| Project/Area Number |
22500325
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2010-2011) |
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Principal Investigator |
UCHIHARA Toshiki 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (10223570)
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| Co-Investigator(Renkei-kenkyūsha) |
ORIMO Satoshi 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (10392359)
HASHIMOTO Makoto 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (50189502)
WADA Masaaki 大阪大学, 情報科学研究所, 教授 (80192821)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 神経変性疾患 / シヌクレイン / パーキンソン病 / 電子顕微鏡 / tau isoform / profile shift / 免疫電顕 / 軸索 / Pale neurite / αシヌクレイン / 3リピートタウ |
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| Research Abstract |
We traced the Lewy pathology in human brain and demonstrated its initiation at distal axon and subsequent centripetal extension. Expected dysfunction at distal axons, detectable as a decreased myocardial uptake of MIBG, is a reasonable candidate for early and specific diagnosis of Lewy body disease. In contrast, tau deposition start as 4R deposits in dendrites, which may undertake transition to 3R tau with centripetal progression, as we demonstrated with double labeling for 3R/4R tau. We also established a new method to compare light and immunoelectron microscopic findings of the same lesion, which is potentially useful to bridge molecular changes to lesion formation.
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