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Studying the neural network involving the innate behavior in the olfactory system

Research Project

Project/Area Number 22500354
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionThe University of Tokyo

Principal Investigator

SAITO Harumi  東京大学, 大学院・理学系研究科, 特任助教 (20311342)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords嗅覚受容体 / 恐怖行動 / 神経回路
Research Abstract

The aim of present study is to investigate the neural network of fear response behavior coursed by the stimulation of fox odor “2,4,5-trimethylth iazoline (TMT)”. In order to clarify the functional domain of freezing behavior in the brain, we first identified the ORs (olfactory receptors) specifically activated by TMT and making the knock-out and knock-in mouse for the deletion and activation of olfactory neurons using these ORs. We also established the assay system analyzing the neural activity and behavior using unanesthetized mouse.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 Other

All Journal Article (1 results) Presentation (6 results)

  • [Journal Article] Agonist-Independent Receptor Activity

    • Author(s)
      Nakashima A, Takeuchi H Imai T Saito H Nishizumi H Sakano H In Press
    • Journal Title

      Regulates Axon Targeting of Olfactory Neurons

    • Related Report
      2012 Final Research Report
  • [Presentation] Isolation of odorantreceptor genes for fearful responses in the mouse2012

    • Author(s)
      齊藤治美
    • Organizer
      日本生理学会
    • Place of Presentation
      信州大学(長野・松本)
    • Year and Date
      2012-03-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Isolation of odorant receptor genes for fearful responses in the mouse2012

    • Author(s)
      齊藤治美
    • Organizer
      日本生理学会
    • Place of Presentation
      信州大学(長野・松本)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Isolation of odorantreceptor genes for fearful responses in the mouse2011

    • Author(s)
      齊藤治美
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ(神奈川・横浜)
    • Year and Date
      2011-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Isolation of odorant receptor genes for fearful responses in the mouse2011

    • Author(s)
      齊藤治美
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ(神奈川・横浜)
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Isolation of odorantreceptor genes for fearful responses in the mouse2011

    • Author(s)
      斉藤治美
    • Organizer
      Frontiers in Neuroscience
    • Place of Presentation
      国際高等研究所(京都府・木津川市)
    • Year and Date
      2011-12-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Isolation of odorant receptor genes for fearful responses in the mouse2011

    • Author(s)
      齊藤治美
    • Organizer
      Frontiers in Neuroscience
    • Place of Presentation
      国際高等研究所(京都府・木津川市)
    • Year and Date
      2011-12-06
    • Related Report
      2011 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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