Identification and characterization of microRNAs involved in molecular mechanism of emotional memory
Project/Area Number |
22500328
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Gunma University |
Principal Investigator |
KOJIMA Nobuhiko 群馬大学, 大学院・医学系研究科, 准教授 (80215251)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 恐怖条件づけ / microRNA / 扁桃体 / 遺伝子発現 / マイクロアレイ / 情動記憶 / マイクロアレイ解析 / 海馬 / 脳・神経 / 発現制御 |
Research Abstract |
Exploring the molecular mechanism underlying emotional memory is important for understanding not only how the brain works, but also how psychiatric disorder such as PTSD occurs. It has been known that expression of genes involved in the formation and maintenance of long-term fear memory is dynamically changed during the processes of emotional memory. In this study to know the contribution of microRNA in the processes of fear memory formation, genome-wide screening of microRNAs whose expression is altered in the amygdala after fear conditioning using microRNA microarray. As a result,13 microRNAs were identified: 3 were increased and 10 were decreased. Investigation of the role of these microRNAs will allow us a better understanding of the new aspects of communication between the synapse and the nucleus underlying the long-term retention of emotional memory.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice2011
Author(s)
Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N
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Journal Title
Neurobiology of Disease
Volume: 42
Issue: 3
Pages: 404-414
DOI
Related Report
Peer Reviewed
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