Role of the newly identified area in primate dorsomedial prefrontal conrtex in the integrative regulation of behavioral strategies.

• Project/Area Number: 22500349
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Tohoku University
• Principal Investigator: MATSUZAKA Yoshiya 東北大学, 大学院・医学系研究科, 講師 (30312557)
• Co-Investigator(Kenkyū-buntansha): SHIMA Keisetsu 東北大学, 大学院・医学系研究科, 助教 (60124583)
• Co-Investigator(Renkei-kenkyūsha): SAKAMOTO Kazuhiro 東北大学, 電気通信研究所, 助教 (80261569)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: システム神経生理 / ニューロインフォマティクス / 背内側前頭前野 / 前頭前野 / ニューロン / 活動電位 / 行動戦術 / ニホンザル / 戦略 / 戦術

Research Abstract

Monkeys performed a task in which consecutively given cues allowed them to narrow down the response strategy and the action out of multiple possible choices. Neuronal activity recorded in the dorsomedial prefrontal cortex indicates that neurons in this region

Research Products

• [Journal Article] Participation of neurons in multiple sectors of medial frontal cortex undergoes dynamic alterations depending on the demand for volitional control of action (2013)
  • Author(s): Yoshiya Matsuzaka, Tetsuya Akiyama, Hajime Mushiake
  • Journal Title: Experimental Brain Res Volume: 229 Issue: 3 Pages: 395-405
  • DOI: 10.1007/s00221-013-3454-z
  • Peer Reviewed
• [Journal Article] Neuronal representation of task performance in the media frontal cortex undergoes dynamic alterations dependent upon the demand for volitional control of action (2013)
  • Author(s): Matsuzaka, Y et al
  • Journal Title: Experimental Brain Research Volume: Epub. ahead of print
  • Peer Reviewed
• [Journal Article] Optogenetically Induced Seizure and the Longitudinal Hippocampal Network Dynamics (2013)
  • Author(s): Osawa, S et al
  • Journal Title: PLoS ONE Volume: Epub. ahead of print
  • Peer Reviewed
• [Journal Article] Frequency-dependent entrainment of neocortical slow oscillation to repeated optogenetic stimulation in the anesthetized rat (2012)
  • Author(s): Kuki T, Ohshiro T, Ito S, Ji G, Fukazawa Y, Matsuzaka Y, Yawo H, Mushiake H.
  • Journal Title: Neurosci Res Volume: 75 Issue: 1 Pages: 35-45
  • DOI: 10.1016/j.neures.2012.10.007
  • Peer Reviewed
• [Journal Article] Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics. (2012)
  • Author(s): Matsuzaka Y, Akiyama T, Tanji J, Mushiake H.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 109 Issue: 12 Pages: 4633-8
  • DOI: 10.1073/pnas.1119971109
  • Peer Reviewed
• [Journal Article] Bio-amplifier with driven shield inputs to reduce electrical noise and its application to laboratory teaching of electro- physiology (2012)
  • Author(s): Matsuzaka Y, Ichihara T, Abe T, Mushiake H
  • Journal Title: J Undergrad Neurosci Educ Volume: 10
  • Peer Reviewed
• [Journal Article] Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling (2012)
  • Author(s): Aizawa E, Sato Y, Kochiyama T, Saito N, Izumiyama M, Morishita J, Kanazawa M, Shima K, Mushiake H, Hongo M, Fukudo S
  • Journal Title: Gastroenterology Volume: 143(5) Issue: 5 Pages: 1188-1198
  • DOI: 10.1053/j.gastro.2012.07.104
  • Peer Reviewed
• [Journal Article] Neuronal activity in the primate dorsomedial prefrontal cortex contributes to strategic selection of response tactics (2012)
  • Author(s): Matsuzaka, et al
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 4633-4638
  • Peer Reviewed
• [Journal Article] Bio-amplifier with driven shield inputs to reduce electrical noise and its application to laboratory teaching of electrophysiology (2012)
  • Author(s): Matsuzaka, et al
  • Journal Title: Journal of Undergraduate Neuroscience Education Volume: 10 Pages: 118-124
  • Peer Reviewed
• [Journal Article] Roles of the medial frontal cortices in the selection, storage and retrieval of response tactics in a voluntary arm-reaching task (2011)
  • Author(s): Matsuzaka Y, et al
  • Journal Title: Neurosci Res Volume: 71
• [Journal Article] Deciphering elapsed time and predicting action timing from neuronal population signals (2011)
  • Author(s): S.Shinomoto, T.Omi, A.Mita, H.Mushiake, K.Shima, Y.Matsuzaka, J.Tanji
  • Journal Title: Frontiers in Computational Neuroscience Volume: 5 Pages: 29-29
  • DOI: 10.3389/fncom.2011.00029
  • Peer Reviewed
• [Journal Article] Analysis of functional connectivity among cortical layersduring optogenetically induced perturbations (2011)
  • Author(s): Kuki T, Matuzaka Y, Fukazawa Y, Yawo H, Mushiake H.
