| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Metabotropic glutamate receptors (mGluRs) play crucial roles in higher brain functions such as learning and memory formation. The purpose of this researchproject is to identify novel signal transduction mechanisms of mGluRs and to elucidate the whole picture of mGluR-mediated regulation of synaptic function. Analysis of characteristic long C-terminal intracellular domain of mGluR1a revealed novel protein regions that controls intracellular localization of receptor molecules. Furthermore, screening of cDNA library using newly-developed yeast three-hybrid system successfully identify novel mGluR-interacting molecules. These results may improve the molecular understanding of synaptic regulation of central nervous system, and newly-identified molecules may become the candidate of drug development for neuropsychiatric diseases.
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