analysis of synaptic transmission
Project/Area Number |
22500333
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 受容体 / グルタミン酸受容体 / カルシウム結合蛋白 / カルシウムチャンネル / カルモデュリン / シナプス伝達 / CaBP1 |
Research Abstract |
I identified novel mGluR-binding proteins which regulate synaptic transmission in a unique fashion. Then, I developed a high-through put analysis system for the receptorprotein interactions. Using this assay methods, I screened about 1000 drugs commonly used clinically to examine if they modulate the protein-interaction properties. I found several drugs which either enhance or diminish the interaction. The finding would be a basis of development of new therapeutics or a clue to possible sides effects of the drugs.
|
Report
(4 results)
Research Products
(3 results)