages: 378-379

    • Related Report
      2012 Final Research Report
  • [Journal Article] Rhabdoid tumor2010

    • Author(s)
      平戸純子
    • Journal Title

      病理と臨床

      Volume: 臨時増刊号 28 Pages: 428-429

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] 脳幹部神経膠腫2010

    • Author(s)
      平戸純子
    • Journal Title

      日本臨牀

      Volume: 68 Pages: 146-149

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 髄芽腫2010

    • Author(s)
      平戸純子
    • Journal Title

      日本臨牀

      Volume: 68 Pages: 180-183

    • Related Report
      2010 Annual Research Report
  • [Presentation] Atypicalteratoid/rhabdoidtumorの病理2012

    • Author(s)
      平戸純子
    • Organizer
      第58回日本病理学会近畿支部学術集会
    • Place of Presentation
      兵庫医科大学講堂(兵庫県)
    • Year and Date
      2012-09-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Atypical teratoid/rhabdoid tumorの病理

    • Author(s)
      平戸純子
    • Organizer
      第58回日本病理学会近畿支部学術集会
    • Place of Presentation
      西宮市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Analysis of Chromosome 19q13.42 Amplification in Embryonal Brain Tumors with Ependymoblastic Multilayered Rosettes.

    • Author(s)
      Sumihito Nobusawa
    • Organizer
      The 16th Congress of the European Federation of Neurological Societies.
    • Place of Presentation
      Stockform
    • Related Report
      2012 Annual Research Report
  • [Book] 癌診療指針のための病理診断プラクティス脳腫瘍2012

    • Author(s)
      平戸純子
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi