Comprehensive analysis of TDP-43 target genes and binding proteins

• Project/Area Number: 22500322
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Meiji Pharmaceutical University
• Principal Investigator: SATOH Jun-ichi 明治薬科大学, 薬学部, 教授 (30274591)
• Co-Investigator(Kenkyū-buntansha): 天竺桂 弘子 明治薬科大学, 薬学部, 助教 (80434190)
• Co-Investigator(Renkei-kenkyūsha): 有馬 邦正 明治薬科大学, 薬学部, 助教 (20250227)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: TDP-43 / 標的遺伝子 / 結合タンパク質 / 分子ネットワーク / 筋萎縮性側索硬化症 / 神経細胞死 / 次世代シークエンサー / バイオインフォマティクス / インターラクトーム / ブロテオミクス / ブロテインアレイ

Research Abstract

TAR DNA-binding protein-43 (TDP-43) is an evolutionarily conservednuclear protein that regulates gene expression by forming a multimolecular complex with a wide varietyof target RNAs and interacting proteins. Abnormally phosphorylated, ubiquitinated, and aggregatedTDP-43 proteins constitute a principal component of neuronal and glial cytoplasmic and nuclearinclusions in the brains of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), establishing a novel clinical entity designated TDP-43 proteinopathy. Althoughincreasing evidence suggests that the neurodegenerative process underlying ALS and FTLD isattributable to a toxic gain of function or a loss of cellular function of TDP-43, the precise molecularmechanisms remain largely unknown. Recent advances in systems biology enable us to characterize theglobal molecular network extracted from large-scale data of the genome, transcriptome, and proteomewith the pathway analysis tools of bioiformatics endowed with a comprehensive knowledge base. Thepresent study was conducted to characterize the comprehensive molecular network of TDP-43 targetRNAs and interacting proteins, recently identified by deep sequencing with next-generation sequencersand mass spectrometric analysis. Our results propose the systems biological view that TDP-43 serves as a molecular coordinator of the RNA-dependent regulation of gene transcription and translation pivotal for performing diverse neuronal functions and that the disruption of TDP-43-mediated molecularcoordination induces neurodegeneration in ALS and FTLD.

Research Products

• [Journal Article] Accumulation of a repulsiveaxonal guidance molecule RGMa in amyloidplaques: a possible hallmark of regenerativefailure in Alzheimer's disease brains. (2013)
  • Author(s): Satoh J, Tabunoki H, Ishida T, Saito Y,Arima K.
  • Journal Title: Neuropathology and Applied Neurobiology Volume: 39(2) Issue: 2 Pages: 109-120
  • DOI: 10.1111/j.1365-2990.2012.01281.x
  • Peer Reviewed
• [Journal Article] A comprehensive profile of ChIP-Seq-based STAT1 trgetgenes suggests the complexity ofSTAT1-mediated gene regulatorymechanisms. (2013)
  • Author(s): Satoh J, Tabunoki H.
  • Journal Title: Gene Regulation and SystemsBiology Volume: in press Pages: 41-56
  • DOI: 10.4137/grsb.s11433
  • Peer Reviewed
• [Journal Article] Molecular network ofChIP-Seq-based vitamin D receptor targetgenes. (2013)
  • Author(s): Satoh J, Tabunoki H.
  • Journal Title: Multiple Sclerosis Volume: in press Issue: 8 Pages: 1035-1045
  • DOI: 10.1177/1352458512471873
  • Peer Reviewed
• [Journal Article] Ubiquilin-1 immunoreactivity isconcentrated on Hirano bodies anddystrophic neurites in Alzheimer's diseasebrains. (2013)
  • Author(s): Satoh J, Tabunoki H, Ishida T, Saito Y,Arima K.
  • Journal Title: Neuropathology and Applied Neurobiology Volume: in press Issue: 7 Pages: 817-830
  • DOI: 10.1111/nan.12036
  • Peer Reviewed
• [Journal Article] Reactive astrocytes express the potassium channel Kir4.1 inactive multiple sclerosis lesions. (2013)
  • Author(s): Satoh J, Tabunoki H, Ishida T, Saito Y,Konno H, Arima K.
  • Journal Title: Clinical andExperimental Immunology Volume: in press Issue: 1 Pages: 19-28
  • DOI: 10.1111/cen3.12011
  • Peer Reviewed
• [Journal Article] Immunohistochemicalcharacterization of gamma-secretaseactivating protein expression in Alzheimer'sdisease brains. (2012)
  • Author(s): Satoh J, Tabunoki H, Ishida T, Saito Y, Arima K.
