Modulatory effects ofperineuronalglial cells on neuronal activities of pyramidal cells

• Project/Area Number: 22500352
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Yamagata University
• Principal Investigator: YAMAZAKI Yoshihiko 山形大学, 医学部, 准教授 (10361247)
• Research Collaborator: KANEKO Kenya 山形大学, 医学部, 技術専門職員
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 海馬 / グリア / 錐体細胞 / 活動電位 / 発火周波数 / CA1 / グリア細胞 / 静止膜電位

Research Abstract

We identified perineuronal glial cells (PNG) of pyramidal cells in CA1 region of the rat hippocampus. The maximum firing frequency of the pyramidal cells accompanying the PNG was significantly smaller than that of the pyramidal cells without PNG. Direct depolarization of PNG increased the firing frequency of action potentials of pyramidal cells, especially in the initial phase of the depolarization. These results indicate that the PNG modulate the activity of pyramidal cells constitutively and activity-dependently.

Research Products

• [Journal Article] Increased astrocytic ATP release results in enhanced excitability of the hippocampus. (2012)
  • Author(s): Lee HU, Yamazaki Y, Tanaka KF, Furuya K, Sokabe M, Hida H, Takao K, Miyakawa T, Fujii S, Ikenaka K.
  • Journal Title: These^† authors contributed equally to this work Volume: 61 Issue: 2 Pages: 210-224
  • DOI: 10.1002/glia.22427
  • Peer Reviewed
• [Journal Article] Activation of inositol 1, 4, 5-trisphosphate receptors during preconditioning low-frequency stimulation leads to reversal of long-term potentiation in hippocampal CA1 neurons (2012)
  • Author(s): Yamazaki Y
  • Journal Title: Neuroscience Volume: 207 Pages: 1-11
  • DOI: 10.1016/j.neuroscience.2012.01.045
  • Peer Reviewed
• [Journal Article] NMDA receptor-mediated Ca(2+) influx triggers nucleocytoplasmic translocation of diacylglycerol kinase ζ under oxygen-glucose deprivation conditions, an in vitro model of ischemia, in rat hippocampal slices (2012)
  • Author(s): Suzuki Y, Yamazaki Y, Hozumi Y, Okada M, Tanaka T, Iseki K, Ohta N, Aoyagi M, Fujii S, Goto K.
  • Journal Title: Histochem CellBiol Volume: 137 Issue: 4 Pages: 499-511
  • DOI: 10.1007/s00418-011-0907-y
  • Peer Reviewed
• [Journal Article] Suppressive effect of preconditioning low-frequency stimulation on subsequent induction of long-term potentiation by high frequency stimulation in hippocampal CA3 neurons (2012)
  • Author(s): Yamazaki Y, Fujii S, Goto J, Sugihara T, Sugita M, Fujiwara H, Kaneko K, Aihara T, Mikoshiba K
  • Journal Title: Brain Research Volume: Vol.1449 Pages: 15-23
  • DOI: 10.1016/j.brainres.2012.02.025
  • Peer Reviewed
• [Journal Article] Role of inositol 1,4,5-trisphosphate receptors in the post synaptic expression of guinea pig hippocampal mossy fiber depotentiation (2011)
  • Author(s): Yamazaki Y
  • Journal Title: Brain Res Volume: 1387 Pages: 19-28
  • DOI: 10.1016/j.brainres.2011.02.088
  • Peer Reviewed
• [Journal Article] Impaired hippocampal long-term potentiation and failure of learning in β1,4-N-acetylgalactosaminyl transferase gene transgenic mice (2011)
  • Author(s): Ikarashi K, Fujiwara H, Yamazaki^* Y, Goto JI, Kaneko K, Kato H, Fujii S, Sasaki H, Fukumoto S, Furukawa K, Waki H, Furukawa K.
  • Journal Title: corresponding^* author Volume: 21 Issue: 10 Pages: 1373-1381
  • DOI: 10.1093/glycob/cwr090
  • Peer Reviewed
• [Journal Article] Nicotine facilitates long-term potentiation induction in oriens-lacunosum moleculare cells via Ca^<2+> entry through nonα7 nicotinic acetylcholine receptors (2010)
  • Author(s): Jia Y, Yamazaki Y, Nakauchi S, Ito K-I, Sumikawa K.
  • Journal Title: These^ authors contributed equally to this work Volume: 31 Issue: 3 Pages: 463-476
  • DOI: 10.1111/j.1460-9568.2009.07058.x
  • Peer Reviewed
