Analysis of novel intracellular signal transduction mechanism of metabotropic glutamate receptor.

• Project/Area Number: 22500332
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kyoto University
• Principal Investigator: MORIYOSHI Koki 京都大学, 医学部附属病院, 医員 (50263091)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: mGluR / スリーハイブリッド / 細胞内情報伝達 / 神経科学 / シグナル伝達 / グルタミン酸受容体 / 蛋白質

Research Abstract

Metabotropic glutamate receptors (mGluRs) play crucial roles in higher brain functions such as learning and memory formation. The purpose of this researchproject is to identify novel signal transduction mechanisms of mGluRs and to elucidate the whole picture of mGluR-mediated regulation of synaptic function. Analysis of characteristic long C-terminal intracellular domain of mGluR1a revealed novel protein regions that controls intracellular localization of receptor molecules. Furthermore, screening of cDNA library using newly-developed yeast three-hybrid system successfully identify novel mGluR-interacting molecules. These results may improve the molecular understanding of synaptic regulation of central nervous system, and newly-identified molecules may become the candidate of drug development for neuropsychiatric diseases.

Research Products

• [Journal Article] PD-1 Regulates the Growth of Human Mastocytosis Cells (2013)
  • Author(s): Kataoka TR, Fujimoto M, Moriyoshi K, Koyanagi I, Ueshima C, Kono F, Tsuruyama T, Okayama Y, Ra C, Haga H
  • Journal Title: Allergology International Volume: 62 Issue: 1 Pages: 99-104
  • DOI: 10.2332/allergolint.12-OA-0450
  • NAID: 130004477172
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Presentation] Multiple protein regions control cell surface expression of mGluR1a (2010)
  • Author(s): Moriyoshi K
  • Organizer: Annual Meeting of Society for Neuroscience
  • Place of Presentation: アメリカ合衆国、サンディエゴ・コンベンションセンター
  • Year and Date: 2010-10-16
• [Presentation] Multiple protein regions control cell surface expression of mGluR1a. (2010)
  • Author(s): 森吉弘毅
  • Organizer: 北米神経科学会年会(Annual Meeting of Society for Neuroscience)
  • Place of Presentation: アメリカ・サンディエゴ・コンベンションセンター
  • Year and Date: 2010-10-16
• [Presentation] クバプロ、ブレインサイエンス・レビュー (2010)
  • Author(s): 森吉弘毅
  • Place of Presentation: 264
• [Book] ブレインサイエンス・レビュー2010 (2010)
  • Author(s): 森吉弘毅, 他11名
  • Total Pages: 264
  • Publisher: クバプロ