| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
nNOS producs not only NO, but also ROS through uncoupling reaction. In this study, we investigated NO/ROS signaling, a novel concept for cellular signal transduction. In PC12 cells expressing nNOS splice variants, treatment with MPP+activated the NO/ROS signaling to form a second messenger, 8-nitro-cGMP. We found a novel signal pathway leading to cell death through 8-nitro-cGMP formation.
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