• [Journal Article] Intracellular calcium ion dynamics involved in long-term potentiation in hippocampal CA1 neurons in mice lacking the IP3 type 1 receptor (2010)
  • Author(s): Yoshioka, Yamazaki, et al.
  • Journal Title: Neuroscience Research Volume: 67 Pages: 149-155
  • Peer Reviewed
• [Journal Article] Modulation of neuronal activities by interactions between neurons and glial cells (2010)
  • Author(s): Yamazaki, et al.
  • Journal Title: Hirosaki Medical Journal Volume: 60 Pages: 174-180
• [Journal Article] Involvement of IP3 receptors in synaptic plasticity induced in hippocampal CA1 neurons by low-frequency stimulation (2010)
  • Author(s): Fujii, Yamazaki, et al.
  • Journal Title: Neuroscience Volume: 168 Pages: 346-358
  • Peer Reviewed
• [Journal Article] 海馬神経回路におけるニコチンの作用 (2010)
  • Author(s): 山崎良彦
  • Journal Title: 日本薬理学雑誌 Volume: 136 Pages: 31-35
  • Peer Reviewed
• [Presentation] 海馬白板のオリゴデンドロサイト脱分極による活動電位の軸索伝導に対する修飾効果 (2012)
  • Author(s): 山崎良彦
  • Organizer: 第4回光操作研究会(招待講演)
  • Place of Presentation: 岡崎市,自然科学研究機構岡崎カンファレンスセンター
  • Year and Date: 2012-09-27
• [Presentation] Facilitative effects of oligodendrocytes depolarization on the axonal conduction in the white matter of murine hippocampus (2012)
  • Author(s): Yamazaki Y.
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋市,名古屋国際会議場
  • Year and Date: 2012-09-20
• [Presentation] Modulatory effects of periinterneuronal oligodendrocyte on interneuronal firing inCA1 region of rat hippocampus (2012)
  • Author(s): Yamazaki Y.
  • Organizer: 第89回日本生理学会大会
  • Place of Presentation: 松本市,松本文化会館
  • Year and Date: 2012-03-29
• [Presentation] Modulatory effects of peri-interneuronal oligodendrocyte on interneuronal firing inCA1 region of rat hippocampus (2012)
  • Author(s): Yamazaki Y, et al.
  • Organizer: 第89回 日本生理学会大会
  • Place of Presentation: 松本(松本文化会館)
  • Year and Date: 2012-03-29
• [Presentation] Oligodendrocyte dysfunction hypothesis in schizophrenia and beyond (2012)
  • Author(s): Tanaka K, Yamazaki Y, et al.
  • Organizer: 第85回 日本薬理学会年会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2012-03-15
• [Presentation] Facilitative effects of oligo- dendrocytes depolarization on the axonal conduction in the white matter of murine hippocampus (2012)
  • Author(s): 山崎良彦
  • Organizer: 第35回 日本神経科学大会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 海馬白板のオリゴデンドロサイト脱分極による活動電位の軸索伝導に対する修飾効果 (2012)
  • Author(s): 山崎良彦
  • Organizer: 第4回 光操作研究会
  • Place of Presentation: 自然科学研究機構 岡崎カンファレンスセンター（岡崎市）
  • Invited
• [Presentation] 介在ニューロン付随性オリゴデンドロサイトによる介在ニューロン発火に対する修飾効果 (2010)
  • Author(s): 山崎良彦
  • Organizer: 第43回東北生理談話会
  • Place of Presentation: 秋田市,秋田大学
  • Year and Date: 2010-10-16
• [Presentation] 介在ニューロン付随性オリゴデンドロサイトによる介在ニューロン発火に対する修飾効果 (2010)
  • Author(s): 山崎良彦
  • Organizer: 第43回東北生理談話会
  • Place of Presentation: 秋田
  • Year and Date: 2010-10-16
• [Presentation] Properties of perineuronal oligodendrocytes and its modulatory effects on neuronal activities in CA1 region of rat hippocampus (2010)
  • Author(s): Yamazaki Y.
  • Organizer: The 29th Naito Conference "Glia world-dynamic function of glial cells in the brain"(招待講演)
  • Place of Presentation: 神奈川県葉山町,湘南国際村センター
  • Year and Date: 2010-10-07
• [Presentation] Properties of perineuronal oligodendrocytes and its modulatory effects on neuronal activities in CA1 region of rat hippocampus (2010)
  • Author(s): Yamazaki, Yoshihiko
  • Organizer: The 29th Naito Conference"Glia World-Dynamicfunction of glial cells in the brain"
  • Place of Presentation: Hayama, Kanagawa(招待講演)
  • Year and Date: 2010-10-07
• [Remarks]
  • URL: http://www.id.yamagata-u.ac.jp/PhysiologyII/Physiol2-J.html
• [Remarks]
  • URL: http://www.id.yamagata-u.ac.jp/PhysiologyII/Physiol2-J.html
• [Remarks]
  • URL: http://www.id.yamagata-u.ac.jp/PhysiologyII/Physiol2-J.html