Hippocampal neuronal dematuration as a mechanism of action of antidepressant drugs
| Project/Area Number |
22500342
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAI Atsushi 日本医科大学, 医学部, 助教 (30386156)
IKEDA Yumiko 日本医科大学, 医学部, 助教 (10386154)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 神経科学 / 脳神経疾患 / 薬理学 / 生理学 / 行動学 / 抗うつ薬 / 海馬 / 神経細胞 / シナプス / 行動解析 / ストレス / 不安 |
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| Research Abstract |
We examined the effect of the antidepressant fluoxetine on behavior and hippocampal neurons in mice. A high dose of fluoxetine induced behavioral abnormalities including a marked day-to-day fluctuation of activity levels that correlated with functional dematuration of hippocampal neurons. In mice chronically treated with corticosterone that model depressive disorder, neuronal dematuration was facilitated. These results suggest that neuronal dematuration is enhanced in certain pathological states and that the induction of dematuration in the healthy state could contribute to adverse effects of antidepressants.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] The immature dentate gyrus represents a shared phenotype of mouse models of epilepsy and psychiatric disease.2013
Author(s)
Shin R, Kobayashi K, Hagihara H, Kogan JH, Miyake S, Tajinda K, Walton NM, Gross AK, Heusner CL, Chen Q, Tamura K, Miyakawa T, Matsumoto M.
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Journal Title
Bipolar Disord
Volume: －
Issue: 4
Pages: 405-421
DOI
Related Report
Peer Reviewed
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[Journal Article] Synaptosomal-associated protein 25 mutation induces immaturity of the dentate granule cells of adult mice.2013
Author(s)
Ohira K, Kobayashi K, Toyama K, Nakamura HK, Shoji H, Takao K, Takeuchi R, Yamaguchi S, Kataoka M, Otsuka S, Takahashi M, Miyakawa T.
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Journal Title
Molecular Brain
Volume: 6
Issue: 1
Pages: 12-12
DOI
Related Report
Peer Reviewed
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[Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013
Author(s)
Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
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Journal Title
Neuropsychopharmacology
Volume: 38(8)
Issue: 8
Pages: 1409-25
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice.2012
Author(s)
Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, Tamura H, Shiosaka S, Suzuki H, Miyakawa T, Fujiyoshi Y, Doi T.
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Journal Title
Mol Brain
Volume: 5
Issue: 1
Pages: 43-43
DOI
NAID
Related Report
Peer Reviewed
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