analysis of synaptic transmission

Research Project

Project/Area Number	22500333
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Neurochemistry/Neuropharmacology
Research Institution	Kyoto University
Principal Investigator	NAKAJIMA Yoshiaki 京都大学, 大学院・医学研究科, 准教授 (10300724)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	受容体 / グルタミン酸受容体 / カルシウム結合蛋白 / カルシウムチャンネル / カルモデュリン / シナプス伝達 / CaBP1
Research Abstract	I identified novel mGluR-binding proteins which regulate synaptic transmission in a unique fashion. Then, I developed a high-through put analysis system for the receptorprotein interactions. Using this assay methods, I screened about 1000 drugs commonly used clinically to examine if they modulate the protein-interaction properties. I found several drugs which either enhance or diminish the interaction. The finding would be a basis of development of new therapeutics or a clue to possible sides effects of the drugs.