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Role of the newly identified area in primate dorsomedial prefrontal conrtex in the integrative regulation of behavioral strategies.

Research Project

Project/Area Number 22500349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionTohoku University

Principal Investigator

MATSUZAKA Yoshiya  東北大学, 大学院・医学系研究科, 講師 (30312557)

Co-Investigator(Kenkyū-buntansha) SHIMA Keisetsu  東北大学, 大学院・医学系研究科, 助教 (60124583)
Co-Investigator(Renkei-kenkyūsha) SAKAMOTO Kazuhiro  東北大学, 電気通信研究所, 助教 (80261569)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsシステム神経生理 / ニューロインフォマティクス / 背内側前頭前野 / 前頭前野 / ニューロン / 活動電位 / 行動戦術 / ニホンザル / 戦略 / 戦術
Research Abstract

Monkeys performed a task in which consecutively given cues allowed them to narrow down the response strategy and the action out of multiple possible choices. Neuronal activity recorded in the dorsomedial prefrontal cortex indicates that neurons in this region

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (58 results)

All 2013 2012 2011 2010 Other

All Journal Article (19 results) (of which Peer Reviewed: 14 results) Presentation (28 results) (of which Invited: 1 results) Remarks (6 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] Participation of neurons in multiple sectors of medial frontal cortex undergoes dynamic alterations depending on the demand for volitional control of action2013

    • Author(s)
      Yoshiya Matsuzaka, Tetsuya Akiyama, Hajime Mushiake
    • Journal Title

      Experimental Brain Res

      Volume: 229 Issue: 3 Pages: 395-405

    • DOI

      10.1007/s00221-013-3454-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal representation of task performance in the media frontal cortex undergoes dynamic alterations dependent upon the demand for volitional control of action2013

    • Author(s)
      Matsuzaka, Y et al
    • Journal Title

      Experimental Brain Research

      Volume: Epub. ahead of print

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optogenetically Induced Seizure and the Longitudinal Hippocampal Network Dynamics2013

    • Author(s)
      Osawa, S et al
    • Journal Title

      PLoS ONE

      Volume: Epub. ahead of print

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequency-dependent entrainment of neocortical slow oscillation to repeated optogenetic stimulation in the anesthetized rat2012

    • Author(s)
      Kuki T, Ohshiro T, Ito S, Ji G, Fukazawa Y, Matsuzaka Y, Yawo H, Mushiake H.
    • Journal Title

      Neurosci Res

      Volume: 75 Issue: 1 Pages: 35-45

    • DOI

      10.1016/j.neures.2012.10.007

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics.2012

    • Author(s)
      Matsuzaka Y, Akiyama T, Tanji J, Mushiake H.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 109 Issue: 12 Pages: 4633-8

    • DOI

      10.1073/pnas.1119971109

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bio-amplifier with driven shield inputs to reduce electrical noise and its application to laboratory teaching of electro- physiology2012

    • Author(s)
      Matsuzaka Y, Ichihara T, Abe T, Mushiake H
    • Journal Title

      J Undergrad Neurosci Educ

      Volume: 10

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling2012

    • Author(s)
      Aizawa E, Sato Y, Kochiyama T, Saito N, Izumiyama M, Morishita J, Kanazawa M, Shima K, Mushiake H, Hongo M, Fukudo S
    • Journal Title

      Gastroenterology

      Volume: 143(5) Issue: 5 Pages: 1188-1198

    • DOI

      10.1053/j.gastro.2012.07.104

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics2012

    • Author(s)
      Matsuzaka, et al
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Pages: 4633-4638

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bio-amplifier with driven shield inputs to reduce electrical noise and its application to laboratory teaching of electrophysiology2012

    • Author(s)
      Matsuzaka, et al
    • Journal Title

      Journal of Undergraduate Neuroscience Education

      Volume: 10 Pages: 118-124

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the medial frontal cortices in the selection, storage and retrieval of response tactics in a voluntary arm-reaching task2011

    • Author(s)
      Matsuzaka Y, et al
    • Journal Title

      Neurosci Res

      Volume: 71

    • Related Report
      2012 Final Research Report
  • [Journal Article] Deciphering elapsed time and predicting action timing from neuronal population signals2011

    • Author(s)
      S.Shinomoto, T.Omi, A.Mita, H.Mushiake, K.Shima, Y.Matsuzaka, J.Tanji
    • Journal Title