  • Journal Title: Neuropathology and AppliedNeurobiology Volume: 38(2) Issue: 2 Pages: 132-141
  • DOI: 10.1111/j.1365-2990.2011.01206.x
  • Peer Reviewed
• [Journal Article] Phosphorylated Sykexpression is enhanced in Nasu-Hakoladisease brains. (2012)
  • Author(s): Jinnai K, Futamura N, Kobayashi M,Toyoshima I, Yoshioka T, Enomoto K, AraiN, SaitoY, Arima K.
  • Journal Title: Neuropathology Volume: 32(2) Issue: 2 Pages: 149-157
  • DOI: 10.1111/j.1440-1789.2011.01256.x
  • Peer Reviewed
• [Journal Article] Molecular network of microRNAtargets in Alzheimer's disease brains. (2012)
  • Author(s): Satoh J.
  • Journal Title: Experimental Neurology Volume: 235(2) Issue: 2 Pages: 436-446
  • DOI: 10.1016/j.expneurol.2011.09.003
  • Peer Reviewed
• [Journal Article] Geneexpression profile of THP-1 monocytesfollowing knockdown of DAP12, a causativegene for Nasu-Hakola disease. (2012)
  • Author(s): Satoh J, Shimamura Y, Tabunoki H.
  • Journal Title: Cellular andMolecular Neurobiology Volume: 32(3) Issue: 3 Pages: 337-343
  • DOI: 10.1007/s10571-011-9769-z
  • Peer Reviewed
• [Journal Article] Molecular networkprofiling of U373MG human glioblastomacells following induction of apoptosis bynovel marine-derived anti-cancer1,2,3,4-tetrahydroisoquinoline alkaloids. (2012)
  • Author(s): Tabunoki H, Saito N, Suwanborirux K,Charupant K, Satoh J.
  • Journal Title: Cancer Cell International Volume: 12(1) Issue: 1 Pages: 1-14
  • DOI: 10.1186/1475-2867-12-14
  • Peer Reviewed
• [Journal Article] Dystrophic neurites expressC9orf72 in Alzheimer's disease brains. (2012)
  • Author(s): Satoh J, Tabunoki H, Ishida T, Saito Y,Arima K.
  • Journal Title: Alzheimer's Research and Therapy Volume: 4(4) Issue: 4
  • DOI: 10.1186/alzrt136
  • Peer Reviewed
• [Journal Article] Molecular network analysis ofhuman microRNA targetome: from cancersto Alzheimer's disease. (2012)
  • Author(s): Satoh J.
  • Journal Title: BioData Mining Volume: 5(1) Issue: 1
  • DOI: 10.1186/1756-0381-5-17
  • Peer Reviewed
• [Journal Article] Immunohistochemicalcharacterization of microglia inNasu-Hakola disease brains. (2011)
  • Author(s): Satoh J, Tabunoki H, Ishida T, Yagishita S,Jinnai K, Futamura N, Kobayashi M,Toyoshima I, Yoshioka T, Enomoto K, AraiN, Arima K.
  • Journal Title: Neuropathology Volume: 31(4) Issue: 4 Pages: 363-375
  • DOI: 10.1111/j.1440-1789.2010.01174.x
  • Peer Reviewed
• [Journal Article] Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family (2011)
  • Author(s): Numasawa, Y., Yamaura, C., Ishihara, S., Shintani, S., Yamazaki, M., Tabunoki, H., Satoh, JI.
  • Journal Title: European Journal of Neurology Volume: 18 Issue: 9 Pages: 1179-1183
  • DOI: 10.1111/j.1468-1331.2010.03311.x
  • Peer Reviewed
• [Journal Article] Non-phosphorylatedFTY720 induces apoptosis of humanmicroglia by activating SREBP2. (2011)
  • Author(s): Yoshino T, Tabunoki H, Sugiyama S, IshiiK, Kim SU, Satoh J.
  • Journal Title: Cellularand Molecular Neurobiology Volume: 31(7) Issue: 7 Pages: 1009-1020
  • DOI: 10.1007/s10571-011-9698-x
  • Peer Reviewed
• [Journal Article] BmDJ-1 is a keyregulator of oxidative modification in thedevelopment of the silkworm (2011)
  • Author(s): Tabunoki H, Ode H, Banno Y, Katsuma S,Shimada T, Mita K, Yamamoto K, Sato R,Ishii-Nozawa R, Satoh J.
