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Identification of glioma progenital cells and their niche

Research Project

Project/Area Number 22500323
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research Institution公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011)

Principal Investigator

KOMORI Takashi  公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, 研究員 (90205526)

Co-Investigator(Kenkyū-buntansha) SASAKO Atsushi  埼玉医科大学, 医学部, 教授 (80225862)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords悪性神経膠腫 / 前駆細胞 / 病理形態 / 遺伝子解析 / 乏突起膠腫 / 悪性膠腫 / 脳腫瘍 / 予後 / ヒト悪性膠腫 / chondroitin sulfate proteoglycan / astroctoma / oligodendroglioma / glioblastoma
Research Abstract

In the first step of the study, anti-CSPG4 antibodies, a maker for NG2 glia, failed to disclose constituent tumor cells in human malignant glioma tissues. We then characterized oligodendroglioma that express Olig2, a transcription factor acted on oligodendrocyte progenitors. Our study revealed that classic oligodendroglioma is a distinct monoclonal tumor that harbors isocitrate dehydrogenases-1 (IDH1) R132H mutation and chromosome 1p/19 co-deletion but lacks p53 and CIC expression.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (22 results)

All 2013 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (11 results) (of which Invited: 3 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Dysembryoplastic neuroeithelial tumor, a pure glial Tumor? Immunohistochemical and morphometric studies2013

    • Author(s)
      Komori T, Arai N
    • Journal Title

      Neuropathology

      Volume: in press Issue: 4 Pages: 459-468

    • DOI

      10.1111/neup.12033

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intraoperative flow cytometry analysis of glioma tissue for rapid determination of tumor presence and its histopathological grade2013

    • Author(s)
      Shioyama T, Muragaki Y, Maruyama T, Komori T, Iseki H
    • Journal Title

      J Neurosurg

      Volume: 118 Issue: 6 Pages: 1232-1238

    • DOI

      10.3171/2013.1.jns12681

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological features of sellar region xanthogranuloma: correlation with Rathke's cleft cyst2013

    • Author(s)
      Amano K, Kubo O, Komori T, et al
    • Journal Title

      Brain Tumor Pathology

      Volume: 30 Issue: 4 Pages: 233-241

    • DOI

      10.1007/s10014-012-0130-0

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic and management difficulties in a case of multiple intracranial juvenile xanthogranuloma2013

    • Author(s)
      Chiba, K
    • Journal Title

      Brain Tumor Pathology

      Volume: in press

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Papillary tumor of the pineal region: a case involving isocitrate dehydrogenase2012

    • Author(s)
      Ishida A, Shibuya M, Komori T, et al
    • Journal Title

      IDH) genotyping

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clear cells are associated with proliferative activity in ependymoma: a quantitative study2012

    • Author(s)
      Ishizawa K, Komori T, Aihara Y, et al
    • Journal Title

      Clin Neuropathol

      Volume: 31 Pages: 146-151

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathologic diversity of glioneuronal tumor with neuropil-like islands2012

    • Author(s)
      Ishizawa K, et al
    • Journal Title

      Clinical Neuropathology

      Volume: 31 Pages: 67-76

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolated neurosarcoidosis in the medulla oblongata involving the fourth ventricle: a case report2011

    • Author(s)
      Lee JH, Takai K, Ota M, Komori T, Taniguchi M
    • Journal Title

      British Journal of Neurosurgery

      Volume: 27 Issue: 3 Pages: 393-395

    • DOI

      10.3109/02688697.2012.741736

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mixed neuronal-glial tumor-概念と病理学的問題点2011

    • Author(s)
      小森隆司
    • Journal Title

      東京女子医科大学雑誌

      Volume: 81巻、特別号 Pages: 37-44

    • NAID

      110008439097

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Standardization of pathological diagnosis of oligodendrogliomas2013

    • Author(s)
      Komori T
    • Place of Presentation
      Mumbai、India
    • Year and Date
      2013-03-22
    • Related Report
      2012 Final Research Report
  • [Presentation] てんかん原生脳腫瘍の組織学的スペクトラム:特に神経細胞性分化について2012

    • Author(s)
      小森隆司
    • Organizer
      第53回日本神経病理学会シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2012-06-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Standardization of Pathological Diagnosis of Oligodendrogliomas2012

    • Author(s)
      Komori T
    • Organizer
      The 4th International Symposium of Brain Tumor Pathology
    • Place of Presentation
      名古屋
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Glioneuronal tumor with neuropil-like islands5例におけるisocitrate dehydrogemase 1 (IDH1)の免疫組織化学的検討2011

    • Author(s)
      石澤圭介、廣瀬隆則、小森隆司、他
    • Organizer
      第52回日本神経病理学会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Pediatric brain tumor of posterior fossa2011

    • Author(s)
      Komori T
    • Organizer
      8th Meeting of Asian Society for Neuro-Oncology
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2011-05-27
    • Related Report
      2012 Final Research Report
  • [Presentation] グリオーマ悪性度分類標準化の試み2011

    • Author(s)
      小森隆司 佐々木惇、廣瀬隆則、他
    • Organizer
      第29回日本脳腫瘍病理学会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] グリオーマ悪性度分類標準化の試み2011

    • Author(s)
      小森隆司, 他
    • Organizer
      第29回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Grade II glioma再発症例における初回治療時の再発予測因子の検討2010

    • Author(s)
      丸山隆志、小森隆司, 他
    • Organizer
      第28回日本脳腫瘍病理学会
    • Place of Presentation
      大阪市中央公会堂
    • Year and Date
      2010-05-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] Standardization of Pathological Diagnosis of Oligodendrogliomas

    • Author(s)
      Komori, T
    • Organizer
      4th International Symposium of Brain Tumor Pathology
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] てんかん原生脳腫瘍の組織学的スペクトラム

    • Author(s)
      小森隆司
    • Organizer
      第53回日本神経病理学会
    • Place of Presentation
      新潟市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Standardization of Pathological Diagnosis of Oligodendrogliomas

    • Author(s)
      Komori,T
    • Organizer
      The 10th Meeting of Asian Society for Neuro-Oncology
    • Place of Presentation
      Mumbai, India
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 神経細胞系腫瘍 癌診療指針のための病理診断プラクティス 脳腫瘍 169-1852012

    • Author(s)
      小森隆司
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report
  • [Remarks] 東京都医学研・脳神経病理データベース

    • URL

      http://pathologycenter.jp/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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