      Frontiers in Computational Neuroscience

      Volume: 5 Pages: 29-29

    • DOI

      10.3389/fncom.2011.00029

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of functional connectivity among cortical layersduring optogenetically induced perturbations2011

    • Author(s)
      Kuki T, Matuzaka Y, Fukazawa Y, Yawo H, Mushiake H.
    • Journal Title

      Neurosci Res

      Volume: 71

    • Related Report
      2012 Final Research Report
  • [Journal Article] Deciphering elapsed time and predicting action timing from neuronal population signals2011

    • Author(s)
      Shinomoto, et al
    • Journal Title

      Front Comput Neurosci

      Volume: 5 Pages: 29-39

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of functional connectivity among cortical layers during optogen etically induced perturbations2011

    • Author(s)
      Kuki, et al
    • Journal Title

      Neurosci Res

      Volume: 71

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Roles of the medial frontal cortices in the selection, storage and retrieval of response tactics in a voluntary arm-reaching task2011

    • Author(s)
      Matsuzaka, et al
    • Journal Title

      Neurosci Res

      Volume: 71

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Optimization of neuronal representation of action in primate supplementary motor area2010

    • Author(s)
      Matsuzaka Y, et al
    • Journal Title

      J Physiol Sci

      Volume: 60

    • Related Report
      2012 Final Research Report
  • [Journal Article] Opto-current-clamp actuation of cortical neurons using a strategically designed channel- rhodopsin2010

    • Author(s)
      Wen L, Wang H, Tanimoto S, Egawa R, Matsuzaka Y, Mushiake H, Ishizuka T, Yawo H.
    • Journal Title

      PLoS ONE

      Volume: 5 Issue: 9 Pages: 1-13

    • DOI

      10.1371/journal.pone.0012893

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Deficits in action selection based on numericalinformation after inactivation of the posterior parietal cortex in monkeys2010

    • Author(s)
      Sawamura H, Shima K, Tanji J.
    • Journal Title

      J Neurophysiol

      Volume: 104 Pages: 902-910

    • URL

      http://jn.physiology.org/content/104/2/902.long

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Opto-current-clamp actuation of cortical neurons using a strategically de signed channelrhodopsin2010

    • Author(s)
      Wen-L, 他
    • Journal Title

      Plos-One

      Volume: 5 Pages: 12890-12890

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] てんかん発作における海馬長軸方向ネットワークの重要性:オプトジェネティクスを用いた海馬けいれんモデルでの検討2013

    • Author(s)
      大沢伸一郎,岩崎真樹,保坂亮介,松坂義哉,富田浩史,石塚徹,菅野江里子,奥村栄一,八尾寛,中里信和,虫明元,冨永悌二
    • Organizer
      第36回日本てんかん外科学会
    • Place of Presentation
      岡山市
    • Year and Date
      2013-01-17
    • Related Report
      2012 Final Research Report
  • [Presentation] てんかん発作における海馬長軸方向ネットワークの重要性:オプトジェネティクスを用いた海馬けいれんモデルでの検討2013

    • Author(s)
      大沢 伸一郎 他
    • Organizer
      第36回日本てんかん外科学会
    • Place of Presentation
      岡山市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Artifact-less observation and low mortality compared with conventional animal models of seizures. It is promising tool to study the mechanism of ictogenesis2012

    • Author(s)
      Osawa S, Iwasaki M, Hosaka R, Matsuzaka Y, Tomita H, Ishizuka T, Sugano E, Okumura E, Yawo H, Nakasato N, Tominaga T, Mushiake H.
    • Organizer
      66th American Epilepsy Society Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2012-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 光感受性イオンチャンネルを用いた新しい海馬てんかん発作モデル2012

    • Author(s)
      大沢伸一郎、保坂亮介、松坂義哉、富田浩史、石塚徹、菅野江里子、奥村栄一、八尾寛、中里信和、富永悌二、虫明元
    • Organizer
      第46回日本てんかん学会
    • Place of Presentation
      東京都
    • Year and Date
      2012-10-11
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Separate population of prefrontal neurons represent forthcoming tactics and action at the time of encoding and execution2012

    • Author(s)
      松坂義哉、虫明元
    • Organizer
      第35回日本神経科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of the high frequency activity during the up state of optogenetically entrained neocortical slow oscillation in the anesthetized rat cortex2012

    • Author(s)
      九鬼敏伸、大城朝一、深澤有吾、 松坂 義哉、八尾寛、虫明元
    • Organizer
      第35回日本神経科学会大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] The role of the supplementary eye field in evaluating outcomes during an oculomotor search task2012