  • Journal Title: Bombyx mori.PLoS One Volume: 6(3) Issue: 3 Pages: e17683-e17683
  • DOI: 10.1371/journal.pone.0017683
  • Peer Reviewed
• [Journal Article] Comprehensiveanalysis of human microRNA targetnetworks. (2011)
  • Author(s): Satoh J, Tabunoki H.
  • Journal Title: BioData Mining Volume: 4 Issue: 1
  • DOI: 10.1186/1756-0381-4-17
  • Peer Reviewed
• [Journal Article] A Japanese case withNasu-Hakola disease of DAP12 genemutation exhibiting precuneushypoperfusion. (2011)
  • Author(s): Nakamagoe K, Shioya A, Yamaguchi T,Takahashi H, Koide R, Monzen T, Satoh J,Tamaoka A.
  • Journal Title: Internal Medicine Volume: 50(22) Pages: 2839-2844
  • URL: http://dx.doi.org/10.2169/internalmedicine.50.5891
  • Peer Reviewed
• [Journal Article] BmDJ-1 is a key regulator of oxidative modification in the development of the silkworm, Bombyx mori (2011)
  • Author(s): Tabunoki H, Ode H, Banno Y, Katsuma S, Shimada T, Mita K, Yamamoto K, Sato R, Ishii-Nozawa R, Satoh J
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] 神経変性と神経炎症の分子ネットワーク解析.脳内免疫システム:明らかになる神経疾患との関わり (2011)
  • Author(s): 佐藤準一
  • Journal Title: 細胞工学 Volume: 30 Pages: 1028-1035
• [Journal Article] 分子ネットワークからみた多発性硬化症の創薬標的分子.特集I神経免疫の新展開 (2011)
  • Author(s): 佐藤準一
  • Journal Title: 炎症と免疫 Volume: 19 Pages: 543-552
• [Journal Article] Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. (2011)
  • Author(s): Satoh J, Tabunoki H, Ishida T, Yagishita S, Jinnai K, Futamura N, Kobayashi M, Toyoshima I, Yoshioka T, Enomoto K, Arai N, Arima K
  • Journal Title: Neuropathology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Stable expression of neurogenin 1induces LGR5, a novel stem cell marker, inan immortalized human neural stem cell line HB1.F3. (2010)
  • Author(s): Satoh J, Obayashi S, Tabunoki H, Wakana T,Kim SU.
  • Journal Title: Cellular and MolecularNeurobiology Volume: 30(3) Issue: 3 Pages: 415-426
  • DOI: 10.1007/s10571-009-9466-3
  • Peer Reviewed
• [Journal Article] TDP-43 dimerizes in human cells in culture. (2010)
  • Author(s): Shiina Y, Arima K, Tabunoki H, Satoh J.
  • Journal Title: Cellular and Molecular Neurobiology Volume: 30(4) Issue: 4 Pages: 641-652
  • DOI: 10.1007/s10571-009-9489-9
  • Peer Reviewed
• [Journal Article] AberrantmicroRNA expression in the brains ofneurodegenerative diseases: miR-29adecreased in Alzheimer disease brainstargets neuro navigator-3. (2010)
  • Author(s): Shioya M, Obayashi S, Tabunoki H, ArimaK, Saito Y, Ishida T, Satoh J.
  • Journal Title: Neuropathologyand Applied Neurobiology Volume: 36(49) Issue: 4 Pages: 320-330
  • DOI: 10.1111/j.1365-2990.2010.01076.x
  • Peer Reviewed
• [Journal Article] MicroRNAs and their therapeuticpotential for human diseases: AberrantmicroRNA expression in Alzheimer diseasebrains. (2010)
  • Author(s): Satoh J.
  • Journal Title: Journal of Pharmacological Sciences Volume: 114(3) Pages: 269-275
  • URL: http://dx.doi.org/10.1254/jphs.10R11FM
  • Peer Reviewed
• [Journal Article] Bioinformatics approach toidentifying molecular biomarkers andnetworks in multiple sclerosis. (2010)
  • Author(s): Satoh J.