  • Journal Title: Neurosci Res Volume: 71
• [Journal Article] Deciphering elapsed time and predicting action timing from neuronal population signals (2011)
  • Author(s): Shinomoto, et al
  • Journal Title: Front Comput Neurosci Volume: 5 Pages: 29-39
  • Peer Reviewed
• [Journal Article] Analysis of functional connectivity among cortical layers during optogen etically induced perturbations (2011)
  • Author(s): Kuki, et al
  • Journal Title: Neurosci Res Volume: 71
• [Journal Article] Roles of the medial frontal cortices in the selection, storage and retrieval of response tactics in a voluntary arm-reaching task (2011)
  • Author(s): Matsuzaka, et al
  • Journal Title: Neurosci Res Volume: 71
• [Journal Article] Optimization of neuronal representation of action in primate supplementary motor area (2010)
  • Author(s): Matsuzaka Y, et al
  • Journal Title: J Physiol Sci Volume: 60
• [Journal Article] Opto-current-clamp actuation of cortical neurons using a strategically designed channel- rhodopsin (2010)
  • Author(s): Wen L, Wang H, Tanimoto S, Egawa R, Matsuzaka Y, Mushiake H, Ishizuka T, Yawo H.
  • Journal Title: PLoS ONE Volume: 5 Issue: 9 Pages: 1-13
  • DOI: 10.1371/journal.pone.0012893
  • Peer Reviewed
• [Journal Article] Deficits in action selection based on numericalinformation after inactivation of the posterior parietal cortex in monkeys (2010)
  • Author(s): Sawamura H, Shima K, Tanji J.
  • Journal Title: J Neurophysiol Volume: 104 Pages: 902-910
  • URL: http://jn.physiology.org/content/104/2/902.long
  • Peer Reviewed
• [Journal Article] Opto-current-clamp actuation of cortical neurons using a strategically de signed channelrhodopsin (2010)
  • Author(s): Wen-L, 他
  • Journal Title: Plos-One Volume: 5 Pages: 12890-12890
  • Peer Reviewed
• [Presentation] てんかん発作における海馬長軸方向ネットワークの重要性:オプトジェネティクスを用いた海馬けいれんモデルでの検討 (2013)
  • Author(s): 大沢伸一郎,岩崎真樹,保坂亮介,松坂義哉,富田浩史,石塚徹,菅野江里子,奥村栄一,八尾寛,中里信和,虫明元,冨永悌二
  • Organizer: 第36回日本てんかん外科学会
  • Place of Presentation: 岡山市
  • Year and Date: 2013-01-17
• [Presentation] てんかん発作における海馬長軸方向ネットワークの重要性：オプトジェネティクスを用いた海馬けいれんモデルでの検討 (2013)
  • Author(s): 大沢 伸一郎 他
  • Organizer: 第36回日本てんかん外科学会
  • Place of Presentation: 岡山市
• [Presentation] Artifact-less observation and low mortality compared with conventional animal models of seizures. It is promising tool to study the mechanism of ictogenesis (2012)
  • Author(s): Osawa S, Iwasaki M, Hosaka R, Matsuzaka Y, Tomita H, Ishizuka T, Sugano E, Okumura E, Yawo H, Nakasato N, Tominaga T, Mushiake H.
  • Organizer: 66th American Epilepsy Society Annual Meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2012-11-13
• [Presentation] 光感受性イオンチャンネルを用いた新しい海馬てんかん発作モデル (2012)
  • Author(s): 大沢伸一郎、保坂亮介、松坂義哉、富田浩史、石塚徹、菅野江里子、奥村栄一、八尾寛、中里信和、富永悌二、虫明元
  • Organizer: 第46回日本てんかん学会
  • Place of Presentation: 東京都
  • Year and Date: 2012-10-11
• [Presentation] Separate population of prefrontal neurons represent forthcoming tactics and action at the time of encoding and execution (2012)
  • Author(s): 松坂義哉、虫明元
  • Organizer: 第35回日本神経科学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-17
• [Presentation] Analysis of the high frequency activity during the up state of optogenetically entrained neocortical slow oscillation in the anesthetized rat cortex (2012)
  • Author(s): 九鬼敏伸、大城朝一、深澤有吾、 松坂 義哉、八尾寛、虫明元
  • Organizer: 第35回日本神経科学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-17
• [Presentation] The role of the supplementary eye field in evaluating outcomes during an oculomotor search task (2012)
  • Author(s): Kawaguchi N, Sakamoto K, Furusawa Y, Tanji J, Aoki M, Mushiake H.
