| Project/Area Number |
22500343
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKUBO Tadashi 北里大学, 医学部, 准教授 (10450719)
SATO Asako 北里大学, 医学部, 臨時職員(研究員) (10465932)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | ドーパミン受容体 / 遺伝子操作マウス / パーキンソン病 / 運動調節 / 協調運動 / 学習記憶 / 遺伝子工学 / 運動制御 / 大脳基底核 / 遺伝子操作動物 / マウス / 発生工学 / ドキシサイクリン |
|---|
| Research Abstract |
In Parkinson disease the degeneration of nigro-striatal dopamine neuron leads to depletion of dopamine and motor deficit. It is known that D1 and D2 dopamine receptors (D1R, D2R) expressed in the medium spiny neurons of striatum are involved to motor control. However, the regulatory mechanism of motor control via D1R and D2R remains to be clarified. In this study we found the conditional D1R-expressing mice controlled by Tet-off system showed decrease of motor activity in the homecage when D1R expression was suppressed in adult stage. This finding was opposite to the marked increase of motor activity of D1R KO mice. These suggest the presence or absence of D1R expression during mouse development is closely related to up-regulation or down-regulation of motor activity in adult stage.
|