  • Journal Title: Clinical andExperimental Neuroimmunology Volume: 1(3) Issue: 3 Pages: 127-140
  • DOI: 10.1111/j.1759-1961.2010.00013.x
  • Peer Reviewed
• [Journal Article] Protein microarray analysis identifies cyclic nucleotide phosphodiesterase as an interactor of Nogo-A. (2010)
  • Author(s): Sumiyoshi K, Obayashi S, Tabunoki H, Arima K, Satoh J
  • Journal Title: Neuropathology Volume: 30 Pages: 7-14
  • NAID: 10029319754
  • Peer Reviewed
• [Journal Article] Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized human neural stem cell line HB1.F3. (2010)
  • Author(s): Satoh J, Obayashi S, Tabunoki H, Wakana T, Kim SU
  • Journal Title: Cellular and Molecular Neurobiology Volume: 30 Pages: 415-426
  • Peer Reviewed
• [Journal Article] TDP-43 dimerizes in human cells in culture. (2010)
  • Author(s): Shiina Y, Arima K, Tabunoki H, Satoh J
  • Journal Title: Cellular and Molecular Neurobiology Volume: 30 Pages: 641-652
  • Peer Reviewed
• [Journal Article] Aberrant microRNA expression in the brains of neurodegenerative diseases : miR-29a decreased in Alzheimer disease brains targets neuron navigator-3. (2010)
  • Author(s): Shioya M, Obayashi S, Tabunoki H, Arima K, Saito Y, Ishida T, Satoh J
  • Journal Title: Neuropathology and Applied Neurobiology Volume: 36 Pages: 320-330
  • Peer Reviewed
• [Journal Article] MicroRNAs and their therapeutic potential for human diseases : Aberrant microRNA expression in Alzheimer disease brains. (2010)
  • Author(s): Satoh J
  • Journal Title: Journal of Pharmacological Sciences Volume: 114 Pages: 269-275
  • Peer Reviewed
• [Journal Article] Bioinformatics approach to identifying molecular biomarkers and networks in multiple sclerosis. (2010)
  • Author(s): Satoh J
  • Journal Title: Clinical and Experimental Neuroimmunology Volume: 1 Pages: 127-140
  • Peer Reviewed
• [Journal Article] 多発性硬化症病変分子のネットワーク解析ヒト免疫疾患研究の新展開-From clinic to bench. (2010)
  • Author(s): 佐藤準一
  • Journal Title: 日本臨床免疫学会会誌 Volume: 33 Pages: 182-188
• [Journal Article] Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family. (2010)
  • Author(s): Numasawa Y, Yamaura C, Shintani S, Yamazaki M, Tabunoki H, Satoh J
  • Journal Title: European Journal of Neurology Volume: (in press)
  • Peer Reviewed
• [Presentation] Molecular network profiling ofU373MG human glioblastoma cellsfollowing induction of apoptosis by novelmarine-derived anti-cancer1,2,3,4-tetrahydroisoquinoline alkaloids. (2012)
  • Author(s): Satoh J.
  • Organizer: TheJSPS 3rd Medicinal Chemistry Seminar ofAsia/Africa Scientific Platform Program.
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-12-04
• [Presentation] Isolationand characterization of SOD1 and SOD2 insilkworm Bombyx mori. (2012)
  • Author(s): Nojima Y, Tabunoki H, Satoh J.
  • Organizer: The JSPS 3rdMedicinal Chemistry Seminar of Asia/AfricaScientific Platform Program.
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-12-04
• [Presentation] Identification of a key uric acid synthesisregulator in a novel silkworm Bombyx morimodel of Parkinson's disease. (2012)
  • Author(s): Kawana N, Tabunoki H, Nojima Y, Satoh J.
  • Organizer: The JSPS 3rdMedicinal Chemistry Seminar of Asia/Africa Scientific Platform Program.
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-12-04
• [Presentation] Molecular networkanalysis of ChIP-Seq-based vitamn D Targetgenes. (2012)
  • Author(s): Satoh J, Tabunoki H.
  • Organizer: The 11th International Congress of Neuroimmunolog
  • Place of Presentation: Boston, MA, USA
  • Year and Date: 2012-11-06
• [Presentation] Accumulation of arepulsive axonal guidance molecule RGMain amyloid plaques: a pathological hallmarkof regeneration failure in Alzheimer'sdisease brains. Keystone Symposia onMoleular and Cellular Biology. (2012)
  • Author(s): Satoh J, Tabunoki H.
  • Organizer: Aging andDiseases of Aging.
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-10-25
• [Presentation] Immunohistochemical characterization ofgamma-secretase activating protein (GSAP)expression in Alzheimer's disease brains. (2012)
  • Author(s): Satoh J, Tabunoki H, Arima K.