  • Organizer: 第35回日本 神経科学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2012-09-17
• [Presentation] Time-development of excitation- inhibition balance in the prefrontal cortex during a path-planning task (2012)
  • Author(s): Sakamoto K, Saito N, Yoshida S, Katori Y, Tanji J, Aihara K, Mushiake H.
  • Organizer: 第35回日本神経科学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2012-09-17
• [Presentation] 行動戦術の選択におけるサル後内側前頭前野の役割 (2012)
  • Author(s): 松坂義哉
  • Organizer: 第5回東北大学脳科学コアセンターセミナー
  • Place of Presentation: 仙台
  • Year and Date: 2012-08-24
• [Presentation] オプトジェネティクスを用いた新たなけいれんモデル (2012)
  • Author(s): 大沢伸一郎、岩崎真樹、保坂亮介、松坂義哉、富田浩史、石塚徹、八尾寛、中里信和、虫明元、冨永悌二
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本市
  • Year and Date: 2012-03-29
• [Presentation] Separate population of prefrontal neurons represent forthcoming tactics and action at the time of encoding and execution (2012)
  • Author(s): 松坂 義哉 他
  • Organizer: 第35回日本神経科学会大会
  • Place of Presentation: 名古屋市
• [Presentation] 行動戦術の選択におけるサル後内側前頭前野の役割 (2012)
  • Author(s): 松坂 義哉
  • Organizer: 第五回東北大学脳神経科学コアセンターセミナー
  • Place of Presentation: 仙台市
  • Invited
• [Presentation] Analysis of the high frequency activity during the up state of optogenetically entrained neocortical slow oscillation in the anesthetized rat cortex (2012)
  • Author(s): 九鬼 敏伸 他
  • Organizer: 第35回日本神経科学会大会
  • Place of Presentation: 名古屋市
• [Presentation] Artifact-less observation and low mortality compared with conventional animal models of seizures. It is promising tool to study the mechanism of icto-genesis. (2012)
  • Author(s): Oosawa, S et al
  • Organizer: 66th American Epilepsy Society Annual Meeting
  • Place of Presentation: San Diego, CA, USA
• [Presentation] 反応タクティックスの選択、記憶、読み出しにおける前頭葉内側皮質の役割 (2011)
  • Author(s): 松坂, 他
  • Organizer: 第34回日本神経科学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-09-16
• [Presentation] 反応タクティックスの選択、記憶、 読み出しにおける前頭葉内側皮質の役 割 (2011)
  • Author(s): Matsuzaka Y、Saito S、Tanji J、Mushiake H
  • Organizer: 第34回日本神経科学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-09-14
• [Presentation] 光遺伝学による大脳皮質神経活動撹乱時の層間結合性の解析 (2011)
  • Author(s): 九鬼敏伸、松坂義哉、深澤有吾、八尾寛、虫明元
  • Organizer: 第34回日本神経科学会大会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-09-14
• [Presentation] Supervisory role of the primate medial prefrontal cortex in the selection of response tactics (2011)
  • Author(s): Matsuzaka Y, Mushiake H, Tanji J.
  • Organizer: 第1回 東北大学脳科学国際シンポジウム
  • Place of Presentation: 仙台市
  • Year and Date: 2011-01-21
• [Presentation] Optocurrent-clamp actuation of cortical neurons using a strategically designed channel- rhodopsin (2011)
  • Author(s): Wen L, Wang H, Tanimoto S, Egawa R, Matsuzaka Y, Mushiake H, Isizuka T, Yawo H.
  • Organizer: 第1回 東北大学脳科学国際シンポジウム
  • Place of Presentation: 仙台市
  • Year and Date: 2011-01-21
• [Presentation] Supervisory role of the primate medial prefrontal cortex in the selection of response tactics. (2011)
  • Author(s): Yoshiya Matsuzaka, Hajime Mushiake, Jun Tanji
  • Organizer: 第1回東北大学脳科学国際シンポジウム2011
  • Place of Presentation: 仙台
  • Year and Date: 2011-01-21
• [Presentation] 新世代チャネルロドプシンのデザイン-評価-神経科学への応用 (2010)
  • Author(s): 八尾寛、王紅霞、温磊、石塚徹、松坂義哉、虫明元
  • Organizer: 第48回日本生物物理学会年会
  • Place of Presentation: 仙台市
  • Year and Date: 2010-09-20
• [Presentation] Neurons in the primate posterior medial prefrontal cortex respond to the clues as to the response rules of forthcoming actions. (2010)
  • Author(s): Yoshiya Matsuzaka, Hajime Mushiake
  • Organizer: Neuro2010 Japan
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-03
• [Presentation] Neurons in the primate posterior medial prefrontal cortex respond to the clues as to the response rules of forthcoming actions (2010)
  • Author(s): Matsuzaka Y, Mushiake H.
