Identification of glioma progenital cells and their niche
| Project/Area Number |
22500323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
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Principal Investigator |
KOMORI Takashi 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 研究員 (90205526)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKO Atsushi 埼玉医科大学, 医学部, 教授 (80225862)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 悪性神経膠腫 / 前駆細胞 / 病理形態 / 遺伝子解析 / 乏突起膠腫 / 悪性膠腫 / 脳腫瘍 / 予後 / ヒト悪性膠腫 / chondroitin sulfate proteoglycan / astroctoma / oligodendroglioma / glioblastoma |
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| Research Abstract |
In the first step of the study, anti-CSPG4 antibodies, a maker for NG2 glia, failed to disclose constituent tumor cells in human malignant glioma tissues. We then characterized oligodendroglioma that express Olig2, a transcription factor acted on oligodendrocyte progenitors. Our study revealed that classic oligodendroglioma is a distinct monoclonal tumor that harbors isocitrate dehydrogenases-1 (IDH1) R132H mutation and chromosome 1p/19 co-deletion but lacks p53 and CIC expression.
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Report
(4 results)
Research Products
(22 results)