  • Organizer: The 64th Annual Meeting of American Academy of Neurology. New Orleans
  • Place of Presentation: LA,USA
  • Year and Date: 2012-04-25
• [Presentation] TDP-43標的遺伝子と結合タンパクの分子ネットワーク解析 (2012)
  • Author(s): 佐藤準一、島村悦光、野島陽水、天竺桂弘子
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2012-03-29
• [Presentation] Geneexpression profile of THP-1 monocytesfollowing knockdown of DAP12, a causativegene for Nasu-Hakola disease. (2012)
  • Author(s): Satoh J, Shimamura Y, Tabunoki H.
  • Organizer: The 7thInternational Conference on Rare Diseasesand Orphan Drugs.
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-02-05
• [Presentation] Banno Y,Satoh J. BmDJ-1 is a key regulator ofoxidative modification in the developmentof the silkworm, Bombyx mori. 2011 Annual (2011)
  • Author(s): Tabunoki H, Shimada T, Mita K
  • Organizer: Meeting of the Society for Neuroscience.Washington DC
  • Place of Presentation: USA
  • Year and Date: 2011-11-14
• [Presentation] BmDJ-1 is a key regulator of oxidative modification in the development of the silkworm, Bombyx mori (2011)
  • Author(s): Tabunoki H, Shimada T, Mita K, Banno Y, Satoh J
  • Organizer: 2011 Annual Meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-14
• [Presentation] BmDJ-1 is a keyregulator of oxidative modification in thedevelopment of the silkworm, Bombyx mori. (2011)
  • Author(s): Tabunoki H, Banno Y, Katsuma S, ShimadaT, Mita K, Satoh J.
  • Organizer: Queenstown Molecular Biology Meetings2011.
  • Place of Presentation: Queenstown, New Zealand
  • Year and Date: 2011-08-30
• [Presentation] Molecular networkanalysis of microRNA targets suggestsaberrant expression of cell cycle regulatorsin Alzheimer's disease brains. (2011)
  • Author(s): Satoh J, Tabunoki H.
  • Organizer: The 9thInternational Workshop on AdvancedGenomics. Revolution of Genome Science.
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2011-07-12
• [Presentation] Molecular network analysis of microRNA targets suggests aberrant expression of cell cycle regulators in Alzheimer's disease brains (2011)
  • Author(s): Satoh J, Tabunoki H
  • Organizer: The 9th International Workshop on Advanced Genomics
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2011-07-12
• [Presentation] Immunohistochemical characterization ofmicroglia in Nasu-Hakola disease brains. (2011)
  • Author(s): Satoh J, Tabunoki H, Arima K.
  • Organizer: The 63rd Annual Meeting of AmericanAcademy of Neurology.
  • Place of Presentation: Honolulu, HI, USA
  • Year and Date: 2011-04-12
• [Presentation] Immunohistochemical characterization of microglia in Nasu-Hakola disease brains (2011)
  • Author(s): Satoh J, Tabunoki H, Arima K
  • Organizer: 63rd Annual Meeting of American Academy of Neurology
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2011-04-12
• [Presentation] TDP-43インターラクトームの分子ネットワーク解析 (2011)
  • Author(s): 佐藤準一、吉野隆、小口翔、天竺桂弘子
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: Shizuoka, Japan
  • Year and Date: 2011-03-28
• [Presentation] Comprehensive analysis of human microRNA target networks. (2010)
  • Author(s): Satoh J, Tabunoki H
  • Organizer: 2010 Annual conference of the Japanese Society for Bioinformatics
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2010-12-14
• [Presentation] Ishida T,Jinnai K, Arima K. Immunopathogenesis of brain lesions of Nasu-Hakola disease. (2010)
  • Author(s): Satoh J, Tabunoki H, Kim SU
  • Organizer: The10th International Congress ofNeuroimmunology.
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-10-27
• [Presentation] Immunopathogenesis of brain lesions of Nasu-Hakola disease. (2010)
  • Author(s): Satoh J, Tabunoki H, Kim SU, Ishida T, Jinnai K, Arima K
  • Organizer: 10th International Congress of Neuroimmunology
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-10-27
• [Presentation] Immunopathogenesis ofNasu-Hakola disease brain lesions. (2010)
  • Author(s): Satoh J, Tabunoki H, Kim SU, Ishida T,Jinnai K, Arima K.