  • Organizer: Neuro 2010 Japan
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-01
• [Presentation] Dynamic causal modeling of effective connectivity during rule changes inirritable bowel syndrome (2010)
  • Author(s): Aizawa E, Sato Y, Kochiyama T, Morisita J, Kanazawa M, Shima K, Hongo M, Mushiake H, Fukudo S.
  • Organizer: Neuro 2010 Japan
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-01
• [Presentation] A neurocomputational model for amodal completion in ambiguous figures (2010)
  • Author(s): Sakamoto K, Kumada T, Yano M.
  • Organizer: Neuro 2010 Japan
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-01
• [Presentation] Transition of information representation in a multi-stable attractor model of the prefrontal cortex (2010)
  • Author(s): Katori Y, Sakamoto K, Mushiake H, Aihara K.
  • Organizer: Neuro 2010 Japan
  • Place of Presentation: 神戸市
  • Year and Date: 2010-09-01
• [Presentation] 次世代チャネルロドプシン光駆動による大脳皮質神経回路の賦活化 (2010)
  • Author(s): 温磊、王紅霞、松坂義哉、虫明元、石塚徹、八尾寛
  • Organizer: 文部科学省「脳科学研究戦略推進プログラム」平成22年度第一分科会
  • Place of Presentation: 札幌市
  • Year and Date: 2010-07-27
• [Presentation] 次世代チャネルロドプシン光駆動による大脳皮質神経回路の賦活化 (2010)
  • Author(s): 温磊、王紅霞、松坂義哉、虫明元、石塚徹、八尾寛
  • Organizer: 文部科学省「脳科学研究戦略推進プログラム」平成22年度第一分科会
  • Place of Presentation: 札幌
  • Year and Date: 2010-07-27
• [Remarks]
  • URL: http://www.tohoku.ac.jp/japanese/2012/02/press20120223-02.html
• [Remarks]
  • URL: http://www.med.tohoku.ac.jp/news/1283.html
• [Remarks] 前頭前野に行動戦術の使い分けに関わる新しい領域を発見
  • URL: http://www.med.tohoku.ac.jp/nsgcoe/ja/upload/MushiakePNAS120228.pdf
• [Remarks] オプトジェネティクスによるてんかん発作モデルの開発
  • URL: http://www.med.tohoku.ac.jp/uploads/130411pressrelease2.pdf
• [Remarks]
  • URL: http://www.med.tohoku.ac.jp/article/show/id/1283
• [Remarks]
  • URL: http://www.neurophysiology.med.tohoku.ac.jp
• [Patent(Industrial Property Rights)] 生体用微小神経電極針体及び生体用微 小神経電極針体の製造方法 (2012)
  • Inventor(s): 古澤義人、 松坂義哉 、中島敏、小林 弘、中台康紀、高橋善和
  • Industrial Property Rights Holder: 古澤義人、 松坂義哉 、中島敏、小林 弘、中台康紀、高橋善和
  • Industrial Property Number: 2012-222928
  • Filing Date: 2012-10-05
• [Patent(Industrial Property Rights)] 神経用電極 (2012)
  • Inventor(s): 加納宣彦、斉藤克己、虫明元、松坂義哉、川口典彦
  • Industrial Property Rights Holder: 加納宣彦、斉藤克己、虫明元、松坂義哉、川口典彦
  • Industrial Property Number: 2012-177078
  • Filing Date: 2012-08-09
• [Patent(Industrial Property Rights)] 筋電位をトリガーとする磁気刺激装置 (2012)
  • Inventor(s): 出江伸一、高木敏行、永富良一、松坂義哉、石井賢治、中里信和
  • Industrial Property Rights Holder: 出江伸一、高木敏行、永富良一、松坂義哉、石井賢治、中里信和
  • Filing Date: 2012-02-12
• [Patent(Industrial Property Rights)] 生体用微小神経電極針体及び生体用微小神経電極針体の製造方法 (2012)
  • Inventor(s): 古澤義人、松坂義哉、中島敏、小林弘、中台康紀、高橋善和
  • Industrial Property Rights Holder: 古澤義人、松坂義哉、中島敏、小林弘、中台康紀、高橋善和
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-222928
  • Filing Date: 2012-10-05
• [Patent(Industrial Property Rights)] 筋電位をトリガーとする磁気刺激装置 (2012)
  • Inventor(s): 出江, 他
  • Industrial Property Rights Holder: 出江, 他
  • Filing Date: 2012-02-12