    • Author(s)
      Kawaguchi N, Sakamoto K, Furusawa Y, Tanji J, Aoki M, Mushiake H.
    • Organizer
      第35回日本 神経科学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Time-development of excitation- inhibition balance in the prefrontal cortex during a path-planning task2012

    • Author(s)
      Sakamoto K, Saito N, Yoshida S, Katori Y, Tanji J, Aihara K, Mushiake H.
    • Organizer
      第35回日本神経科学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2012-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 行動戦術の選択におけるサル後内側前頭前野の役割2012

    • Author(s)
      松坂義哉
    • Organizer
      第5回東北大学脳科学コアセンターセミナー
    • Place of Presentation
      仙台
    • Year and Date
      2012-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] オプトジェネティクスを用いた新たなけいれんモデル2012

    • Author(s)
      大沢伸一郎、岩崎真樹、保坂亮介、松坂義哉、富田浩史、石塚徹、八尾寛、中里信和、虫明元、冨永悌二
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市
    • Year and Date
      2012-03-29
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Separate population of prefrontal neurons represent forthcoming tactics and action at the time of encoding and execution2012

    • Author(s)
      松坂 義哉 他
    • Organizer
      第35回日本神経科学会大会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 行動戦術の選択におけるサル後内側前頭前野の役割2012

    • Author(s)
      松坂 義哉
    • Organizer
      第五回東北大学脳神経科学コアセンターセミナー
    • Place of Presentation
      仙台市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Analysis of the high frequency activity during the up state of optogenetically entrained neocortical slow oscillation in the anesthetized rat cortex2012

    • Author(s)
      九鬼 敏伸 他
    • Organizer
      第35回日本神経科学会大会
    • Place of Presentation
      名古屋市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Artifact-less observation and low mortality compared with conventional animal models of seizures. It is promising tool to study the mechanism of icto-genesis.2012

    • Author(s)
      Oosawa, S et al
    • Organizer
      66th American Epilepsy Society Annual Meeting
    • Place of Presentation
      San Diego, CA, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 反応タクティックスの選択、記憶、読み出しにおける前頭葉内側皮質の役割2011

    • Author(s)
      松坂, 他
    • Organizer
      第34回日本神経科学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 反応タクティックスの選択、記憶、 読み出しにおける前頭葉内側皮質の役 割2011

    • Author(s)
      Matsuzaka Y、Saito S、Tanji J、Mushiake H
    • Organizer
      第34回日本神経科学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 光遺伝学による大脳皮質神経活動撹乱時の層間結合性の解析2011

    • Author(s)
      九鬼敏伸、松坂義哉、深澤有吾、八尾寛、虫明元
    • Organizer
      第34回日本神経科学会大会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-09-14
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Supervisory role of the primate medial prefrontal cortex in the selection of response tactics2011

    • Author(s)
      Matsuzaka Y, Mushiake H, Tanji J.
    • Organizer
      第1回 東北大学脳科学国際シンポジウム
    • Place of Presentation
      仙台市
    • Year and Date
      2011-01-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Optocurrent-clamp actuation of cortical neurons using a strategically designed channel- rhodopsin2011

    • Author(s)
      Wen L, Wang H, Tanimoto S, Egawa R, Matsuzaka Y, Mushiake H, Isizuka T, Yawo H.
    • Organizer
      第1回 東北大学脳科学国際シンポジウム
    • Place of Presentation
      仙台市
    • Year and Date
      2011-01-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Supervisory role of the primate medial prefrontal cortex in the selection of response tactics.2011

    • Author(s)
      Yoshiya Matsuzaka, Hajime Mushiake, Jun Tanji
    • Organizer
      第1回東北大学脳科学国際シンポジウム2011
    • Place of Presentation
      仙台
    • Year and Date
      2011-01-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新世代チャネルロドプシンのデザイン-評価-神経科学への応用2010

    • Author(s)
      八尾寛、王紅霞、温磊、石塚徹、松坂義哉、虫明元
    • Organizer
      第48回日本生物物理学会年会
    • Place of Presentation
      仙台市
    • Year and Date
      2010-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Neurons in the primate posterior medial prefrontal cortex respond to the clues as to the response rules of forthcoming actions.2010