  • Organizer: The 14thInternational Congress of Immunology.
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] Immunopathogenesis of Nasu-Hakola disease brain lesions. (2010)
  • Author(s): Satoh J, Tabunoki H, Kim SU, Ishida T, Jinnai K, Arima K
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] Immunohistochemical characterization of gamma-secretase activating protein (GSAP) expression in Alzheimer’s disease brains.
  • Author(s): Satoh J
  • Organizer: The 64th Annual Meeting of American Academy of Neurology.
  • Place of Presentation: New Orleans, LA, USA
• [Presentation] Accumulation of a repulsive axonal guidance molecule RGMa in amyloid plaques: a pathological hallmark of regeneration failure in Alzheimer’s disease brains.
  • Author(s): Satoh J
  • Organizer: Keystone Symposia on Molecular and Cellular Biology. Aging and Diseases of Aging.
  • Place of Presentation: Tokyo, Japan
• [Presentation] Molecular network analysis of ChIP-Seq-based vitamn D Target genes.
  • Author(s): Satoh J
  • Organizer: The 11th International Congress of Neuroimmunology.
  • Place of Presentation: Boston, MA, USA
• [Book] Gene expression profiling and pathway analysis for identification ofmolecular targets in MS. In MultipleSclerosis Immunology - a Foundation forCurrent and Future Treatments, ed by (2013)
  • Author(s): Satoh J.
  • Publisher: GranB and Yamamura T. Springer, Dordrecht,Netherands, in press
• [Book] Gene expression profiling and pathway analysis for identification of molecular targets in MS. In Multiple Sclerosis Immunology - a Foundation for Current and Future Treatments. (2013)
  • Author(s): Satoh J
  • Publisher: Springer
• [Book] Molecular network analysis oftarget RNAs and interacting proteins ofTDP-43, a causative gene forneurodegenerative diseases ALS/FTLD. InTechnological Advancements inBiomedicine for Healthcare Applications, edby (2012)
  • Author(s): Satoh J.
  • Publisher: Wu J. IGI Global, Hershey, Pennsylvania
• [Book] Human microRNA targetomeindicates a specialized role of microRNAs inregulation of oncogenesis. In SystemsBiology in Cancer Research and DrugDiscovery, ed by Azumi AS. (2012)
  • Author(s): Satoh J.
  • Publisher: Springer,Dordrecht, Netherlands
• [Book] Molecular network analysis of target RNAs and interacting proteins of TDP-43, a causative gene for neurodegenerative diseases ALS/FTLD. In Technological Advancements in Biomedicine for Healthcare Applications. (2012)
  • Author(s): Satoh J
  • Total Pages: 22
  • Publisher: IGI Global
• [Book] Human microRNA targetome indicates a specialized role of microRNAs in regulation of oncogenesis. In Systems Biology in Cancer Research and Drug Discovery. (2012)
  • Author(s): Satoh J
  • Total Pages: 20
  • Publisher: Springer
• [Book] Biomedical Engineering and Cognitive Neuroscience for Healthcare : Interdisciplinary Applications. Molecular network analysis of target RNAs and interacting proteins of TDP-43, a causative gene for the neurodegenerative diseases ALS/FTLD (2011)
  • Author(s): Satoh J
  • Publisher: IGI Global(in press)
• [Book] Systems Biology and Cancer. Human microRNA targetome indicates a specialized role of microRNAs in regulation of oncogenesis (2011)
  • Author(s): Satoh J
  • Publisher: Springer(in press)
• [Book] アクチュアル脳・神経疾患の臨床.最新アプローチ.多発性硬化症と視神経脊髄炎.網羅的遺伝子発現解析からみた病因・病態.多発性硬化症の病態と診断.病因・病態をめぐって (2011)
  • Author(s): 佐藤準一
  • Publisher: 中山書店(in press)
• [Book] プロトアレイによるタンパク質インターラクトーム解析.創薬研究のためのタンパク質・プロテオミクス解析技術 (2010)
  • Author(s): 佐藤準一
  • Total Pages: 6
  • Publisher: 羊土社
• [Remarks]
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• [Remarks] 明治薬科大学バイオインフォマティクス研究室ホームページ
  • URL: http://www.my-pharm.ac.jp/~satoj/
• [Remarks]
  • URL: http://www.my-pharm.ac.jp/~satoj/
• [Remarks]
  • URL: http://www.my-pharm.ac.jp/~satoj/