The mechanism of anorectic effect from MCH1R antagonism in the peripheral tissue
| Project/Area Number |
22500331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
濱田 洋司 名古屋大学, 医学(系)研究科(研究院), 准教授 (20293706)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | メラニン凝集ホルモン / 阻害剤 / G蛋白共役受容体 / 摂食調節 / 神経科学 |
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| Research Abstract |
We have developed a non-peptide antagonist formelanin-concentrating hormone receptor 1 (MCH1R), TPI1361-17 (TPI). TPI does not crossblood brain barrier, and the intra-peritoneal administration cause prominent anorexiceffect in mice, which suggest MCH system localize in peripheral tissues, as well as incentral nervous systems. Oral glucose load reduced MCH level in circulation. In thediet-induced obese mice, TPI reduced body weight, food intake, and improved insulinresistance. These results suggest that MCH system localize in peripheral tissues and itmay regulate energy homeostasis.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide Y gene in rats2012
Author(s)
Ozawa Y, Arima H, Banno R, Ito Y, Goto M, Morishita Y, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y
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Journal Title
Neuroreport
Volume: 23(11)
Pages: 673-5
Related Report
Peer Reviewed
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[Journal Article] Lesion of area postrema attenuated hyperphagic responses to glucoprivation, but not transcriptional activation of the neuropeptide Y gene in rats.2012
Author(s)
Ozawa Y, Arima H, Banno R, Ito Y, Goto M, Morishita Y, Sugimura Y, Ozaki N, Nagasaki H, Oiso Y.
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Journal Title
Neuroreport
Volume: 23
Pages: 673-675
Related Report
Peer Reviewed
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[Journal Article] Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor：TNF-α enhances GPR84 expression in adipocytes2012
Author(s)
Nagasaki H, Kondo T, Fuchigami M, Hashimoto H, Sugimura Y, Ozaki N, Arima H, Ota A, Oiso Y, Hamada Y
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Journal Title
FEBS Letters
Volume: 586
Pages: 368-372
Related Report
Peer Reviewed
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[Journal Article] Palmitate induces apoptosis inSchwann cells via bothceramide-dependent and independentpathways2011
Author(s)
Suzuki J, Akahane K, Nakamura J, Naruse K, Kamiya H, Himeno T, NakamuraN, Shibata T, Kondo M, Nagasaki H,Fujiya A, Oiso Y, Hamada Y
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Journal Title
Neuroscience
Volume: 176
Pages: 188-198
Related Report
Peer Reviewed
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[Journal Article] Low-serum culture system improvesthe adipogenic ability of visceral adipose tissue-derived stromalcells2011
Author(s)
Nagasaki H, Shang Q, Suzuki T,Hashimoto H, Yoshimura T, Kondo TA,Ozaki T, Maruyama S, Jomori T, Oiso Y,Hamada Y.
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Journal Title
Cell Biol Int
Volume: 35
Pages: 559-568
Related Report
Peer Reviewed
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