    • Author(s)
      Yoshiya Matsuzaka, Hajime Mushiake
    • Organizer
      Neuro2010 Japan
    • Place of Presentation
      神戸
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Neurons in the primate posterior medial prefrontal cortex respond to the clues as to the response rules of forthcoming actions2010

    • Author(s)
      Matsuzaka Y, Mushiake H.
    • Organizer
      Neuro 2010 Japan
    • Place of Presentation
      神戸市
    • Year and Date
      2010-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Dynamic causal modeling of effective connectivity during rule changes inirritable bowel syndrome2010

    • Author(s)
      Aizawa E, Sato Y, Kochiyama T, Morisita J, Kanazawa M, Shima K, Hongo M, Mushiake H, Fukudo S.
    • Organizer
      Neuro 2010 Japan
    • Place of Presentation
      神戸市
    • Year and Date
      2010-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] A neurocomputational model for amodal completion in ambiguous figures2010

    • Author(s)
      Sakamoto K, Kumada T, Yano M.
    • Organizer
      Neuro 2010 Japan
    • Place of Presentation
      神戸市
    • Year and Date
      2010-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] Transition of information representation in a multi-stable attractor model of the prefrontal cortex2010

    • Author(s)
      Katori Y, Sakamoto K, Mushiake H, Aihara K.
    • Organizer
      Neuro 2010 Japan
    • Place of Presentation
      神戸市
    • Year and Date
      2010-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代チャネルロドプシン光駆動による大脳皮質神経回路の賦活化2010

    • Author(s)
      温磊、王紅霞、松坂義哉、虫明元、石塚徹、八尾寛
    • Organizer
      文部科学省「脳科学研究戦略推進プログラム」平成22年度第一分科会
    • Place of Presentation
      札幌市
    • Year and Date
      2010-07-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代チャネルロドプシン光駆動による大脳皮質神経回路の賦活化2010

    • Author(s)
      温磊、王紅霞、松坂義哉、虫明元、石塚徹、八尾寛
    • Organizer
      文部科学省「脳科学研究戦略推進プログラム」平成22年度第一分科会
    • Place of Presentation
      札幌
    • Year and Date
      2010-07-27
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tohoku.ac.jp/japanese/2012/02/press20120223-02.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.med.tohoku.ac.jp/news/1283.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 前頭前野に行動戦術の使い分けに関わる新しい領域を発見

    • URL

      http://www.med.tohoku.ac.jp/nsgcoe/ja/upload/MushiakePNAS120228.pdf

    • Related Report
      2012 Annual Research Report
  • [Remarks] オプトジェネティクスによるてんかん発作モデルの開発

    • URL

      http://www.med.tohoku.ac.jp/uploads/130411pressrelease2.pdf

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.tohoku.ac.jp/article/show/id/1283

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.neurophysiology.med.tohoku.ac.jp

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 生体用微小神経電極針体及び生体用微 小神経電極針体の製造方法2012

    • Inventor(s)
      古澤義人、 松坂義哉 、中島敏、小林 弘、中台康紀、高橋善和
    • Industrial Property Rights Holder
      古澤義人、 松坂義哉 、中島敏、小林 弘、中台康紀、高橋善和
    • Industrial Property Number
      2012-222928
    • Filing Date
      2012-10-05
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 神経用電極2012

    • Inventor(s)
      加納宣彦、斉藤克己、虫明元、松坂義哉、川口典彦
    • Industrial Property Rights Holder
      加納宣彦、斉藤克己、虫明元、松坂義哉、川口典彦
    • Industrial Property Number
      2012-177078
    • Filing Date
      2012-08-09
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Patent(Industrial Property Rights)] 筋電位をトリガーとする磁気刺激装置2012

    • Inventor(s)
      出江伸一、高木敏行、永富良一、松坂義哉、石井賢治、中里信和
    • Industrial Property Rights Holder
      出江伸一、高木敏行、永富良一、松坂義哉、石井賢治、中里信和
    • Filing Date
      2012-02-12
    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 生体用微小神経電極針体及び生体用微小神経電極針体の製造方法2012

    • Inventor(s)
      古澤義人、松坂義哉、中島敏、小林弘、中台康紀、高橋善和
    • Industrial Property Rights Holder
      古澤義人、松坂義哉、中島敏、小林弘、中台康紀、高橋善和
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-222928
    • Filing Date
      2012-10-05
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 筋電位をトリガーとする磁気刺激装置2012

    • Inventor(s)
      出江, 他
    • Industrial Property Rights Holder
      出江, 他
    • Filing Date
      2012-02-12
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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